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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 中年直立性低血压和晕倒的风险显示文摘每年有1/3老年人晕倒。直立性低血压(orthostatic hypotension,OH)被认为是晕倒的重要危险因素之一,但先前对此研究的结论并不一致。 | Juraschek SP Daya N Appel LJ Miller ER Windham BG Pompeii L Griswold ME Kucharska-Newton A Selvin E 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 3 |
| 3 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 4 | Differential growth factor regulation of N-cadherin expression and motility in normal and malignant oral epithelium显示文摘 | Diamond ME Sun L Ottaviano AJ | 2008 | J Cell Sci2008，121，13： | 1 |
| 5 | The profibrinolytic effect of activated protein C in clots formed front plasma is TAFI-dependent 显示文摘 | Bajzar L Nesheim ME Traey PB | 1996 | Blood1996，88，6： | 1 |
| 6 | Effects of residual and reapplied biosolids on performance and mineral status of grazing beef steers显示文摘 | Tiffany M E Me Dowell L R O'connor G A etal | 2002 | Journal of Animal Science2002，80，： | 1 |
| 7 | Gardnerella vaginalis in perpubertal girls显示文摘 | Bartley DL Morgan L Rinsza ME | 1987 | Am J Dis Child1987，14，9： | 1 |
| 8 | CD8+- T- cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventionl CD4+ T cells显示文摘 | Casciotti L Ely K Williams ME | 2002 | Infect Immune2002，70，2： | 1 |
| 9 | Acetaldehyde increases the activity and gene expression of urokinase type plasminogen activator in a hepatic stellate cell line显示文摘 | Rodrīguez-Fragoso L Alvarez R Reyes-Esparza JA Garcés ME | 1999 | Toxicology1999，137，： | 1 |
| 10 | Ferbrile reactions to platelet transfusion: the effect of increased IL-6 levels in concentrates prepared by the platelet- rich plasma mothod显示文摘 | Muller L Wonters E Petermans ME | 1998 | Transfusion1998，40，7： | 1 |
| 11 | Tissue-specific plantar fascia-stretching exercise enhances outcomes in patients with ch ronic heel pain: A prospective, randomized study显示文摘 | DiGiovanni BF Nawoczenski DA L intal ME | 2003 | J Bone Joint Surg Am2003，85，： | 1 |
| 12 | Quality of different chondroitin sulfate preparations in relation to their therapeutic activity显示文摘 | MEERW ME BOUT J V D | 2009 | J Pharm Pharmacol2009，61，10： | 1 |
| 13 | The determinants of national innovative capacity显示文摘 | FurmanJ L Porter ME Stern S | 2002 | Research Policy2002，31，6： | 1 |
| 14 | Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis:nonresistant cells die by nonapoptotie cell death显示文摘 | Berdiel-Acer M Bohem ME López-Doriga A | 2011 | Neoplasia2011，13，10： | 1 |
| 15 | Corneal morphology and sensitivity in lattice dystrophy type Ⅱ (familial amyloidosis,Finnish type)显示文摘 | Rosenberg ME Tervo TM Gallar J Acosta MC Muller L J Moilanen JA | | 0，，3： | 1 |
| 16 | Serum soluble urokinase-type plasminogen activator receptor levels and idiopathic FSGS in children:a single-center report 显示文摘 | Bock ME Price HE Gallon L | 2013 | Clin J Am Soc Nephrol2013，8，8： | 1 |
| 17 | Regulation of ubiquitination?mediated protein degradation by survival kinases in cancer显示文摘 | Yamaguchi H Hsu]L Hung Me | 2012 | Front Oncol2012，2，： | 1 |
| 18 | Part 14 :pediatric advanced life support : 2010 American Heart AssociationGuidelines for Cardiopulmonary Resuscitation and EmergencyCardiovascular Care 显示文摘 | Kleinman ME Chameides L Schexnayder SM | 2010 | Circulation2010，122，183： | 1 |
| 19 | Broad, hybrid capture-based next-generation sequencing identifies actionable genomic alterations inlung adenocarcinomas otherwise negative for such alterations by othergenomic testing approaches 显示文摘 | Drilon A Wang L Arcila ME | 2015 | Clin Cancer Res2015，21，16： | 1 |
| 20 | A disintegrin and metal- loprotease protein- 12 as a novel marker for the diagnosis of ec- topic pregnancy显示文摘 | Rausch ME Beer L Sarnmel MD | 2011 | Fertil Steril2011，95，： | 1 |
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