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| 1 | Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis显示文摘BACKGROUND Timely differentiation of biliary atresia(BA)from other infantile cholestatic diseases can impact patient outcomes.Additionally,non-invasive staging of fibrosis after Kasai hepatoportoenterostomy has not been widely standardized.Shear wave elastography is an ultrasound modality that detects changes in tissue stiffness.The authors propose that the utility of elastography in BA can be elucidated through meta-analysis of existing studies.AIM To assess the utility of elastography in:(1)BA diagnosis,and(2)post-Kasai fibrosis surveillance.METHODS A literature search identified articles that evaluated elastography for BA diagnosis and for post-Kasai follow-up.Twenty studies met criteria for meta-analysis:Eleven for diagnosis and nine for follow-up post-Kasai.Estimated diagnostic odds ratio(DOR),sensitivity,and specificity of elastography were calculated through a random-effects model using Meta-DiSc software.RESULTS Mean liver stiffness in BA infants at diagnosis was significantly higher than in non-BA,with overall DOR 24.61,sensitivity 83%,and specificity 79%.Post-Kasai,mean liver stiffness was significantly higher in BA patients with varices than in patients without,with DOR 16.36,sensitivity 85%,and specificity 76%.Elastography differentiated stage F4 fibrosis from F0-F3 with DOR of 70.03,sensitivity 96%,and specificity 89%.Elastography also differentiated F3-F4 fibrosis from F0-F2 with DOR of 24.68,sensitivity 85%,and specificity 81%.CONCLUSION Elastography has potential as a non-invasive modality for BA diagnosis and surveillance post-Kasai.This paper’s limitations include inter-study method heterogeneity and small sample sizes.Future,standardized,multi-center studies are recommended. | Ellen S Wagner Hussien Ahmed H Abdelgawad Meghan Landry Belal Asfour Mark B Slidell Ruba Azzam | 2022 | World Journal of Gastroenterology2022，28，32： | 5 |
| 2 | PicoJava: a direct execution engine for Java bytecode 显示文摘 | MeGhan H O' Connor J M | 1998 | Computer1998，31，10： | 1 |
| 3 | Feeding enriched omega-3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-land cholesterol levels显示文摘 | DENIS M MEDEIROS MEGHAN H | 2007 | Nutrition Research2007，27，5： | 1 |
| 4 | Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder显示文摘 | Manpreet K Singh Kiki D Chang Michael C Chen Ryan G Kelley Amy Garrett Myles M Mitsunaga Layla Bararpour Meghan Howe Allan L Reiss Ian H Gotlib | 2012 | Bipolar Disorders2012，，6： | 1 |
| 5 | A com- parison of direct versus self-report measures for assessing phys- ical activity in adults: A systematic review显示文摘 | STEPHANIE A P KRISTI B A MEGHAN E H etal | 2008 | Inter J Behav Nutr and Phy2008，5，6： | 1 |
| 6 | Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1显示文摘 | Zhang Z Lu H Huan F Meghan C Yang X Wang Y | 2014 | Int J Cancer2014，134，7： | 1 |
| 7 | Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C显示文摘 | Robin H Tarek H Meghan C | 2003 | Journal of the International Neuropsychological Society2003，9，： | 1 |
| 8 | Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome显示文摘Intraductal papillary mucinous neoplasm(IPMN) is a mucin-producing epithelial neoplasm that carries a risk of progression to invasive pancreatic ductal adenocarcinoma.Lynch syndrome is an autosomal dominant condition caused by germline mutations in mismatch repair genes such as MSH2 that lead to microsatellite instability and increased risk of tumor formation.Although families with Lynch syndrome have an increased risk of pancreatic cancer, a clear connection between Lynch syndrome and IPMN has not been drawn.We present a report of a 58 year-old Caucasian woman with multiple cancers and a germline mutation of MSH2 consistent with Lynch syndrome.A screening abdominal computed tomography scan revealed a dilated main pancreatic duct and cystic ductular structure in the uncinate process that were consistent with IPMN of the main pancreatic duct on excision.Immunohistochemistry and polymerase chain reaction of the patient's pancreas specimen did not reveal microsatellite instability or mismatch repair gene loss of expression or function.Our findings may be explained by the fact that loss of mismatch repair function and microsatellite instability is a late event in neoplastic transformation.Given the relative rarity of main duct IPMN, its appearance in the setting of somatic MSH2 mutation suggests that IPMN may fit into the constellation of Lynch syndrome related malignancies. | Meghan R Flanagan Arjun Jayaraj Wei Xiong Matthew M Yeh Wendy H Raskind Venu G Pillarisetty | 2015 | World Journal of Gastroenterology2015，21，9： | 1 |
| 9 | Feeding enriched omega- 3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-1 and cholesterol levels显示文摘 | DENIS M MEDEIROS MEGHAN H | 2007 | Nutrition Research2007，27，5： | 1 |
| 10 | Sport participation Motivation in Young Adolescent Girls:The Role of Friendship Quality and Self-Concept 显示文摘 | Meghan H McDonough Peter R E Crocker | 2005 | Research Quarterly for Exercise and Sport2005，76，： | 1 |
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