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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Delayed activation of insulin-like growth factor-1 recepor/Src/Mapk/kgr-1 signaling regulates clusterin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 3 | Delayed activation of insulin-like growth factor-1 recepor/Src/Mapk/kgr-1 signaling regulates clusterin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 4 | Mi- croalgae to biofuels lifecycle assessment--multiple pathway evalua- tion 显示文摘 | Jason C Quinn Gordon T Smith Cara Meghan Downes | 2014 | Algal Research2014，4，4： | 1 |
| 5 | Adiponectin differentially regulates cytokines in porcine macrophages显示文摘 | Meghan C Wulster-Radclie Kolapo M | 2004 | Biochemical Biophysical Research Communications2004，316，3： | 1 |
| 6 | Delayed activation of insulin-like growth factor-1 reeepor/Src/Mapk/kgr-1 signaling regulates clusterin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | | 0，，14： | 1 |
| 7 | 150 years of trea- ting severe traumatic brain injury: a systematic review of progress in mortality显示文摘 | Stein S C Georgoff P Meghan S | 2010 | J Neurotrauma2010，27，7： | 1 |
| 8 | Adiponectin differentially regulates cytokinesIn porcine macrophages 显示文摘 | Meghan C Wulster- Redclie Kolapo M | 1997 | Stroke1997，28，3： | 1 |
| 9 | Metrics for ranking the performance of supercomputers显示文摘 | Tzu Y C Meghan G Beth S | 2006 | CTWatch2006，2，4： | 1 |
| 10 | Valuing special forest products harvesting : a two-steptravel cost recreation demand analysis显示文摘 | Meghan Starbuck C Susan J Alexander Robert P Berrens | 2004 | Journal of ForestEconomics2004，10，1： | 1 |
| 11 | Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder显示文摘 | Manpreet K Singh Kiki D Chang Michael C Chen Ryan G Kelley Amy Garrett Myles M Mitsunaga Layla Bararpour Meghan Howe Allan L Reiss Ian H Gotlib | 2012 | Bipolar Disorders2012，，6： | 1 |
| 12 | Delayed activation of insulin like growth factor-1 receptor/Src/Mapk/kgr-1 Singnaling regulates clustenin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 13 | Simulating changes in forest recreation demand and associated economic impacts due to fire and fuels management activities 显示文摘 | Meghan Starbuck C Berrens R P McKee M | 2006 | Forest Policy and Eco- nomics2006，8，1： | 1 |
| 14 | Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-γ-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling显示文摘 | MEGHAN E P RISH K P DAVID C S | 2006 | J Immunol2006，176，8： | 1 |
| 15 | Adiponectin differentially regulates cytokines in porcine macrophages 显示文摘 | Meghan C Wulster Radclie Kolapo M | 2004 | Biochemical Biophysical Research Communications2004，316，3： | 1 |
| 16 | Horizontal and Vertical Structureof Easterly Waves in the Pacific ITCZ 显示文摘 | Yolande L S George N K Meghan F C | 2008 | Journal of the atmospheric scihences2008，65，： | 1 |
| 17 | Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression,a pro -survival factor显示文摘 | Tracy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 18 | Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1显示文摘 | Zhang Z Lu H Huan F Meghan C Yang X Wang Y | 2014 | Int J Cancer2014，134，7： | 1 |
| 19 | Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C显示文摘 | Robin H Tarek H Meghan C | 2003 | Journal of the International Neuropsychological Society2003，9，： | 1 |
| 20 | Adiponeetin differentially regulates eytokines in porcine macrophages显示文摘 | Meghan C Wulster-Radclie Kolapo M | 2004 | Biochemical Biophysical Research Communications2004，316，3： | 1 |
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