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| 1 | Protective Effect of Dimethyl-4,4'-Dimethoxy-5,6,5',6'-Dimethylene Dioxybiphenyl-2,2'-Dicarboxylate (DDB) against Carcinogen-Induced Rat Liver Nuclear DNA Damage显示文摘The protective effect fDDB against carcinogen-induced DNA damage was examined in the present investigation.Preincubation of rat liver nuclei with DDB(1mmol·L^-1)resulted in 60% inhibition of binding of ^3H-benzo(a)pyrene to nuclear DNA.unscheduled DNA synthesis(UDS)induced by aflatoxin B1(10^-7mol·L^-1) in freshly isolated rat hepatocytes was also inhibited by DDB(10^-6-10^-3mol·L^-1).Oral administation of DDB at 200mg·k^-1once daily for 3 d induced a significant increase of liver cytosol glutathione-S-transferase and microsomal UDPG-transferase activity in mice.These results indicate that DDB is able to directly or indirectly antagonize certain carcinogen-induced DNA damages. | QlNG WEIGUO1 AND LIU GENGTAODepartment of Pharmacology, Institute of Materia Medico, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050,ChinaBeijing Institute for Cancer Research, Da-Hong-Luo-Chang Street, West District, Beijing, 100034 China.To whom correspondence should be addressed. | 1992 | Biomedical and Environmental Sciences1992，5，3： | 4 |
| 2 | Professor Zhou Jin-huang,a pioneer in the pharmacologyintegrating traditional Chinese medicineand western medicine显示文摘Professor Zhou was born in 1909 when the lastdriperial dynasty, Qing dynasty, went near its end andmodern sciences including medical sciences began totake root in China. Modern schools and universitieswere established to substitute the old private tutoringsystem in which only one teacher was needed to handlea group of young pupils of different ages. Zhou re-ceived both types of education and was finally | LIU Gan-zhong( Professor of Pharmacology,Dept Materia Medico and Pharmacology,China-Japan Friendship Hospital) | 1989 | 中国药理学与毒理学杂志1989，3，3： | 2 |
| 3 | Differential gene expression induced by insulin and IGF-Ⅱ through the insulin receptor isoform A显示文摘 | Pandini G Medico E Conte E | 2003 | J Biol Chem2003，278，42： | 1 |
| 4 | The MET oncogene drives a genetic programme linking cancer to haemostasis显示文摘 | Boccaccio C Sabatino G Medico E | 2005 | Nature2005，434，7031： | 1 |
| 5 | The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype显示文摘 | Francesca De Bacco Elena Casanova Enzo Medico Serena Pellegatta Francesca Orzan Raffaella Albano Paolo Luraghi Gigliola Reato Antonio D’Ambrosio Paola Porrati Monica Patanè Emanuela Maderna Bianca Pollo Paolo M. Comoglio Gaetano Finocchiaro Carla Boccacci | 2012 | Cancer Research2012，，17： | 1 |
| 6 | Letrozole combined with gonadotropin-releasing hormone analog for metastatic male breast cancer 显示文摘 | Di Lauro L Viei P Del Medico P | 2013 | Breast Cancer Res Treat2013，141，1： | 1 |
| 7 | Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer显示文摘 | De Bacco F Luraghi P Medico E | 2011 | J Natl Cancer Inst2011，103，8： | 1 |
| 8 | Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth显示文摘 | Medico E Gentile A Celso CL | 2001 | Cancer Res2001，61，15： | 1 |
| 9 | Cancer and blood coagulation显示文摘 | Boccaccio C Medico E | 2006 | Cell Mol Life Sci2006，63，9： | 1 |
| 10 | The MET oncogene is a functional marker ofa glioblastoma stem cell subtype显示文摘 | De Bacco F Casanova E Medico E | 2012 | Cancer Res2012，72，17： | 1 |
| 11 | Cancer and blood coagu- lation显示文摘 | BACCACCIO C MEDICO E | 2006 | Cell Md Life Sci2006，63，： | 1 |
| 12 | A pilot study of circulating miR-NAs as potential biomarkers of early stage breast cancer显示文摘 | Zhao H Shen J Medico L | 2010 | PLoSOne2010，5，10： | 1 |
| 13 | New Kamenev-type oscillation criteria for second-order differential equations on a measure chain显示文摘 | Medico A Knog Q | 2005 | Computers Math Appl2005，50，： | 1 |
| 14 | FLAME, A novel fuzzy clustering method for the analysis of DNA microarray data显示文摘 | Fu L Medico E F | 2007 | BMC Bioinformatics2007，8，： | 1 |
| 15 | Cancer and blood coagulation 显示文摘 | Boccaccio C Medico E | 2006 | Cell Mol Life Sci2006，63，9： | 1 |
| 16 | A pilot study of circulating miR- NAs as potential biomarkers of early stage breast cancer显示文摘 | Zhao H Shen J Medico L | 2010 | PLoS One2010，5，13： | 1 |
| 17 | Cancer and blood coagulation 显示文摘 | Baccaccio C Medico E | 2006 | Cell MdLife Sci2006，63，9： | 1 |
| 18 | Pharmacotherapy in the Critically Ill Obese Patient显示文摘 | Charles J. Medico Patrick Walsh | 2010 | Critical Care Clinics2010，，4： | 1 |
| 19 | Raynaud's phenomenon in undifferentiated connective tissue disease (UCTD)显示文摘 | De Angelis R Cerioni A Del Medico P | 2005 | Clin Rheumatol2005，24，2： | 1 |
| 20 | The impact of weather forecast improvements on large scale hydrology: analysing a decade of forecasts of the European Flood Alert System 显示文摘 | Pappenberger F Thielen J Del Medico M | 2011 | Hydrological Processes2011，25，7： | 1 |
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