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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | WJSC 6^(th) Anniversary Special Issues(1):Hematopoietic stem cell transplantation Allogeneic hematopoietic cell transplant for acute myeloid leukemia:Current state in 2013 and future directions显示文摘Acute myeloid leukemia(AML)represents a heterogeneous group of high-grade myeloid neoplasms of the elderly with variable outcomes.Though remissioninduction is an important first step in the management of AML,additional treatment strategies are essential to ensure long-term disease-free survival.Recent pivotal advances in understanding the genetics and molecular biology of AML have allowed for a risk-adapted approach in its management based on relapse-risk.Allogeneic hematopoietic cell transplantation(allo-HCT)represents an effective therapeutic strategy in AML providing the possibility of cure with potent graft-versus-leukemia reactions,with a demonstrable survival advantage in younger patients with intermediate-or poor-risk cytogenetics.Herein we review the published data regarding the role of allo-HCT in adults with AML.We searched MEDLINE/PubMed and EMBASE/Ovid.In addition,we searched reference lists of relevant articles,conference proceedings and ongoing trial databases.We discuss the role of allo-HCT in AML patients stratified by cytogenetic-and molecular-risk in first complete remission,as well as allo-HCT as an option in relapsed/refractory AML.Besides the conventional sibling and unrelated donor allografts,we review the available data and recent advances for alternative donor sources such as haploidentical grafts and umbilical cord blood.We also discuss conditioning regimens,including reduced intensity conditioning which has broadened the applicability of allo-HCT.Finally we explore recent advances and future possibilities and directions of allo-HCT in AML.Practical therapeutic recommendations have been made where possible based on available data and expert opinion. | Abraham S Kanate Marcelo C Pasquini Parameswaran N Hari Mehdi Hamadani | 2014 | World Journal of Stem Cells2014，6，2： | 6 |
| 3 | Aneuploidy rate in sper- matozoa of selected men with severe teratozoospermia显示文摘 | Mehdi M Gmidene A Brahem S | 2012 | Androlo- gia2012，44，： | 1 |
| 4 | Robust stability and stabilization of a class of singular systems with multiple time varying delays显示文摘 | Saadni S M Chaabane M Mehdi D | 2006 | Asian J of Control2006，8，1： | 1 |
| 5 | Optimal surface adjustment of HAYSTACK antenna显示文摘 | Mehdi S Zarghamee Joseph Antebi Frank W Kan | 1995 | IEEE Trans1995，43，1： | 1 |
| 6 | Serological survey ofToxoplasma gondii in schizophrenia patients referred to Psychi-atric Hospital,Sari City,Iran显示文摘 | Ahmad D Mehdi S Sayed HH | 2010 | Trop Biomed2010，27，3： | 1 |
| 7 | A high performance and intrin- sically secure key establishment protocol for wireless sensor net- works显示文摘 | ALl F MEHDI B HOSSEIN S | 2011 | Computer Networks2011，55，8： | 1 |
| 8 | The effect of different dispersants on the physical properties of nano CoAl2 04 ceramic ink-jet ink 显示文摘 | Masoud P Atasheh S G Mehdi G | 2015 | Ceramics International2015，41，： | 1 |
| 9 | Suppression of NF-kB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes:Implications for the treatment of osteoarthritis 显示文摘 | Mehdi S Thio J Gundula ST | 2007 | biochemical pharmacology2007，73，： | 1 |
| 10 | Controlling the degradation rate of bioactive magnesium implants by electrophoretic deposition of akermanite coating 显示文摘 | Mehdi R Mohammadhossein F Omid S | 2014 | Ceramics International2014，40，3： | 1 |
| 11 | Preparation and properties of aqueous polyurethane dispersions显示文摘 | Mohaghegh S Mohamrnad Seyed Barikani Mehdi | 2005 | Iran Polym J Eng Ed2005，14，2： | 1 |
| 12 | Task-space control of robot manipulators with null-space compliance显示文摘 | Hamid S Luigi V Mehdi K | 2014 | IEEE Transactions on Robotics2014，2，30： | 1 |
| 13 | Soil bulk density and crop yield under eleven consecutive years of corn with different tillage and residue practices in a sandy loam soil in central Canada显示文摘 | Dam R F Mehdi B B Burgess M S E | 2005 | Soil &Tillage Research2005，84，： | 1 |
| 14 | Preparation, charac- terization, and application of an enzyme-immobilized mag- netic microreactor for flow injection analysis 显示文摘 | Nomura A Suin S Mehdi O O | 2004 | Anal Chem2004，76，： | 1 |
| 15 | Kinetic modeling for- mulation of the methanol to olefin process: Parameter esti- mation显示文摘 | MEHDI S HUSSEIN B JAFAR T | 2014 | Journal of Industrial and Engineering Chemis- try2014，，20： | 1 |
| 16 | Aneuploidy rate in spermatozoa of selected men with severe teratozoospermia显示文摘 | Mehdi M Gmidene A Brahem S | 2012 | Andrologia2012，44，： | 1 |
| 17 | Vehicle evaluation of the performance of magneto-rheological dampers for heavy truck suspensions显示文摘 | DAVID S MEHDI A | 2001 | Vibration and Acoustics2001，123，： | 1 |
| 18 | Recycling of PVC wastes显示文摘 | MEHDI S S BAKHSHANDEH G R | | 0，，04： | 1 |
| 19 | Soil bulk density and crop yield under eleven consecutive years of corn with different tillage and residue practices in a sandy loam soil in central Canada显示文摘 | Dam R F Mehdi B B Burgess M S E | | 0，，01： | 1 |
| 20 | The effects of splinting periodon- tally compromised removable partial denture abutments on bone stresses:a three-dimensional finite element study 显示文摘 | Allahyar G Mehdi A Mahasti S | 2010 | Dent S2010，5，1： | 1 |
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