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| 1 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 2 | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?显示文摘AIM: To study the levels of adiponectin in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD) in comparison with control group.METHODS: Thirty-five patients who had elevated serum aminotransferase levels with bright liver and 34 healthy volunteers without liver disease were evaluated. Age,gender and body mass index (BMI) were recorded. Fasting plasma glucose, insulin, adiponectin, proinsulin and lipid profile were measured. A standard oral glucose tolerance test (OGTT) with insulin response was performed and the index of insulin resistance was calculated according to the homeostasis model assessment (HOMA) method.RESULTS: According to the OGTT results, none of the participants had diabetes. Serum adiponectin levels were statistically significantly lower in patients with NAFLD than in control group (8.14±3.4 μg/mL vs12.4±9.4 μg/mL,respectively, P<0.01). A statistically significant correlation was found between adiponectin and BMI (r: -0.33, P<0.01),HOMA (r: -0.26, P<0.05), proinsulin (r: -0.32, P<0.01),AST (r: -0.25, P<0.05), ALT (r: -0.26, P<0.05) or GGT (r: -0.22, P<0.05). In multiple regression analysis models,adiponectin levels were the only predictor of NAFLD in males, whereas in female group it was the BMI.CONCLUSION: Low adiponectin level might be a predictor of NAFLD especially in male nondiabetics. | Haluk Sargin Mehmet Sargin Hülya Gozu Asuman Orcun Gülcan Baloglu Murat Ozisik Mesut Seker Oya Uygur-Bayramicli | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 3 | Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer显示文摘 | Cengiz Gemici Mehmet Sargin Oya Uygur-Bayramicli Alpaslan Mayadagli Gokhan Yaprak Resat Dabak Mihriban Kocak | 2013 | Radiotherapy and Oncology2013，，2： | 1 |
| 4 | Variable length open contour track-ing using a deformable trellis显示文摘 | Mehmet Emre Sargin Alphan Altnok Bangalore SManiunath | 2011 | IEEE Trans on ImageProcessing2011，20，4： | 1 |
| 5 | Endoscopic scoring of late gastrointestinal mucosal damage after adjuvant radiochemotherapy显示文摘瞄准:与一个内视镜的得分系统在胃肠的粘膜上评估 chemoradiation 的迟了的效果并且把它比作一个临床的得分系统。方法:去在胃的外科以后收到 chemoradiation 的 24 个病人在完成的 chemoradiation 以后在外科和一年以后经历了内视镜检查法四 wk。上面的胃肠的调查结果根据世界组织为消化内视镜检查法(OMED ) 建议的一个系统被记录,临床的得分用完了 RTOG-EORTC 放射病态得分系统。结果:在没有重要内视镜的差别胃并且在 chemoradiation 以后的肠粘膜(P >
0.05 ) 并且在内视镜的分数和临床的分数之间没有协会。内视镜的变化是最小的。结论:在在有胃的癌症的操作病人的 chemoradiation 以后的迟了的效果能客观地与一个内视镜的得分系统被评估,这个系统比临床的得分系统优异。 | Resat Dabak Oya Uygur-Bayramicli Cengiz Gemici Dilek Yavuzer Mehmet Sargin Mehmet Yildirim | 2006 | World Journal of Gastroenterology2006，12，27： | 0 |
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