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| 1 | Silicon carbide resonant tuning fork for microsensing applications in high-temperature and high G-shock environments显示文摘We present the fabrication and testing of a silicon carbide(SiC)balanced mass double-ended tuning fork that survives harsh environments without compromising the device strain sensitivity and resolution bandwidth.The device features a material stack that survives corrosive environments and enables high-temperature operation.To perform high-temperature testing,a specialized setup was constructed that allows the tuning fork to be characterized using traditional silicon electronics.The tuning fork has been operated at 600 ℃ in the presence of dry steam for short durations.This tuning fork has also been tested to 64 000 G using a hard-launch,soft-catch shock implemented with a light gas gun.However,the device still has a strain sensitivity of 66 Hz/με and strain resolution of 0.045 με in a 10 kHz bandwidth.As such,this balanced-mass double-ended tuning fork can be used to create a variety of different sensors including strain gauges,accelerometers,gyroscopes,and pressure transducers.Given the adaptable fabrication process flow,this device could be useful to micro-electro-mechanical systems(MEMS) designers creating sensors for a variety of different applications. | David R Myers Kan Bun Cheng Babak Jamshidi Robert G Azevedo Debbie G Senesky Li Chen Mehran Mehregany Muthu B J Wijesundara Albert P Pisano | 2012 | Engineering Sciences2012，10，5： | 6 |
| 2 | Predictive biomarkers in precision medicine and drug development against lung cancer显示文摘The molecular characterization of various cancers has shown that cancers with the same origins,histopathologic diagnoses,and clinical stages can be highly heterogeneous in their genetic and epigenetic alterations that cause tumorigenesis.A number of cancer driver genes with functional abnormalities that trigger malignant transformation and that are required for the survival of cancer cells have been identified.Therapeutic agents targeting some of these cancer drivers have been successfully developed,resulting in substantial improvements in clinical symptom amelioration and outcomes in a subset of cancer patients.However,because such therapeutic drugs often benefit only a limited number of patients,the successes of clinical development and applications rely on the ability to identify those patients who are sensitive to the targeted therapies.Thus,biomarkers that can predict treatment responses are critical for the success of precision therapy for cancer patients and of anticancer drug development.This review discusses the molecular heterogeneity of lung cancer pathogenesis;predictive biomarkers for precision medicine in lung cancer therapy with drugs targeting epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase(ALK),c-ros oncogene 1 receptor tyrosine kinase[ROSl),and immune checkpoints;biomarkers associated with resistance to these therapeutics;and approaches to identify predictive biomarkers in anticancer drug development.The identification of predictive biomarkers during anticancer drug development is expected to greatly facilitate such development because it will increase the chance of success or reduce the attrition rate.Additionally,such identification will accelerate the drug approval process by providing effective patient stratification strategies in clinical trials to reduce the sample size required to demonstrate clinical benefits. | Bingliang Fang Reza J Mehran John V Heymach Stephen G Swisher | 2015 | Chinese Journal of Cancer2015，34，7： | 5 |
| 3 | Morbidity and mortality rates in elderly patients undergoing PTCA显示文摘 | Lindsay J Bedly VM Mehran R | 1994 | Am Heart J1994，1，： | 1 |
| 4 | Mechanisms and results of balloon angioplasty for the treatment of in-stent restenosis显示文摘 | Mehran R Mintz GS Popma J | 1996 | Am J Cardiol1996，78，： | 1 |
| 5 | Novel Ag + ion-selective electrodes based on two new mixed azathinether crowns containing a 1, lO-phenanthroline sub-unit 显示文摘 | Mojtaha S Mehran J Vito L | 2002 | Anal ( him Acta2002，462，2： | 1 |
| 6 | Epidural versus ON-Q local anesthetic-infiltrating catheter for post-thoracotomy pain control显示文摘 | Gebhardt R Mehran RJ Soliz J | 2013 | J Cardiothorac Vasc Anesth2013，27，3： | 1 |
| 7 | Bivalirudin in pa- tients undergoing primary angioplasty for acute myocardial in- farction (HORIZONS- AMI): 1- year results of a randomised controlled trial 显示文摘 | Mehran R Lansky A J Witzenbichler B | 2009 | Lancet2009，374，9696： | 1 |
| 8 | Supercharged pedicled jejunal interposition for esophageal replacement:a 10-year experience显示文摘 | Blackmon S H Correa A M Skoracki R Chevray P M Kim M P Mehran R J | 2012 | Ann Thorac Surg2012，94，： | 1 |
| 9 | Mechanisms and results of balloon angioplasty for the treatment of in-stent restenosis显示文摘 | Mehran R Mintz G S Popma J J | 1996 | Am J Cardiol1996，78，： | 1 |
| 10 | Safety and efficacy of bivalirudin monotherapy in patients with non-ST segment elevation myocardial infarction undergoing PCI: results from the ACUITY study显示文摘 | Souza C F Mehran R Kirtane A J | 2013 | J Am Coll Cardiol2013，62，1851： | 1 |
| 11 | Relationship between the ischemic threshold at the onset of wall-motion abnormality on semisupine exercise echocardiography and the extent of coronary artery disease显示文摘 | Elsa Abitbol Jean-Luc Monin Jér?me Garot Mehrane Monchi Stéphanie Russel Anne-Marie Duval Pascal Gueret | 2003 | Journal of the American Society of Echocardiography2003，，2： | 1 |
| 12 | Optimization of enzymatic degumming process for rice bran oil using response surface methodology 显示文摘 | Mehran J Alizadeh M Pirozifard M | 2008 | LWT-Food Science and Technology2008，41，10： | 1 |
| 13 | Early stent thrombosis in patients with acute coronary syndromes treated with drug- eluting and bare metal stents: the Acute Catheterization and Urgent Intervention Triage Strategy trial显示文摘 | 5oki J Lansky AJ Mehran R | 2009 | Circulation2009，119，5： | 1 |
| 14 | Bivalirudinin patients undergoing primary angioplasty for acute myocardial infarction (HORIZONS-AMI) : l-year results of a ran- domised controlled trial 显示文摘 | Mehran R Lansky A J Witzenbichler B | 2009 | Lancet2009，374，9696： | 1 |
| 15 | Survival ralated to nodal stares after sleeve resection for lung cancer 显示文摘 | MEHRAN RJ DESLAURIERS J PIRAUX M | 1994 | Thorac Cardiovasc Surg1994，102，2： | 1 |
| 16 | Sex - based differences in bleeding and long term adverse events after percutaneous coronary intervention for acute myocardial infarc- tion:Three year results from the HORIZONS- AMI trial显示文摘 | Yu J Roxana Mehran MD Liliana Grinfeld MD | 2015 | Cath- eter Cardiol Inte2015，85，3： | 1 |
| 17 | Mechanisms and results of balloon angioplasty for the treatment of in-stent restenosis显示文摘 | Mehran R Mintz G S Popma J J | 1996 | Am J Cardiol1996，78，： | 1 |
| 18 | Survival related to nodal status after sleeve resection for lung cancer显示文摘 | Mehran RJ Deslauriers J Piraux M | | 0，，02： | 1 |
| 19 | Impact of chronic kidney disease on early ( 30' day ) and late ( 1 - year ) outcomes of patients with acute coronary syndromes treated with alternative antithrombotic treatment strategies:an ACUI- TY ( Acute Catheterization and Urgent Intervention Triage strat- egy) substudy 显示文摘 | MEHRAN R NIKOLSKY E LANSKY A J | 2009 | JACC Cardiovasc Interv2009，2，8： | 1 |
| 20 | Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention显示文摘 | Eugenia Nikolsky Roxana Mehran Diane Turcot Eve D Aymong Gary S Mintz Zoran Lasic Alexandra J Lansky Emmanouil Tsounias Jeffrey W Moses Gregg W Stone Martin B Leon George D Dangas | 2004 | The American Journal of Cardiology2004，，3： | 1 |
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