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| 1 | Startup and operation of anaerobic EGSB reactor treating palm oil mill effluent显示文摘A bench-scale expanded granular sludge bed (EGSB) reactor was applied to the treatment of palm oil mill effuent (POME). The reactor had been operated continuously at 35°C for 514 d, with organic loading rate (OLR) increased from 1.45 to 17.5 kg COD/(m3·d). The results showed that the EGSB reactor had good performance in terms of COD removal on the one hand, high COD removal of 91% was obtained at two days’ of hydraulic retention time (HRT), and the highest OLR of 17.5 kg COD/(m3·d). On the other hand, only 46% COD in raw POME was transformed into biogas in which the methane content was about 70% (V/V). A 30-d intermittent experiment indicated that the maximum transformation potential of organic matter in raw POME into methane was 56%. Volatile fatty acid (VFA) accumulation was observed in the later operation stage, and this was settled by supplementing trace metal elements. On the whole, the system exhibited good stability in terms of acidity and alkalinity. Finally, the operational problems inherent in the laboratory scale experiment and the corresponding countermeasures were also discussed. | ZHANG Yejian YAN Li CHI Lina LONG Xiuhua MEI Zhijian ZHANG Zhenjia | 2008 | Journal of Environmental Sciences2008，20，6： | 18 |
| 2 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 3 | Regulating Effects of Novel CpG Chitosan-nanoparticles on Immune Responses of Mice to Porcine Paratyphoid Vaccines显示文摘Objective To study the regulating effects of a novel CpG oligodeoxynuleotide and the synergistic effect of chitosan-nanoparticles (CNP) with CpG on immune responses of mice, which were used to develop a novel immunoadjuvant to boost immune response to conventional vaccines. Methods A novel CpG ODN containing 11 CpG motifs was synthesized and its bioactivities to stimulate the proliferation of lymphocytes of pig in vitro were detected. Then it was entrapped with CNP prepared in our laboratory by the method of ionic cross linkage, and immunized Kunming mice were co-inoculated with paratyphoid vaccine. The peripheral blood was collected weekly from the tail vein of inoculated mice to detect the contents of IgG, IgA, IgM, and specific antibody against salmonella as well as the levels of interleukin-2 (IL2), IL-4, and IL-6 by SABC-ELISA assay. The numbers of leucocytes, monocytes, granuloytes, and lymphocytes were calculated separately using the routine method. The experimental mice were orally challenged with virulent salmonella 35 days after inoculation. Results This CpG ODN could remarkably provoke the proliferation of lymphocytes of pig in vitro in contrast with the control (P<0.05). Compared with those of the control, immunoglobulins, including IgG, IgA, IgM, and specific antibodies to paratyphoid vaccine, increased significantly in sera from the CpG or CpG-CNP-vaccinated mice (P<0.05). IL-2, IL-4, and IL-6 increased remarkably in sera from immunized mice (P<0.05). The leucocytes, monocytes, granuloytes, and lymphocytes of the mice immunized with CpG or CpG-CNP were also increased in number (P<0.05). After the challenge, these immunity values were elevated in the mice vaccinated with CpG or CpG-CNP. The immunized mice all survived, while the control mice fell ill with evident lesions with diffuse hemorrhage in stomach, small intestine, and peritoneum. Conclusions CpG ODN entrapped with CNP is a promising effective immunoadjuvant for vaccination, which promotes humoral and cellular immune responses, enhances immunity and resistance against salmonella by co-administration with paratyphoid vaccine. | MAN-LIANG FU SAN-CHENG YING MEI WU HUI LI KAI-YUAN WU YI YANG HUAN ZHANG CHI CHENG ZE-ZHOU WANG XIU-YING WANG XUE-BING LV YI-ZHENG ZHANG RONG GAO | 2006 | Biomedical and Environmental Sciences2006，19，4： | 8 |
| 4 | Kindlin-2 expression in adult tissues correlates with their embryonic origins显示文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development. | ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan | 2014 | Science China(Life Sciences)2014，57，7： | 8 |
| 5 | Osteoblast/fibroblast coculture derived bioactive ECM with unique matrisome profile facilitates bone regeneration显示文摘Extracellular matrix(ECM)with mimetic tissue niches was attractive to facilitate tissue regeneration in situ via recruitment of endogenous cells and stimulation of self-healing process.However,how to engineer the complicate tissue specific ECM with unique matrisome in vitro was a challenge of ECM-based biomaterials in tissue engineering and regenerative medicine.Here,we introduced coculture system to engineer bone mimetic ECM niche guided by cell-cell communication.In the cocultures,fibroblasts promoted osteogenic differentiation of osteoblasts via extracellular vesicles.The generated ECM(MN-ECM)displayed a unique appearance of morphology and biological components.The advantages of MN-ECM were demonstrated with promotion of multiple cellular behaviors(proliferation,adhesion and osteogenic mineralization)in vitro and bone regeneration in vivo.Moreover,proteomic analysis was used to clarify the molecular mechanism of MN-ECM,which revealed a specific matrisome signature.The present study provides a novel strategy to generate ECM with tissue mimetic niches via cell-cell communication in a coculture system,which forwards the development of tissue-bioactive ECM engineering along with deepening the understanding of ECM niches regulated by cells for bone tissue engineering. | Mei Li Anqi Zhang Jiajing Li Jing Zhou Yanan Zheng Chi Zhang Dongdong Xia Haijiao Mao Jiyuan Zhao | 2020 | Bioactive Materials2020，5，4： | 7 |
| 6 | Serum Hepatitis B Surface Antigen Quantitation Can Reflect Hepatitis B Virus in the Liver and Predict Treatment Response显示文摘 | Henry Lik–Yuen Chan Vincent Wai–Sun Wong Ada Mei–Ling Tse Chi–Hang Tse Angel Mei–Ling Chim Hoi–Yun Chan Grace Lai–Hung Wong Joseph Jao–Yiu Sung | 2007 | Clinical Gastroenterology and Hepatology2007，，12： | 7 |
| 7 | Experiments and Simulation of Thermal Behaviors of the Dual-drive Servo Feed System显示文摘The machine tool equipped with the dual-drive servo feed system could realize high feed speed as well as sharp precision. Currently, there is no report about the thermal behaviors of the dual-drive machine, and the current research of the thermal characteristics of machines mainly focuses on steady simulation. To explore the influence of thermal characterizations on the precision of a jib boring machine assembled dual-drive feed system, the thermal equilibrium tests and the research on thermal-mechanical transient behaviors are carried out. A laser interferometer, infrared thermography and a temperature-displacement acquisition system are applied to measure the temperature distribution and thermal deformation at different feed speeds. Subsequently, the finite element method(FEM) is used to analyze the transient thermal behaviors of the boring machine. The complex boundary conditions, such as heat sources and convective heat transfer coefficient, are calculated. Finally, transient variances in temperatures and deformations are compared with the measured values, and the errors between the measurement and the simulation of the temperature and the thermal error are 2 ℃ and 2.5 μm, respectively. The researching results demonstrate that the FEM model can predict the thermal error and temperature distribution very well under specified operating condition. Moreover, the uneven temperature gradient is due to the asynchronous dual-drive structure that results in thermal deformation. Additionally, the positioning accuracy decreases as the measured point became further away from the motor, and the thermal error and equilibrium period both increase with feed speeds. The research proposes a systematical method to measure and simulate the boring machine transient thermal behaviors. | YANG Jun MEI Xuesong FENG Bin ZHAO Liang MA Chi SHI Hu | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 6 |
| 8 | MATHEMATICAL MODEL FOR CONTINUOUS DETECTION OF CURRENT EFFICIENCY IN ALUMINUM PRODUCTION显示文摘INTRODUCTIONThemathematicalmodelsforcalculationofcurenteficiencyinaluminareductionhavebenreportedbymanyinvestigators,mostofwh... | Zeng Shuiping Institute of Fuzzy Control, North China University of Technology, Beijing 100041, P. R. China Liu Yexiang and Mei Chi Department of Nonferrous Metallurgy, Central South University of Technology, Changsha 410083, P. R. China | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 5 |
| 9 | Efficacy of Getong Tongluo Capsule(葛酮通络胶嚢)for Convalescent-Phase of Ischemic Stroke and Primary Hypertension:A Multicenter,Randomized,Double-Blind,Controlled Trial显示文摘Objective:To evaluate whether the efficacy of Getong Tongluo Capsule(葛酮通络胶囊,GTC,consisted of total flavone of Radix Puerariae)on improving patients'quality of life and lowering blood pressure are superior to the extract of Ginkgo biloba(EGB)for patients with convalescent-phase ischemic stroke and primary hypertension.Methods:This randomized,positive-drug-and placebo-controlled,double-blind trial was conducted from September 2015 to October 2017.Totally 477 eligible patients from 18 hospitals in China were randomly assigned in a 2:1:1 ratio to the following interventions,twice a day for 12 weeks:(1)GTC 250 mg plus EGB-matching placebo 40 mg(237 cases,GTC group),(2)EGB 40 mg plus GTC-matching placebo 250 mg(120 cases,EGB group)or(3)GTC-matching placebo 250 mg plus EGB-matching placebo 40 mg(120 cases,placebo group).Moreover,all patients were orally administered aspirin enteric-coated tablets 100 mg,once a day fo r 12 weeks.The primary outcome was the Barthel Index(Bl).The secondary outcomes included the control rate of blood pressure and National Institutes of Health Stroke Scale(NIHSS)scores.The incidence and severity of adverse events(AEs)were calculated and assessed.Results:The Bl relative independence rates,the clinical recovery rates of NIHSS,and the total effective rates of NIHSS in the GTC and EGB groups were significantly higher than the placebo group at 12 weeks after treatment(P<0.05),and no statistical significance was found between the GTC and EGB groups(P>0.05).The control rate of blood pressure in the GTC group was significantly higher than the EGB and placebo groups at 12,18 and 24 weeks after treatment(P<0.01).There were no statistically significant differences in the incidences of AEs,adverse drug reactions,or serious AEs among the 3 groups(P>0.05).Conclusion:GTC exhibited significant efficacy in improving patients'quality of life as well as neurological function and controlling hypertension. | ZHAO Qian-yu TANG Rong-hua LU Guo-xiong CAO Xu-zheng LIU Lu-ran ZHANG Ji-hua ZHANG Jin-tao XU Bin WEI Hong-tao YANG Miao WEI Ling ZHANG Mei ZHU Wen-zong WANG Hong LI Hong-lin MA Li-ping ZHONG Chi GAO Yan-jie ZHANG Na REN Shan CHEN Lu LIU Yun-hai CHEN Zhi-gang | 2021 | Chinese Journal of Integrative Medicine2021，27，4： | 3 |
| 10 | Consensus on clinical management of tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO)is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23(FGF23)production by a tumor,which often arises from a mesenchymal origin.[1-3]Most clinical symptoms of TIO are the consequences of prolonged FGF23-mediated hypophosphatemia as muscle weakness,bone pain,impaired mobility,and fractures.[4]Clinical diagnosis and management of TIO are challenging because knowledge about this condition is still restricted to a few specialized centers,leading to delay in diagnosis and appropriate treatment.The scope of the present consensus is to provide up-to-date guidance on the assessment and treatment of TIO. | Yan Jiang Xiang Li Li Huo Yong Liu Wei Lyu Lian Zhou Wei Yu Huan-Wen Wu Xiao-Ping Xing Mei Li Ou Wang Yue Chi Rui-Zhi Jiajue Yu Pei Jian-Min Liu Jian-Ming Ba Qiao Zhang Zhi-Feng Sheng Zhen-Lin Zhang Jia-Jun Zhao Salvatore Minisola Wei-Bo Xia on behalf of Chinese Society of Osteoporosis and Bone Mineral Research and Chinese Society of Endocrinology | 2021 | Chinese Medical Journal2021，，11： | 3 |
| 11 | Surface characterization of metal oxides-supported activated carbon fiber catalysts for simultaneous catalytic hydrolysis of carbonyl sulfide and carbon disulfide显示文摘The sol–gel method was used to synthesize a series of metal oxides-supported activated carbon fiber (ACF) and the simultaneous catalytic hydrolysis activity of carbonyl sulfide (COS)and carbon disulfide (CS2) at relatively low temperatures of 60°C was tested.The effects of preparation conditions on the catalyst properties were investigated,including the kinds and amount of metal oxides and calcination temperatures.The activity tests indicated that catalysts with 5 wt.%Ni after calcining at 400°C (Ni(5)/ACF(400)) had the best performance for the simultaneous catalytic hydrolysis of COS and CS2.The surface and structure properties of prepared ACF were characterized by scanning electron microscope-energy disperse spectroscopy (SEM-EDS),Brunauer–Emmett–Teller (BET),X-ray diffraction (XRD),carbon dioxidetemperature programmed desorption (CO2-TPD) and diffuse reflectance Fourier transform infrared reflection (DRFTIR).And the metal cation defects were researched by electron paramagnetic resonance (EPR) method.The characterization results showed that the supporting of Ni on the ACF made the ACF catalyst show alkaline and increased the specific surface area and the number of micropores,then improved catalytic hydrolysis activity.The DRFTIR results revealed that-OH species could facilitate the hydrolysis of COS and CS2;-COO and-C–O species could facilitate the oxidation of catalytic hydrolysate H2S.And the EPR results showed that high calcination temperature conditions provide more active reaction center for the COS and CS2 adsorption. | Kunlin Li Chi Wang Ping Ning Kai Li Xin Sun Xin Song Yi Mei | 2020 | Journal of Environmental Sciences2020，32，10： | 3 |
| 12 | Effects of Cerium on Microstructures and Mechanical Properties of Zn-22%Al Vibration Damping Alloy显示文摘Using natural aging and artificial aging treatment, the effects of cerium on microstructures and mechanical properties of Zn 22%Al vibration damping alloy were studied by optical microscope, transmission electron microscope and scanning electron microscope. The results show that cerium can refine the microstructure of Zn 22%Al alloy, slow the grain growth and retain the equiaxial degree during aging. The strength of Zn 22%Al (0 07%~0 20%)Ce alloy and Zn 22%Al alloy remains constant after aging below the hot rolling temperature of 80 ℃, and cerium can improve the strength and the stability of mechanical properties of Zn 22%Al alloy. | PANG Shao ping, SHI Yun bao, LI Jun, YANG Bin jiu, QUAN Mei hua, QIAO Yan hui, ZHANG Chi zhong (College of Mechanical Engineering, Beihua University, Jilin 132021, China) | 2000 | Journal of Rare Earths2000，18，4： | 3 |
| 13 | Simulation of moving boundary of the reaction shaft in a flash smelting furnace显示文摘As to solve the online monitoring of the inner temperatur e and freezing profile of the reaction shaft of flash smelting furnace, simulation of the wall in the reaction shaft in a flash smelting furnace was made through numerical computation. The computational results are very near the data got in s ite. The error of the moving boundary is approximately 3%, and that of the tempe rature is less than 5%. It is proved that the simulation software is applicable for practice to monitor the temperature and moving boundary inside the hearth on line. Based on a large number of the data computed, the relation between the cha nge of the moving boundary and inner temperature is summarized, and the great in fluence of the cooling system on the forming and stability of the moving boundar y inside the hearth is emphasized, which provide the theoretical bases for optim izing the flash smelting operation. | CHEN Zhuo 1,MEI Chi 1,CHEN Hong-rong 1,MO Jiao 2 (1 Institute on Simulation and Optimization of Pyro-installation, Central Sout h University, Changsha 410083, China 2 Science School, Beijing University of Posts and Telecommunications, Beijing 1 | 2001 | Journal of Central South University2001，13，3： | 3 |
| 14 | Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis显示文摘 | Julian J. Lum Daniel E. Bauer Mei Kong Marian H. Harris Chi Li Tullia Lindsten Craig B. Thompson | 2005 | Cell2005，，2： | 3 |
| 15 | A Novel Chitosan CpG Nanoparticle Regulates Cellular and Humoral Immunity of Mice显示文摘Objective To develop a safe and novel immunoadjuvant to enhance the immunity and resistance of animals against E. coli infection. Methods An 88-base immunostimulatory oligodeoxynuleotide containing eleven CpG motifs (CpG ODN) was synthesized and amplified by PCR. The chitosan nanoparticle (CNP) was prepared by ion linking method to entrap the CpG ODN that significantly promotes the proliferation of lymphocytes of pig in vitro. Then the CpG- CNP was inoculated into 21-day old Kunming mice, which were orally challenged with virulent K88/K99 E. Coli 35 days after inoculation. Blood was collected from the tail vein of mice on days 0, 7, 14, 21, 28, 35, 42, and 49 after inoculation to detect the changes and content of immunoglobulins, cytokines and immune cells by ELISA, such as IgG, IgA, IgM, IL-2, IL-4, and IL-6. Results The CpG provoked remarkable proliferation of lymphocytes of pig in vitro in comparison with that of control group (P<0.05). The inoculation with CpG-CNP significantly raised the content of IgG, IgM, and IgA in the sera of immunized mice ( P<0.05). The levels of IL-2, IL-4, and IL-6 in the mice significantly increased in comparison with those in controls (P<0.05), so was the number of white blood cells and lymphocytes in immunized mice. The humoral and cellular immunities were significantly enhanced in immunized mice, which resisted the infection of E. coli and survived, while the control mice manifested evident symptoms and lesions of infection. Conclusions CpG-CNP can significantly promote cellular and humoral immunity and resistance of mice against E. coli infection, and can be utilized as an effective adjuvant to improve the immunoprotection and resistance of porcine against infectious disease. | KAI-YUAN WU MEI WU MAN-LIANG FU HUI LI YI YANG HUAN ZHANG CHI CHENG ZE-ZHOU WANG XIU-YING WANG XUE-BING Lü DI-GUANG LIU HUA LI RONG GAO | 2006 | Biomedical and Environmental Sciences2006，19，2： | 3 |
| 16 | Incidence and Risk Factors of Obstetric Anal Sphincter Injuries after Various Modes of Vaginal Deliveries in Chinese Women显示文摘 | Tung Chi Wai Cheon Willy Cecilia Tong Wai Mei Anny Leung Hau Yee | 2015 | Chinese Medical Journal2015，，18： | 2 |
| 17 | Integration of biological method and membrane technology in treating palm oil mill effluent显示文摘手掌油工业是在马来西亚的最重要的 agro 工业,但是它的 by-product-palm 给工厂自河(梨果) 上油,形成了大威胁浇环境。在过去的十年,几个处理和处理方法被建议了并且调查了解决这 problem.A 二阶段的飞行员规模植物为梨果处理被设计并且构造。厌氧的消化和氧气的简历降级组成了第一个生物阶段,当时极端过滤(UF ) 和逆渗透(RO ) 膜单位作为第二个膜分离阶段被联合。在厌氧的扩展小粒的污泥床( EGSB )上反应堆,在梨果的大约43%有机物被变换成简历气体,和到达的货到付款减小效率93%和22%在 EGSB 和下列氧气的反应堆, respectively.With 在第一个生物阶段的处理,推迟的固体和油也减少了到低度。都,这些减轻了犯规的膜并且延长了膜生活。在膜过程单位,几乎所有推迟的固体被 UF 膜捕获,当 RO 膜排除了大多数溶解固体时或从 RO 的无机的盐渗入。在整个处理过程以后,在 BOD 和货到付款表示的梨果的有机物几乎彻底地被移开。推迟的固体和颜色不在 RO 是可检测的渗入更多,和矿物质元素仅仅在踪迹数量存在(除了 K 和 Na ) 。高质量的自河是清晰的并且当锅炉喂水,能被使用。 | ZHANG Yejian YAN Li QIAO Xiangli CHI Lina NIU Xiangjun MEI Zhijian ZHANG Zhenjia | 2008 | Journal of Environmental Sciences2008，20，5： | 2 |
| 18 | Healing effects of heparin on acetic acid-induced gastric ulcers in rats显示文摘HealingefectsofheparinonaceticacidinducedgastriculcersinratsYangLi,QiBingMeiandChiHinChoDepartmentofPharmacology,FacultyofMe... | Yang Li, Qi Bing Mei and Chi Hin Cho Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5 Sassoon Road, Hong Kong (Li Y, Mei QB and Cho CH) | 1998 | Chinese Medical Journal1998，，1： | 2 |
| 19 | HARDNESS AND WEAR RESISTANCE OF ELECTROLESS NICKEL DEPOSITS显示文摘INTRODUCTIONElectrolesNiPdepositshavebeenwidelyusedindiversefieldsfortheiruniquecombinationofpropertiessuchascorosionresist... | Zhang Yongzhong, Zhang Kui, Fan Jianzhong and Zhang Shaoming General Research Institute for Nonferrous Metals, Beijing 100088, P. R. China Yao Mei School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, P. R. Chi | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 2 |
| 20 | Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds显示文摘 | Min‐Hsiung Pan Ching‐Shu Lai Mei‐Ling Tsai Chi‐Tang Ho | 2014 | Mol. Nutr. Food Res2014，，1： | 2 |
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