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| 1 | Aggregation-induced emission: a coming-of-age ceremony at the age of eighteen显示文摘Aggregation-induced emission(AIE) has drawn great attention worldwide for its unique optical phenomenon and huge potential applications. Since coined by Ben Zhong Tang et al. in 2001, AIE has been deeply investigated and widely utilized in many important areas, such as organic light-emitting diode(OLED), sensor, and bio-imaging. Herein, we highlight some important progress of AIE in these eighteen years, including the exploration of internal mechanism and potential applications. Furthermore,some other interestingly emissive behaviors, originating but distinguishing from the AIE concept, are presented. It is anticipated an overall understanding about AIE could be easily caught from this short review for scientists, no matter whether they are involved in this exciting and rising research area or not. | Jie Yang Zhenguo Chi Weihong Zhu Ben Zhong Tang Zhen Li | 2019 | Science China Chemistry2019，62，9： | 25 |
| 2 | Swelling of clay minerals in ammonium leaching of weathered crust elution-deposited rare earth ores显示文摘The effect of hydrated radius, cation valence, pH and solution concentration on the zeta potential of clay minerals was investigated, and the relation between zeta potential of clay minerals and swelling was discussed in different leaching agents as well. The results show that the zeta potential of clay minerals decreases with the hydrated ionic radius increasing. It could be seen that the zeta potential of the clay minerals in AICl_3 solution is positive,whereas that in NH_4C1, KCl and MgCl_2 solution is negative. And the zeta potential of clay minerals increases with the cation valence increasing. Moreover, the zeta potential of clay minerals decreases with the solution pH increasing,whereas that increases with the solution concentration increasing in different ammonium solutions. In addition,the swelling of clay minerals decreases while the zeta potential of clay minerals increasing in different ammonium solutions. The ability of compound ammonium to inhibit the swelling of clay minerals is lower than that of single ammonium solution. | Zhen-Yue Zhang Zheng-Yan He Fang Zhou Cheng-Bin Zhong Ning-Jie Sun Ru-An Chi | 2018 | Rare Metals2018，37，1： | 15 |
| 3 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 4 | Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography显示文摘AIM: To investigate microvascular changes in eyes with central retinal vein occlusion(CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these changes and best-corrected visual acuity(BCVA) and retinal thickness. METHODS: Twenty-eight eyes of 28 patients with macular edema caused by CRVO were included in this retrospective study. All patients received a single intravitreal conbercept injection to treat macular edema. BCVA and the results of optical coherence tomography angiography(OCTA) automatic measurements of the vessel density in the superficial(SCP) and deep retinal capillary plexus(DCP), the foveal avascular zone(FAZ) area, the FAZ perimeter(PERIM), the vessel density within a 300-μm wide ring surrounding the FAZ(FD-300), the acircularity index(AI), the choriocapillaris flow area, and retinal thickness were recorded before and at one month after treatment and compared with the results observed in age-and sexmatched healthy subjects. RESULTS: The vessel density in the SCP and DCP, the FD-300, and the flow area of the choriocapillaris were allsignificantly lower in CRVO eyes than in healthy eyes, while the AI and retinal thickness were significantly higher(all P<0.05). After treatment, retinal thickness was significantly decreased, and the mean BCVA had markedly improved from 20/167 to 20/65(P=0.0092). The flow area of the choriocapillaris was also significantly improved, which may result from the reduction of shadowing effect caused by the attenuation of macular edema. However, there were no significant changes in SCP and DCP vessel density after treatment. The flow area of the choriocapillaris at baseline was negatively correlated with retinal thickness.CONCLUSION: OCTA enables the non-invasive, layerspecific and quantitative assessment of microvascular changes both before and after treatment, and can therefore be used as a valuable imaging tool for the evaluation of the follow-up in CRVO patients. | Yang Deng Qi-Wen Zhong Ai-Qi Zhang Xiao-Juan Cai Ming-Zhi Lu Shao-Chong Zhang Li-Shi Su Hui Chen Ying Lin Li-Mei Sun Guan-Di Chen Li-Ting Zhong Chen-Jin Jin Wei Chi | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 13 |
| 5 | Process mineralogy of Weishan rare earth ore by MLA显示文摘Mineral liberation analyser(MLA) was applied to quantitatively analyze the rare earth ore from Weishan in Shandong. Mineralogy parameters, such as mineral composition, occurrence states of rare earth elements(REEs) and valuable elements, mineral embedded grain size distribution, mineral association and liberation, are obtained. Results show that the contents of REEs and other valuable elements mainly contained in the ore were La 1.02 wt%, Ce 4.29 wt%, Pr 0.34 wt%, Nd 0.84 wt%, Sr 3.4 wt%and Ba 26.53 wt%, respectively. The REEs mainly occur in bastnaesite and carbocernaite in the form of independent mineral and the contents of bastnaesite and carbocernaite in the ore were 5.96 wt% and12.30 wt%, respectively. 67.34% of strontium occurs in carbocernaite and the rest occurs in celestobarite and strontianite mineral. 92.71% of barium occurs in barite. Liberation of main rare-earth minerals such as bastnaesite and carbocernaite is more than 80% when the grinding fineness is78.42% passing 74 μm. The research results could be employed to provide detailed basic theoretical data for further improvement of the beneficiation process flow and the processing index of rare earth ore, the recycling of other valuable minerals and the comprehensive utilization of tailings. | Caili Xu Chengbin Zhong Renliang Lyu Yaoyang Ruan Zhenyue Zhang Ru'an Chi | 2019 | Journal of Rare Earths2019，37，3： | 12 |
| 6 | High power triboelectric nanogenerator based on printed circuit board (PCB) technology显示文摘从我们的环境收获机械精力获得稳定、高的力量产量由于便携式的电子学的快开发吸引了集中的兴趣。在这个工作,组织磁盘的摩擦电 nanogenerator (TENG ) 基于成熟印刷电路板(聚氯联苯) 被准备为有效地在空间改进利用的技术和合成结构。在 CHS 作为的窗户和呆滞的修正,窗户 shading 设备和太阳的国内热水系统的 1e 采纳的一个狭窄的栅栏翻新措施。在这份报纸,焦点作为一项 retrofit 措施在 CHS 在用阶段变化材料(脉冲编码调制) 的热存储的采纳以后。结果显示那与融化 23 的温度使用脉冲编码调制 ? 訄吗?? | Changbao Han Chi Zhang Wei Tang Xiaohui Li Zhong Lin Wang | 2015 | Nano Research2015，8，3： | 10 |
| 7 | Magnetohydrodynamics (MHD) numerical simulations on the interaction of the solar wind with the magnetosphere: A review显示文摘The magnetosphere is the outermost layer of the geospace, and the interaction of the solar wind with the magnetosphere is the key element of the space weather cause-and-effect chain process from the Sun to Earth, which is one of the most challenging scientific problems in the geospace weather study. The nonlinearity, multiple component, and time-dependent nature of the geospace make it very difficult to describe the physical process in geospace using traditional analytic analysis approach. Numerical simulations, a new research tool developed in recent decades, have a deep impact on the theory and application of the geospace. MHD simulations started at the end of the 1970s, and the initial study was limited to two-dimensional (2D) cases. Due to the intrinsic three-dimensional (3D) characteristics of the geospace, 3D MHD simulations emerged in the 1980s, in an attempt to model the large-scale structures and fundamental physical processes in the magnetosphere. They started to combine with the space exploration missions in the 1990s and make comparisons with observations. Physics-based space weather forecast models started to be developed in the 21st century. Currently only a few space-power countries such as USA and Japan have developed 3D magnetospheric MHD models. With the rapid advance of space science in China, we have developed a new global MHD model, namely PPMLR-MHD, which has high order spatial accuracy and low numerical dissipation. In this review, we will briefly introduce the global 3D MHD modeling, especially the PPMLR-MHD code, and summarize our recent work based on the PPMLR-MHD model, with an emphasis on the interaction of interplanetary shocks with the magnetosphere, large-scale current systems, reconnection voltage and transpolar potential drop, and Kelvin-Helmholtz (K-H) instability at the magnetopause. | WANG Chi GUO XiaoCheng PENG Zhong TANG BinBin SUN TianRan LI WenYa HU YouQiu | 2013 | Science China Earth Sciences2013，56，7： | 10 |
| 8 | Enhancing mineral liberation of a Canadian rare earth are with microwave pretreatment显示文摘Liberation. as an attribute of mineralogy characteristic. whose impacts on finely disseminated Canadian rare earth ore was studied with microwave pretreatment. Samples of a light rare earth ore along with mostly ankerite and biotite as dominant gangue minerals as well as bastnaesite, strontianite and goethite as dominated minerals were exposed to further comminution by ball mill and microwave pretreatment fragmentation. Mineralogical characteristics were analyzed by using a mineral liberation analyzer(MLA).The results indicated that tight association mutually penetrates among dominated minerals in the range size of -300 + 212 μm and 212 + 150 μm and gangue minerals in the form of adjacent type. fine vein type. shell type and packing type. Temperature in the ore samples pre-treated by microwave can rapidly rise to 250 ℃ with microwave power of 0-1.5 kW and microwave time of 0-2 min. Applying the microwave pretreatment merely reduces the hardness of the ore causing the fracture of rare earth ore, but this does not transform or change the original mineralogy characteristics of the ore samples. On the basis of above study. the liberation value of bastnaesite, strontianite and goethite with microwave pretreatment is greater than with conventional comminution when the liberation class is above 75%. The distribution of particle size of rare earth ore samples is better with microwave pretreatment than with conventional comminution for particle size of 7.4 × 10^(-5) m. With microwave pretreatment, the theoretical grade-recovery of bastnaesite. strontianite and goethite in the rare earth ore attains better results than with conventional comminution at a given grade. | Chengbin Zhong Caili Xu Renliang Lyu Zhenyue Zhang Xiaoyan Wu Ru'an Chi | 2018 | Journal of Rare Earths2018，36，2： | 10 |
| 9 | Multilayered electret films based triboelectric nanogenerator显示文摘摩擦电 nanogenerator (TENG ) 是基于薄电影的表面接触充电把周围的机械精力变换成电的一台简单、合算的设备。有限表面费用密度可以影响 TENG 的全面表演。在这份报纸,基于的 TENG (E-TENG ) 由日冕制作了收费的一部新奇驻极体电影被建议那极大地作为与使遭到联系充电的那些相比提高薄电影的有效表面费用密度。E-TENG 的电线走火电流,转移电的费用密度,和开电路的电压被调查了,用控告电压,针尖距离和时间以便探索最佳的不同日冕试验性的条件。E-TENG 的电线走火电流,转移电的费用密度,和开电路的电压比那些平常的 polytetrafluoroethylene (PTFE ) 拍摄基于的 TENG 的被发现是大约七大倍。基于日冕收费,几 multilayered E-TENGs 被制作了,并且有层的不同数字的 E-TENGs 的电线走火电流,转移电的费用密度,和开电路的电压为完成最佳的表演被学习。这个工作为改进有效表面费用密度并且从而增加 TENG 的输出能力提供一条有效途径,它将极大地在自我动力的便携式的电子学和传感器网络支持 TENG 应用程序。 | Tao Zhou Limin Zhang Fei Xue Wei Tang Chi Zhang Zhong Lin wang | 2016 | Nano Research2016，9，5： | 10 |
| 10 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 11 | Effect of Combined Application of Organic Fertilizer and Chemical Fertilizer in Different Ratios on Growth,Yield and Quality of Fluecured Tobacco显示文摘The effect of different ratio of organic and inorganic fertilizers on the growth and the yield and quality of flue-cured tobacco was studied.Using randomized blocks design,the data of the test materials K326 were analyzed by using variance analysis,significance test and other methods.The release efficiency of organic fertilizer in the soil was slower,and the effect of organic fertilizer on the growth of tobacco plants was worse than that of chemical fertilizers,and under 25% organic fertilizer + 75% chemical fertilizer treatment,the quality of the fluecured tobacco was good.Under the treatment of 50% organic fertilizer + 50% chemical fertilizer,the production of flue-cured tobacco was high and the ratio of first-class tobacco was high.It is suggested that the organic fertilizer application ratio should be 25%-50% in the agricultural production. | Bing LIANG Kun HUANG Yali FU Hongguang LI Chi WANG Xiaotian ZHONG Qinghua LU Chengxiao HU | 2017 | Asian Agricultural Research2017，9，12： | 9 |
| 12 | Experimental study on MSW gasification and melting technology显示文摘以便开发市政的稳固的浪费(MSW ) 气化和融化的技术,二预备试验和一个原则综合实验分别地被完成。当时, MSW 的气化特征在 500 750 ° C 被学习等价比率(嗯) 是 0.2 0.5 使用使流体化床的 gasifier。当温度是 550 700 ° C 时并且嗯是 0.2 0.4, syngas 的低热价值(LHV ) 到达 4000 12000 kJ/Nm3。苍蝇灰的融化的特征用一个改正床炉子在 1100 1460 ° C 被调查。超过 99.9% 戴奥辛能被分解,这被证明并且很重金属当温度是 1100 1300 ° C 时,能被团结。原则综合实验在使流体化床的气化和打漩融化系统被执行。MSW 在 550 650 ° C 高效地被气化,打漩融化炉子稳定地并且过去在 1200 1300 ° C 坚持说 95% 苍蝇灰能被打漩融化炉子抓住。结果提供了实际经验和基本数据开发 MSW 气化和融化的技术。 | XIAO Gang JIN Bao-sheng ZHONG Zhao-ping CHI Yong NI Ming-jiang CEN Ke-fa XIAO Rui HUANG Ya-ji HUANG He | 2007 | Journal of Environmental Sciences2007，19，11： | 7 |
| 13 | Enhanced performance of GaN nanobelt-based photodetectors by means of piezotronic effects显示文摘轧紫外(紫外) 光电探测器(PD ) 在严厉环境由于他们的化学稳定性吸引了巨大的注意。尽管联系 Schottky 的基于陷阱的紫外 PD 比欧姆的接触的与更好的性能被实现了,在本地 Schottky 接触的障碍高度怎么控制传感器表演,仍然保持未知。在这个工作, piezotronic 效果被采用在本地接触调节 Schottky 障碍高度(SBH ) 并且因此提高组织的联系 Schottky 的 metal-semiconductor-metal (MSM ) 的表演轧了基于的 nanobelt (NB ) PD。一般来说,当在设备上使用紧张时, PD 的反应水平被 piezotronic 效果显然提高。PD 的 responsivity 被 18% 增加,并且敏感被提高由从 22% ~ 31% ,当与轻紧张从 12 ~ 2 W/cm2 由 325 nm 激光照亮了时。小心地用乐队结构图学习机制表明 PD 表演的观察改进从变化导致了外部紧张以及轻紧张引起的 SBH。使用 piezotronic 效果因此提供一个实际方法提高由做的 PD 的表演不仅轧,而且另外的 wurtzite 和锌闪锌矿家庭材料。 | Ruomeng Yu Caofeng Pan Youfan Hu Lin Li Hongfei Liu Wei Liu Soojin Chua Dongzhi Chi Zhong Lin Wang | 2013 | Nano Research2013，6，10： | 6 |
| 14 | Evidence-Based Chinese Medicine Clinical Practice Guideline for Stomach Pain in Hong Kong显示文摘Stomach pain in Chinese medicine(CM) is a very common disorder in clinical practice and it has been listed as one of the pilot three conditions in Hong Kong to develop evidence-based CM clinical practice guidelines(CM CPGs). The aim of this stomach Pain CPG is to summarize the treatment methods of stomach pain with CM and evaluate reasonably, then to guide local licensed CM practitioners and provide beneficial reference for social medical decision makers and patients. In this manuscript, we defined stomach pain in CM and the category of chronic gastritis in Western medicine. The clinical manifestation, CM pattern classification, and CM intervention including herbal medicine treatment based on pattern differentiation, symptomatic treatment, acupuncture treatment, regulation and nursing were illustrated. | ZHONG Linda LD SHI Nan-nan DAI Liang ZIEA Tat Chi NG Bacon TANG Xu-dong BIAN Zhao-xiang LU Ai-ping | 2017 | Chinese Journal of Integrative Medicine2017，23，10： | 6 |
| 15 | Adaptive optical focusing through perturbed scattering media with a dynamic mutation algorithm显示文摘Optical imaging through or inside scattering media, such as multimode fiber and biological tissues, has a significant impact in biomedicine yet is considered challenging due to the strong scattering nature of light. In the past decade, promising progress has been made in the field, largely benefiting from the invention of iterative optical wavefront shaping, with which deep-tissue high-resolution optical focusing and hence imaging becomes possible. Most of the reported iterative algorithms can overcome small perturbations on the noise level but fail to effectively adapt beyond the noise level, e.g., sudden strong perturbations. Reoptimizations are usually needed for significant decorrelation to the medium since these algorithms heavily rely on the optimization performance in the previous iterations. Such ineffectiveness is probably due to the absence of a metric that can gauge the deviation of the instant wavefront from the optimum compensation based on the concurrently measured optical focusing.In this study, a square rule of binary-amplitude modulation, directly relating the measured focusing performance with the error in the optimized wavefront, is theoretically proved and experimentally validated. With this simple rule, it is feasible to quantify how many pixels on the spatial light modulator incorrectly modulate the wavefront for the instant status of the medium or the whole system. As an example of application, we propose a novel algorithm, the dynamic mutation algorithm, which has high adaptability against perturbations by probing how far the optimization has gone toward the theoretically optimal performance. The diminished focus of scattered light can be effectively recovered when perturbations to the medium cause a significant drop in the focusing performance, which no existing algorithms can achieve due to their inherent strong dependence on previous optimizations. With further improvement, the square rule and the new algorithm may boost or inspire many applications, such as high-resolution optical imaging and stimulation, in instable or dynamic scattering environments. | HUANHAO LI CHI MAN WOO TIANTING ZHONG ZHIPENG YU YUNQI LUO YUANJIN ZHENG XIN YANG HUI HUI PUXIANG LAI | 2021 | Photonics Research2021，9，2： | 6 |
| 16 | Clinical diagnosis and treatment of alpha-fetoprotein-negative small hepatic lesions显示文摘Objective: We examined 103 cases over the last five years and discussed diagnosis and treatment of alpha- fetoprotein (AFP)-negative small hepatic lesions. Background: Small hepatic lesions (less than 2 cm in diameter) usually have no typical imaging characteristics and therefore are difficult to diagnose, especially when AFP tests provide a negative result. Methods: A total of 103 patients with AFP-negative small hepatic lesions from January 2003 to December 2008 were retrospectively reviewed. Differential diagnosis was performed by digital subtraction angiography (DSA), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), contrast-enhanced ultrasound (CEUS), or positron emission tomography-computed tomography (PET-CT) based on the multiplicity of lesions. Ninety-four patients with suspected cancers underwent partial hepatectomy. Clinical data were collected from hospital records and follow-up questionnaires. Results: Hepatocellular carcinoma (HCC) diagnostic sensitivity of DSA, DCE-MRI, CEUS and PET-CT was 88.2%, 93.9%, 88.9% and 88.9%, respectively. The surgery-related complication rate was 6.4%. Prognosis was good, with 1- and 3-year survival rates of 98.8% and 76.1%, respectively. Conclusions: DSA, DCE-MRI, CEUS and PET-CT are valuable for diagnosis of small hepatic lesions. Partial hepatectomy is a preferred surgical procedure. Surgery for small liver cancers usually has little risk and good prognosis, therefore it can be actively applied in suspected HCC cases. | Yiyao Xu Xin Lu Yilei Mao Xinting Sang Haitao Zhao Shunda Du Haifeng Xu Yongliang Sun Huayu Yang Tianyi Chi Zhiying Yang Shouxian Zhong Jiefu Huang | 2013 | Chinese Journal of Cancer Research2013，25，4： | 6 |
| 17 | Triboelectrification induced UV emission from plasmon discharge显示文摘紫外有的高精力的电磁的放射广泛地在工业生产和科学研究领域被使用。在这个工作,深紫外的轻排出物用 triboelectrification 被获得没有任何额外的电源供应的导致的血浆分泌物。由在聚合物和石英玻璃之间的机械磨擦,摩擦电费用引起一个变化电场,它可以带低压力气体(Ar-Hg ) 的血浆分泌物并且给出 253.7 nm 照耀。连续磨擦引起的紫外光能使三色的黄磷激动并且负担得起明亮白的轻排出物。一个紫外消毒实验证明 98% Escherichia coli 能被紫外照耀在 30 min 打死,它表明有好消毒效果的一台自我动力的消毒仪器被制作。这个工作提供一个新奇图案用低频率的机械磨擦制作一台自我动力的紫外轻射出设备并且认识到联合 triboelectrification 和血浆光,它可以进一步在特殊情形扩展紫外光的申请。 | Chang Bao Han Chi Zhang Jingjing Tian Xiaohui Li Limin Zhang Zhou Li Zhong Lin Wang | 2015 | Nano Research2015，8，1： | 5 |
| 18 | Lipid nanoparticle-encapsulated mRNA antibody provides longterm protection against SARS-CoV-2 in mice and hamsters显示文摘Monoclonal antibodies represent important weapons in our arsenal to against the CO VID-19 pandemic.However,this potential is severely limited by the time-consuming process of developing effective antibodies and the relative high cost of manufacturing.Herein,we present a rapid and cost-effective lipid nanoparticle(LNP)encapsulated-mRNA platform for in vivo delivery of SARS-CoV-2 neutralization antibodies.Two mRNAs encoding the light and heavy chains of a potent SARS-CoV-2 neutralizing antibody HB27,which is currently being evaluated in clinical trials,were encapsulated into clinical grade LNP formulations(named as mRNA-HB27-LNP).I n vivo characterizatio n dem on strated that intravenous administratio n of mRNA-HB27-LNP in mice resulted in a longer circulating half-life compared with the original HB27 antibody in protein format.More importantly,a single prophylactic administration of mRNA-HB27-LNP provided protection against SARS-CoV-2 challenge in mice at 1,7 and even 63 days post administration.In a close contact transmission model,prophylactic administration of mRNA-HB27-LNP prevented SARS-CoV-2 in fecti on betwee n hamsters in a dose-depende nt mariner.Overall,our results dem on strate a superior Ion g-term protect!on agai nst SARS-CoV-2 conferred by a single administration of this unique mRNA antibody,highlight!ng the potential of this universal platform for antibody-based disease prevention and therapy against COVID-19 as well as a variety of other infectious diseases. | Yong-Qiang Deng Na-Na Zhang Yi-Fei Zhang Xia Zhong Sue Xu Hong-Ying Qiu Tie-Cheng Wang Hui Zhao Chao Zhou Shu-Long Zu Qi Chen Tian-Shu Cao Qing Ye Hang Chi Xiang-Hui Duan Dan-Dan Lin Xiao-Jing Zhang Liang-Zhi Xie Yu-Wei Gao Bo Ying Cheng-Feng Qin | 2022 | Cell Research2022，32，4： | 5 |
| 19 | Nosocomial Infection Surveillance in a Tuberculosis Specialized Hospital in China显示文摘Nosocomial infections(NIs) are a critical issue affecting the quality of healthcare. In this study, we performed a retrospective study to explore the incidence rates, mortality rates, and microbial spectrum of NIs in Beijing Chest Hospital, a tuberculosis(TB) specialized hospital in China. Our data demonstrate that the overall incidence rate of inpatients with NIs slightly decreased from 2012 to 2016, which may be associated with the implementation of hand hygiene measures, while the mortality rates associated with NI did not significantly change. In addition, the species distribution of NIs was quite different from that presented in previous reports, and Klebsiella pneumoniae was the most frequently isolated microorganism. | XIE Zhong Yao HUANG Guo Fang GAO Hui CHI Yu Qing WANG Yan Xia PANG Yu WANG Jing Ping | 2017 | Biomedical and Environmental Sciences2017，30，9： | 5 |
| 20 | The association between orthostatic blood pressure changes and subclinical target organ damage in subjects over 60 years old显示文摘Background Although recent studies have indicated that both orthostatic hypotension and orthostatic hypertension independently predict cardiovascular events,the underlying mechanisms are still controversial.The aim of the study was to investigate the relationships between orthostatic changes and organ damage in subjects over 60 years old.Methods This is a prospective observational cohort study.One thousand nine hundred and ninety-seven subjects over 60 years old were enrolled.Participants were grouped according to whether they had a drop>20 mmHg in systolic or>10 mmHg in diastolic BP(orthostatic hypotension),an increase in mean orthostatic systolic blood pressure>20 mm Hg(orthostatic hypertension),or normal changes within 3 min of orthostatism.Multiple regression modeling was used to investigate the relationship between orthostatic hypotension,orthostatic hypertension and subclinical organ damage with adjustment for confounders.Results Orthostatic hypotension and orthostatic hypertension were found in 461(23.1%)and 189(9.5%)participants,respectively.Measurement of carotid intima-media thickness(IMT),brachial-ankle pulse wave velocity(baPWV),clearance of creatinine,and microalbuminuria were associated with orthostatic hypotension;measurement of IMT and baPWV were associated with orthostatic hypertension in a cruse model.After adjustment,IMT[odds ratio(OR),95%confidence interval(CI)per one-SD increment:1.385,1.052-1.823;P=0.02],baPWV(OR=1.627,95%CI:1.041-2.544;P=0.033)and microalbuminuria(OR=1.401,95%CI:1.002-1.958;P=0.049)were still associated with orthostatic hypotension,while orthostatic hypertension was only associated with IMT(OR=1.730,95%CI:1.143-2.618;P=0.009).Conclusions Orthostatic hypotension seems to be independently correlated with increased carotid atherosclerosis,arterial stiffness and renal damage in subjects over 60 years old.Orthostatic hypertension correlates with carotid atherosclerosis only. | Hong-Jie CHI Hai-Jun FENG Xiao-Jiao CHEN Xiao-Tao ZHAO En-Xiang ZHANG Yi-Fan FAN Xian-Chen MENG Jiu-Chang ZHONG Shou-Ling WU Jun CAI | 2019 | Journal of Geriatric Cardiology2019，16，5： | 5 |
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