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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Preassembly and ligand-induced restructuring of the chains of the IFN-γ receptor complex: the roles of Jak kinases, Statl and the receptor chains显示文摘 | Christopher D Krause Natasha Lavnikova Junxia Xie Erwen Mei Olga V Mirochnitchenko Yiwei Jia Robin M Hochstrasser Sidney Pestka | 2006 | Cell Research2006，16，1： | 7 |
| 3 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 4 | Effect of MCI-154,a calcium sensitizer,on calcium sensitivity of myocardial contractile system in endotoxemic rats显示文摘 | Mei J M Hu D Y Chen H S | 2000 | Acta Pharmacol Sin2000，21，： | 2 |
| 5 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 6 | One stop shop IV: taxonomic update with molecular phylogeny for important phytopathogenic genera: 76-100 (2020)显示文摘This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and fungus-like organisms.This paper focuses on one family:Erysiphaceae and 24 phytopathogenic genera:Armillaria,Barrio-psis,Cercospora,Cladosporium,Clinoconidium,Colletotrichum,Cylindrocladiella,Dothidotthia,,Fomitopsis,Ganoderma,Golovinomyces,Heterobasidium,Meliola,Mucor,Neoerysiphe,Nothophoma,Phellinus,Phytophthora,Pseudoseptoria,Pythium,Rhizopus,Stemphylium,Thyrostroma and Wojnowiciella.Each genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.Species confirmed with pathogenicity studies are denoted when data are available.Six of the genera are updated from previous entries as many new species have been described. | Ruvishika S.Jayawardena Kevin D.Hyde Yi Jyun Chen Viktor Papp Balázs Palla Dávid Papp Chitrabhanu S.Bhunjun Vedprakash G.Hurdeal Chanokned Senwanna Ishara S.Manawasinghe Dulanjalee L.Harischandra Ajay Kumar Gautam Shubhi Avasthi Boontiya Chuankid Ishani D.Goonasekara Sinang Hongsanan XiangYu Zeng Kapila K.Liyanage NingGuo Liu Anuruddha Karunarathna Kalani K.Hapuarachchi Thatsanee Luangharn Olivier Raspé Rashika Brahmanage Mingkwan Doilom Hyang B.Lee Liu Mei Rajesh Jeewon Naruemon Huanraluek Napalai Chaiwan Marc Stadler Yong Wang | 2020 | Fungal Diversity2020，，4： | 2 |
| 7 | Comparison of fractional Inhibitory concentration index with response surface modeling for characterization of in vitro interaction of antifungals against itraconazole-susceptible and -resistant asporgillus fumigatus isolates 显示文摘 | TE DORSTHORST D T A VERWEIJ P E MEIS J F G M | 2002 | Antimicrob Agents Chemother2002，46，3： | 1 |
| 8 | Computer modelling and tooling design for near net shaped components using hot isostatic pressing 显示文摘 | YUAN W X MEI J SAMAROV V SELIVERSTOV D WU X | 2007 | Journal of Materials Processing Technology2007，182，123： | 1 |
| 9 | Thermal history of carbon fiber polymer matrix composite, evaluated by electrical resistance measurement显示文摘 | MEI Zhen CHUNG D D L | 2001 | Thermochimica Acta2001，369，12： | 1 |
| 10 | Triptolide modulates T-ceil inflammaloly responses and ameliorales experimenlal autoitnmune encephalomyelitis显示文摘 | Wang Y Mei Y Feng D | 2008 | J Neurosci Res2008，86，11： | 1 |
| 11 | Effect of chitosan structure propertiesand molecular weight on the intranasal absorption oftetramethylpyrazine phosphate in rats 显示文摘 | Mei D’Mao S Sun W ef al | 2008 | Eur J Pharm Biopharm2008，70，3： | 1 |
| 12 | Reversible lithiumion storage in silve~treated nanoscale hollow porous silicon particles 显示文摘 | D Y Chen X Mei G Ji | 2012 | Angewandte Chemic International Edition2012，51，10： | 1 |
| 13 | A Multiple Maximum Scatter Difference Discriminant Criterion for Facial Feature Extraction显示文摘 | Song F X Zhang D Mei D Y | | 0，，： | 1 |
| 14 | Influence of Dietary β-Alanine and Histidine on the Oxidative Stability of Pork显示文摘 | Li Mei Cromwell G L Crum A D | | Meat Science0，49，1： | 1 |
| 15 | Improved treatment of the open boundary in the method of Lattice Boltzmann equation 显示文摘 | YU D MEI R SHYY W | 2005 | Progress in Computational Fluid Dynamics2005，5，12： | 1 |
| 16 | (-)-Epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune-mediated liver injury显示文摘 | Wang Y Mei Y Feng D | 2006 | Clin Exp Immunol2006，145，3： | 1 |
| 17 | On the water impact of general two-dimensional sections 显示文摘 | Mei X Lui Y Yue D K P | 1999 | Applied Ocean Research1999，21，1： | 1 |
| 18 | Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade显示文摘 | YANG D L YAO J MEI C S | 2012 | Proc Natl Acad Sci USA2012，109，19： | 1 |
| 19 | 查看详情显示文摘 | Mei D C Xie G Z Cao L Wu D J | | 0，，： | 1 |
| 20 | Compositionally graded Ti6A14V/ TiC made by direct laser fabrication using powder and wire 显示文摘 | Wang F D Mei J Wu X H | 2007 | Materials and Design2007，28，： | 1 |
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