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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | Activation of β- catenin sigzraling in articular chondrocytes leads to osteoarthritis - like phenotype in adult β - catenin conditional activation mice 显示文摘 | Mei Z Dezhi T Qiuqian W | 2009 | J Bone Miner Res2009，1，： | 1 |
| 3 | Effect of matrix composition on the microstructure of in-situ synthesized TiC particulate reinforced ironbased composites 显示文摘 | Mei Z Yan Y W Cui K | 2003 | Materials Letters2003，57，3： | 1 |
| 4 | Activating transcription factor 3 up-regulated by c-Jun NH (2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons 显示文摘 | Mei Y Yuan Z Song B | 2008 | Neuroscience2008，151，3： | 1 |
| 5 | The role of VE-cadherin in osteo- sarcoma cells 显示文摘 | Zhang L Z Mei J Qian Z K | 2010 | Pathol Oncol Res2010，16，1： | 1 |
| 6 | Assessment of iron status in US pregnant women from the National Health and Nutrition Examination Survey (NHANES), 1999 - 2006显示文摘 | MEI Z G COGSWELL M E LOOKER A C | 2011 | Am J Clin Nutr2011，93，： | 1 |
| 7 | The crustal and upper mantle structures beneath the northeastern margin of Tibet显示文摘 | Shen X Z Mei X P Zhang Y S | 2011 | Bull Seismol Soc Am2011，101，6： | 1 |
| 8 | Relation of body mass index and waist to height ratio to cardiovascular disease risk factors in children and adolescents:The Bogalusa Heart Study显示文摘 | Freedman DS Kahn HS Mei Z | | 0，，01： | 1 |
| 9 | Hole-conductor-free meso- scopic TiO2/CHaNH3PbIa heterojunction solar cells based on anatase nanosheets and carbon counter electrodes显示文摘 | Rong Y Ku Z Mei A | 2014 | J Phys Chem Lett2014，5，12： | 1 |
| 10 | A real time video fire flame and smoke detection algorithm 显示文摘 | Yu C Mei Z Zhang X | 2013 | Procedia Engineering2013，62，： | 1 |
| 11 | Conjugation of Substituted Naphthalimides to Polyamines as Cytotoxic Agents Targeting the Akt/mTOR Signal Pathway 显示文摘 | Tian Z Y Xie S Q Mei Z H | 2009 | Org Biomol Chem2009，7，22： | 1 |
| 12 | Analysis of transient wave propa- gation in an arbitrary frequency-dispersive media using the associated Laguerre functions in the FDTD-MOD method显示文摘 | Jung B H Mei Z Sarkar T K | 2012 | Microwave and Optical Technology Letters2012，54，4： | 1 |
| 13 | 查看详情显示文摘 | Mei D C Xie G Z Cao L Wu D J | | 0，，： | 1 |
| 14 | First-Principles Study of Lattice Dynamics and Thermodynamics of TiO2 Polymorphs 显示文摘 | Mei Z G Wang Y Shang S L | 2011 | Inorg Chem2011，50，： | 1 |
| 15 | C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebmfish embryogenesis显示文摘 | Mei J Zhang Q Li Z | 2008 | Dev Biol2008，319，2： | 1 |
| 16 | A model for flow induced by steady air venting and air sparging显示文摘 | Mei C C Cheng Z Ng C O | 2002 | Applied Mathematical Modeling2002，26，7： | 1 |
| 17 | Effect of matrix composition on the microstructure of in situ synthesized TiC particle reinforced iron-based composite显示文摘 | Mei Z Yan Y W Cui K | 2003 | Materials Letters2003，57，21： | 1 |
| 18 | Gene actions of QTL affecting several agronomic traits resolved in a recombinant inbred rice population and two backcross populations显示文摘 | Mei H W Li Z K Shu Q Y | | 0，，4： | 1 |
| 19 | 查看详情显示文摘 | Mei D C Xie G Z Zhang L | | 0，，： | 1 |
| 20 | Uhrasensitive One-step Rapid Visual Detection of Bisphenol A in Water Samples by Label-free Aptasensor显示文摘 | MEI Z CHU H CHEN W | 2013 | Biosensors and Bioelectronics2013，39，1： | 1 |
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