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| 1 | SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can lead to respiratory illness and multi-organ failure in critically ill patients.Although the virus-induced lung damage and inflammatory cytokine storm are believed to be directly associated with coronavirus disease 2019(COVID-19)clinical manifestations,the underlying mechanisms of virus-triggered inflammatory responses are currently unknown.Here we report that SARS-CoV-2 infection activates caspase-8 to trigger cell apoptosis and inflammatory cytokine processing in the lung epithelial cells.The processed inflammatory cytokines are released through the virus-induced necroptosis pathway.Virus-induced apoptosis,necroptosis,and inflammation activation were also observed in the lung sections of SARS-CoV-2-infected HFH4-hACE2 transgenic mouse model,a valid model for studying SARS-CoV-2 pathogenesis.Furthermore,analysis of the postmortem lung sections of fatal COVID-19 patients revealed not only apoptosis and necroptosis but also massive inflammatory cell infiltration,necrotic cell debris,and pulmonary interstitial fibrosis,typical of immune pathogenesis in the lung.The SARS-CoV-2 infection triggered a dual mode of cell death pathways and caspase-8-dependent inflammatory responses may lead to the lung damage in the COVID-19 patients.These discoveries might assist the development of therapeutic strategies to treat COVID-19. | Shufen Li Yulan Zhang Zhenqiong Guan Huiling Li Meidi Ye Xi Chen Jun Shen Yiwu Zhou Zheng-Li Shi Peng Zhou Ke Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 2 | SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses显示文摘SARS-CoV-2 infection can trigger strong inflammatory responses and cause severe lung damage in COVID-19 patients with critical illness.However,the molecular mechanisms by which the infection induces excessive inflammatory responses are not fully understood.Here,we report that SARS-CoV-2 infection results in the formation of viral Z-RNA in the cytoplasm of infected cells and thereby activates the ZBP1-RIPK3 pathway.Pharmacological inhibition of RIPK3 by GSK872 or genetic deletion of MLKL reduced SARS-CoV-2-induced IL-1βrelease.ZBP1 or RIPK3 deficiency leads to reduced production of both inflammatory cytokines and chemokines during SARS-CoV-2 infection both in vitro and in vivo.Furthermore,deletion of ZBP1 or RIPK3 alleviated SARS-CoV-2 infection-induced immune cell infiltration and lung damage in infected mouse models.These results suggest that the ZBP1-RIPK3 pathway plays a critical role in SARS-CoV-2-induced inflammatory responses and lung damage.Our study provides novel insights into how SARS-CoV-2 infection triggers inflammatory responses and lung pathology,and implicates the therapeutic potential of targeting ZBP1-RIPK3 axis in treating COVID-19. | Shufen Li Yulan Zhang Zhenqiong Guan Meidi Ye Huiling Li Miaomiao You Zhenxing Zhou Chongtao Zhang Fan Zhang Ben Lu Peng Zhou Ke Peng | 2023 | Cell Research2023，33，3： | 0 |
| 3 | Enhanced desulfurization performance of hybrid membranes using embedded hierarchical porous SBA-15显示文摘The utilization of materials with a hierarchical porous structure as multi-functional additives is highly attractive in the preparation of hybrid membranes.In this study,novel hybrid membranes are designed by embed-ding hierarchical porous Santa Barbara Amorphous 15(SBA-15)with a dual-pore architecture(micropores and mesopores)for pervaporation desulfurization.The SBA-15 with cylindrical mesopores provides molecular transport expressways to ensure improved permeability,while micropores on the wall have molecular sieving effects that are essential for the enhancement of permselectivity of thiophene molecules.Considering thiophene/n-octane mixture as a model system,the hybrid membrane with embedded 6 wt-%SBA-15 exhibits optimal pervaporation desulfurization performance with a permeation flux of 22.07 kg·m^-2·h^-1 and an enrichment factor of 6.76.Moreover,the detailed structure and properties of hybrid membranes are systematically characterized.This study demonstrates the immense potential of hierarchical porous materials as additives in membranes to simultaneously increase permeability and permselectivity. | Ye Zhang Jian Song Josue Quispe Mayta Fusheng Pan Xue Ga Mei Li Yimeng Song Meidi Wang Xingzhong Cao Zhongyi Jiang | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 0 |
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