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| 1 | Polyacrylic acid sodium salt film entrapped Ag-nanocubes as molecule traps for SERS detection显示文摘提高表面的拉曼光谱学(重量的单位) 是为踪迹化学药品的一种快分析技术;然而,吸附 analytes 要求活跃重量的单位底层,因此为底层与需要的亲密关系限制目标种类到那些。这里我们现在的联网的 polyacrylic 酸钠盐(PAAS ) 电影骗诱 Ag-nanocubes (作为 Ag-nanocubes@PAAS 表示了) 作为为有或没有高亲密关系的 analytes 的有效重量的单位底层。一次 analyte 水的答案在干燥 Ag-nanocubes@PAAS 底层上被扔,嗜酒的 PAAS 变得肿强迫 Ag-nanocubes 松开,当时在在 Ag-nanocubes 之中的空隙弥漫的 analytes。当弄干时, PAAS 缩小并且拉 Ag-nanocubes 回到他们的以前的聚集的状态,当 PAAS 网络为重量的单位察觉在在 Ag-nanocubes 之间的小差距耽搁 analytes 时。没有强壮的亲密关系,策略为 Ag 为不仅 singleanalytes 而且 multi-analytes 被证明有效,在环境在能吸附、非能吸附的污染物质的基于重量的单位的同时的 multi-analyte 察觉显示出它的潜力。 | Zhulin Huang Guowen Meng Qing Huang Bin Chen Fei Zhou Xiaoye Hu Yiwu Qian Haibin Tang Fangming Han Zhaoqin Chu | 2014 | Nano Research2014，7，8： | 6 |
| 2 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 3 | SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can lead to respiratory illness and multi-organ failure in critically ill patients.Although the virus-induced lung damage and inflammatory cytokine storm are believed to be directly associated with coronavirus disease 2019(COVID-19)clinical manifestations,the underlying mechanisms of virus-triggered inflammatory responses are currently unknown.Here we report that SARS-CoV-2 infection activates caspase-8 to trigger cell apoptosis and inflammatory cytokine processing in the lung epithelial cells.The processed inflammatory cytokines are released through the virus-induced necroptosis pathway.Virus-induced apoptosis,necroptosis,and inflammation activation were also observed in the lung sections of SARS-CoV-2-infected HFH4-hACE2 transgenic mouse model,a valid model for studying SARS-CoV-2 pathogenesis.Furthermore,analysis of the postmortem lung sections of fatal COVID-19 patients revealed not only apoptosis and necroptosis but also massive inflammatory cell infiltration,necrotic cell debris,and pulmonary interstitial fibrosis,typical of immune pathogenesis in the lung.The SARS-CoV-2 infection triggered a dual mode of cell death pathways and caspase-8-dependent inflammatory responses may lead to the lung damage in the COVID-19 patients.These discoveries might assist the development of therapeutic strategies to treat COVID-19. | Shufen Li Yulan Zhang Zhenqiong Guan Huiling Li Meidi Ye Xi Chen Jun Shen Yiwu Zhou Zheng-Li Shi Peng Zhou Ke Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 4 | The staphylococcal nuclease prevents biofilm formation in Staphylococcus aureus and other biofilm-forming bacteria显示文摘The staphylococcal nuclease, encoded by the nuc1 gene, is an important virulence factor of Staphylococcus aureus. However, the physiological role of the nuclease has not been fully characterized. The current study observed that biofilm development could be prevented in staphylococcal nuclease-producing strains of S. aureus; however, when the nuc1 gene was knocked out, the ability to form a biofilm significantly increased. Scanning electron and confocal scanning laser microscopy were used to evaluate the role of the nuc1 gene in biofilm formation. Moreover, the nuc1 gene product, staphylococcal nuclease, and recombinant NUC1 protein were found to have a visible effect on other biofilm-forming bacteria, such as Pseudomonas aeruginosa, Actinobacillus pleuropneumoniae, and Haemophilus parasuis. The current study showed a direct relationship between staphylococcal nuclease production and the prevention of biofilm development. The findings from this study underscore the important role of staphylococcal nuclease activity to prevent biofilm formation in S. aureus. They also provided evidence for the biological role of staphylococcal nucleases in other organisms. | TANG JunNi KANG MingSong CHEN HuanChun SHI XianMing ZHOU Rui CHEN Juan DU YiWu | 2011 | Science China(Life Sciences)2011，54，9： | 2 |
| 5 | Compositional dependence of hydrogenation performance of Ti-Zr-Hf-Mo-Nb high-entropy alloys for hydrogen/tritium storage显示文摘A series of Ti-Zr-Hf-Mo-Nb high-entropy alloys with different Mo concentrations were developed as candidate materials for hydrogen/tritium storage in solid phase.The crystal structures and hydrogenation properties of the Ti-Zr-Hf-Mo-Nb alloys were investigated by X-ray diffraction and differential scanning calorimetry techniques.All the alloys have a body-centred cubic single phase structure.The results demonstrate that the cell volume of the Ti-Zr-Hf-Mo-Nb hydride decreases with increasing Mo concentration,which reduces their thermal stability.The theoretical calculation proposes that the lower binding energy of the Ti-Zr-Hf-Mo-Nb hydride decreases the thermal stability of Ti-Zr-Hf-Mo-Nb alloys with higher Mo content.The great hydrogenation performance for all the Ti-Zr-Hf-Mo-Nb alloys is owing to their reversible single-phase transformation during the hydrogen absorption-desorption cycle,which would be bene ficial to improving the hydrogen recycling rate and preventing the disproportionation.The compositional dependence of the hydrogenation performance of the Ti-Zr-Hf-Mo-Nb alloys was established and will be useful in designing novel hydrogen/tritium storage materials to satisfy the requirements of diffe rent application fields in hydrogen,solar thermal and nuclear energy. | Huahai Shen Jutao Hu Pengcheng Li Gang Huang Jianwei Zhang Jinchao Zhang Yiwu Mao Haiyan Xiao Xiaosong Zhou Xiaotao Zu Xinggui Long Shuming Peng | 2020 | Journal of Materials Science & Technology2020，52，20： | 2 |
| 6 | Intrusions of Kuroshio and Shelf Waters on Northern Slope of South China Sea in Summer 2015显示文摘The northern slope region of the South China Sea(SCS) is a biological hot spot characterized by high primary productivity and biomasses transported by cross-shelf currents, which support the spawning and growth of commercially and ecologically important fish species. To understand the physical and biogeochemical processes that promote the high primary production of this region, we conducted a cruise from June 10 and July 2, 2015. In this study, we used fuzzy cluster analysis and optimum multiparameter analysis methods to analyze the hydrographic data collected during the cruise to determine the compositions of the upper 55-m water masses on the SCS northern slope and thereby elucidate the cross-slope transport of shelf water(SHW) and the intrusions of Kuroshio water(KW). We also analyzed the geostrophic currents derived from acoustic Doppler current profiler measurements and satellite data. The results reveal the surface waters on the northern slope of the SCS to be primarily composed of waters originating from South China Sea water(SCSW), KW, and SHW. The SCSW dominated a majority of the study region at percentages ranging between 60% and 100%. We found a strong cross-slope current with speeds greater than 50 cms^(-1) to have carried SHW into and through the surveyed slope area, and KW to have intruded onto the slope via mesoscale eddies, thereby dominating the southwestern section of the study area. | LI Denghui ZHOU Meng ZHANG Zhaoru ZHONG Yisen ZHU Yiwu YANG Chenghao XU Mingquan XU Dongfeng HU Ziyuan | 2018 | Journal of Ocean University of China2018，17，3： | 2 |
| 7 | The explicit expressions for phase shifts ofN-soliton solution of KdV equation显示文摘 | ZHOU GUANGHUI FAN MAOFA DUAN YIWU | 1997 | I1 Nuovo Cimento1997，112，： | 1 |
| 8 | Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples显示文摘Dear Editor,Almost one-half of COVID-19 patients have symptoms of liver injury.However,the molecular characteristics in the COVID-19 liver remain unknown.Therefore,the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver.Here,we have identifed signifcant proteomic changes for the first time in the liver of COVID-19 patients.We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection in the liver. | Ling Leng Ruiyuan Cao Jie Ma Luye LV Wei Li Yunping Zhu Zhihong Wu Manli Wang Yiwu Zhou Wu Zhong | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 9 | Fatal delayed cardiac tamponade due to rupture of micro-pseudo-aneurysm of left anterior descending coronary artery following stab to the chest显示文摘 | Jingjun Xing Shangxun Li Lin Zhang Yi Yang Yijie Duan Wenhe Li Yiwu Zhou | 2014 | Cardiovascular Pathology2014，，： | 1 |
| 10 | In situ growth and mortality of mesozooplankton during the austral fall and winter in Marguerite Bay and its vicinity显示文摘 | Zhou Meng Zhu Yiwu Peterson J O | 2004 | Deep-Sea Research Part II: Topical Studies in Oceanography2004，51，1719： | 1 |
| 11 | The Upper 1000-m Slope Currents North of the South Shetland Islands and Elephant Island Based on Ship Cruise Observations显示文摘While the Antarctic Slope Current(ASC) has been intensively studied for the East Antarctica slope area and the Weddell Sea, its fate in the western Antarctic Peninsula(WAP) region remains much less known. Data from two cruises conducted near the South Shetland Islands(SSIs) and the Elephant Island(EI), one in austral summer of 2004 and one in austral winter of 2006, were analyzed to provide a broad picture of the circulation pattern over the continental slope of the surveyed area, and an insight into the dynamical balance of the circulation. The results indicate that southwestward currents are present over the upper slope in the study area, indicating the ASC in the WAP region. Near the Shackleton Gap(SG) north of the EI, the southwestward slope currents near the shelf break are characterized by a water mass colder and fresher than the ambient water, which produces cross-slope density gradients and then vertical shear of the along-slope(or along-isobath) velocity. The vertical shear is associated with a reversal of the along-slope current from northeastward at surface to southwestward in deeper layers, or a depth-intensification of the southwestward slope currents. The water mass with temperature and salinity characteristics similar to the observed cold and fresh water is also revealed on the southern slope of the Scotia Sea, suggesting that this cold and fresh water is originated from the Scotia Sea slope and flows southwestward through the SG. Over the shelf north of the SSIs, the cold and fresh water mass is also observed and originates mainly from the Bransfield Strait. In this area, vertical structure of the southwestward slope currents is associated with the onshore intrusion of the upper Circumpolar Deep Water that creates cross-slope density gradients. | DU Guangqian ZHANG Zhaoru ZHOU Meng ZHU Yiwu ZHONG Yisen | 2018 | Journal of Ocean University of China2018，17，2： | 1 |
| 12 | Modification of polysulfide sealant with polysulfide polythio-urethane-urea显示文摘 | Quan Yiwu He Peng Zhou Baijie | | 0，，04： | 1 |
| 13 | COVID-19:A Challenge for Forensic and Pathological Researchers显示文摘Coronavirus disease 2019(COVID-19)emerged in Wuhan,Hubei province,in December 2019,then spread rapidly in a very short time resulting in thousands of deaths.Unfortunately,details about the pathological mechanisms involved in the disease-including those associated with death-are currently scant.It is important to perform autopsies and pathological examinations of patients who have died from COVID-19 as soon as possible.This is the responsibility of forensic and pathological researchers,but it does pose various challenges.Such autopsies should be conducted in an isolated operating room under constantly maintained negative pressure.The examiners should be protectively equipped in accordance with biosafety level 3 requirements.It is essential to disinfect the room,facilities,instruments,and materials after the procedure and to dispose of all wastes appropriately.Cautious and precise operations during autopsies and pathological examinations will minimize the possibility of viral transmission.As many autopsies of COVID-19 patients as possible should be performed,until a detailed understanding of the mechanisms involved in COVID-19 pathogenesis and death has been attained. | Huang Sizhe- Wang Rongshuai Wang Yunyun Zhang Junchao Zhang Youyou Guan Chuhuai Zhang Jie Yu Yalei Tian Qishuo Qu Guoqiang Liu Qian Zhou Yiwu Ren Liang Liu Liang | 2020 | Journal of Forensic Science and Medicine2020，6，2： | 0 |
| 14 | Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo显示文摘Neutralizing monoclonal antibodies(mAb)are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection.The continuous emergence of new SARS-CoV-2 variants worldwide has increased the urgency for the development of new mAbs.In this study,we immunized mice with the receptor-binding domain(RBD)of the SARS-CoV-2 prototypic strain(WIV04)and screened 35 RBDspecific mAbs using hybridoma technology.Results of the plaque reduction neutralization test showed that 25 of the mAbs neutralized authentic WIV04 strain infection.The 25 mAbs were divided into three categories based on the competitive enzyme-linked immunosorbent assay results.A representative mAb was selected from each category(RD4,RD10,and RD14)to determine the binding kinetics and median inhibitory concentration(IC_(50))of WIV04 and two variants of concern(VOC):B.1.351(Beta)and B.1.617.2(Delta).RD4 neutralized the B.1.617.2 variant with an IC50 of 2.67 ng/mL;however,it completely lost neutralizing activity against the B.1.351 variant.RD10 neutralized both variants with an IC50 exceeding 100 ng/mL;whereas RD14 neutralized two variants with a higher IC50(>1 mg/mL).Animal experiments were performed to evaluate the protective effects of RD4 and RD10 against various VOC infections.RD4 could protect Adv-hACE2 transduced mice from B.1.617.2 infection at an antibody concentration of 25 mg/kg,while RD10 could protect mice from B.1.351 infection at an antibody concentration of 75 mg/kg.These results highlight the potential for future modifications of the mAbs for practical use. | Qianran Wang Lu Peng Yanqiu Nie Yanni Shu Huajun Zhang Zidan Song Yufeng Li Hengrui Hu Liushuai Li Xi Wang Jia Liu Jiang Li Zhengli Shi Fei Deng Yu Guo Yiwu Zhou Bing Yan Zhihong Hu Manli Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 15 | Upregulation of E-cadherin by the combination of methionine restriction and HDAC2 intervention for inhibiting gastric carcinoma metastasis显示文摘Invasion and metastasis are the leading causes of death in individuals with malignant tumors,including gastric cancer.In this study,we aim to explore the effect and related mechanisms of methionine restriction(MR)on gastric carcinoma metastasis.In the MR cell model,gastric carcinoma cells are cultured in the MR medium,and in the animal model,BALB/c nude rodents are administered with a methionine-free diet after receiving injections of MKN45 cells into the caudal vein.Transwell assay is used to detect cell invasion and migration.Chromatin im-munoprecipitation is performed to investigate the levels of H3K9me2,H3K27Ac,and H3K27me3 in the E-cadherin promoter.The results show that MR inhibits gastric carcinoma cell migration,invasion,and lung metastasis.MR increases E-cadherin while reducing the H3K27me3 level in the E-cadherin promoter.E-cadherin expression in gastric carcinoma cells is adversely regulated by HDAC2.Overexpressing HDAC2 reduces the H3K27Ac level in the E-cadherin promoter,while interfering with HDAC2 increases the H3K27Ac level.HDAC2 interference under MR conditions further upregulates E-cadherin expression and inhibits gastric carcinoma cell migration,invasion,and lung metastasis.MR combined with HDAc2 interference promotes E-cadherin expression by mediating the me-thylation and acetylation of E-cadherin,thus inhibiting the invasion,migration,and lung metastasis of gastric carcinoma cells.Our study provides a new theoretical basis for the inhibitory effect of MR on gastric cancer. | Yifan Li Chenxi Liu Lin Xin Chuan Liu Jiaqing Cao Zhenqi Yue Jie Sheng Yiwu Yuan Qi Zhou Zhiyang Liu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，1： | 0 |
| 16 | Effects of glucocorticoid and glucocorticoid receptors on stress-induced neurogenesis suppression显示文摘Studies have shown that cerebral ischemia activates neurogenesis and that stress inhibits neurogenesis. However, the role of stress hormone levels on neurogenesis following cerebral ischemia remains poorly understood. The present study explored the possible regulatory mechanisms of adult neurogenesis under pathological conditions by examining changes and regulation of glucocorticoid receptors in adult rats subjected to transient unilateral middle cerebral artery suture occlusion. Corticosterone levels gradually increased following middle cerebral artery occlusion, and the number of glucocorticoid receptor-positive cells decreased. The number of 5-bromodeoxyuridine- and nestin-positive cells significantly increased at 1 and 2 weeks after ischemia. A large number of doublecortin-positive cells migrated from the hippocampus to the cortex. At 3 weeks post-surgery, the number of 5-bromodeoxyuridine- and nestin-positive cells significantly reduced in the subventricular zone. Increased corticosterone levels decreased vascular endothelial cell proliferation and neurogenesis, and the number of glucocorticoid receptor-positive cells decreased. In the sham surgery group, vascular endothelial cell proliferation related to post-ischemic cerebral rehabilitation was not detected. Corticosterone levels increased, but the number and distribution of glucocorticoid receptor-positive cells were not changed. However, normal neurogenesis and migration of neural stem cells existed in the adult rat brain in the sham surgery group. Results suggested that glucocorticoid receptors influenced neurogenesis and were negatively regulated by glucocorticoid levels following focal cerebral ischemia and reperfusion. | Xin Zhou Jiapei Dai Dan Liu Shangxun Li Yiwu Zhou | 2010 | Neural Regeneration Research2010，5，17： | 0 |
| 17 | Guide to forensic pathology practice for death cases related to coronavirus disease 2019(COVID-19)(Trial draft)显示文摘Autopsy is of great significance for elucidating the pathological changes,pathogenesis and cause of death of Coronavirus Disease 2019(COVID-19)and can provide a theoretical basis for scientific and accurate prevention and control of its outbreak.Based on related laws and regulations,such as the Law of the People's Republic of China on Prevention and Control of Infectious Diseases,clinical manifestations and epidemiological characteristics of COVID-19 and guidelines on the prevention and control of this epidemic,combined with the practical work of forensic pathology examinations,we developed the Guide to Forensic Pathology Practice for Death Cases Related to Coronavirus Disease 2019(COVID-19)(Trial Draft).This guide describes the background investigation of the death cases,autopsy room requirements,personal pre-vention and protections,external examinations,autopsy practices and auxiliary examinations,and thus offers a reference for forensic and pathological examination institutions and staff. | Danmi Mao Nan Zhou Da Zheng Jiacheng Yue Qianhao Zhao Bin Luo Dawei Guan Yiwu Zhou Bingjie Hu Jianding Cheng(Translated) | 2020 | Forensic Sciences Research2020，5，1： | 0 |
| 18 | -bola virus mucin-like glycoprotein (Emuc) nduces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo显示文摘 | Yun-Jia Ning Zhenyu Kang Jingjun Xing Yuan-Qin Min Dan Liu Kuan Feng Manli Wang Fei Deng Yiwu Zhou Zhihong Hu Hualin Wang | 2018 | Protein & Cell2018，9，4： | 0 |
| 19 | Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque显示文摘Dear Editor,COVID-19 caused by SARS-Co V-2,is still a big threat to human populations around the world.As of Jan 2022,over 292 million cases were reported worldwide with more than 5.4 million deaths.After it was first reported in China in December 2019,the virus kept circulating and evolving and several variants with different transmissibility emerged in different countries and regions(WHO,2021a). | Ge Gao Xue Hu Yiwu Zhou Juhong Rao Xiaoyu Zhang Yun Peng Jiaxuan Zhao Yanfeng Yao Kunpeng Liu Mengying Liang Hang Liu Fei Deng Han Xia Chao Shan Zhiming Yuan | 2022 | Virologica Sinica2022，37，2： | 0 |
| 20 | 全国两会代表、委员谈标准显示文摘More than 5,000 of China’s political,business and social elite converged in Beijing in early March for the country’s most important annual meeting-the“Two Sessions”,which refers to the back-to-back meetings of two China’s major political bodies-the National People’s Congress(NPC)and Chinese People’s Political Consultative Conference(CPPCC). | Yang Zhen Deng Zhonghan Mai Jiaomeng Wang Yongtian Dong Mingzhu Ding Lei Lei Jun An Ting Zhang Tianren Ji Guifeng Liu Muhua Zhou Yunjie Zhao Yiwu Han Yongjin Guan Peijun Ni Minjing Zhao Dachun Lan Minbo | 2021 | China Standardization2021，，3： | 0 |
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