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| 1 | A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction显示文摘Regeneration of Intervertebral disc(IVD)is a scientific challenge because of the complex structure and composition of tissue,as well as the difficulty in achieving bionic function.Here,an anatomically correct IVD scaffold composed of biomaterials,cells,and growth factors were fabricated via three-dimensional(3D)bioprinting technology.Connective tissue growth factor(CTGF)and transforming growth factor-β3(TGF-β3)were loaded onto polydopamine nanoparticles,which were mixed with bone marrow mesenchymal stem cells(BMSCs)for regenerating and simulating the structure and function of the nucleus pulposus and annular fibrosus.In vitro experiments confirmed that CTGF and TGF-β3 could be released from the IVD scaffold in a spatially controlled manner,and induced the corresponding BMSCs to differentiate into nucleus pulposus like cells and annulus fibrosus like cells.Next,the fabricated IVD scaffold was implanted into the dorsum subcutaneous of nude mice.The reconstructed IVD exhibited a zone-specific matrix that displayed the corresponding histological and immunological phenotypes:primarily type II collagen and glycosaminoglycan in the core zone,and type I collagen in the surrounding zone.The testing results demonstrated that it exhibited good biomechanical function of the reconstructed IVD.The results presented herein reveal the clinical application potential of the dual growth factors-releasing IVD scaffold fabricated via 3D bioprinting.However,the evaluation in large mammal animal models needs to be further studied. | Binbin Sun Meifei Lian Yu Han Xiumei Mo Wenbo Jiang Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，1： | 5 |
| 2 | High-precision,gelatin-based,hybrid,bilayer scaffolds using melt electro-writing to repair cartilage injury显示文摘Articular cartilage injury is a common disease in the field of orthopedics.Because cartilage has poor self-repairing ability,medical intervention is needed.Using melt electro-writing(MEW)technology,tissue engineering scaffolds with high porosity and high precision can be prepared.However,ordinary materials,especially natural polymer materials,are difficult to print.In this study,gelatin was mixed with poly(lactic-co-glycolic acid)to prepare high-concentration and high-viscosity printer ink,which had good printability and formability.A composite scaffold with full-layer TGF-β1 loading mixed with hydroxyapatite was prepared,and the scaffold was implanted at the cartilage injury site;microfracture surgery was conducted to induce the mesenchyme in the bone marrow.Quality stem cells thereby promoted the repair of damaged cartilage.In summary,this study developed a novel printing method,explored the molding conditions based on MEW printing ink,and constructed a bioactive cartilage repair scaffold.The scaffold can use autologous bone marrow mesenchymal stem cells and induce their differentiation to promote cartilage repair. | Yu Han Bo Jia Meifei Lian Binbin Sun Qiang Wu Benlin Sun Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，7： | 2 |
| 3 | The commonly used antimicrobial additive triclosan is a liver tumor promoter显示文摘 | YUEH Meifei TANIGUCHI K CHEN Shujuan | 2014 | Proceedings of the National Academy of Sciences of the United States of America2014，111，17： | 1 |
| 4 | Tibetan tectonic evolution inferred from spatial and temporal variations in post-collisional magmatism显示文摘 | Chung Sunlin Chu Meifei Zhang Y | 2005 | Earth Science Reviews2005，68，： | 1 |
| 5 | Design and performance of the LLRF control system for CSNS linac显示文摘Objective The China Spallation Neutron Source(CSNS)linac is designed with beam energy of 80 MeV and a peak current of 15 mA in the first phase.It consists of RFQ,two bunchers of medium-energy beam transmission line,four DTL tanks and one debuncher of linac-to-ring beam transmission line.Correspondingly,eight online RF power sources are used to power these accelerators.In order to stabilize the amplitude,phase and resonant frequency of the RF accelerating field,and minimize beam loss,we have established digital low-level RF(LLRF)control system.Methods The LLRF system includes RF reference line,analog module(AM),clock distribution module,digital control module(DCM),high-power protection module,timing and RF interlock module and so on.The DCM is mainly responsible for the stability of the RF field amplitude and phase,and RF interlock module can quickly cut off the RF drive in case of arc in the RF transmission system,VSWR over threshold or cavity vacuum fault and so on.Result During beam commissioning,all of eight online units of LLRF control system were operating stably and reliably.The amplitude and phase variations of the linac fields have been achieved about±0.4%and±0.15°with 10-mA beam loading,much better than the design requirements of±1%in amplitude and±1°in phase.Conclusion With the help of this system,we achieved stable operation under different beam loads.Also,many important progresses have been achieved in the LLRF control system for amore convenient operation and a higher stability performance.This article describes the design and implementation of the LLRF for CSNS linac. | Linyan Rong Zhencheng Mu Jian Li Zhexin Xie Wenzhong Zhou Bo Wang Maliang Wan Meifei Liu Xinan Xu | 2020 | Radiation Detection Technology and Methods2020，4，2： | 1 |
| 6 | InfluenceofTiO2particlesonrheologicalpropertyandmicrostructureofPA6chips显示文摘 | HanJian Zhang Meifei ZhangShunhua etal | 2010 | Rare Metal MaterialsandEngineering2010，39，： | 1 |
| 7 | Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats显示文摘 | Liyun Xie Meiling Zhang Baijun Dong Mimi Guan Meifei Lu Zhifeng Huang Hongchang Gao Xiaokun Li | 2011 | Diabetes Research and Clinical Practice2011，，： | 1 |
| 8 | A columnar multi-layer sliding triboelectric nanogenerator for water wave energy harvesting independent of wave height and direction显示文摘The ocean,with its highly variable and complex meteorological conditions,harbors enormous renewable resources.Triboelectric nanogenerators(TENGs),which possess unique advantages,show exciting prospects in water wave energy collection.How to design and optimize TENGs to cover all characteristic water wave energies and achieve efficient energy utilization is emergent.In this paper,we carefully designed and fabricated a columnar multi-layer sliding TENG(CMLS-TENG)that can harvest water wave energy independent of wave height and direction.Drive rods with a hollow acrylic spherical shell were introduced to deliver wave energy,ensuring that the CMLS-TENG can work in all directions from 0°to 360°.Based on the sliding structure,switching the optimized CMLS-TENG is independent of wave heights.The optimized CMLS-TENG can achieve a total power density of 730 mW/m^(3) at a wave height of only 4.8 cm regardless of wave direction,which can illuminate multiple light-emitting diodes(LEDs)to provide lighting and provide power to a watch and a hygrometer for temperature and humidity monitoring.This work provides new choices and hopes for the effective collection of full-range water wave energy. | Xue Miao Hanxiao Yang Zekun Li Meifei Cheng Yilin Zhao Lingyu Wan Aifang Yu Junyi Zhai | 2024 | Nano Research2024，17，4： | 0 |
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