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| 1 | Advanced fabrication for electrospun three-dimensional nanofiber aerogels and scaffolds显示文摘Electrospinning is a versatile strategy for creating nanofiber materials with various structures,which has broad application for a myriad of areas ranging from tissue engineering,energy harvesting,filtration and has become one of the most important academic and technical activities in the field of material science in recent years.In addition to playing a significant role in the construction of two-dimensional(2D)nanomaterials,electrospinning holds great promise as a robust method for producing three-dimensional(3D)aerogels and scaffolds.This article reviews and summarizes the recent advanced methods for fabricating electrospun three-dimensional nanofiber aerogels and scaffolds,including gas foaming,direct electrospinning of 3D nanofibrous scaffold,short nanofibers assembling into 3D aerogels/scaffolds,3D printing,electrospray,origami and cell sheet engineering,centrifugal electrospinning,and other methods.Besides,intriguing formation process,crosslinking pathway,properties,and applications of 3D aerogels and scaffolds are also introduced.Taken together,these aerogels and scaffolds with various excellent features present tremendous potential in various fields. | Yujie Chen Muhammad Shafiq Mingyue Liu Yosry Morsi Xiumei Mo | 2020 | Bioactive Materials2020，5，4： | 12 |
| 2 | Electrospinning nanofiber scaffolds for soft and hard tissue regeneration显示文摘Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and organs.The three fundamental pillars of tissue engineering are scaffolds,cells,and biomolecules.Electrospun nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected pores.In this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue engineering.We first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial fabrication.Next,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament applications.Finally,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas. | Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi Allison E.Fetz Gary L.Bowlin Mohamed El-Newehy Xiumei Mo | 2020 | Journal of Materials Science & Technology2020，59，24： | 5 |
| 3 | A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction显示文摘Regeneration of Intervertebral disc(IVD)is a scientific challenge because of the complex structure and composition of tissue,as well as the difficulty in achieving bionic function.Here,an anatomically correct IVD scaffold composed of biomaterials,cells,and growth factors were fabricated via three-dimensional(3D)bioprinting technology.Connective tissue growth factor(CTGF)and transforming growth factor-β3(TGF-β3)were loaded onto polydopamine nanoparticles,which were mixed with bone marrow mesenchymal stem cells(BMSCs)for regenerating and simulating the structure and function of the nucleus pulposus and annular fibrosus.In vitro experiments confirmed that CTGF and TGF-β3 could be released from the IVD scaffold in a spatially controlled manner,and induced the corresponding BMSCs to differentiate into nucleus pulposus like cells and annulus fibrosus like cells.Next,the fabricated IVD scaffold was implanted into the dorsum subcutaneous of nude mice.The reconstructed IVD exhibited a zone-specific matrix that displayed the corresponding histological and immunological phenotypes:primarily type II collagen and glycosaminoglycan in the core zone,and type I collagen in the surrounding zone.The testing results demonstrated that it exhibited good biomechanical function of the reconstructed IVD.The results presented herein reveal the clinical application potential of the dual growth factors-releasing IVD scaffold fabricated via 3D bioprinting.However,the evaluation in large mammal animal models needs to be further studied. | Binbin Sun Meifei Lian Yu Han Xiumei Mo Wenbo Jiang Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，1： | 5 |
| 4 | In vitro evaluation of electrospun gelatin-glutaraldehyde nanofibers显示文摘 | Jianchao ZHAN Yosry MORSI Hany EI-HAMSHARY Salem S. AL-DEYAB Xiumei MO | 2016 | Frontiers of Materials Science2016，10，1： | 4 |
| 5 | Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction显示文摘It is a big challenge to develop a polyethylene terephthalate(PET)artificial ligament with excellent osteogenetic activity to enhance graft-bone integration for ligament reconstruction.Herein,we evaluated the effect of biomineralization(BM)and electrodeposition(ED)method for depositing calcium-phosphate(CaP)on the PET artificial ligament in vitro and in vivo.Scanning electron microscopy and energy-dispersive X-Ray spectrometer mapping analysis revealed that the ED-CaP had more uniform particles and element distribution(Ca,P and O),and thermogravimetric analysis showed there were more CaP on the PET/ED-CaP than the PET/BM-CaP scaffold.Moreover,the hydrophilicity of PET scaffolds was significantly improved after CaP deposition.In vitro study showed that CaP coating via BM or ED method could improve the attachment and proliferation of MC3T3-E1 cells,and ED-CaP coating significantly increased osteogenic differentiation of the cells,in which the Wnt/β-catenin signaling pathway might be involved.In addition,radiological,histological and immunohistochemical results of in vivo study in a rabbit anterior cruciate ligament(ACL)reconstruction model demonstrated that the PET/BM-CaP and PET/ED-CaP scaffolds significantly improved graft-bone integration process compared to the PET scaffold.More importantly,larger areas of new bone ingrowth and the formation of fibrocartilage tissue were observed at 12 weeks in the PET/ED-CaP group,and the biomechanical tests showed increased ultimate failure load and stiffness in PET/ED-CaP group compared to PET/BM-CaP and PET group.Therefore,ED of CaP is an effective strategy for the modification of PET artificial ligament and can enhance graft-bone integration both in vitro and in vivo. | Jiangyu Cai Qianqian Zhang Jiebo Chen Jia Jiang Xiumei Mo Chuanglong He Jinzhong Zhao | 2021 | Bioactive Materials2021，6，3： | 4 |
| 6 | Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound显示文摘Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation.Electrospun nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner.Herein,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive agents.Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities.Furthermore,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation.The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin��6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW. | Atta ur Rehman Khan Kai Huang Mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi Zhao Jinzhong Xiumei Mo | 2021 | Bioactive Materials2021，6，9： | 3 |
| 7 | Changes in Vegetation and Assessment of Meteorological Conditions in Ecologically Fragile Karst Areas显示文摘Meteorological conditions have an important impact on changes of vegetation in ecologically fragile karst areas.This study aims to explore a method for quantitative evaluation of these meteorological conditions. We analyzed the changing trend of vegetation during 2000–2018 and the correlations between vegetation changes and various meteorological factors in karst rocky areas of Guangxi Zhuang Autonomous Region, China. Key meteorological factors in vegetation areas with varying degrees of improvement were selected and evaluated at seasonal timescale. A quantitative evaluation model of comprehensive influences of meteorological factors on vegetation was built by using the partial least-square regression(PLS). About 91.45% of the vegetation tended to be improved, while only the rest 8.55% showed a trend of degradation from 2000 to 2018. Areas with evident vegetation improvement were mainly distributed in the middle and northeast, and those with obvious vegetation degradation were scattered. Meteorological factors affecting vegetation were significantly different among the four seasons. Overall, high air humidity, small temperature difference in spring and autumn, and low daily minimum temperature and air pressure were favorable conditions. Low temperature in winter as well as high temperature in summer and autumn were unfavorable conditions. The Climate Vegetation Index(CVI) model was established by PLS using the maximum, minimum, and average temperatures;vapor pressure;rainfall;and air pressure as key meteorological factors. The Enhanced Vegetation Index(EVI) was well fitted by the CVI model, with the average coefficient of determination(r2) and root mean square error(RMSE) of 0.856 and 0.042, respectively. Finally, an assessment model of comprehensive meteorological conditions was built based on the interannual differences in CVI. The meteorological conditions in the study area in 2014 were successfully evaluated by combining the model and selected seasonal key meteorological factors. | Yanli CHEN Weihua MO Yonglin HUANG Jianfei MO Xiaohan HUANG Xiumei WEN | 2021 | Journal of Meteorological Research2021，35，1： | 3 |
| 8 | Progress on Li3VO4 as a Promising Anode Material for Li-ion Batteries显示文摘 | Jun Mo Xiumei Zhang Junjie Liu Jingang Yu Zhian Wang Zaichun Liu Xinhai Yuan Chunjiao Zhou Ruilian Li Xiongwei Wu Yuping Wu | 2017 | Chinese Journal of Chemistry2017，35，12： | 3 |
| 9 | Stem cell homing-based tissue engineering using bioactive materials显示文摘 | Yinxian YU Binbin SUN Chengqing YI Xiumei MO | 2017 | Frontiers of Materials Science2017，11，2： | 2 |
| 10 | Electrospun silk fibroin/poly(L-lactide-ecaplacton)graft with platelet-rich growth factor for inducing smooth muscle cell growth and infiltration显示文摘The construction of a smooth muscle layer for blood vessel through electrospinning method plays a key role in vascular tissue engineering.However,smooth muscle cells(SMCs)penetration into the electrospun graft to form a smooth muscle layer is limited due to the dense packing of fibers and lack of inducing factors.In this paper,silk fibroin/poly(L-lactide-e-caplacton)(SF/PLLA-CL)vascular graft loaded with platelet-rich growth factor(PRGF)was fabricated by electrospinning.The in vitro results showed that SMCs cultured in the graft grew fast,and the incorporation of PRGF could induce deeper SMCs infiltrating compared to the SF/PLLA-CL graft alone.Mechanical properties measurement showed that PRGF-incorporated graft had proper tensile stress,suture retention strength,burst pressure and compliance which could match the demand of native blood vessel.The success in the fabrication of PRGF-incorporated SF/PLLA-CL graft to induce fast SMCs growth and their strong penetration into graft has important application for tissue-engineered blood vessels. | Anlin Yin Gary L.Bowlin Rifang Luo Xingdong Zhang Yunbing Wang Xiumei Mo | 2016 | Regenerative Biomaterials2016，3，4： | 2 |
| 11 | The Tribological Properties of the Hot-extrusion Nylon Coating in the Oil Well Environment显示文摘 | Mo Yimin Pan Yunping Wang Xiumei | 2003 | Journal of Wuhan University of Technology:Materials Science Edition2003，18，4： | 1 |
| 12 | Genipincrosslinked gelatin nanofibers for tissue engineering显示文摘 | Su Yah Mo Xiumei | | 0，，： | 1 |
| 13 | Electrospun collagen-chitosan-TPU nanofibrous scaffolds for tissue engineered tubular grafts显示文摘 | Chen Huang Rui Chen Qinfei Ke Yosry Morsi Kuihua Zhang Xiumei Mo | | 0，，： | 1 |
| 14 | Effect of total phenolics from Laggera alata on acute and chronic inflammation models显示文摘 | Yihang Wu Changxin Zhou Liyan Song Xiangping Li Shuyun Shi Jianxia Mo Haiyong Chen Hua Bai Xiumei Wu Jun Zhao Rongping Zhang Xiaojiang Hao Handong Sun Yu Zhao | 2006 | Journal of Ethnopharmacology2006，，2： | 1 |
| 15 | Fabrication of chitosan/silk fibroin composite uanofibers for wound-dressing applications 显示文摘 | Cai Zengxiao Mo Xiumei Zhang Kuihua | 2010 | International Journal of Molecular Sciences2010，11，9： | 1 |
| 16 | Green Electrospun Silk Fibroin Nanofibers Loaded with Cationic Ethosomes for Transdermal Drug Delivery显示文摘Transdermal drug delivery system(TDDS)facilitates the controlled release of active ingredients penetrating through the skin,avoiding the liver first pass effect.Electrospinning is a simple process to fabricate ultrafine fibers with a higher specific surface area,making them excellent candidates for drug delivery.In current work,a novel silk fibroin(SF)nanofiber loaded with cationic ethosomes(CEs)was prepared via green electrospinning.The data of Fourier transform infrared spectroscopy(FTIR)and laser scanning confocal microscopy(LSCM)confirmed the existence of CEs in the SF nanofibers.The morphology of the nanofibers was not significantly affected by the incorporation of CEs as shown by scanning electron microscopy(SEM)images.The CEs-loaded SF nanofibrous patch(CEs-SFnP)showed good cytocompatibility as proved by both cell counting Kit-8(CCK-8)assay and SEM.Using doxorubicin hydrochloride(Dox)as a model drug,the transdermal performance of CEs-SFnP was evaluated through Franz diffusion cell against mouse skin.The results indicated that CEs-SFnP can effectively deliver drug into the skin,with a much higher permeation rate than the normal nanofibers without CEs.The as-spun CEs-SFnP in this study could find promising applications in TDDS. | HONG Huoyan ZHANG Dongdong UN Si HAN Feng WANG Kaili JIANG Di WU Jinglei MO Xiumei WANG Hongsheng | 2021 | Chemical Research in Chinese Universities2021，37，3： | 1 |
| 17 | Mechanical properties of eleetrospun collagen - ehitosan complex single fibers and membrane 显示文摘 | Chen Zonggang Wei Bo Mo Xiumei | 2009 | Mater Sci Eng C Mar Biol Appl2009，29，8： | 1 |
| 18 | Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Tissue injury leads to gradients of chemoattractants,which drive multiple processes for tissue repair,including the inflam-matory response as well as endogenous cell recruitment.However,a limited time window for the gradients of chemoattract-ants as well as their poor stability at the injury site may not translate into healthy tissue repair.Consequently,intelligent multifunctional scaffolds with the capability to stabilize injury-induced cytokines and chemokines hold great promise for tissue repair.Vascular endothelial growth factor(VEGF)plays a significant role in wound healing by promoting angiogen-esis.The overarching objective of this research was to develop intelligent multifunctional scaffolds with the capability to endogenously recruit VEGF and promote wound healing via angiogenic and immunomodulatory dual functions.Prominin-1-derived peptide(PR1P)was encapsulated into electrospun poly(L-lactide-coglycolide)/gelatin(P/G)-based bandages.The sustained release of PR1P recruited VEGF in situ,thereby stabilizing the protein concentration peak in vivo and affording a reparative microenvironment with an adequate angiogenic ability at the wound site.Meanwhile,PR1P-recruited VEGF-induced macrophage reprogramming towards M2-like phenotypes further conferred immunomodulatory functions to the bandages.These dual functions of proangiogenesis and immunomodulation formed a cascade amplification,which regulated matrix metalloproteinases(MMP-9)as well as inflammatory factors(nuclear factor(NF)-κb,tumor necrosis factor(TNF)-α)in the wound microenvironment via the VEGF/macrophages/microenvironment axis.Consequently,the bandages realized multifunctional regeneration in splinted excisional wounds in rats,with or without diabetes,affording a higher skin append-age neogenesis,sensory function,and collagen remodeling.Conclusively,our approach encompassing in situ recruitment of VEGF at the injury site with the capability to promote immunomodulation-mediated tissue repair affords a promising avenue for scarless wound regeneration,which may also have implications for other tissue engineering disciplines. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，1： | 1 |
| 19 | Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications显示文摘 | CAI Zengxiao MO Xiumei ZHANG Kuihua | 2010 | International Journal of Molecular Sciences2010，11，9： | 1 |
| 20 | al Electrospinning P(LLA-CL)nanofiber:a biomimetic Extracelluer Matrix for smooth muscle cell and endothelial cell proliferation显示文摘 | Xiumei Mo CY Xu M Kotaki et | 2004 | Biomaterials2004，25，10： | 1 |
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