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| 1 | Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study显示文摘Attention deficit hyperactivity disorder(ADHD)is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor(DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity(Re Ho) and functional connectivity(FC). Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD44-repeat/4-repeat(4 R/4 R) allele(n = 30) or the DRD42-repeat(2 R) allele(n = 19). The results showed that participants with the DRD4 2 R allele had decreased Re Ho bilaterally in the posterior lobes of the cerebellum, while Re Ho was increased in the left angular gyrus. Compared with participants carrying the DRD4 4 R/4 R allele, those with the DRD4 2 R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children. | ANDan Qian Xin Wang Huiru Liu Jiejie Tao Jiejie Zhou Qiong Ye Jiance Li Chuang Yang Jingliang Cheng Ke Zhao Meihao Wang | 2018 | Neuroscience Bulletin2018，34，3： | 10 |
| 2 | Resting state brain default network in patients with motor aphasia resulting from cerebral infarction显示文摘To explore the brain default mode network(DMN)in patients with motor aphasia resulting from cerebral infarction,we used resting state functional magnetic resonance imaging(fMRI)to investigate the possible neural mechanism.Thirteen patients with motor aphasia resulting from cerebral infarction and ten matched controls were selected in this study.All subjects were examined using resting state fMRI.We chose the posterior cingulate cortex as the region of interest and then used functional connectivity analysis to calculate the DMN functional connectivity and analyze differences in the functional connectivity between the two groups.Compared with normal controls,aphasia patient group showed a significantly decreased functional connectivity in bilateral medial frontal gyrus,superior frontal gyrus,middle frontal gyrus,middle temporal gyrus,precuneus and cuneus.The aphasia patient group showed increased functional connectivity mainly in bilateral medial frontal gyrus,middle frontal gyrus,inferior frontal gyrus,precentral gyrus,insula.The DMN in cerebral infarction motor aphasia patients showed significantly decreased functional connectivity in the resting state.The DMN most likely plays an important role in motor aphasia resulting from cerebral infarction.Furthermore,functional connectivity in the brain regions surrounding the left and right Broca’s areas was significantly enhanced due to compensatory mechanisms.This may be helpful for the recovery of language function in cerebral infarction patients with motor aphasia. | Xin Wang Meihao Wang Weizhuo Wang Huiru Liu Jiejie Tao Chuang Yang Jiance Li | 2014 | Chinese Science Bulletin2014，59，31： | 9 |
| 3 | Functional Analysis of Phosphate Transporter OsPHT4 Family Members in Rice显示文摘The transport of phosphate between cytoplasm and subcellular compartments is critical for plant metabolic regulation.We conducted bioinformatic analysis,heterologous expression in yeast,gene expression pattern and subcellular localization analysis to characterize the possible functions of OsPHT4 gene family in rice.Together with the PHT4 genes from higher plants,OsPHT4s can be classified into six distinct groups.OsPHT4;1-OsPHT4;4 are targeted to chloroplasts,and OsPHT4;6-1 and OsPHT4;6-2 are located to Golgi apparatus.OsPHT4 proteins can mediate inorganic phosphate(Pi)transport in yeast.In addition,dynamic transcriptional changes determined by qRT-PCR revealed different expression profiles of OsPHT4 genes in response to phosphate starvation,salicylic acid,abscisic acid and salt stress treatments.These results suggested that OsPHT4 proteins are involved in Pi distribution between the cytoplasm and chloroplast or Golgi apparatus and also involved in stress responses. | Li Ruili Wang Jiaoling Xu Lei Sun Meihao Yi Keke Zhao Hongyu | 2020 | Rice science2020，27，6： | 1 |
| 4 | Molecular characterization of glutaredoxin 2 from Ostrinia furnacalis显示文摘Glutaredoxins(GRXs)play very important roles in maintaining intracellular redox homeostasis.In the present study,the full-length cDNA sequence encoding GRX2,named OfurGRX2(GenBank accession no.GU393246),was obtained from Ostrinia furnacalis,using reverse transcription polymerase chain reaction and rapid amplification of cDNA ends.Sequence analysis revealed that the open reading frame of OfurGRX2 consists of 351 nucleotides encoding 116 amino acid residues with a predicted molecular weight of 12.6 kDa.Homolog research revealed that OfurGRX2 shares a common active site,CPYC/CPFC,with other insect counterparts.Expression profiles revealed that OfurGRX2 is a ubiquitous gene expressed in insect heads,fat bodies,epidermises,mid guts and muscles.The OfurGRX2 transcript peaked in 36-h larvae of 4th instars,and then suddenly declined in the molting stage.Hormone treatment experiments revealed that 20-hydroxyecodyson(20e)significantly induces the expression of the OfurGRX2 transcript,whereas juvenile hormone(JH)counteracts 20e effects.Adverse stress factors(including starvation,ultraviolet light,mechanical injury,Escherichia coli exposure,and high and low temperatures)dramatically induced OfurGRXGRX2 transcript expression,which confirmed for the first time that GRX2 play important roles in insecta during exposure to adverse environments. | Shiheng AN Ying ZHANG Tiantian WANG Meihao LUO Chaohai LI | 2013 | Integrative Zoology2013，8，1： | 0 |
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