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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Clinical findings and diagnostic tests in Creutzfeldt-Jakob disease and variant Creutzfeldt-Jakob disease显示文摘 | Krasnianski A Meissner B Heinemann U | 2004 | Folia Neuropathol2004，42，： | 1 |
| 3 | Estimation of age at death based on quantitation of the 4977-bp deletion of human mitochondrial DNA in skeletal muscle显示文摘 | von Wurmb N Schimansky B | 1999 | Forensic Sci Int1999，105，2： | 1 |
| 4 | Development of a fixed bed bio reactor for the expansion of human hematopoietie progenitor cells 显示文摘 | Meissner Schroder B Herfurth C | 1999 | Cytotechnology1999，，22： | 1 |
| 5 | Risk factor analysis in differentiated thyroid cancer显示文摘 | Cady B Sedgcoick CE Meissner WA | 1979 | Cancer1979，43，： | 1 |
| 6 | The major function of a metallothionein from the aquatic fungus Heliscus lugdunensis is cadmium detoxification显示文摘 | Loebus J Leitenmaier B Meissner D | 2013 | J Inorg Biochem2013，127，： | 1 |
| 7 | Integrating molecular information into treatment of childhood acute lymphoblastic leukemia-a perspective from the BFM Study Group 显示文摘 | Stanulla M Carlo G Meissner B | 2007 | Blood Cells Mol Dis2007，39，2： | 1 |
| 8 | Therapeutic effects of pre-gelatinized maca (lepidium peruvianum ehacon) used as a non-hormonal alternative to HRT in perimenopausal women - clinical pilot study显示文摘 | Henry O Meissner HW Reich B | 2006 | Int J Biomed Sci2006，2，2： | 1 |
| 9 | Markers of plasma coagulation and fibrinolysis after acute deep venous thrombosis显示文摘 | MEISSNER W ZIERLER B | 2000 | J Vase Surg2000，32，5： | 1 |
| 10 | Sensitivity of the Pacific white shrimp, Penaeus vannamei, to aflatoxin B1 显示文摘 | Ostrowski - Meissner H T LeaMaster B R Duerr E O | 1995 | Aquaculture1995，131，： | 1 |
| 11 | IKZF1 deletion is an independent predictor of outcome in pediatric acute lyrnpho- blastic leukemia treated according to the ALL-BFM 2000 pro- tocol显示文摘 | Dorge P Meissner B Zimmermann M | 2013 | Haematologica2013，98，3： | 1 |
| 12 | Cutting edge: Impaired MHC Class I expression in mice deficient for Nlrc5/class transactivator显示文摘 | BISWAS A MEISSNER T B KAWAI T | 2012 | Journal of Immunology2012，189，2： | 1 |
| 13 | Capillary zone electrophoresis and ion chromatography in the low mg/l range applied to the determination of anions in hydrogen peroxide显示文摘 | MEISSNER T H EISENBEISS F JASTORFF B | 1998 | J of Chromatography A1998，829，： | 1 |
| 14 | NLR FAMILY member NLRC5 is a transcript regulator of MHC class I genes显示文摘 | MEISSNER T B LI A BISWAS A | 2010 | PANS2010，107，13： | 1 |
| 15 | Geochemical proxies of North American freshwater routing during the Younger Dryas cold event显示文摘 | Carlson A E Clark P U Haley B A Klinkhammer G P Simmons K Brook E J Meissner K J | | 0，，： | 1 |
| 16 | A now route to carbon black filled poly HIPES显示文摘 | B Meissner J | 1994 | Polymer Sci1994，18，： | 1 |
| 17 | Variable effects of anti-diabetic drugs in animal models of myocardial ischemia and remodeling:a translational perspective for the cardiologist显示文摘 | Yin M Westenbrink B D Meissner M | 2013 | Int J Cardiol2013，169，6： | 1 |
| 18 | Inborn errors of carbohydrate metabolism显示文摘 | Mayatepek E Hoffmann B Meissner T | 2010 | Best Pract Res Clin Gastroentero12010，24，5： | 1 |
| 19 | Secondary chronic venous disorders显示文摘 | Meissner MH Eklof B Smith PC | | 0，，： | 1 |
| 20 | The fastest contracting muscles of nonmammalian vertebrates express only one isoform of the ryanodine receptor显示文摘 | O'Brien J Meissner G Block B A | 1993 | Biophys J1993，65，6： | 1 |
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