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| 1 | High-entropy(La_(0.2)Nd_(0.2)Sm_(0.2)Eu_(0.2)Gd_(0.2))_(2)Ce_(2)O_(7):A potential thermal barrier material with improved thermo-physical properties显示文摘High-entropy oxides(HEOs)are widely researched as potential materials for thermal barrier coatings(TBCs).However,the relatively low thermal expansion coefficient(TEC)of those materials severely restricts their practical application.In order to improve the poor thermal expansion property and further reduce the thermal conductivity,high-entropy(La_(0.2)Nd_(0.2)Sm_(0.2)Eu_(0.2)Gd_(0.2))_(2)Ce_(2)O_(7) is designed and synthesized in this work.The as-prepared multicomponent material is formed in a simple disordered fluorite structure due to the high-entropy stabilization effect.Notably,it exhibits a much higher TEC of approximately 12.0×10^(−6) K^(−1) compared with those of other high-entropy oxides reported in the field of TBCs.Besides,it presents prominent thermal insulation behavior with a low intrinsic thermal conductivity of 0.92 W·m^(−1)·K^(−1) at 1400℃,which can be explained by the existence of high concentration oxygen vacancies and highly disordered arrangement of multicomponent cations in the unique high-entropy configuration.Through high-temperature in-situ X-ray diffraction(XRD)measurement,this material shows excellent phase stability up to 1400℃.Benefiting from the solid solution strengthening effect,it shows a higher hardness of 8.72 GPa than the corresponding single component compounds.The superior thermo-physical performance above enables(La_(0.2)Nd_(0.2)Sm_(0.2)Eu_(0.2)Gd_(0.2))_(2)Ce_(2)O_(7) a promising TBC material. | Yun XUE Xiaoqin ZHAO Yulong AN Yijing WANG Meizhen GAO Huidi ZHOU Jianmin CHEN | 2022 | Journal of Advanced Ceramics2022，11，4： | 7 |
| 2 | In-situ formation of layer-like Ag_(2)MoO_(4)induced by high-temperature oxidation and its effect on the self-lubricating properties of NiCoCrAlYTa/Ag/Mo coatings显示文摘Ag-Mo-O ternary oxide has attracted growing attention because of its potential as a solid lubricant at high temperatures.This work designs and prepares NiCoCrAlYTa/Ag/Mo composite coating,performed using high velocity oxy-fuel(HVOF)spraying technology.The environment temperature plays an important role in the microstructure and phases as well as lubricant properties of NiCoCrAlYTa/Ag/Mo coatings.When the environment temperature is above 600℃,the outer diffusion and oxidation of Ag and Mo lead to the formation of Ag2 MoO4 on the coating surface.Layer-like Ag2 MoO4 could form a continuous lubricant film at 800℃and consequently let the composite coating present the best tribological properties.Meanwhile,a small number of hard particles could play a good bearing role during friction and improve the tribological properties of the composite coating. | Enkang Hao Yulong An Jie Chen Xiaoqin Zhao Guoliang Hou Jianmin Chen Meizhen Gao Fengyuan Yan | 2021 | Journal of Materials Science & Technology2021，，16： | 4 |
| 3 | Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene显示文摘The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases(TALENs) technology to generate Leptin receptor(Lepr) knockout rats on the Sprague Dawley(SD) genetic background. Through direct injection of in vitro transcribed m RNA of TALEN pairs into SD rat zygotes, somatic mutations were induced in two of three resulting pups. One of the founders carrying bi-allelic mutation exhibited early onset of obesity and infertility. The other founder carried a chimeric mutation which was efficiently transmitted to the progenies. Through phenotyping of the resulting three lines of rats bearing distinct mutations in the Lepr locus, we found that the strains with a frame-shifted or premature stop codon mutation led to obesity and metabolic disorders. However, no obvious defect was observed in a strain with an in-frame 57 bp deletion in the extracellular domain of Lepr. This suggests the deleted amino acids do not significantly affect Lepr structure and function. This is the first report of generating the Lepr mutant obese rat model in SD strain through a reverse genetic approach. This suggests that TALEN is an efficient and powerful gene editing technology for the generation of disease models. | Yuting Chen Wenqing Lu Na Gao Yi Long Yanjiao Shao Meizhen Liu Huaqing Chen Shixin Ye Xueyun Ma Mingyao Liu Dali Li | 2017 | Science China(Life Sciences)2017，60，2： | 4 |
| 4 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 5 | Surface-deformation monitoring in the permafrost regions over the Tibetan Plateau,using Sentinel-1 data显示文摘Differential Interferometric Synthetic Aperture Radar(D-In SAR) has been widely used to measure surface deformation over the Tibetan Plateau. However, the accuracy and applicability of the D-In SAR method are not well estimated due to the lack of in-situ validation. In this paper, we mapped the seasonal and long-term displacement of Tanggula(TGL) and Liangdaohe(LDH) permafrost regions with a stack of Sentinel-1 acquisitions using the Small Baseline Subset In SAR(SBAS-In SAR) method. In the TGL region, with its dry soils and sparse vegetation, the In SAR-derived surface-deformation trend was consistent with ground-based leveling results; long-term changes of the active layer showed a settlement rate of around 1 to 3 mm/a due to the melting of ground ice, indicating a degrading permafrost in this area. Around half of the deformation was picked up on monitoring, in contrast with in-situ measurements in LDH, implying that the D-In SAR method remarkably underestimated the surface-deformation. This phenomenon may be induced by the large soil-water content, high vegetation coverage, or a combination of these two factors in this region. This study demonstrates that surface deformation could be mapped accurately for a specific region with Sentinel-1 C-band data, such as in the TGL region.Moreover, although the D-In SAR technology provides an efficient solution for broad surface-deformation monitoring in permafrost regions, it shows a poor performance in the region with high soil-water content and dense vegetation coverage. | ZhenMing Wu Lin Zhao Lin Liu Rui Zhu ZeShen Gao YongPing Qiao LiMing Tian HuaYun Zhou MeiZhen Xie | 2018 | Research in Cold and Arid Regions2018，10，2： | 2 |
| 6 | Study of self-assembly TiO_2 nanostructures and their applications in photo-degradation(catalysis) and photo-detection(UV sensors)显示文摘A generalized and fundamental approach to molecular self-assembly synthesis of TiO_2 nanostructures is reported in this article.The formation mechanism of the nanostructures was proposed in detail.The products were characterized by X-ray diffraction,scanning electron microscopy,and transmis- | Meizhen Gao | 2016 | 功能材料信息2016，13，6： | 1 |
| 7 | Traits of chlorophyll fluorescence in 99 plant species from the sparse-elm grassland in Hunshandak Sandland显示文摘 | Li Yonggeng Li Linghao Jiang Gaoming Niu Shuli Liu Meizhen Gao Leiming Peng Yu Jiang Chuangdao | 2004 | Photosynthetica2004，42，： | 1 |
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