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| 1 | 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling显示文摘AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the vehicle.TNBS+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the vehicle.Histologic scoring of inflammation and fibrosis was performed.Colonic production of transforming growth factor(TGF)-βwas measured by ELISA.Colon fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western blot.Expression of the tight junction proteins,occludin and claudin-1,were assessed by Western blot.Colon proteasome activities(chymotrypsin-like and trypsinlike activities)were assessed.RESULTS:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P<0.01).Furthermore,fibrosis and inflammation scores were higher in TNBS-treated rats compared to control rats(P<0.01 for both).Colonic production of TGF-βproduction tended to be higher in TNBS-treated rats(P<0.06).Fibrosis-related proteins such as phospho-p38,phospho-SMAD2/3,and PPARγwere significantly higher in TNBS-treated rats compared to control rats(all P<0.05).TNBS rats had a higher expression of Akt compared to control rats(P<0.01).Tight junction proteins were modified by repeated TNBS challenge:colon occludin expression rose significantly(P<0.01),whereas claudin-1 expression fell(P<0.01).Bortezomib inhibition significantly decreased chymotrypsin-like activity(P<0.05),but had no significant effect on trypsin-like activity(P>0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLUSION:Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-βsignaling.Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions. | Emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte Guillaume Savoye Rachel Marion-Letellier | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 2 | Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders显示文摘AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for compliance.METHODS The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of intention-to-treat.RESULTS Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI. | Clémence Bildstein ChloéMelchior Guillaume Gourcerol Estelle Boueyre Valérie Bridoux Eric Vérin Anne-Marie Leroi | 2017 | World Journal of Gastroenterology2017，23，11： | 3 |
| 3 | Comparative assessment of the antimicrobial susceptibility of Staphylococcus aureus isolates from bovine mastitis in biofilm versus planktonic culture显示文摘 | Melchior M B Fink-Gremmels J Gaastra W | 2006 | J Vet Med B Infect Dis Vet Public Health2006，53，7： | 1 |
| 4 | Pregnenolone and pregnenolone sulfate,alone and with ethanol,in mice on the plus-maze显示文摘 | MELCHIOR C L RITZMANN R F | 1994 | Pharmacol Biochem Behav1994，48，4： | 1 |
| 5 | Apoptoic and antiproliferative effects of fumonisin B1 in human keratinocytes fibroblasts, esophaheal, epithelial cells and hepatoma cells 显示文摘 | Tolleson WH Melchior WBJr Morris M | 1996 | Carcinogenesis1996，17，： | 1 |
| 6 | Calculating can-order policies for the joint replenishment problem by the compensation approach显示文摘 | Melchior P | 2002 | European Journal of Operational Research2002，141，： | 1 |
| 7 | Restricted time-remembering policies for the inventory rationing problem显示文摘 | Melchiors P | 2002 | International Journal of Production Economics2002，81，2： | 1 |
| 8 | Xylitol production from eucalyptus wood hydrolysates extracted with organic solvents显示文摘 | Costa Queiroz R H Melchior E de Souza A M | 1997 | Process Biochemistry1997，32，7： | 1 |
| 9 | Recent developments aqueous two - component polyurethane (2K - PUR) coatings显示文摘 | MELCHIORS M KOBUSCH C JURGENS E | 2000 | Progress Organic Coatings2000，40，14： | 1 |
| 10 | Induction of stilbene synthase by Botrytis cinerea in cultured grapevine cells显示文摘 | Liswidowati Melchior F Hohmann F | 1991 | Planta1991，183，： | 1 |
| 11 | Inventory rationing in an (s,Q) inventory model with lost sales and two demand classes显示文摘 | Melchiors P Dekker R Kleijn M J | 2000 | Journal of the Operational Research Society2000，51，1： | 1 |
| 12 | Hip and distal arm fracture rates in peri-and postmenopausal insulin-treated diabetic females显示文摘 | Melchior TM Sorensen H Torp-Pedersen C | 1994 | J Intern Med1994，236，2： | 1 |
| 13 | Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients显示文摘 | Erik S. Stroes Melchior C. Nierman Janneke J. Meulenberg Remco Franssen Jaap Twisk C Pieter Henny Mario M. Maas Aeilko H. Zwinderman Colin Ross Eleonora Aronica Katherine A. High Marcel M. Levi Michael R. Hayden John J. Kastelein Jan Albert Kuivenhoven | 2008 | Arteriosclerosis Thrombosis and Vascular Biology2008，，12： | 1 |
| 14 | Recent developments in aqueous two-component polyurethane (2K-PUR) coatings显示文摘 | Martin Melchiors Michael Sonntag Claus Kobusch | 2000 | Progress in Organic Coatings2000，，40： | 1 |
| 15 | 'Graffiti resistsnt waterborne 2Kpolyurethane coatings显示文摘 | MELCHIORS M LAAS H J MUNZMAY TH | 2006 | European Coatings2006，，17： | 1 |
| 16 | Biofilms: a role in recurrent mastitis infections? 显示文摘 | Melchior M B Vaarkamp H Fink-Gremmels J | 2006 | Vet J2006，171，3： | 1 |
| 17 | Why are manual workers at high risk of upper limb disorders? The role of physical work factors in a random sample of workers in France( the Pays de la Loire study) 显示文摘 | Melchior M Roquelaure Y Evanoff B | 2006 | Occup Environ Med2006，63，11： | 1 |
| 18 | SUMO:Regulating the regulator显示文摘 | Bossis G Melchior F | | 0，，： | 1 |
| 19 | The WNT receptor FZD7 contributes self-renewal signaling of human embryonic stem cells显示文摘 | Melchior K Weiss J Zaehres H | 2008 | Biol Chem2008，389，7： | 1 |
| 20 | SUMO modification of the ubiquitin-conjugating en- zyme E2-25K 显示文摘 | Pichler A Knipscheer P Oberhofer E van Dijk W J K6rner R Olsen JV Jentsch S Melchior F Sixma T K | 2005 | Nature Struet Mol Biol2005，12，： | 1 |
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