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| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | Theoretical and experimental investigation of infrared properties of tapered silver/silver halide-coated hollow waveguides显示文摘 | Bledt C M Melzer J E Harrington J A | 2013 | Appl Opt2013，52，16： | 1 |
| 3 | Synthesis and self-organization of PPV-based block copolymers for photonic ap- plications显示文摘 | Boer B de Stalmach U Melzer C | 2001 | Synthetic Metals2001，121，13： | 1 |
| 4 | Reduction of right ventricular pacing in patients with sinus node dysfunction using an enhanced AV algorithm显示文摘 | Melzer C Sowelam S Sheldon TJ | 2005 | Pacing Clin Electrophysio12005，28，6： | 1 |
| 5 | Echocardiographic AV-interval optimization in patients with reduced left ventricular function 显示文摘 | Melzer C Borges AC Knebel F | 2004 | Cardiovasc Ultrasound2004，2，： | 1 |
| 6 | Reduction of right ventricular pacing in patients with sinus node dysfunction using an enhanced AV search algrithom显示文摘 | Melzer C Sowelam S Sheldon TJ | 2005 | PACE2005，28，1： | 1 |
| 7 | Examination of the pathology of the rotator cuff显示文摘 | Refior HJ Krodel A Melzer C | 1987 | Arch Orthop Trauma Surg1987，106，： | 1 |
| 8 | The Role of Ca^2 + Ions in Excitation-contraction Coupling of Skeletal Muscle Fibres 显示文摘 | MELZER W HERRMANN-FRANK A LUTTGAU H C | 1995 | Biochim Biophys Acta1995，1241，1： | 1 |
| 9 | Mineral matter transformation during Sasol-Lurgi fixed bed dry bottom gasification-utilization of HT-XRD and FactSage modelling显示文摘 | van Dyk J C Melzer S Sobiecki A | 2006 | Minerals Engineering2006，19，10： | 1 |
| 10 | Reduction of right ventricular pacing in patients with sinus node dysfunction using an enhanced search AV algorithm显示文摘 | Melzer C Sowelam S Sheldon TJ | 2005 | Pacing Clin Electrophysiol2005，28，： | 1 |
| 11 | A light-and temperatureentrained circadian clock controls expression of transcripts encoding nuclear proteins with homology to RNA-binding proteins in meristematic tissue 显示文摘 | Heintzen C Melzer S Fischer R | 1994 | Plant J1994，5，： | 1 |
| 12 | Cognitive impairment in elderly people: population based estimate of the future in England, Scotland, and Wales显示文摘 | MELZER D ELY M BRAYNE C | 1997 | BMJ1997，315，： | 1 |
| 13 | The value of FDG- PET in the diagnosis of large-vessel vasculitis and the assessment of ac- tivity and extent of disease 显示文摘 | Walter MA Melzer RA Schindler C | 2005 | Eur J Nucl Med Mol Imaging2005，32，： | 1 |
| 14 | Clinical studies on the efficacyand safety of padma 28,a complex herbal formulation from Tibet-an medicine: an overview显示文摘 | Vennos C Melzer J Sailer R | 2013 | Forsch Komplementarmed2013，20，2： | 1 |
| 15 | Cognitive impairment in elderly people:population based estimate of the future in England, Scotland and Wales显示文摘 | Melzer D Ely M Brayne C | 1997 | BMJ1997，315，： | 1 |
| 16 | A combined system of lagoon and constructed wetland for an effective wastewater treatment显示文摘 | Weinhart S Melzer A | 2003 | Water Res2003，37，： | 1 |
| 17 | Mineral matter transformation during Sasol-Lurgi fixed bed dry bottom gasification-utilization of HT-XRD and Factsage modeling 显示文摘 | VANDYK J C MELZER S SOBIECKI A | 2006 | Miner Eng2006，19，10： | 1 |
| 18 | Outcomes in UK patients with hospitalacquired bacteraemia and the risk of catheter-associated urinary tract infections显示文摘 | Melzer M Welch C | 2013 | Postgrad Med J2013，89，1052： | 1 |
| 19 | Mould powder inves- tigations for high speed casting显示文摘 | Kromhout J A Liebske C Melzer S | 2009 | Ironmaking and Steelmak- ing2009，36，4： | 1 |
| 20 | Renal replacement therapy with high-cut off hemofilters:Impact of convection and diffusion on cytokine clearances and protein status显示文摘 | Morgera S Sloeinski T Melzer C | 2004 | Am J Kidney Dis2004，43，3： | 1 |
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