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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Facility relia-bility issues in network p-median problems:Strategiccentralization and co-location effects显示文摘 | Berman O Krass D Menezes M B C | 2007 | OperationResearch2007，55，2： | 1 |
| 3 | Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates显示文摘 | Menezes J C J M D S Kamat S P Cavaleiro J A S | 2011 | Eur J Med Chem2011，46，2： | 1 |
| 4 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 5 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 6 | Review of guidelines for the use of combined forecasts 显示文摘 | MENEZES L M DE BUNN D W TAYLOR J W | 2000 | European Journal of Operational Research2000，120，1： | 1 |
| 7 | V2O 5 nanoparticles obtained from a synthetic bariandite-like vanadium oxide:Synthesis, characterization and electrochemical behavior in an ionic liquid 显示文摘 | MENEZES W G REIS D M BENEDETTI T M | 2009 | J Colloid Interf Sci2009，337，2： | 1 |
| 8 | Preventionof invasive cervical cancer in the United States:past, present, and future显示文摘 | Pierce Campbell C M Menezes L J Paskett E D | 2012 | Cancer Epidemiol Biomarkers Prey2012，21，9： | 1 |
| 9 | Pharmacokinetics of long-circulating liposomes 显示文摘 | ALLEN T M HANSEN C B DE MENEZES D E L | 1995 | Adv Drug Deliv Rev1995，16，23： | 1 |
| 10 | Review of guidelines for the use of combined forecasts 显示文摘 | Menezes L M Bunn D W Taylor J W | 2000 | European Journal of Operational Research2000，120，： | 1 |
| 11 | Applying Nagata patches to smooth discretized surfaces used in 3D frictional contact problems显示文摘 | Neto D M Oliveira M C Menezes L F Alves J L | 2014 | Computer Methods in Applied Mechanics and Engineering2014，271，29： | 1 |
| 12 | Review of guidelines for the use of combined forecasts显示文摘 | Menezes L M Bunn D W | 2000 | European Journal of Operational Research2000，120，1： | 1 |
| 13 | Numerical simulation of tensile tests of prestrained sheets显示文摘 | Menezes L F Fernandes J V Rodrigues D M | | 0，，1： | 1 |
| 14 | Facility reliability issues in network p-median problems: strategic centralization and co-location effects显示文摘 | Berman O Krass D Menezes M B C | 2007 | Operations Research2007，55，： | 1 |
| 15 | Review of guidelines for the use of combined forecasts显示文摘 | Bunn D W | 2000 | European J of Operational Research2000，120，1： | 1 |
| 16 | Facility reliability issues in network p-median problems: Strategic centralization and co-location effeets显示文摘 | Berman O Krass D Menezes M B C | 2007 | Operations Research2007，55，2： | 1 |
| 17 | Methylphenidate improves fatigue scores in Parkinson disease:A randomized controlled trial显示文摘 | Mendon D A Menezes K Jog M S | 2007 | Movement Disorders2007，22，14： | 1 |
| 18 | Facility reliability issues in network p-median problems: strategic centralization and co-location Effects 显示文摘 | Berman O Krass D Menezes M B C | 2007 | Operation Research2007，55，2： | 1 |
| 19 | Facility Reliability Issues in Network P-median Problems Strategic Centralization and Co-location Effects 显示文摘 | BERMAN O KRASS D MENEZES M B C | 2007 | Operation Research2007，55，2： | 1 |
| 20 | Selective targeting of immunoliposomal doxorubicin against hu man multiple myeloma in vitro and ex vivo显示文摘 | Lopes de Menezes D E Pilarski L M Belch A R Allen T M | 2000 | Biochim Biophys Acta2000，1466，12： | 1 |
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