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| 1 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 2 | An overview of the environmental finance policies in China: retrofitting an integrated mechanism for environmental management显示文摘 | Wei LI Mengze HU | 2014 | Frontiers of Environmental Science & Engineering2014，8，3： | 24 |
| 3 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 4 | Manganese salts function as potent adjuvants显示文摘Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines.To date,only a few adjuvants have been approved for use in humans,among which aluminum-containing adjuvants are the only ones widely used.However,the medical need for potent and safe adjuvants is currently continuously increasing,especially those triggering cellular immune responses for cytotoxic T lymphocyte activation,which are urgently needed for the development of efficient virus and cancer vaccines.Manganese is an essential micronutrient required for diverse biological activities,but its functions in immunity remain undefined.We previously reported that Mn^(2+) is important in the host defense against cytosolic dsDNA by facilitating cGAS-STING activation and that Mn^(2+)alone directly activates cGAS independent of dsDNA,leading to an unconventional catalytic synthesis of 2′3′-cGAMP.Herein,we found that Mn^(2+) strongly promoted immune responses by facilitating antigen uptake,presentation,and germinal center formation via both cGAS-STING and NLRP3 activation.Accordingly,a colloidal manganese salt(Mn jelly,MnJ)was formulated to act not only as an immune potentiator but also as a delivery system to stimulate humoral and cellular immune responses,inducing antibody production and CD4^(+)/CD8^(+)T-cell proliferation and activation by either intramuscular or intranasal immunization.When administered intranasally,MnJ also worked as a mucosal adjuvant,inducing high levels of secretory IgA.MnJ showed good adjuvant effects for all tested antigens,including T cell-dependent and T cell-independent antigens,such as bacterial capsular polysaccharides,thus indicating that it is a promising adjuvant candidate. | Rui Zhang Chenguang Wang Yukun Guan Xiaoming Wei Mengyin Sha Mengran Yi Miao Jing Mengze Lv Wen Guo Jing Xu Yi Wan Xin-Ming Jia Zhengfan Jiang | 2021 | Cellular & Molecular Immunology2021，18，5： | 7 |
| 5 | Composite Sinusoidal Nanograting With Long-Range SERS Effect for Label-Free TNT Detection显示文摘一合成一个维(1D ) 瞄准没有标签的表面的 Ag 正弦曲线 nanograting 提高了散布的拉曼(重量的单位) 有柔韧、可再现的改进的 TNT 的察觉被讨论。周期的正弦曲线 SiO 2 栅栏由 Ag 蒸发跟随了的 1D 基于表面电浆子电磁声子(SPP ) 为可再现、有效的重量的单位底层的创造被建议。1D 正弦曲线 nanograting 和它的远程的重量的单位效果的最佳的结构被使用有限差别时间领域(FDTD ) 分析。模拟重量的单位改进因素(EF ) 能是同样可能的 5 个数量级。这重量的单位底层被干扰影印石版术技术准备,它的重量的单位表演被 Rh6G 察觉实验测试,并且实际测试 EF 是大约 10 4 。TNT 的没有标签的重量的单位察觉能力在实验被表明。 | Cheng XIAO Zhibin CHEN Mengze QIN Dongxiao ZHANG Lei FAN | 2018 | Photonic Sensors2018，8，3： | 4 |
| 6 | Three new species of Atkinsoniella from China (Hemiptera:Cicadellidae:Cicadellini)显示文摘 | MengZ H YangMF NiJQ | 2010 | Zootaxa2010，，2654： | 1 |
| 7 | Two new species of Stenatkina Young,1986 from China with comparative notes on the female genitalia (Hemiptera:Cicadellidae:Cicadellini)显示文摘 | MengZ H Yang M F LiZZ | 2012 | Zootaxa2012，3231，： | 1 |
| 8 | Reward Programs and Tacit Collusion 显示文摘 | Kim Byung-Do Mengze Shi and Kannan Srinlvasan | 2001 | Marketing Science2001，，2： | 1 |
| 9 | Money Talks to Online Opinion Leaders:What Motivates Opinion Leaders to Make Social-Network Referrals?显示文摘 | Mengze S Wojnicki A C | 2014 | Journal of Advertising Research2014，54，1： | 1 |
| 10 | Money Talks to Online Opinion Leaders What Motivates Opinion Leaders To Make Social-Network Referrals? 显示文摘 | Mengze S Wojnicki A C | 2014 | Journal of Advertising Research2014，，1： | 1 |
| 11 | Exactness and algorithm of an objective penaltyfunction 显示文摘 | MengZ Q Dang C Y Jiang M Xu X S ShenR | 2012 | Journal of Global Optimization2012，，： | 1 |
| 12 | Reward programs and tacit collusion显示文摘 | Kim Byung-Do Shi Mengze Srinivasan K | 2001 | Marketing Science2001，20，2： | 1 |
| 13 | Effects of blowing sand fine particles on plasma membrane permeability and fluidity, and intracellular calcium levels of rat alveolar macrophages显示文摘 | GengH MengZ ZhangQ | 2005 | Toxicol Lett2005，157，12： | 1 |
| 14 | Manganese enhances the antitumor function of CD8^(+)T cells by inducing type I interferon production显示文摘The presence of cytosolic DNA at tumor sites and the activation of the cGAS-STING pathway have been implicated in the activation of antitumor immune responses.1,2,3 Manganese (Mn) is a necessary trace element for intracellular activities. It plays important roles in development, digestion, reproduction, antioxidant defense, energy production, immunity, and neuronal activity regulation.4 Mn was reported to enhance cGAS-STING activation through increased sensitivity to dsDNA during viral infections.5 However, it is unclear whether Mn can enhance antitumor immune functions. Here, we revealed that Mn2+ could inhibit the development of murine hepatocellular carcinoma (HCC) through immune modulations. It upregulated IFN-γ and TNF-α production in splenic and tumor-infiltrating CD8+ T cells. Moreover, Mn2+ significantly increased type I interferon (IFN) production and type I IFN-stimulated gene (ISG) expression in tumor-bearing mice. Further analysis revealed that myeloid cells could upregulate type I IFN production and increase costimulatory molecule expression upon Mn2+ stimulation. In vivo depletion of CD8+ T cells or treatment of IFNAR KO mice diminished the antitumor activity of Mn2+, suggesting that the antitumor function of Mn2+ is dependent on both CD8+ T cells and type I IFN signaling. Our results provide evidence to support Mn2+ as a novel agent that can be incorporated into cancer immunotherapy. | Yuan Song Yonghao Liu Huey Yee Teo Zuhairah Binte Hanafi Yu Mei Ying Zhu Yen Leong Chua Mengze Lv Zhengfan Jiang Haiyan Liu | 2021 | Cellular & Molecular Immunology2021，18，6： | 1 |
| 15 | Product and Pricing Decisions in Crowdfunding显示文摘 | Hu Ming Li Xi and Shi Mengze 2015 | 2015 | Marketing Science2015，34，3： | 1 |
| 16 | Study of elemental mercury oxidation over an SCR catalyst with calcium chloride addition显示文摘 | Zhang Mengze Wang Peng Dong Yong | 2014 | Chemical Engineering Journal2014，253，： | 1 |
| 17 | Reward Programs and Tacit Collusion显示文摘 | Byung-Do Kim Mengze Shi Kannan Srinivasan | 2001 | Marketing Science2001，，： | 1 |
| 18 | Reward Programs and Tacit CoUusion 显示文摘 | Kim Byung-Do Mengze Shi and Kannan Srinivasan | 2001 | Marketing Science2001，20，2： | 1 |
| 19 | The Firm's Management of Social Interactions显示文摘 | David Godes Dina Mayzlin Yubo Chen Sanjiv Das Chrysanthos Dellarocas Bruce Pfeiffer Barak Libai Subrata Sen Mengze Shi Peeter Ver- legh | 2005 | Marketing Letters2005，16，34： | 1 |
| 20 | The Belt and Road Initiative from Three Theoretical Perspectives显示文摘Efforts have generally been made from policy considerations to interpret reasons for the proposition of the Belt and Road Initiative and its global layout.Though they are of some significance,such a grand initiative certainly has its own internal theoretical basis.This paper is in the opinion that the spillover effect of oversized economy,the extension of the value chain and its climbing effect,as well as channel suitability and location orientation constitute the endogenous driving forces of the Belt and Road Initiative.Each of the three theoretical perspectives has its own internal realistic basis,all of which may offer some reference that is conducive to understanding the practice and future development of the Belt and Road Initiative. | Fu Mengz | 2019 | Contemporary International Relations2019，29，2： | 1 |
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