|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression显示文摘AIM: To investigate the expression pattern of clusterin in colorectal adenoma-carcinoma-metastasis series, and to explore the potential role of dusterin in multistage colorectal tumorigenesis and progression.METHOD:S: A colorectal carcinoma (CRC)-tissue microarray (TMA), which contained 85 advanced CRCs including 43 cases of Dukes B, 21 of Dukes C and 21 of Dukes D tumors, were used for assessing the expression of clusterin (clone 41D) and tumor cell apoptotic index (AI) by immunohistochemistry and TUNEL assay, respectively. Moreover the potential correlation of dusterin expression with the patient'sclinical-pathological features were also examined. RESULTS: The positive staining of clusterin in different colorectal tissues was primarily a cytoplasmic pattern. Cytoplasmic overexpression of clusterin was detected in none of the normal coloredal mucosa, 17% of the adenomas, 46% of the primary CRCs, and 57% of the CRC metastatic lesions. In addition, a significant positive correlation between overexpression of clusterin and advanced clinical (Dukes) stage was observed (P<0.01). Overexpression of cytoplasmic clusterin in CRCs was inversely correlated with tumor apoptotic index (P<0.01), indicating the anti apoptotic function of cytoplasmic clusterin in CRCs.CONCLUSION: These data suggests that overexpression of cytoplasmic dustin might be involved in the tumorigenesis and/or progression of CRCs. The anti-apoptotic function of cytoplasmic dusterin may be responsible, at least in part, for the development and biologically aggressive behavior of CRC. | DanXie JonathanS.T.Sham Wei-FenZeng Li-HongChe MengZhang Hui-XiWu Han-LiangLin Jian-MingWen SzeHangLau LiangHu Xin-YuanGuan | 2005 | World Journal of Gastroenterology2005，11，21： | 4 |
| 2 | Modulated fatty acid desaturation via overexpression of two distinct ω‐3 desaturases differentially alters tolerance to various abiotic stresses in transgenic tobacco cells and plants显示文摘 | MengZhang RivkaBarg MinganYin YardenaGueta‐Dahan AliciaLeikin‐Frenkel YehiamSalts SaraShabtai GozalBen‐Hayyim | 2005 | The Plant Journal2005，，3： | 2 |
| 3 | A New Deoxygenation Method for Taxanes Using Hypophosphorous Acid显示文摘An efficient and practical radical chain deoxygenation method by phosphorus centered radicals generated from hypophosphorous acid was developed in the synthesis of analogues of paclitaxel. | JunGU MengZHANG DaLiYIN JiYuGUO XiaoTianLIANG | 2004 | Chinese Chemical Letters2004，15，6： | 1 |
| 4 | Development of a CD28 Receptor Binding -based Screen and identification of ABiologically Active Inhibitor显示文摘 | MengZhang MariaWiekowski etal | 1998 | Anal Biochem1998，256，1： | 1 |
| 5 | Seroprevalence of neutralizing antibodies against adenovirus type 26 and 35 in healthy populations from Guangdong and Shandong provinces,China显示文摘Human adenoviruses type 26(HAdV26)and type 35(HAdV35)have increasingly become the choice of adenovirus vectors for vaccine application.However,the population pre-existing immunity to these two adenoviruses in China,which may reduce vaccine efficacy,remains largely unknown.Here,we established micro-neutralizing(MN)assays to investigate the seroprevalence of neutralizing antibodies(nAbs)against HAdV26 and HAdV35 in the general population of Guangdong and Shandong provinces,China.A total of 1184 serum samples were collected,47.0%and 15.8%of which showed HAdV26 and HAdV35 nAb activity,respectively.HAdV26-seropositive individuals tended to have more moderate nAbs titers(201-1000),while HAdV35-seropositive individuals appeared to have more low nAbs titers(72-200).The seropositive rates of HAdV26 and HAdV35 in individuals younger than 20 years old were very low.The seropositive rates of HAdV26 increased with age before 70 years old and decreased thereafter,while HAdV35 seropositive rates did not show similar characteristics.Notably,the seropositive rates and nAb levels of both HAdV26 and HAdV35 were higher in Guangdong Province than in Shandong Province,but did not exert significant differences between males and females.The seroprevalence between HAdV26 and HAdV35 showed little correlation,and no significant cross-neutralizing activity was detected.These results clarified the characteristics of the herd immunity against HAdV26 and HAdV35,and provided information for the rational development and application of HAdV26 and HAdV35 as vaccine vectors in China. | Haisu Yi Qian Wang Jiankai Deng Hengchun Li Yingkun Zhang Zhilong Chen Tianxin Ji Wenming Liu Xuehua Zheng Qinghua Ma Xinxin Sun Yudi Zhang Xuegao Yu Mengzhang He Ling Chen Ying Feng | 2022 | Virologica Sinica2022，37，5： | 0 |
| 6 | An Unusual Formation of Cyclic Sulfite at C-4 and C-5 Positions of Taxane显示文摘An unusual formation of cyclic sulfite at C-4 and C-5 positions of taxane was accomplished by treatment of compound 1 with excess MeSO2Cl/Et3N and a possible mechanism was proposed. | MengZHANG DaLiYIN JiYuGUO XiaoTianLIANG | 2004 | Chinese Chemical Letters2004，15，9： | 0 |
| 7 | Reduction of 1-Deoxy-13-oxotaxanes显示文摘Reduction of 1-deoxy-13-oxotaxanes has been studied under different reaction conditions. Some interesting reactions were reported. | MengZHANG DaLiYIN JiYuGUO XiaoTianLIANG | 2005 | Chinese Chemical Letters2005，16，7： | 0 |
| 8 | Microwave-assisted Allylic Oxidation at C-13 Position of 14-Deoxysinenxan A显示文摘Microwave-assisted allylic oxidation at C-13 position of 14-deoxysinenxan A was described. This new method (150℃/10 min/5 bar on microwave synthesizer) led to a better yield of compound 1 and shorter reaction time. | JunGU MengZHANG DaLiYIN JiYuGUO XiaoTianLIANG | 2005 | Chinese Chemical Letters2005，16，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员