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| 1 | Transformers in computational visual media:A survey显示文摘Transformers,the dominant architecture for natural language processing,have also recently attracted much attention from computational visual media researchers due to their capacity for long-range representation and high performance.Transformers are sequence-to-sequence models,which use a selfattention mechanism rather than the RNN sequential structure.Thus,such models can be trained in parallel and can represent global information.This study comprehensively surveys recent visual transformer works.We categorize them according to task scenario:backbone design,high-level vision,low-level vision and generation,and multimodal learning.Their key ideas are also analyzed.Differing from previous surveys,we mainly focus on visual transformer methods in low-level vision and generation.The latest works on backbone design are also reviewed in detail.For ease of understanding,we precisely describe the main contributions of the latest works in the form of tables.As well as giving quantitative comparisons,we also present image results for low-level vision and generation tasks.Computational costs and source code links for various important works are also given in this survey to assist further development. | Yifan Xu Huapeng Wei Minxuan Lin Yingying Deng Kekai Sheng Mengdan Zhang Fan Tang Weiming Dong Feiyue Huang Changsheng Xu | 2022 | Computational Visual Media2022，8，1： | 6 |
| 2 | Lercanidipine hydrochloride versus felodipine sustained-release for mild-to-moderate hypertension: a multi-center, randomized clinical trial显示文摘 | Ying Wu Mengdan Xu Hao Wang Xin Xu Shuiping Zhao Mei Zhang Huigen Jin Jinchuan Yan Bangning Wang Jianbin Gong Xiang Lu Jianqiang Peng Qiuyan Dai | 2014 | Current Medical Research & Opinion2014，，1： | 1 |
| 3 | CFD studies on the separation performance of a new combined gas–solid separator used in TMSR-SF显示文摘In order to comply with discharge standards, a gas–solid separator is used to remove solid particles from the thorium molten salt reactor-solid fuel (TMSR-SF) system. As a key component, it directly determines system energy efficiency. However, current gas–solid separators, based on activated carbon adsorption technology, result in high pressure drops and increased maintenance costs. In the present study, a new combined gas–solid separator was developed for the TMSR-SF. Based on a simplified computational fluid dynamics (CFD) model, the gas–solid twophase flow and the motion trajectory of solid particles were simulated for this new separator using commercial ANSYS 16.0 software. The flow and separation mechanism for this structure were also been discussed in terms of their velocity effects and pressure field distributions, and then the structure was optimized based on the influence of key structural parameters on pressure and separation efficiency. The results showed that the standard k–ε model could be achieved and accurately simulated the new combined separator. In this new combined gas–solid separator, coarse particles are separated in the first stage using rotating centrifugal motion, and then fine particles are filtered in the second stage, giving a separation efficiency of up to 96.11%. The optimum blade inclination angle and numbers were calculated to be 45° and four, respectively. It implicated that the combined separator could be of great significance in a wide variety of applications. | Mengdan Wu Ning Zhang Jinguo Zhai Guo-Yan Zhou Shan-Tung Tu | 2019 | Nuclear Science and Techniques2019，30，9： | 1 |
| 4 | Ultra-thin robust CNT@GC film integrating effective electromagnetic shielding and flexible Joule heating显示文摘The demand for lightweight,thin electromagnetic interference(EMI)shielding film materials with high shielding effectiveness(SE),excellent mechanical properties,and stability in complex environments is particularly pronounced in the realm of flexible and portable electronic products.Here,we developed an ultra-thin film(CNT@GC)in which the glassy carbon(GC)layer wrapped around and welded carbon nanotubes(CNTs)to form a core-shell network structure,leading to exceptional tensile strength(327.2 MPa)and electrical conductivity(2.87×10^(5) S·m^(−1)).The CNT@GC film achieved EMI SE of 60 dB at a thickness of 2µm after post-acid treatment and high specific SE of 3.49×10^(5) dB·cm^(2)·g^(−1),with comprehensive properties surpassing those of the majority of previous shielding materials.Additionally,the CNT@GC film exhibited Joule heating capability,reaching a surface temperature of 135℃at 3 V with a fast thermal response of about 0.5 s,enabling anti-icing/de-icing functionality.This work presented a methodology for constructing a robust CNT@GC film with high EMI shielding performance and exceptional Joule heating capability,demonstrating immense potential in wearable devices,defense,and aerospace applications. | Ding Zhang Chunhui Wang Meng Li Weixue Meng Shipeng Zhang Mengdan Yang Xinguang Huang Yingjiu Zhang Yuanyuan Shang Anyuan Cao | 2024 | Nano Research2024，17，5： | 0 |
| 5 | BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation显示文摘Lung cancer is one of the most prevalent and malignant cancers,among which lung adenocarcinoma(LUAD)accounts for the majority and remains a major cause of cancer-related mortality worldwide(Cui et al.,2019).Despite the growing intensity of research on the pathobiology and progression of lung cancer and the fact that many genes have been identified as potential drivers and targets for therapy(Luo et al.,2019;Zhang et al.,2019),the treatment and prognosis of lung cancer patients have hardly improved.Therefore,this study aimed to investigate the precise mechanism of lung cancer development and explore efficient diagnostic and therapeutic methods for clinical treatment. | Mengdan YU Qianwei ZHAO Jinxia LI Fang XU Zhibiao ZHANG Yixian LIU Liping DAI Bingxia ZHANG Jianying ZHANG Jintao ZHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，9： | 0 |
| 6 | Conductive hydrogels incorporating carbon nanoparticles:A review of synthesis,performance and applications显示文摘As one of the most rapidly expanding materials,hydrogels have gained increasing attention in a variety of fields due to their biocompatibility,degradability and hydrophilic properties,as well as their remarkable adhesion and stretchability to adapt to different surfaces.Hydrogels combined with carbon-based materials possess enhanced properties and new functionalities,in particular,conductive hydrogels have become a new area of research in the field of materials science.This review aims to provide a comprehensive overview and up-to-date examination of recent developments in the synthesis,properties and applications of conductive hydrogels incorporating several typical carbon nanoparticles such as carbon nanotubes,graphene,carbon dots and carbon nanofibers.We summarize key techniques and mechanisms for synthesizing various composite hydrogels with exceptional properties,and represented applications such as wearable sensors,temperature sensors,supercapacitors and human-computer interaction reported recently.The mechanical,electrical and sensing properties of carbon nanoparticles conductive hydrogels are thoroughly analyzed to disclose the role of carbon nanoparticles in these hydrogels and key factors in the microstructure.Finally,future development of conductive hydrogels based on carbon nanoparticles is discussed including the challenges and possible solutions in terms of microstructure optimization,mechanical and other properties,and promising applications in wearable electronics and multifunctional materials. | Shipeng Zhang Bo Zhao Ding Zhang Mengdan Yang Xinguang Huang Lei Han Kun Chen Xinjian Li Rui Pang Yuanyuan Shang Anyuan Cao | 2023 | Particuology2023，，12： | 0 |
| 7 | Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming显示文摘Retinoic acid(RA)and 2-phospho-L-ascorbic acid trisodium salt(AscPNa)promote the reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells.In the current studies,the lower abilities of RA and AscPNa to promote reprogramming in the presence of each other suggested that they may share downstream pathways at least partially.The hypothesis was further supported by the RNA-seq analysis which demonstrated a high-level overlap between RA-activated and AscPNa activated genes during reprogramming.In addition,RA upregulated Glut1/3,facilitated the membrane transportation of dehydroascorbic acid,the oxidized form of L-ascorbic acid,and subsequently maintained intracellular L-ascorbic acid at higher level and for longer time.On the other hand,AscPNa facilitated the mesenchymal-epithelial transition during reprogramming,downregulated key mesenchymal transcriptional factors like Zeb1 and Twist1,subsequently suppressed the expression of Cyp26a1/b1 which mediates the metabolism of RA,and sustained the intracellular level of RA.Furthermore,the different abilities of RA and AscPNa to induce mesenchymal-epithelial transition,pluripotency,and neuronal differentiation explain their complex contribution to reprogramming when used individually or in combination.Therefore,the current studies identified a positive feedback between RA and AscPNa,or possibility between vitamin A and C,and further explored their contributions to reprogramming. | Mengdan Zhang Qian Li Tingting Yang Fei Meng Xiaowei Lai Lining Liang Changpeng Li Hao Sun Jiaqi Sun Hui Zheng | 2020 | Cell Regeneration2020，9，1： | 0 |
| 8 | Chemokine Ligand 13 Expression is Abundant in the Tumor Microenvironment and Indicates Poor Prognosis of Kidney Clear Cell Carcinoma显示文摘The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma(KIRC)and its correlation with tumor-infiltrating immune cells(TIICs).A monoclonal antibody against CXCL13 with high affinity and purity was generated in our lab for western blot and immunohistochemistry(IHC).Bioinformatic analysis was performed based on bulk-seq data from the Cancer Genome Atlas(TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB and PanglaoDB.Results showed that high CXCL13 expression in TME was associated with shorter progression-free survival(PFS),disease-specific survival(DSS),and overall survival(OS).KIRC cell lines,as well as several other cancer cell lines,had negative CXCL13 expression.IHC staining from the Human Protein Atlas(HPA)and our tissue array indicated that CXCL13 might be mainly expressed by TIICs,but not KIRC tumor cells.CXCL13 expression was strongly and positively correlated withγδT cell abundance in TME.Besides,γδT cell infiltration was associated with poor survival of KIRC.Methylation 450k array data showed that CXCL13 promoter hypomethylation was common in TIICs.The methylation level of cg16361705 within the CXCL13 promoter might play an important role in modulating CXCL13 transcription.In conclusion,our study revealed that CXCL13 expression andγδT cell infiltration in TME is associated with unfavorable survival of KIRC.TIICs,most possiblyγδT cells,are the dominant source of CXCL13 in KIRC TME. | MENGDAN WU MENGYAO SUN QINHUAI LAI YIN LU YUYIN FU YUJIA PENG WEIRONG LAI LISHI ZENG SHENGYAN ZHAO YUYAN LI ZHIXIONG ZHANG XIAOFENG CHEN FAN QIAO YIWEN ZHANG SHIJIE ZHOU LANTU GOU JINLIANG YANG | 2021 | BIOCELL2021，45，3： | 0 |
| 9 | Metabolic fate of dietary sialic acid and its infuence on gut and oral bacteria显示文摘In recent years,the biological functions of human milk oligosaccharides and the potential toxic efects of red meat on human health have attracted considerable attention.Sialic acid is an important carbohydrate in milk and red meat,corresponding to sialylated oligosaccharides and N-glycolylneuraminic acid(NeuGc,one type of sialic acid).Herein,we reviewed the metabolic fate of dietary sialic acid in the body and their efects on gut and oral microbes.In summary,dietary NeuAc monomer is directly excreted through urine after being assimilated through the intestines and is not utilized by the human body;in contrast,dietary NeuGc from red meat is easily utilized by the human body and can be incorporated into the brain and other organs.Sialoglycans can be partially utilized by the human body,but they do not afect the cognitive development and growth of children.Dietary sialic acid may mainly regulate the growth and metabolism of gastrointestinal microbiota and human health and development through the gut–brain axis. | Jianrong Wu Zhang Leilei Mengdan Qiang Hongtao Zhang Xiaobei Zhan | 2022 | Systems Microbiology and Biomanufacturing2022，2，1： | 0 |
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