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| 1 | RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy显示文摘RNA splicing contributes to a broad spectrum of posttranscriptional gene regulation during normal development, as well as pathological manifestation of heart diseases. However, the functional role and regulation of splicing in heart failure remain poorly understood. RNA binding protein (RBP), a major component of the splicing machinery, is a critical factor in this process. RNA binding motif protein 24 (RBM24) is a tissue-specific RBP which is highly expressed in human and mouse heart. Previous studies demonstrated the functional role of RBM24 in the embryonic heart development. However, the role of RBM24 in postnatal heart development and heart disease has not been investigated. In this paper, using conditional RBM24 knockout mice, we demonstrated that ablation of RBM24 in postnatal heart led to rapidly progressive dilated cardiomyopathy (DCM), heart failure, and postnatal lethality. Global splicing profiling revealed that RBM24 regulated a network of genes related to cardiac function and diseases. Knockout of RBM24 resulted in misregulation of these splicing transitions which contributed to the subsequent development of cardiomyopathy. Notably, our analysis identified RBM24 as a splice factor that determined the splicing switch of a subset of genes in the sacomeric Z-disc complex, including Titin, the major disease gene of DCM and heart failure. Together, this study identifies regulation of RNA splicing by RBM24 as a potent player in remodeling of heart during postnatal development, and provides novel mechanistic insights to the pathogenesis of DCM. | Jing Liu Xu Kong Mengkai Zhang Xiao Yang Xiuqin Xu | 2019 | Protein & Cell2019，10，6： | 2 |
| 2 | The Stagnant Export Upgrading in Northeast China:Evidence from Value-added Tax Reform显示文摘China's 2004 value-added tax(VAT)pilot reform in the Northeast region,which changed the VAT from production type to consumption type,introduced a sizable tax credit for fixed investment in manufacturing industries,leading to more investment and higher productivity at firm level.This paper,however,uses difference-in-difference estimation and finds a negative structural effect;that is,the VAT pilot reform leads to a reduction in the export sophistication of Northeast cities relative to other cities in China,and the results hold for a battery of robustness checks.It is found that resources are reallocated towards less-sophisticated industries.As the products with higher export sophistication are more skill and research and development(R&D)intensive,the shortfalls of skilled labor and R&D spending hinder the upgrading process.With a new round of revitalization plans in the Northeast,policymakers should be cautious with similar structural effects and focus on increasing skilled labor supply and R&D investment. | Yan Du Mengkai Yang Jing Li Yunong Li | 2020 | China & World Economy2020，28，4： | 1 |
| 3 | Photoluminescence properties ofZnS nanoparticles co-doped with Pb^2+ and Cu^2+显示文摘 | Ping Yang Mengkai LU Dong XU | 2001 | Chemical Physics Letters2001，336，： | 1 |
| 4 | Pho- toluminescence of Cu+-doped and Cu2+-doped ZnS nanocrystallites显示文摘 | Yang Ping Song ChunfengsLv Mengkai | 2002 | Journal of Physics and Chemis- tiy of Solids2002，63，4： | 1 |
| 5 | Enhanced blue emission from Eu, Dy co-doped sol-gel Al2O3-SiO2 glasses 显示文摘 | Song Chunfeng Yang Ping Lu Mengkai | 2003 | Journal of Physics and Chemistry of Solids2003，64，： | 1 |
| 6 | Photoluminescence characteristics of ZnS nanocrystallites co-doped with Co 2+ and Cu 2+显示文摘 | Ping Yang Mengkai Lü Guangjun Zhou DuoRong Yuan Dong Xu | 2001 | Inorganic Chemistry Communications2001，，12： | 1 |
| 7 | Systematic research on RE 2 Zr 2 O 7 (RE显示文摘 | Aiyu Zhang Mengkai Lü Zhongsen Yang Guangjun Zhou Yuanyuan Zhou | 2007 | Solid State Sciences2007，，1： | 1 |
| 8 | Effect of processing parameters on the luminescence intensity of Sr3 (VO4)2 :Eu3+ nanocrystals via combustion synthesis显示文摘 | Haiping Zhang Mengkai Lu Zhongsen Yang | 2006 | Jour- nal of Alloys and Compounds2006，426，1： | 1 |
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