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| 1 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 2 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 3 | PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC显示文摘High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains elusive.We recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of CCL5.In this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical resection.Moreover,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)database.Chromatin immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer cells.Furthermore,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 promoter.However,mutation of the binding motif-a completely reversed the luciferase activity.In addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T cells.Based on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 levels.In conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of PDAC.Combined blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels. | Xiuchao Wang Xin Li Xunbin Wei Haiping Jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan Tian Zanmei Xu Jiangyan Zhang Jihui Hao He Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 4 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 5 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 6 | Contamination by persistent toxic substances in surface sediment of urban rivers in Chaohu City, China显示文摘The concentration and spatial distribution of persistent toxic substances (PTS) in the river sediment in Chaohu City, China were investigated. A total of nine surface sediments were collected and the selected PTS pollutants including six heavy metals and nineteen polybrominated diphenyl ethers (PBDEs) were analyzed. The mean heavy metal concentrations (in mg/kg, dry weight) ranged within 0.18-1.53 (Hg), 50.08-200.18 (Cu), 118.70-313.65 (Zn), 50.77-310.85 (Cr), 37.12-92.72 (Pb) and 13.29-197.24 (As), and Cu, Zn and As have been regarded as the main metal pollutants. The levels of PBDEs (1.2-12.1 ng/g) and BDE-209 (2.4-30.5 ng/g) were at the middle level of the global range. BDE-209 was the predominant congener (67.0%-85.7%), which agrees with the fact that technical deca-BDE mixtures are the dominant PBDE formulation in China. The relative high level of PTS pollutants in the western part of the city is probably owing to the intensive agricultural activities and lack of sewerage system there. The ecological risk assessment with the sediment quality guidelines (SOGs) indicates that the urban river sediments in the city have been heavily contaminated by heavy metals with probable ecotoxicological impacts on freshwater organisms and the main toxic pollutants are Hg and As. The results of current study imply that the city, and perhaps many other small cities in China as well, requires immediate pollution control measures with emphasis on not only conventional organic pollutants but also on PTS such as heavy metals and PBDEs. | Feipeng Li Haiping Zhang Xiangzhou Meng Ling Chen Daqiang Yin | 2012 | Journal of Environmental Sciences2012，24，11： | 9 |
| 7 | Depositional architecture of the late Ordovician drowned carbonate platform margin and its responses to sea-level fluctuation in the northern slope of the Tazhong region, Tarim Basin显示文摘The Tazhong Uplift of the late Ordovician is a drowned rimmed carbonate platform. The carbonate rock of the late Ordovician Lianglitage Formation in the northern slope of the Tazhong region is one of the significant petroliferous intervals. Based on petrofacies, depositional cycles, natural gammaray spectrometry and carbon/oxygen isotope data from the Lianglitage Formation, one 2nd-order, three 3rd-order and several 4th-order sequences have been recognized, and the late Ordovician relative sealevel fluctuation curve has been established. The sequences O 3 l-1 and O 3 l-2 on the platform are composed of highstand and transgressive systems tracts, but lack the lowstand systems tract. The sequence O 3 l-3 is a drowning sequence. The sequence O 3 l-1 overlapped the eroded slope and pinched out to the northwest and landward. The highstand systems tract in the sequence O 3 l-2 consists of low-angle sigmoid and high-angle shingled progradation configuration. Major sedimentary facies of the Lianglitage Formation include reef and shoal in the platform margin and lagoon, which can be subdivided into coral-sponge-stromatoporoid reef complex, sand shoal, lime mud mound, and intershoal sea. Reefs, sand shoals and their complex are potential reservoir facies. The reefs and sand shoals in the sequence O 3 l-1 developed in the upper of its highstand systems tract. In the sequence O 3 l-2, the highstand systems tract with an internal prograding configuration is a response to the lateral shifting of the complex of reef and sand shoal. The transgressive systems tract, in particular the sand shoals, developed widely on the slope of the platform margin and interior. The reefs in the sequence O 3 l-3 migrated towards high positions and formed retrograding reefs in the western platform and low relief in the platform interior. Basinward lateral migration of the reefs and pure carbonate rock both characterize highstand systems tract and show that the rise of the relative sea-level was very slow. Shingled prograding stacking pattern of the 4th-order sequences and reefs grow horizontally, which represents the late stage of highstand systems tract and implies relative sealevel stillstand. Reefs migrating towards high land and impure carbonate rock both indicate transgressive systems tract and suggest that the relative sea-level rose fast. Erosional truncation and epidiagenetic karstification represent a falling relative sea-level. The relative sea-level fluctuation and antecedent palaeotopography control the development and distribution of reef complexes and unconformity karst zones. Currently, the composite zone of epidiagenetic karstic intervals and high-energy complexes of reefs and sand shoals with prograding configuration is an important oil and gas reservoir in the northern slope of the Tazhong carbonate platform. | Yang Xiaofa Lin Changsong Yang Haijun Han Jianfa Liu Jingyan Zhang Yanmei Peng Li Jing Bing Tong Jianyu Wang Haiping Li Huanpu | 2010 | Petroleum Science2010，7，3： | 8 |
| 8 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044sxb0b0960906q6kxo.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 9 | Experimental investigation on drag reduction in turbulent boundary layer over superhydrophobic surface by TRPIV显示文摘This study aims at the mechanism of drag reduction in turbulent boundary layer(TBL) with superhydrophobic surface.Comparing the time-resolved particle image velocimetry(TRPIV) measurement results with that of hydrophilic surface,the drag reduction rate over a superhydrophobic surface is approximately10%.To investigate the characteristics of coherent structure in a drag-reduced TBL with superhydrophobic surface,a modified multi-scale spatial locally-averaged structure function is proposed for detecting coherent structure.The conditional sampling and spatial phase-lock average methods are employed to obtain the topology of physical quantities like the velocity fluctuation,spanwise vorticity,and Reynolds stress during eject and sweep process.The results indicate that the suppression of coherent structure burst in the near-wall region is the key mechanism in reducing the skin friction drag for TBL over superhydrophobic surface. | Haiping Tian Jingxian Zhang Erdan Wang Zhaohui Yao Nan Jiang | 2015 | Theoretical & Applied Mechanics Letters2015，5，1： | 7 |
| 10 | Hierarchical Honeycomb-Structured Electret/Triboelectric Nanogenerator for Biomechanical and Morphing Wing Energy Harvesting显示文摘Flexible,compact,lightweight and sustainable power sources are indispensable for modern wearable and personal electronics and small-unmanned aerial vehicles(UAVs).Hierarchical honeycomb has the unique merits of compact mesostructures,excellent energy absorption properties and considerable weight to strength ratios.Herein,a honeycomb-inspired triboelectric nanogenerator(h-TENG)is proposed for biomechanical and UAV morphing wing energy harvesting based on contact triboelectrification wavy surface of cellular honeycomb structure.The wavy surface comprises a multilayered thin film structure(combining polyethylene terephthalate,silver nanowires and fluorinated ethylene propylene)fabricated through high-temperature thermoplastic molding and wafer-level bonding process.With superior synchronization of large amounts of energy generation units with honeycomb cells,the manufactured h-TENG prototype produces the maximum instantaneous open-circuit voltage,short-circuit current and output power of 1207 V,68.5μA and 12.4 mW,respectively,corresponding to a remarkable peak power density of 0.275 mW cm^(−3)(or 2.48 mW g^(−1))under hand pressing excitations.Attributed to the excellent elastic property of self-rebounding honeycomb structure,the flexible and transparent h-TENG can be easily pressed,bent and integrated into shoes for real-time insole plantar pressure mapping.The lightweight and compact h-TENG is further installed into a morphing wing of small UAVs for efficiently converting the flapping energy of ailerons into electricity for the first time.This research demonstrates this new conceptualizing single h-TENG device’s versatility and viability for broad-range real-world application scenarios. | Kai Tao Zhensheng Chen Haiping Yi Ruirong Zhang Qiang Shen Jin Wu Lihua Tang Kangqi Fan Yongqing Fu Jianmin Miao Weizheng Yuan | 2021 | Nano-Micro Letters2021，13，8： | 7 |
| 11 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 12 | Publication trends in studies examining radix notoginseng as a treatment for ischemic brain injury显示文摘Acute ischemic stroke has become a major disease burden with high mortality and morbidity rates. There is a lack of evidence-based medicine confirming the efficacy of common treatments. Panax notoginseng saponins, the main active ingredient of radix notoginseng, have a neuroprotective role in ischemic brain injury, and have been popularized as a maintenance treatment for acute cerebral infarction and its sequelae. We conducted literature searches on the Web of Science, ClinicalTrials.gov, Cochrane Collaboration, CNKI, Wanfang and the China Scientific & Technological Achievements Database and analyzed the experimental and clinical outcomes of studies investigating the use of radix notoginseng in the treatment of ischemic brain injury to improve the understanding of relevant research trends and existing problems. We found that over the past 10 years, China has maintained its interest in Panax notoginseng research, while such studies are scarce on the Web of Science. However, Chinese researchers often focus on the neuroprotective role of radix notoginseng in ischemic brain injury, but there are no large-scale clinical data to confirm its efficacy and safety. There remains a need for more rigorous large-sample randomized controlled clinical trials with long-term follow-up, to determine whether radix notoginseng lowers stroke recurrence and improves patient's quality of life. | Haiping Li Luo Qiang Chunyang Zhang Chaohui Wang Zhenxing Mu Ligang Jiang | 2014 | Neural Regeneration Research2014，9，17： | 5 |
| 13 | Using ORYZA2000 to model cold rice yield response to climate change in the Heilongjiang province, China显示文摘Rice(Oryza sativa L.) is one of the most important staple crops in China. Increasing atmospheric greenhouse gas concentrations and associated climate change may greatly affect rice production. We assessed the potential impacts of climate change on cold rice production in the Heilongjiang province, one of China's most important rice production regions. Data for a baseline period(1961–1990) and the period 2010–2050 in A2 and B2 scenarios were used as input to drive the rice model ORYZA2000 with and without accounting for the effects of increasing atmospheric CO2 concentration. The results indicate that mean,maximum, and minimum temperature during the rice growing season, in the future period considered, would increase by 1.8 °C under the A2 scenario and by 2.2 °C under the B2 scenario compared with those in the baseline. The rate of change in average maximum and minimum temperatures would increase by 0.6 °C per 10-year period under the A2 scenario and by 0.4 °C per 10-year period under the B2 scenario. Precipitation would increase slightly in the rice growing season over the next 40 years. The rice growing season would be shortened and the yield would increase in most areas in the Heilongjiang province. Without accounting for CO2 effect, the rice growing season in the period 2010–2050 would be shortened by 4.7 and 5.8 days,and rice yields would increase by 11.9% and 7.9%, under the A2 and B2 scenarios, respectively.Areas with simulated rice yield increases greater than 30.0% were in the Xiaoxing'an Mountain region. The simulation indicated a decrease in yield of less than 15% in the southwestern Songnen Plain. The rate of change in simulated rice yield was 5.0% and 2.5% per 10 years under the A2 and B2 scenarios, respectively. When CO2 effect was accounted for, rice yield increased by 44.5% and 31.3% under the A2 and B2 scenarios, respectively. The areas of increasing yield were sharply expanded. The area of decreasing yield in the western region of Songnen Plains disappeared when increasing CO2 concentration was considered. The stability of rice yield would increase from 2010 to 2050. Overall, the simulation indicates that rice production will be affected positively by climate change in the next 40 years in the Heilongjiang province, China. | Jingting Zhang Liping Feng Haiping Zou De Li Liu | 2015 | The Crop Journal2015，3，4： | 5 |
| 14 | Modeling the impact of the viaduct on particles dispersion from vehicle exhaust in street canyons显示文摘In this paper,the impact of the viaduct on flow and traffic exhausting particles dispersion within urban street canyons was nu-merically simulated using a computational fluid dynamics(CFD) model.Two-dimensional flow and dispersion of particles from traffic exhausts were modeled using the standard k-? turbulence model.The street canyons with a viaduct at different widths and different heights above the ground are simulated.The results show that the airflow in street canyon is evidently in-fluenced by the viaduct:The position of the main vortex center is changed,especially there are two strong vortexes when the viaduct is placed at 10 m height above the ground.It is found based on the study of the particles number concentrations(PNCs) that the viaduct may mitigate the pollution level in the street canyon sometimes.The impact of the viaduct width on PNCs is stronger than that of the height.The study of PNDs reveals that the mean PNCs at the wall of upwind building increase when a viaduct is placed in street canyon.In addition,it is found based on the study of mean particles residence time(PRT) that the removal of the particles strongly correlates to the mean PNCs.The results indicate that the viaduct is an important factor to in-fluence the flow patterns and particles dispersion in street canyons. | ZHANG ChuanFu WEN Mou ZENG JianRong ZHANG GuiLin FANG HaiPing LI Yan | 2012 | Science China(Technological Sciences)2012，55，1： | 5 |
| 15 | Analysis and assessment of heavy metal contamination in surface water and sediments: a case study from Luan River, Northern China显示文摘重金属 Cu, Ni, Pb, Zn, Cd,和 Cr 的集中从 Luan 河 inChina 在表面水和沉积里被检验,。与在 Cu 和 Ni 的衰落,集中在下游的车站在表面水里发现了。这发现建议水水流是在重金属污染的一个主要解释因素。在河的中间的活动范围观察的许多 Cr, Pb,和 Cd 在本地区域显示重金属污染,尽管 Daheiting 水库下游地在水里的集中有明显的减少。人为的活动贡献重金属污染沉积,这因此是的离开河更远的沉积也建议的在看见的 Cu , Pb ,和 Ni 的重要升起趋势用作环境指示物,与沉积,评价用geo累积索引被进行(我<潜水艇class=“ a-plus-plus ”> geo )和潜在的生态的风险索引( RI )。我 < 潜水艇 class= “ a-plus-plus ” > geo 价值揭示了那 Cd (3.13 ) , Cr (2.39 ) 在 Luan 河里显著地积累了。RI 珍视因为采样车站的大多数(89%) 比 300 高,建议来自 Luan 河的那沉积提出严重生态的风险,与在上面、中间的溪流的比那下游地高的潜在的生态的风险。在水里的 Pb/Ni 和在沉积的 Cr/Ni 之中的好关联被观察。簇分析建议 Cd 可以有各种各样的起源,从人为的来源被导出。 | Zhaoming WANG Ranhao SUN Haiping ZHANG Liding CHEN | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 5 |
| 16 | Ischemic stroke susceptibility gene in a Northern Han Chinese population显示文摘Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the -607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affiliated Hospital of Qingdao University Medical College, China, and 226 healthy controls. Both patients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the -607C/A (rs1946518) polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C alleles than healthy controls. Genotype and allele frequencies of the interleukin-18 -137G/C (rs187238) polymorphism and the -13T/C (rs11024595) polymorphism in the 5'-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hypertension, diabetes mellitus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A allele (C homozygotes) was 2.2-fold greater than in A allele carriers. Overall, our findings suggest that the -13T/C (rs11024595) polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cerebrovascular disease, but the C allele of the -607C/A (rs1946518) polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A allele is likely a protective gene for ischemic cerebrovascular disease. | Haiping Wang Shujuan Shi Wenjing Yan Yan Song Jingjing Zhan Chen Zhang Haiji Wang | 2013 | Neural Regeneration Research2013，8，20： | 4 |
| 17 | The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice显示文摘Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1(AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules.AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein(GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes. | Deyong Ren Yuchun Rao Liwen Wu Qiankun Xu Zizhuang Li Haiping Yu Yu Zhang Yujia Leng Jiang Hu Li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian | 2016 | Journal of Integrative Plant Biology2016，58，6： | 4 |
| 18 | The First OCCCO Pentadentate Chelates:Osmium Mediated Stepwise Oxidations of Terminal Alkynes by Pyridine N-Oxide显示文摘of main observation and conclusion Oxygen atom transfer reactions between alkynes and heteroarene N-oxides are currently mediated by transition metal,such as gold,ruthenium or rhodium,but they have never been catalyzed by osmium.Herein,we report stepwise oxidations of terminal alkynes mediated by an osmium carbolong complex,using pyridine N-oxide as the oxidant,yielding novel aldehyde-or carboxylic acid-coordinated osmapentalyne derivatives selectively.The mechanism was illustrated by density functional theory calculations,providing a new route for oxygen atom transfer between heteroarene N-oxides and alkynes. | Jianfeng Lin Qiannan Xu Xinlei Lin Yuhui Hua Dafa Chen Yonghong Ruan Hong Zhang Haiping Xia | 2020 | Chinese Journal of Chemistry2020，38，11： | 4 |
| 19 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 20 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
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