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| 1 | Intelligent metasurface imager and recognizer显示文摘There is an increasing need to remotely monitor people in daily life using radio-frequency probe signals.However,conventional systems can hardly be deployed in real-world settings since they typically require objects to either deliberately cooperate or carry a wireless active device or identification tag.To accomplish complicated successive tasks using a single device in real time,we propose the simultaneous use of a smart metasurface imager and recognizer,empowered by a network of artificial neural networks(ANNs)for adaptively controlling data flow.Here,three ANNs are employed in an integrated hierarchy,transforming measured microwave data into images of the whole human body,classifying specifically designated spots(hand and chest)within the whole image,and recognizing human hand signs instantly at a Wi-Fi frequency of 2.4 GHz.Instantaneous in situ full-scene imaging and adaptive recognition of hand signs and vital signs of multiple non-cooperative people were experimentally demonstrated.We also show that the proposed intelligent metasurface system works well even when it is passively excited by stray Wi-Fi signals that ubiquitously exist in our daily lives.The reported strategy could open up a new avenue for future smart cities,smart homes,human-device interaction interfaces,health monitoring,and safety screening free of visual privacy issues. | Lianlin Li Ya Shuang Qian Ma Haoyang Li Hanting Zhao Menglin Wei Che Liu Chenglong Hao Cheng-Wei Qiu Tie Jun Cui | 2019 | Light(Science & Applications)2019，8，1： | 5 |
| 2 | DASP: Defect and Dopant ab-initio Simulation Package显示文摘In order to perform automated calculations of defect and dopant properties in semiconductors and insulators, we developed a software package, the Defect and Dopant ab-initio Simulation Package(DASP), which is composed of four modules for calculating:(ⅰ) elemental chemical potentials,(ⅱ) defect(dopant) formation energies and charge-state transition levels,(ⅲ) defect and carrier densities and(ⅳ) carrier dynamics properties of high-density defects. DASP uses the materials genome database for quick determination of competing secondary phases when calculating the elemental chemical potential that stabilizes compound semiconductors. DASP calls the ab-initio software to perform the total energy, structural relaxation and electronic structure calculations of the defect supercells with different charge states, based on which the defect formation energies and charge-state transition levels are calculated. Then DASP can calculate the equilibrium densities of defects and electron and hole carriers as well as the Fermi level in semiconductors under different chemical potential conditions and growth/working temperature. For high-density defects, DASP can calculate the carrier dynamics properties such as the photoluminescence(PL) spectrum and carrier capture cross sections which can interpret the deep level transient spectroscopy(DLTS). Here we will show three application examples of DASP in studying the undoped GaN, C-doped GaN and quasi-one-dimensional SbSeI. | Menglin Huang Zhengneng Zheng Zhenxing Dai Xinjing Guo Shanshan Wang Lilai Jiang Jinchen Wei Shiyou Chen | 2022 | Journal of Semiconductors2022，43，4： | 3 |
| 3 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 4 | One-bit quantization is good for programmable coding metasurfaces显示文摘The information-carrying programmable metasurfaces have found widespread applications in communication, sensing, and other related areas. However, there is a fundamental but unresolved problem,i.e., the rigorous understanding of the quantization of metasurface coding. Here, we theoretically investigate the performance difference between one-bit and continuous information-encoding metasurfaces. To this end,we derive analytical representations of system responses in various cases(single-input single-output, singleinput multiple-output, and multiple-input multiple-output). We analyze the impact of one-bit coding(in contrast to continuous coding) in terms of the resulting channel cross-talk and reduction of information capacity in various representative scenarios from wireless communication and holography. Our main finding indicates that the one-bit coding yields a satisfactory performance in most practical scenarios;we also show that in many cases there are smart ways to mildly relax optimization constraints in order to reduce the performance gap between the one-bit and continuous coding. We expect that our results can provide theoretical guidance for a large variety of metasurface-assisted information systems for electromagnetic waves and other wave phenomena. | Ya SHUANG Hanting ZHAO Menglin WEI Qiang CHENG Shi JIN Tiejun CUI Philipp DEL HOUGNE Lianlin LI | 2022 | Science China(Information Sciences)2022，65，7： | 2 |
| 5 | Signaling pathways in rheumatoid arthritis:implications for targeted therapy显示文摘Rheumatoid arthritis(RA)is an incurable systemic autoimmune disease.Disease progression leads to joint deformity and associated loss of function,which significantly impacts the quality of life for sufferers and adds to losses in the labor force.In the past few decades,RA has attracted increased attention from researchers,the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA,which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets.The current review intends to provide a comprehensive overview of RA,including a general introduction to the disease,historical events,epidemiology,risk factors,and pathological process,highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms,including genetic factors,epigenetic factors,summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA.therapeutic interventions including approved drugs,clinical drugs,pre-clinical drugs,and cutting-edge therapeutic technologies.These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future. | Qian Ding Wei Hu Ran Wang Qinyan Yang Menglin Zhu Meng Li Jianghong Cai Peter Rose Jianchun Mao Yi Zhun Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 6 | Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis显示文摘Progranulin(PGRN)is a multifunctional growth factor involved in many physiolog-ical processes and disease states.The apparent protective role of PGRN and the importance of chondrocyte autophagic function in the progression of osteoarthritis(OA)led us to investi-gate the role of PGRN in the regulation of chondrocyte autophagy.PGRN knockout chondro-cytes exhibited a deficient autophagic response with limited induction following rapamycin,serum starvation,and IL-1b-induced autophagy.PGRN-mediated anabolism and suppression of IL-1b-induced catabolism were largely abrogated in the presence of the BafA1 autophagy inhibitor.Mechanistically,during the process of OA,PGRN and the ATG5eATG12 conjugate form a protein complex;PGRN regulates autophagy in chondrocytes and OA through,at least partially,the interactions between PGRN and the ATG5eATG12 conjugate.Furthermore,the ATG5eATG12 conjugate is critical for cell proliferation and apoptosis.Knockdown or knockout of ATG5 reduces the expression of ATG5eATG12 conjugate and inhibits the chondroprotective effect of PGRN on anabolism and catabolism.Overexpression of PGRN partially reversed this effect.In brief,the PGRN-mediated regulation of chondrocyte autophagy plays a key role in the chondroprotective role of PGRN in OA.Such studies provide new insights into the pathogen-esis of OA and PGRN-associated autophagy in chondrocyte homeostasis. | Yiming Pan Yuyou Yang Mengtian Fan Cheng Chen Rong Jiang Li Liang Menglin Xian Biao Kuang Nana Geng Naibo Feng Lin Deng Wei Zheng Fengmei Zhang Xiaoli Li Fengjin Guo | 2023 | Genes & Diseases2023，10，4： | 0 |
| 7 | Encapsulated carbon nanotube array as a thermal interface material compatible with standard electronics packaging显示文摘Vertically aligned carbon nanotubes arrays(VACNTs)are a promising candidate for the thermal interface material(TIM)of next-generation electronic devices due to their attractive thermal and mechanical properties.However,the environment required for synthesizing VACNTs is harsh and severely incompatible with standard device packaging processes.VACNTs’extremely low in-plane thermal conductivity also limits its performance for cooling hot spots.Here,using a transfer-and-encapsulate strategy,a two-step soldering method is developed to cap both ends of the VACNTs with copper microfoils,forming a standalone Cu-VACNTs-Cu sandwich TIM and avoiding the need to directly grow VACNTs on chip die.This new TIM is fully compatible with standard packaging,with excellent flexibility and high thermal conductivities in both in-plane and through-plane directions.The mechanical compliance behavior and mechanism,which are critical for TIM applications,are investigated in depth using in situ nanoindentation.The thermal performance is further verified in an actual light emitting diode(LED)cooling experiment,demonstrating low thermal resistance,good reliability,and achieving a 17℃ temperature reduction compared with state-of-the-art commercial TIMs.This study provides a viable solution to VACNTs’longstanding problem in device integration and free-end contact resistance,bringing it much closer to application and solving the critical thermal bottleneck in next-generation electronics. | Ruixiang Bai Yangbing Wei Jiyuan Xu Xiaobo Li Menglin Li Ziwen Zou Xinyan Huang Chengyu Liu Yiwei Sun Menglong Hao | 2023 | Nano Research2023，16，8： | 0 |
| 8 | Ciphertext-only fault analysis of GIFT lightweight cryptosystem显示文摘Dear editor,The GIFT cryptosystem was proposed by Banik et al. [1]in CHES 2017. It can be widely applied to protect RFID tags and other low-resource devices. It has an SPN structure with a fixed 128-bit key size and two flexible variants of 64-bit and 128-bit block sizes. In simulations, GIFT achieves good performance and surpasses both SIMON and SKINNY [1]. In 2013, Fuhr et al. [2] proposed a ciphertextonly fault analysis(CFA) of AES for three types of faults:zero-byte fault, zero-nibble fault. | Wei LI Shan CAO Dawu GU Jiayao LI Tianpei CAI Menglin WANG Li SUN Zhiqiang LIU Ya LIU | 2022 | Science China(Information Sciences)2022，65，3： | 0 |
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