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| 1 | Fog Computing Dynamic Load Balancing Mechanism Based on Graph Repartitioning显示文摘Because of cloud computing's high degree of polymerization calculation mode, it can't give full play to the resources of the edge device such as computing, storage, etc. Fog computing can improve the resource utilization efficiency of the edge device, and solve the problem about service computing of the delay-sensitive applications. This paper researches on the framework of the fog computing, and adopts Cloud Atomization Technology to turn physical nodes in different levels into virtual machine nodes. On this basis, this paper uses the graph partitioning theory to build the fog computing's load balancing algorithm based on dynamic graph partitioning. The simulation results show that the framework of the fog computing after Cloud Atomization can build the system network flexibly, and dynamic load balancing mechanism can effectively configure system resources as well as reducing the consumption of node migration brought by system changes. | SONG Ningning GONG Chao AN Xingshuo ZHAN Qiang | 2016 | China Communications2016，13，3： | 8 |
| 2 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 3 | Relaxor behavior of (1-x)Pb(Mg_(1/3)Nb_(2/3))O_3-xPbTiO_3 ceramics显示文摘In the present work, the phase transitions and relaxor behavior of (1-x)Pb(Mg1/3Nb2/3)O3-xPbTiO3 (PMN-PT, x = 0.2―0.4) ferroelectric ceramics have been investigated by means of X-ray diffraction, di-electric spectroscopy, the P-E hysteresis loop measurements and Raman scattering techniques. Structural analysis revealed that with the increase of PbTiO3 content, PMN-PT ceramics experienced a gradual phase transition process from rhombohedral to tetragonal. It is usually believed that such kinds of phase transitions resulted in the linear decrease of relaxation degree. Surprisingly, our analysis of the dielectric spectra revealed that the indicator of the degree of diffuseness γ reached the maximum value near morphotropic phase boundary (MPB) (x = 0.32), then decreased with the further increase of PbTiO3 content. The large dielectric relaxor feature near MPB may be attributed to the for-mation of ordered nanodomains, resulting from complex coexisting nanostructures. Further, the P-E hysteresis loop measurements and Raman analysis of the B-site cation order correlated well with the dielectric measurement results. It was found that the hysteresis loop squareness Rsq received the minimum value while the inverse of the value of full wide of half maximum (FWHM) of A1g mode reached the maximum value at MPB composition, which showed similar trends to γ. | WU NingNing SONG XueMei HOU YuDong ZHU ManKang WANG Chao YAN Hui | 2009 | Chinese Science Bulletin2009，54，7： | 2 |
| 4 | A facile method to synthesize carboxyl-functionalized magnetic polystyrene nanospheres 显示文摘 | Ningning Guan Chao Liu Dejun Sun | 2009 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2009，335，： | 1 |
| 5 | Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke显示文摘 | Chao Jiang Jianping Wang Xin Li Chunling Liu Ningning Chen Yujin Hao | 2009 | Inflammation Research2009，，9： | 1 |
| 6 | The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing显示文摘A thorough interrogation of the immune landscape is crucial for immunotherapy strategy selection and prediction of clinical responses in non-small-cell lung cancer(NSCLC)patients.Single-cell RNA sequencing(scRNA-seq)techniques have prompted the opportunity to dissect the distinct immune signatures between lung adenocarcinoma(LUAD)and lung squamous cell carcinoma(LUSC),the two major subtypes of NSCLC.Here,we performed scRNA-seq on 72,475 immune cells from 40 samples of tumor and matched adjacent normal tissues spanning 19 NSCLC patients,and drew a systematic immune cell transcriptome atlas.Joint analyses of the distinct cellular compositions,differentilly expressed genes(DEGs),cell-cell interactions,pseudotime trajectory,transcriptomic factors and prognostic factors based on The Cancer Genome Atlas(TCGA),revealed the central roles of cytotoxic and effector T and NK cells and the distinct functional macrophages(Mo)subtypes in the immune microenvironment heterogeneity between LUAD and LUSC.The dominant subtype of Mo was FABP4-Mp in LUAD and SPP1-Mo in LUSC.Importantly,we identifieda novel lymphocyte-related Mo cluster,which we named SELENOP-Mo,and further established its antitumor role in both types,especially in LUAD.Our comprehensive depiction of the immune heterogeneity and definition of Mp clusters could help design personalized treatment for lung cancer patients in clinical practice. | Chengdi Wang Qiuxiao Yu Tingting Song Zhoufeng Wang Lujia Song Ying Yang Jun Shao Jingwei Li Yinyun Ni Ningning Chao Li Zhang Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 7 | Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke显示文摘 | Chao Jiang Jianping Wang Xin Li Chunling Liu Ningning Chen Yujin Hao | 2009 | Inflammation Research2009，，9： | 1 |
| 8 | Study on the P2P Cloud Storage Architecture Based on Semantic Hypergraph显示文摘Cloud storage has the characteristics of distributed and virtual, and it makes the ownership rights and management rights of users data separated. The master-slave architecture of cloud storage has a problem of single point failure. In this paper, we provide a cloud storage architecture model based on Semantic equivalence. According to semantic matching degree, this architecture divides the nodes into node cluster by creating semantic tree and maintains system routing through semantic hypergraph. Through simulation experiments show that dividing network into semantic can enhance scalability and flexibility of the system, and it can improve the efficiency of network organization and the security of cloud storage system, at the same time, it can also reduce the cloud data storage and the delay of reading time. | SONG Ningning LIN Ruijie AN Xingshuo GONG Chao YAO Zhiyong | 2015 | China Communications2015，12，S2： | 0 |
| 9 | Expression profile of long non-coding RNAs in the intestine of black rockfish Sebastes schlegelii in response to Edwardsiella tarda infection显示文摘Long non-coding RNAs(lncRNAs)are a class of transcripts longer than 200 bp,which have been emerged as essential regulators in numerous biological processes.Black rockfish(Sebastes schlegelii)is an economic fish that widely cultured in the coastal areas of China,Japan,and South Korea.With the expansion of aquacultural scale,various pathogens have threatened its industry and reduced its economic values.It has been reported that lncRNA were involved in the immune response and metabolic pathway in teleost,while no study is available on identification and functional analysis of lncRNAs in black rockfish so far.Herein,this study was performed to identify lncRNAs in the intestine of black rockfish after Edwardsiella tarda infection.In our results,a total of 9311 lncRNAs were identified through highthroughput sequencing,and 102 lncRNAs were significantly regulated following challenge,which were predicted to target 3348 mRNAs.Results of Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of the se target genes showed they were function in catalytic activity,hydrolase activity,defense response and peptidase activity,which involved in metabolic pathways and immune related pathways.In addition,47 lncRNAs and 8 differentially expressed mRNAs(DEmRNAs)showed co-expression at two or more infection time points with metabolism and immunity functions.Moreover,real-time quantitative PCR(qRT-PCR)was performed to verify the reliability of sequencing gene expression analysis results.This research laid the foundation for further investigation of the regulatory roles of lncRNAs in the intestinal immune response of black rockfish. | Xu YAN Min CAO Qiang FU Ning YANG Ningning WANG Lin SONG Chao LI | 2023 | Journal of Oceanology and Limnology2023，41，1： | 0 |
| 10 | High butanol production by regulating carbon, redox and energy in Clostridia显示文摘Butanol 是有高精力紧张的有希望的 biofuel 并且能被用作汽油代用品。它能被微生物作为一个持续精力生产(例如 Clostridia ) 从低值的生物资源。然而,在 butanol 发酵的低生产率,收益和选择仍然由于有效生产 butanol 主人紧张的缺乏是大挑战。在这篇文章,我们系统地考察 Clostridia 的宿主细胞工程,集中于( 1 )各种各样的策略到重新平衡由调整碳,氧化还原作用或精力的新陈代谢完成高 butanol 生产的新陈代谢的流动,( 2 )在小径操作的挑战,并且( 3 ) proteomics 技术到的应用程序理解细胞内部的新陈代谢。另外,过程工程简短也被描述。这评论的目的是在 Clostridium 的新陈代谢的工程总结以前的研究成就并且提供指导让未来小说紧张建设有效地生产 butanol。 | Jianfa Ou Chao Ma Ningning Xu Yinming Du Xiaoguang (Margaret) Liu | 2015 | Frontiers of Chemical Science and Engineering2015，9，3： | 0 |
| 11 | Syntheses and Antiproliferative Evaluation of 6-Thienyl, 6-Polyphenyl Aryl and 6-Naphthyl Derivatives of 2,4-Diaminopyrido [3,2-d] pyramidine as Non-classical Antifolate Targeting DHFR显示文摘 | YANG Jiajia WANG Meng LI Xia FAN Ningning XUE Liangmin LI Hao TIAN Chao WANG Xiaowei LIU Junyi ZHANG Zhili | 2017 | Chemical Research in Chinese Universities2017，33，4： | 0 |
| 12 | Polymer engineering for electrodes of aqueous zinc ion batteries显示文摘With the increasing demand for scalable and cost-effective electrochemical energy storage,aqueous zinc ion batteries(AZIBs)have a broad application prospect as an inexpensive,efficient,and naturally secure energy storage device.However,the limitations suffered by AZIBs,including volume expansion and active materials dissolution of the cathode,electrochemical corrosion,irreversible side reactions,zinc dendrites of the anode,have seriously decelerated the civilianization process of AZIBs.Currently,polymers have tremendous superiority for application in AZIBs attributed to their exceptional chemical stability,tunable structure,high energy density and outstanding mechanical properties.Considering the expanding applications of AZIBs and the superiority of polymers,this comprehensive paper meticulously reviews the benefits of utilizing polymeric applied to cathodes and anodes,respectively.To begin with,with adjustable structure as an entry point,the correlation between polymer structure and the function of energy storage as well as optimization is deeply investigated in respect to the mechanism.Then,depending on the diversity of properties and structures,the development of polymers in AZIBs is summarized,including conductive polymers,redox polymers as well as carbon composite polymers for cathode and polyvinylidene fluoride-,carbonyl-,amino-,nitrile-based polymers for anode,and a comprehensive evaluation of the shortcomings of these strategies is provided.Finally,an outlook highlights some of the challenges posed by the application of polymers and offers insights into the potential future direction of polymers in AZIBs.It is designed to provide a thorough reference for researchers and developers working on polymer for AZIBs. | Zhi Peng Zemin Feng Xuelian Zhou Siwen Li Xuejing Yin Zekun Zhang Ningning Zhao Zhangxing He Lei Dai Ling Wang Chao Lu | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
| 13 | Nitrogen Analogues of o-Quinodimethane with Unexpected non-Kekule Diradical Character显示文摘 | Tao Li Cheng Cheng Ningning Yuan Lei Wang Chao Chen Gengwen Tan Xinping Wang | 2018 | Chinese Journal of Chemistry2018，36，6： | 0 |
| 14 | Identification and Pathogen Stimulation Patterns of Neuronal Nitric Oxide Synthase(nNOS)in Black Rockfish(Sebastes schlegelii)显示文摘Neuronal nitric oxide synthase(nNOS)was the producer of nitric oxide(NO)which played important gas messenger molecules in biological process.It also can take effect as immune regulation molecule in organism.Black rockfish(Sebastes schlegelii)is an important economic fish which were widely farmed in East Asia countries.Meanwhile,the pathogenic bacteria such as the Edwardsiella tarda and Vibrio anguillarum in seawater always brought serious obstacles to their healthy growth.In order to explore the expression pattern of n NOS gene under the pathogen stimulation and predict its immune function,the n NOS gene in black rockfish named Ssn NOS was identified.It was 3780 bp in length,located on chromosome 6,and contained 27 coding domain sequence(CDs).According to the phylogenetic analysis,the Ssn NOS showed closest relative to the counterpart gene of swamp eel(Monopterus albus).Meanwhile,analysis of Ssn NOS expression in various healthy tissues showed that Ssn NOS expression level was highest in healthy brain tissues,followed by intestinal tissues.In addition,Ssn NOS showed significant expression changes in response to stimulation by two pathogens.Particular in gill,the expression of Ssn NOS after pathogenic stimulation increased significantly.The Elisa analysis showed the Ssn NOS content in gills was much higher than that in other tissues at all time points.Moreover,the expression patterns of Ssn NOS in brain,intestine and kidney after stimulation by pathogens showed a distinct expression pattern which first down-regulated and then up-regulated.Therefore,the Ssn NOS may be an important signaling molecule for fish to respond rapidly in immune stimulation. | YAN Xu WANG Ningning CAO Min LI Chao YANG Ning XUE Ting FU Qiang SONG Lin | 2023 | Journal of Ocean University of China2023，22，3： | 0 |
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