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| 1 | Identification and differentiation of major components in three different “Sheng-ma” crude drug species by UPLC/Q-TOF-MS显示文摘Cimicifugae Rhizoma(Sheng ma) is a Ranunculaceae herb belonging to a composite family and well known in China,has been widely used in traditional Chinese medicine.The Pharmacopoeia of the People's Republic of China contains three varieties(Cimicifuga dahurica(Turcz.),Cimicifuga foetida L.and Cimicifuga heracleifolia Kom.) which have been used clinically as 'Sheng-ma'.However,the chemical constituents of three components of 'Sheng-ma' have never been documented.In this study,a rapid method for the analysis of the main components of 'Sheng-ma' was developed using ultra-high performance liquid chromatography with quadrupole-time-of-flight mass spectrometry(UPLC/Q-TOF-MS).The present study reveals the major common and distinct chemical constituents of C.dahurica,C.foetida and C.heracleifolia and also reports principal component and statistical analyses of these results.The components were identified by comparing the retention time,accurate mass,mass spectrometric fragmentation characteristic ions and matching empirical molecular formula with that of the published compounds.A total of 32 common components and 8 markers for different 'Sheng-ma' components were identified.These findings provide an important basis for the further study and clinical utilities of the three 'Sheng-ma' varieties. | Mengxue Fan Kunming Qin Fei Ding Yuting Huang Xiaoli Wang Baochang Cai | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 4 |
| 2 | An analysis of the status of diagnostic radiology equipment in China显示文摘Objective:To analyze the current situation of diagnostic radiology equipment in Chinese mainland and to understand changes in the past 20 years,including gaps with other countries,in order to provide a scientific basis for the government to formulate relevant policies and regulations,and supplement Chinese data for international organizations.Methods:This survey adopted a uniformly designed questionnaire,which was completed by the investigators or the respondents.The survey was distributed to all medical institutions that provided diagnostic radiology services in 31 provinces,autonomous regions,and municipalities,excluding Hong Kong,Macao,Taiwan,and military,China.Results:The survey showed that in the past 20 years,the number of medical institutions and diagnostic radiology equipment per million population in China has increased substantially.Dental radiology equipment increased nine-fold,and mammography equipment and computed tomography scanners showed a nearly five-fold increase.The four types of diagnostic radiology equipment,general diagnostic,fluoroscopic,mammography,and computed tomography,were associated with the population.Dental radiology equipment and bone mineral densitometers were related only to the gross domestic product(GDP).A large gap remains in the diagnostic radiology equipment per million population between China and the equipment of health-care level(HCL)I countries.Conclusions:An imbalance in the number of units of diagnostic radiology equipment per million population was observed in the different regions,China.Various types of diagnostic radiology equipment,especially mammography equipment and computed tomography scanners,need to be deployed to meet the medical needs of different populations. | Shuxia Hao Mengxue Li Shengnan Fan Hui Xu Jinsheng Cheng Jun Deng | 2023 | Radiation Medicine and Protection2023，4，3： | 0 |
| 3 | Mechanical design of a low β superconducting elliptical cavity for CSNS-II显示文摘Background A lowβsuperconducting elliptical cavity was designed for the China Spallation Neutron Source phase II project(CSNS-II).Methods The method to improve the mechanical stability of the lowβsuperconducting elliptical cavity was introduced,and the corresponding mechanical design was given.The software COMSOL Multiphysics and ANSYS APDL were used to calculate the static Lorentz force detuning factor k_(L)(LFD)and the helium pressure sensitivity factor k_(p)(DFDP)of the bare cavity,which were−4.71 Hz(MV/m)^(−2) and−21.1 Hz/mbar,respectively.The double-ring stiffeners reinforcement scheme was adopted.Results The radii of the double-ring stiffeners were 70 and 135 mm,respectively.The structure design of the helium vessel of the cavity was given.The following is the mechanical parameters of the reinforced cavity,the tuning sensitivity is 199.8 kHz/mm,longitudinal stiffness is 4.76kN/mm,k_(L) and k_(p) were−1.39 Hz(MV/m)^(−2) and 4.67 Hz/mbar,respectively,which met the operating requirements.The tuning sensitivity and stiffness of the reinforced cavity with different wall thicknesses were optimized,and the final wall thickness was selected as 4 mm.Conclusion The mechanical design of CSNS-II 648 MHz five-cell lowβsuperconducting elliptical cavity was introduced systematically in the paper.The LFD,DFDP,and the maximum surface stress of the cavity were reduced by optimizing the cavity wall thickness and the position of the double-ring stiffeners.The reinforced cavity met operational requirements. | Peihua Qu Huachang Liu Yun Wang Bo Li Xiaolei Wu Ahong Li Mengxu Fan Qiang Chen Jun Peng | 2021 | Radiation Detection Technology and Methods2021，5，3： | 0 |
| 4 | The Infection and Pathogenicity of SARS-CoV-2 Variant B.1.351 in hACE2 Mice显示文摘Dear Editor,Since the outbreak of COVID-19 at the end of 2019,its causative agent SARS-Co V-2 has been spreading around the world for one and half a year.During the long global circulation of SARS-Co V-2,mutations in the viral genome gradually emerged and accumulated。 | Qi Chen Xing-Yao Huang Ying Tian Changfa Fan Mengxu Sun Chao Zhou Ruiting Li Rong-Rong Zhang Guizhen Wu Cheng-Feng Qin | 2021 | Virologica Sinica2021，36，5： | 0 |
| 5 | RF design of a compact 648 MHz single spoke cavity at CSNS显示文摘Purpose In order to increase CSNS beam power from 100 to 500 kW,the linac injection energy needs to be increased from 80 to 300 MeV.The combined layout of superconducting spoke cavities and lliptical cavities will be adopted to accelerate H-beam to 300 MeV.In this paper,a compact single spoke cavity withφ50-mm beam aperture was proposed,with the RF performance of the spoke cavity optimized to E_(p)/E_(acc).<5,E_(p)/E_(acc)<9,as well as the good multipacting behavior.Methods CST Microwave Studio was used to optimize the RF performance(E_(peak)/E_(acc),B_(peak)/E_(acc) R/Q)with cavity geometry parameters.After electromagnetic design was finished,multipacting behavior was studied with CST Particle Studio module,and cavity shape modification was made to get a reasonablevalue.Results The simulation got optimum results of E_(peak)/E_(acc)=4.97 and B_(peak)/E_((acc)=8.42 mT/(MV/m),and themax is 1.52at E_(acc)=7.74 MV/m.Conclusion A 648 MHzβ=0.4 single spoke cavity with beam apertureФ50 mm was proposed in the paper.This compact cavity may be a very promising option for CSNS linac upgrading.In addition to the optimization of the RF parameters,the multipacting behavior of the cavity is also studied,and cavity shape is optimized to reducevalue. | Yun Wang Huachang Liu Jianping Dai Peng Sha Ziwei Deng Bo Li Mengxu Fan Ahong Li Peihua Qu Xiaolei Wu Qiang Chen | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
| 6 | A new method for quantifying mitochondrial axonal transport显示文摘线粒体的 Axonal 运输为 neuronal 幸存和功能是批评的。自动地确定并且在质问的一个大数量遗体分析 mitochondrial 运动。这里,我们和一个最新发达的分析包裹用 microfluidic-chamber-cultured 神经原为成像和确定的 axonal mitochondrial 运输报导一个有效方法命名 MitoQuant。这个工具箱为为分析线粒体的动态运动模式在实时 neuronal 轴突和一个短暂速度的分析节目内追踪 mitochondrial 运动由一个自动化节目组成。用这个方法,我们在 vivo 在有教养的哺乳动物的神经原并且在果蝇的马达神经原轴突检验了 axonal mitochondrial 运动。在影响线粒体的 3 个不同范例(温度变化,药处理和基因操作) ,我们证明了这个新方法为在 mitochondrial 运动检测变化高度有效、敏感。方法显著地提高了我们的能力到份量上分析 axonal mitochondrial 运动并且允许我们在没被传统的 kymographic 分析检测的 axonal mitochondrial 运输检测动态变化。 | Mengmeng Chen Yang Li Mengxue Yang Xiaoping Chen Yemeng Chen Fan Yang Sheng Lu Shengyu Yao Timothy Zhou Jianghong Liu Li Zhu Sidan Du Jane Y. Wu | 2016 | Protein & Cell2016，7，11： | 0 |
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