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| 1 | The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome显示文摘MicroRNAs(miRNAs)are a novel class of small,non-coding RNAs that play a significant role in both inflammatory and cardiovascular diseases.Immune cells,especially T helper(Th)cells,are critical in the development of atherosclerosis and the onset of acute coronary syndrome(ACS).To assess whether inflammation-related miRNAs(such as miR-155,146a,21,125a-5p,125b,31)are involved in the imbalance of Th cell subsets in patients with ACS,we measured the expression of related miRNAs in patients with acute myocardial infarction(AMI),unstable angina(UA),stable angina(SA)and chest pain syndrome(CPS);analyzed the relationship between miRNA expression and the frequency of Th cell subsets;and observed the co-expression of miR-155 and IL-17A in peripheral blood mononuclear cells(PBMCs)of patients with ACS.The results showed that the expression of miR-155 in the PBMCs of patients with ACS was decreased by approximately 60%,while the expression of both miR-21 and miR-146a was increased by approximately twofold.The expression patterns of miRNAs in plasma correlated with those in PBMCs,except for miR-21,which was increased by approximately sixfold in the AMI group and showed no significant difference between the UA group and the CPS group.We also found that the expression of miR-155 inversely correlated with the frequency of Th17 cells(r520.896,P,0.01)and that miR-155 was co-expressed with IL-17A in patients with ACS.In conclusion,our study revealed the expression patterns of inflammation-related miRNAs in patients with ACS and found that miR-155 may be associated with Th17 cell differentiation. | Rui Yao Yulan Ma Youyou Du Mengyang Liao Huanhuan Li Wei Liang Jing Yuan Zhijun Ma Xian Yu Hong Xiao Yuhua Liao | 2011 | Cellular & Molecular Immunology2011，8，6： | 32 |
| 2 | Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study显示文摘Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing. | Junqi Wu Chongwu Li Peigen Gao Chenhong Zhang Pei Zhang Lei Zhang Chenyang Dai unpeng Zhang Bowen Shi Mengyang Liu Junmeng Zheng Bo Pan Zhan Chen Chao Zhang Wanqing Liao Weihua Pan Wenjie Fang Chang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 3 | A New Texture Analysis Approach显示文摘A new texture analysis approach by uslng Gibbs random field model is discussed. A parametervector is defined ln order to compute potentlals of textures. It is found that texture features cau be providedby its corresponding parameter vector, and the vector can be estimated in terms of maximum potential. Conclusions can be inferred that this new method based on the maximum potential is valid. | Zhang Zhan Hou Jiechang Liao Mengyang | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 0 |
| 4 | Query Medical Images by Cluster-Based Texture Matching显示文摘Texture is an important attribute for medical image matching and retrieval. We present a texture matching based on clustering texture features which characterize the texture information. We have implemented this technique and tested it in a medical image database of CT images. The test results show that this method has a high efficiency of retrieval. | Yang Wu Xu Hui Guo Hongxing Liao Mengyang(College of Electronic information, Wuhan University, Wuhan 430072,China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，4： | 0 |
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