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| 1 | Classification and management of bile duct injuries显示文摘To review the classification and general guidelines for treatment of bile duct injury patients and their long term results. In a 20-year period, 510 complex circumferential injuries have been referred to our team for repair at the Instituto Nacional de Ciencias Médicasy Nutrición 'Salvador Zubirán' hospital in Mexico City and 198 elsewhere (private practice). The records at the third level Academic University Hospital were analyzed and divided into three periods of time: GⅠ-1990-99 (33 cases), G Ⅱ2000-2004 (139 cases) and GⅢ2004-2008 (140 cases). All patients were treated with a Roux en Y hepatojejunostomy. A decrease in using transanastomotic stents was observed (78% vs 2%, P = 0.0001). Partial segment Ⅳ and Ⅴ resection was more frequently carried out (45% vs 75%, P = 0.2) (to obtain a high bilioenteric anastomosis). Operative mortality (3% vs 0.7%, P = 0.09), postoperative cholangitis (54% vs 13%, P = 0.0001), anastomosis strictures (30% vs 5%, P = 0.0001), short and long term complications and need for reoperation (surgical or radiological) (45% vs 11%, P = 0.0001) were significantly less in the last period. The authors concluded that transition to a high volume center has improved long term results for bile duct injury repair. Even interested and tertiary care centers have a learning curve. | Miguel Angel Mercado Ismael Domínguez | 2011 | World Journal of Gastrointestinal Surgery2011，3，4： | 17 |
| 2 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | Iatrogenic bile duct injury with loss of confluence显示文摘AIM: To describe our experience concerning the surgical treatment of Strasberg E-4(Bismuth Ⅳ) bile duct injuries. METHODS: In an 18-year period, among 603 patients referred to our hospital for surgical treatment of complex bile duct injuries, 53 presented involvement of the hilar confluence classified as Strasberg E4 injuries. Imagenological studies, mainly magnetic resonance imaging showed a loss of confluence. The files of these patients were analyzed and general data were recorded, including type of operation and postoperative outcome with emphasis on postoperative cholangitis, liver function test and quality of life. The mean time of follow-up was of 55.9 ± 52.9 mo(median = 38.5, minimum = 2, maximum = 181.2). All other patients with Strasberg A, B, C, D, E1, E2, E3, or E5 biliary injuries were excluded from this study.RESULTS: Patients were divided in three groups: G1(n = 21): Construction of neoconfluence + Roux-en-Y hepatojejunostomy. G2(n = 26): Roux-en-Y portoenterostomy. G3(n = 6): Double(right and left) Rouxen-Y hepatojejunostomy. Cholangitis was recorded in two patients in group 1, in 14 patients in group 2, and in one patient in group 3. All of them required transhepatic instrumentation of the anastomosis and six patients needed live transplantation.CONCLUSION: Loss of confluence represents a surgicalchallenge. There are several treatment options at different stages. Roux-en-Y bilioenteric anastomosis(neoconfluence, double-barrel anastomosis, portoenterostomy) is the treatment of choice, and when it is technically possible, building of a neoconfluence has better outcomes. When liver cirrhosis is shown, liver transplantation is the best choice. | Miguel-Angel Mercado Mario Vilatoba Alan Contreras Pilar Leal-Leyte Eduardo Cervantes-Alvarez Juan-Carlos Arriola Bruno-Adonai Gonzalez | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 3 |
| 4 | Long-term evaluation of biliary reconstruction after partial resection of segments IV and V in iatrogenic injuries显示文摘 | Miguel ángel Mercado M.D. Carlos Chan M.D. Héctor Orozco M.D. José M. Villalta M.D. Alexandra Barajas-Olivas M.D. Javier Era?a M.D. Ismael Domínguez M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 3 |
| 5 | Transport policy and the provision of mobility options in an aging society: a case study of Ontario, Canada显示文摘 | Ruben Mercado Antonio Páez K. Bruce Newbold | 2010 | Journal of Transport Geography2010，，5： | 2 |
| 6 | Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network显示文摘Parkinson’s disease(PD)is the second most common neurodegenerative disease affecting 1%of the population over 60 years of age.The progressive degeneration of dopaminergic neurons at the substantia nigra pars compacta(SNpc)results in a severe and gradual depletion of dopamine content in the striatum,a phenomena that is responsible for the characteristic motor symptoms of this disease.There is no cure for PD and available treatments only aim to restore dopamine deficits.Administration of the dopamine precursor Levodopa(L-DOPA)is the main temporal palliative treatment that increases overall dopamine levels.However,its chronic use limits its effectiveness and generates a number of adverse effects such as debilitating dyskinesia. | Valentina Castillo Gabriela Mercado Claudio Hetz | 2015 | Neural Regeneration Research2015，10，7： | 2 |
| 7 | Acute myocardial infarction显示文摘 | Boersma E Mercado N Poldermans D | 2003 | Lancet2003，361，： | 1 |
| 8 | Thyrotoxic periodic paralysis in Mexican mestizo patients: a clinical, biochemical and HLA-semlogical study 显示文摘 | Nellen H Mercado M Mendoza V | 1999 | Arch Med Res1999，30，1： | 1 |
| 9 | TheCaMV?35S promoter is highly active on floral organs and pollen of transgenic strawberry plants显示文摘 | M. Cordero Mesa N. Santiago-Doménech F. Pliego-Alfaro M. A. Quesada J. A. Mercado | 2004 | Plant Cell Reports (-)2004，，1： | 1 |
| 10 | Single drop microextraction and gas chromatography–mass spectrometry for the determination of diflufenican, mepanipyrim, fipronil, and pretilachlor in water samples显示文摘 | Lilia Araujo María E. Troconis Dalia Cubillán Jair Mercado Noreiva Villa Avismelsi Prieto | 2013 | Environmental Monitoring and Assessment2013，，12： | 1 |
| 11 | Effect of simultane-ous down-regulation of pectate lyase and endo-(3-l,4-glucanasegenes on strawberry fruit softening显示文摘 | YOUSSEF S M IRAIDA A L^PEZ-ARANDA J M’ RAFAELS VICTORIANO V GIORGIO C ROSARIO B-P FERNAN-DO P-A OUESADA M A MERCADO J A | 2013 | Molecular Breeding2013，31，： | 1 |
| 12 | Characterization of the deposition and materials parameters of thin-film TiNi for micro-actuators and smart materials 显示文摘 | JARDINE A P MADSEN J S MERCADO P G | 2004 | Materials characterization2004，32，： | 1 |
| 13 | Effect of salinity acclimation on oxygen consumption of juvenile of the white shrimp Litopenaeus vannamei显示文摘 | ROSAS C LOPEZ N MERCADO P | 2001 | Journal of Crustacean Biology2001，21，4： | 1 |
| 14 | Characterization of the Deposition and Materials Parameters of Thin-film TiNi for Microactuators and Smart Materials 显示文摘 | Jardine A P Madsen J S Mercado P G | 1994 | Mater Chara1994，32，3： | 1 |
| 15 | Natriuretic peptide type-B can be a marker of reperfusion in patients with pulmonary thromboembo- lism subjected to invasive treatment显示文摘 | ANDRESEN M GONZALEZ A MERCADO M | 2011 | Int J Cardio- vasc Imaging2011，23，： | 1 |
| 16 | Changes in coping style and treatment outcome following motor vehicle accident显示文摘 | Hall PA Marshall J Mercado A | 2011 | Rebabil Psychol2011，56，1： | 1 |
| 17 | Gamma knife radiosurgery and brain metastases:local control,survival,and quality of life显示文摘 | Vesagas TS Aguilar JA Mercado ER | | 0，，5： | 1 |
| 18 | Neural activity associated with metaphor comprehension:spatial analysis显示文摘 | Sotillo M Carretie L Hinojosa J Tapia A. Mercado M | | 0，，373： | 1 |
| 19 | Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress显示文摘 | Mercado N Thimmulappa R Thomas CM | | 0，，02： | 1 |
| 20 | In-plant evaluation of a lactic acid treatment for reduction of bacteria on chilled beef carcasses显示文摘 | CASTILLO A LUCIA L M MERCADO I | 2001 | Food Protection2001，，64： | 1 |
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