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| 1 | 加氢催化裂解技术用于高演化源岩有机质表征研究显示文摘加氢催化裂解技术作为近年来新发展起来的有机质大分子裂解技术,专门应用于大分子中共价键结合小分子的释放。本研究探索该技术应用于含油气沉积盆地高演化油气源岩原生有机质提取的可能性。以塔里木盆地下古生界油气源岩为例,选取了障壁泻湖相、欠补偿盆地相、闭塞欠补偿陆源海湾相、灰泥丘相等四类典型潜在源岩进行了加氢催化裂解实验,结果表明,加氢催化裂解产物中正构烷烃与甾烷的分布特征与上述源岩相完全吻合,证明加氢催化裂解实验可以有效地提取高演化油气源岩的原生有机质,为下一步实现该技术应用于油气源的对比奠定了基础。 | 孙永革 Will Meredith Colin E Snape 柴平霞 | 2008 | 石油与天然气地质2008，29，2： | 13 |
| 2 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 3 | Abnormal nasal glandular secretion in recurrent sinusitis显示文摘 | JENEY E V RAPHAEL G D MEREDITH S D | 1990 | J Allergy Clin Immunol1990，86，： | 1 |
| 4 | Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes 显示文摘 | Gordon E D Mora R Meredith S C | 1987 | J Biol Chem1987，262，16： | 1 |
| 5 | The parentage of classic wine grape, Cabernet sauvignon 显示文摘 | Bowers J E Meredith C P | 1997 | Nature Genetics1997，16，1： | 1 |
| 6 | The Effect of Water Pressure on Hydrocarbon Generation Reactions : Some Inferences from Laboratory Experiments显示文摘 | Carr A D Shape C E Meredith W | 2009 | Petroleum Geoscience2009，，15： | 1 |
| 7 | Mouse model of Parkinsonism:a comparison between subacute MPTP and chronic MPTP/probenecid treatment显示文摘 | Petroske E Meredith GE Callen S | 2001 | Neurosci2001，106，1： | 1 |
| 8 | Women's Jobs, Men's Jobs: Sex Segregation and Emotional Labor 显示文摘 | Mary E G Meredith A N | 2004 | Public Administra- tion Review2004，64，3： | 1 |
| 9 | Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease 显示文摘 | Meredith G E Totterdell S Petroske E | 2002 | Brain Res2002，956，1： | 1 |
| 10 | Mouse model of Parkinsonism:a comparison between subacute MPTP and chronic MPTP/probenecid treatment 显示文摘 | Petroske E Meredith GE Callen S | 2001 | Neuroscience2001，106，3： | 1 |
| 11 | Effects of oral vitamin C on monocyte:Endothelial cell adhesion in healthy subjects显示文摘 | Woollard KJ Loryman CJ Meredith E | 2002 | Biochem Biophys Res Comm2002，294，： | 1 |
| 12 | Increased Expression of SVCT2 in a New Mouse Model Raises Ascorbic Acid in Tissues and Protects against Paraquat-Induced Oxidative Damage in Lung 显示文摘 | HARRISON F E BEST J L MEREDITH M E | 2012 | PLoS ONE2012，7，35： | 1 |
| 13 | Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease显示文摘 | Jin J Meredith G E Chen L | 2005 | Brain Res Mol Brain Res2005，134，1： | 1 |
| 14 | Biological control of Fusarium moniliforme in maize显示文摘 | Bacon C W Yates I E Hinton D M Meredith F | 2001 | Environmental Health Perspectives2001，109，2： | 1 |
| 15 | Mouse model of parkinsonism: a comparison between Subacte MPTP and chronic MPTP/PROBENECID treatment 显示文摘 | Petroske E Meredith GE Callen S | 2001 | Neuroscience2001，106，3： | 1 |
| 16 | Mouse mod- el of Parkinsonism: a comparison between subacute MPTP and chronic MPTP probenecid treatment 显示文摘 | PETROSKE E MEREDITH G E CALLEN S | 2001 | Neuroscience2001，106，3： | 1 |
| 17 | Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment 显示文摘 | Petroske E Meredith GE Callen S | 2001 | Neuroscience2001，106，3： | 1 |
| 18 | Identification of intermediate and branch metabolites resulting from biotrans- formation of 2-benzoxazolinone by Fusariurn verticillioides显示文摘 | Glenn A E Meredith F I Morrison W H | 2003 | Appl Environ Microbiol2003，69，6： | 1 |
| 19 | Improving the quality of care provided at night显示文摘 | Meredith R E | | 0，，8： | 1 |
| 20 | The influence of thermal-stressing (up to 1000°C) on the physical, mechanical, and chemical properties of siliceous-aggregate, high-strength concrete显示文摘 | M.J. Heap Y. Lavallée A. Laumann K.-U. Hess P.G. Meredith D.B. Dingwell S. Huismann F. Weise | 2013 | Construction and Building Materials2013，，： | 1 |
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