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| 1 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 2 | High-dose methylprednisolone can induce remissions in patients with fludarabine- refractory chronic lymphocytic leukaemia显示文摘 | Xu, W Miao, KR Hong, M Zhu, DX Fang, C Dong, HJ Wang, DM Cao, X Li, JY | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 5 |
| 3 | Modulation of fibroblast growth factor-2 receptor binding, dimerization,signaling, and angiogenic activity by a synthetic heparinmimickling polyanionic compound 显示文摘 | Miao HQ Ornitz DM Aingorn E | 1997 | J Clin Invest1997，99，7： | 1 |
| 4 | MR imaging evaluation of the activity of Crohn's disease显示文摘 | Koh DM Miao Y Chinn RJ | 2001 | AJR2001，177，6： | 1 |
| 5 | Conditions affecting hydrodynamics - based gene delivery into mouse liver in vivo 显示文摘 | Feng DM He CX Miao CY | 2004 | Clin Exp Pharmacol Physiol2004，31，12： | 1 |
| 6 | Epidemiological investigations of human rabies in China显示文摘 | Miao S Qing T Wang DM | 2009 | BMC Infect Dis2009，9，1： | 1 |
| 7 | Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic - co -glycolic acid) 显示文摘 | Miao X Tan DM Li J | 2008 | Acta Biomater2008，4，3： | 1 |
| 8 | Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway 显示文摘 | Miao H Wei BR Peehl DM | 2001 | Nat Cell Biol2001，3，5： | 1 |
| 9 | Cognitive behavioral therapy alone and with medication for persistent insomnia 显示文摘 | Yang YB Miao DM Sun YF | 2009 | JAMA2009，302，10： | 1 |
| 10 | MR imaging evaluation of the activity of Crohn's disease显示文摘 | Koh DM Miao Y Chinn RJS | 2001 | AJR2001，，177： | 1 |
| 11 | Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma: A meta- analysis显示文摘 | Miao XH Yao YW Yuan DM | 2012 | J Thorac Dis2012，4，3： | 1 |
| 12 | Activation of EphA receptor tyrosine Kinase inhibits the Ras/MAPK pathway显示文摘 | Miao H Wei B Peehl DM | 2001 | Nature Cell Biol2001，3，5： | 1 |
| 13 | Personality structure model for prediction of neurasthenia in pilots neurasthenic显示文摘 | Dong Y Miao DM Yan GX Huang fu En Mai SH | 1992 | Zhong hua Hangkong Yixue Zazhi(Chin J Aviat Med)1992，3，3： | 1 |
| 14 | Influence of low highdensity lipoprotein cholesterol on arterial stiffening and left ventricular diastolic dysfunction in essential hypertension显示文摘 | Miao DM Ye P Xiao WK | 2011 | J Clin Hypertens2011，13，10： | 1 |
| 15 | Modulation of fibroblast growth factor-2 receptor binding,dimerization,signaling,and angiogenic activity by synthetic heparin-mimiclig polyanionic compound显示文摘 | Miao HQ Omitz DM Aingorn E | 1997 | J Clin Invest1997，99，7： | 1 |
| 16 | Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adeno- carcinoma:a meta-analysis 显示文摘 | Miao XH Yao YW Yuan DM | 2012 | J Thorac Dis2012，4，3： | 1 |
| 17 | MR imaging evaluation of the activity of Crohn's disease显示文摘 | Koh DM Miao Y Chinn RJS | 2001 | AJR2001，177，6： | 1 |
| 18 | Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma: a meta-analysis显示文摘 | Miao XH Yao YW Yuan DM | 2012 | J Thorac Dis2012，4，3： | 1 |
| 19 | Modulation of fibroblast growth fact- or-2 receptor binding,dimerization,signaling,and angiogenic activity by a synthetic heparinmimicking polyanionic compound显示文摘 | Miao HQ Ornitz DM Aingorn E | 1997 | J Clin Invest1997，99，7： | 1 |
| 20 | Over-expression of LSD1 promotes proliferation,migration and invasion in non-small cell lung cancer显示文摘 | Lv TF Yuan DM Miao XH | | 0，，： | 1 |
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