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| 1 | Expenditure of hospital care on cancer in China, from 2011 to 2015显示文摘Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention.However, studies on economic burden of cancers in China are scant and the results are inconsistent.Methods: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces. Only the payments of cancer inpatients happened in grade 2, grade 3 and specialized cancer hospitals were included in the analyses. The total medical payments of cancers in China were estimated based on the ratios of outpatient payments to inpatient payments in specialized cancer hospitals.Results: From 2011 to 2015, the payments of cancer inpatients in China have increased by 84.1% and the total inpatient payments reached 177.1 billion RMB in 2015, accounting for 4.3% of the total health expenditure in China. Based on the ratio of outpatient payments to inpatient payments, the total payments on cancer treatments in China were estimated to be 221.4 billion RMB in 2015. Among different cancer types, the highest payments were the treatment of trachea, bronchus and lung cancer. The major cancer inpatient payments(67.1% in 2015) spent in grade 3 general hospitals and this ratio increased continually from 2011 to 2015. The expenditure of cancer treatments also varies by region with the major expenditure in the eastern region of China.Conclusions: This study estimated the total payments of cancer treatments in China and analyzed how the money was spent on cancer treatments in the recent 5 years, which would provide information for decision makings on the allocation of resources to service provisioning, prevention strategies, research funding, and assessing whether the economic burden of cancer is affordable to the governments. | Yue Cai Ming Xue Wanqing Chen Maogui Hu Zhiwen Miao Lan Lan Rongshou Zheng Qun Meng | 2017 | Chinese Journal of Cancer Research2017，29，3： | 81 |
| 2 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 3 | Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drugresistant sublines显示文摘AIM: To investigate the expression and function of classicalprotein kinase C (PKC) isoenzymes in inducing MDRphenotype in gastric cancer cells.METHODS: Two cell lines were used in the study: gastriccancer cell SGC7901 and its drug-resistant cell SGC7901/VCRstepwise-selected by vincristine 0.3, 0. 7 and 1.0 mg@ L-1 ,respectively. The expression of classical PKC (cPKC)isoenzymes in SGC7901 cells and SGC7901/VCR cells weredetected using immunofluorescent cytochemistry, laserconfocal scanning microscope and Wsstern blot. The effectsof anti-PKC isoenzymes antibody of adriamycinaccumulation in SGC7901/VCR cells were determined usingflow cytometric analysis.RESULTS: (1) SGC7901 cells exhibited positive staining ofPKC-α. SGC7901/VCR cells exhibited stronger staining ofPKC-α than SGC7901 cells. The higher dosage vincristineselected, the much stronger staining of PKC-α was observedon SGC7901/VCR cells. (2) Both SGC7901 and SGC7901/VCRcells exhibited positive staining of PKC-βⅠ and PKC-βⅡ withno significant difference. ( 3 ) Compared with SGC7901,SGC7901/VCR cells had decreased adriamycin accumulationand retention. Accumulation of adriamycin in SGC7901 was5.21 + 2.56 mg@ L-1, in SGC7901/VCR 0.3 was 0.85 + 0.29 mg@L-1 , in SGC7901/VCR 0.7 was 0.81 + 0.32 og@ L-1 , and inSGC7901NCR 1.0 was 0.80 + 0.33 mg @ L-1; Retention ofadriamycin in SGC 7901 was 2.51 + 1.23 mg@L-1, in SGC7901/VCR 0.3 was 0.47 + 0.14 mg@ L-1 , in SGC7901/VCR 0.7 was 0.44 + 0.15 mg@ L-1, and in SGC 7901/VCR 1.0 was 0.41 + 0.1 1mg @ L-1 . (4) Fluorescence intensity presented adriamycinaccumulation in SGC7901/VCR cells was increased from 1.14+0.36 to 2.71 +0.94 when cells were co-incubated with anti-PKC-αbut not with anti-PKC-βⅠ, PKC-βⅡ and PKCγ antibodies.CONCLUSION: PKC-α, but not PKC-βⅠ, PKC-βⅡ or PKCγ,may play a role in multidrug resistance of gastric cancercells SGC7901/VCR. | Ying Han Zhe-Yi Han Xin-Min Zhou Ru Shi Yue Zheng Yong-Quan Shi Ji-Yan Miao Bo-Rong Pan Dai-Ming Fan | 2002 | World Journal of Gastroenterology2002，8，3： | 25 |
| 4 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 5 | Neuroprotective effects of bloodletting at Jing points combined with mild induced hypothermia in acute severe traumatic brain injury显示文摘Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and bloodbrain barrier dysfunction. Furthermore, neurological function was ameliorated, and cellular necrosis and the inflammatory response were lessened. These findings suggest that the combined effects of bloodletting at Jing points(20 μL, twice a day, for 2 days) and mild induced hypothermia(6 hours) are better than their individual effects alone. Their combined application may have marked neuroprotective effects in the clinical treatment of acute severe traumatic brain injury. | Yue Tu Xiao-mei Miao Tai-long Yi Xu-yi Chen Hong-tao Sun Shi-xiang Cheng Sai Zhang | 2016 | Neural Regeneration Research2016，11，6： | 17 |
| 6 | Effect of Tong Xie Yao Fang on endogenous metabolites in urine of irritable bowel syndrome model rats显示文摘BACKGROUND Tong Xie Yao Fang is a representative traditional Chinese prescription for the treatment of liver and spleen deficiency,abdominal pain and diarrhea.It has a unique function in the treatment of gastrointestinal dysfunction including irritable bowel syndrome(IBS),is a common functional bowel disease.Its main symptoms are recurrent abdominal pain,diarrhea,constipation or alternations between diarrhea and constipation.There are obvious differences in metabolites between TCM syndromes.By comparing the body fluid metabolism maps of model animals,metabolomics can discover disease biomarkers,analyze the differences in metabolic pathways and understand the pathological process and the metabolic pathways of substances in the body.Thus,the evaluation of animal models tends to be comprehensive and objective.This may provide further understanding between the interaction between Tong Xie Yao Fang and the IBS model.AIM To evaluate the effect of Tong Xie Yao Fang on IBS rats by using metabolomics method.METHODS Wistar rats were used to establish IBS models,and then randomly divided into four groups:A model control group and three Tong Xie Yao Fang treatment groups(high,medium and low doses).A normal,non-IBS group was established.The rats were treated for 2 wk.On days 0 and 14 of the experimental model,urine was collected for 12 h and was analyzed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.Nine potential biomarkers were identified,and six major metabolic pathways were found to be related to IBS.RESULTS In the study of metabonomics,nine potential biomarkers including L-serine,4-methylgallic acid,L-threonine,succinylacetone,prolyl-hydroxyproline,valylserine,acetyl citrate,marmesin rutinoside and 5-hydroxy-L-tryptophan were identified in urine,which were assigned to amino acids,organic acids,succinyl and glycosides.Furthermore,the metabolic pathway of L-serine,L-threonine and 5-hydroxy-L-tryptophan was found in the Kyoto Encyclopedia of Genes and Genomes,which mainly involved the metabolism of cysteine and methionine,vitamin B6 metabolism,serotonin synapse,tryptophan metabolism,sphingolipid metabolism,digestion,absorption of protein and amino acid metabolism.These pathways are related to intestinal dysfunction,inflammatory syndrome,nervous system dysfunction and other diseases.CONCLUSION Tong Xie Yao Fang has pharmacological effects on IBS,and its mechanism may be related to the metabolism of the nine potential biomarkers identified above in urine. | Xue-Ying Zhao Jian-Wei Wang Yue Yin Kai Li Miao Zhang Fu-Ping Yan | 2019 | World Journal of Gastroenterology2019，25，34： | 14 |
| 7 | Impact of Cardiovascular Disease Deaths on Life Expectancy in Chinese Population显示文摘Objective We aimed to analyze the impact of cardiovascular disease(CVD) deaths on life expectancy(LE) in Chinese population and estimate the percentage reduction in CVD mortality needed to increase LE by 1 year from the current level, a national target of health improvement. Methods We used life tables, cause-elimination life tables, and age decomposition of LE with corrected mortality data from the National Disease Surveillance System in 2010. Results LE at birth of Chinese people was 73.24 years in 2010. Women had a longer LE than men, and urban population had a longer LE than rural population. CVD deaths resulted in a 4.79-year LE loss and premature deaths in people aged 25 to 64 years were responsible for a substantial part of LE loss from CVD. Death from ischemic heart disease and cerebrovascular diseases accounted for 69.2% of LE loss from CVD deaths and death from cerebrovascular diseases was the largest contributor. In rural men, 51.1% LE loss from CVD deaths was caused by cerebrovascular diseases. If there were no changes in mortality rates for all other diseases, a 27.4% reduction in CVD mortality would increase LE by 1 year in Chinese population. Conclusion There is a considerable impact of CVD deaths on LE. A 1-year LE increase in the future requires at least a 27.4% reduction in CVD mortality from the current level. Targeting the rural population and tackling cerebrovascular diseases are important for reaching the national goal of health improvement. | FAN Jie LI Guo Qi LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong | 2014 | Biomedical and Environmental Sciences2014，27，3： | 13 |
| 8 | Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring显示文摘目的: Myostatin 基因是转变生长 factor-β 的一个成员;(TGF-β) 否定地调整骨胳的肌肉生长的家庭。在 Myostatin 的基因多型性被发现在中国女人与山峰骨头矿物质密度(BMD ) 被联系。这研究的目的是调查 Myostatin 是否在山峰 BMD,瘦团(LM ) ,和中国男人的胖质量(FM ) 在正常变化起了一个作用。 | Hua YUE Jin-wei HE Hao ZHANG Chun WANG Wei-wei HU Jie-mei GU Yao-hua KE Wen-zhen FU Yun-qiu HU Miao LI Yu-juan LIU Song-hua WU Zhen-lin ZHANG | 2012 | Acta Pharmacologica Sinica2012，33，5： | 10 |
| 9 | Outcomes of CAG Regimen for Refractory Biphenotypic Acute Leukemia Patients显示文摘Objective To evaluated the efficiency of low-dose cytosine arabinoside plus aclarubicin with concurrent administration of granulocyte colony-stimulating factor (CAG) regimen for refractory biphenotypic acute leukemia (BAL). Methods We treated 5 refractory BAL patients by CAG regimen (10 mg·m-2 cytosine arabinoside subcutaneously administrated every 12 hours, day 1-14; 5-7 mg·m-2 aclarubicin intravenously administrated daily, day 1-8; and concurrently used 200μg·m-2·d-1 granulocyte colony-stimulating factor subcutaneously) from November 2002 to April 2007. The efficacy of the regimen was evaluated by response rate, and the side effects were also measured. Results The complete remission rate was 80%, median duration of absolute neutrophil count< 5.0×108/L and platelet count<2.0×1010/L was day 13 and day 1, respectively; and the infection rate was low (Ⅲ-Ⅳ infection rate, 20.00%). Conclusion CAG regimen as remission induction chemotherapy for BAL patients is effective with a high remission rate and low toxicity. | Guang-sheng He Xiang Zhang De-pei Wu Ai-ning Sun Zheng-ming Jin Hui-ying Qiu Miao Miao Xiao-wen Tang Zheng-zheng Fu Yue Han | 2009 | Chinese Medical Sciences Journal2009，24，3： | 10 |
| 10 | Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families显示文摘 | Jie-mei GU Wen-jin XIAO Jin-wei HE Hao ZHANG Wei-wei HU Yun-qiu HU Miao LI Yu-juan LIU Wen-zhen FU Jin-bo YU Gao GAO Hua YUE Yao-hua KE Zhen-lin ZHANG | 2009 | Acta Pharmacologica Sinica2009，30，12： | 8 |
| 11 | Emergent Endoscopic Retrograde Cholangiopancreatography with Placement of Biliary Double Stents to Salvage Endoscopic Retrograde Cholangiopancreatography-lnduced Stapfer's Type Ⅱ Perforation显示文摘 | Ping Yue Wen-Bo Meng Joseph W Leung Lei Zhang Xiao-Liang Zhu Hui Zhang Hai-Ping Wang Zheng-Feng Wang Ke-Xiang Zhu Long Miao Wen-Ce Zhou Xun Li | 2018 | Chinese Medical Journal2018，，19： | 7 |
| 12 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 13 | Crystalline Silica Promotes Rat Fibrocyte Differentiation in Vitro,and Fibrocytes Participate in Silicosis in Vivo显示文摘Objective The aim of this study was to investigate the effects of Si O2 on fibrocytes and whether fibrocytes participate in silicosis in vivo. Methods A macrophagocyte(AM)/fibrocyte coculture system was established, and AMs were treated with 100 μg/mL SiO 2. Flow cytometry was used to detect the number of fibrocytes. Real‐time PCR was performed to measure the expression of collagen I, collagen III, and α‐SMA mR NA. The levels of collagen I, collagen III, and TGF‐β1 protein were determined by ELISA. Immunohistochemical staining was performed to measure α‐SMA protein expression. A rat silicosis model was induced by intratracheal instillation of SiO 2. Lung histopathological evaluation was conducted using HE and Masson's trichrome staining after 1 and 9 weeks. The number of fibrocytes in peripheral blood or lung tissue of rat was detected by flow cytometry. Double‐color immunofluorescence was applied to identify fibrocytes in the lung tissue. Results Peripheral blood monocytes were found to differentiate into fibrocytes in vitro in a time‐dependent manner, and exposure to crystalline silica might potentiate fibrocyte differentiation. In addition, fibrocytes were able to migrate from peripheral blood to the lung tissue, and the number of fibrocytes was increased after SiO 2 exposure. Conclusion Silica exposure potentiates fibrocyte differentiation, and fibrocytes may participate in silicosis in vivo. | LI Juan YAO Wu HOU Jian Yong Zhang Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao HAO Chang Fu | 2017 | Biomedical and Environmental Sciences2017，30，9： | 7 |
| 14 | Soundscape of the West Lake Scenic Area with profound cultural background—a case study of Evening Bell Ringing in Jingci Temple,China显示文摘From the case study of Evening Bell Ringing at Nanping Hill,one of the West Lake Cultural Landscapes in Hangzhou,China,we investigated the soundscape of a scenic area with a profound cultural background.First,we conducted the soundscape physical index of the area in both winter and spring seasons to analyze its objective graphical expression.Second,we focused on people's reactions to the soundscape in order to obtain a subjective evaluation of each component in the soundscape and integrated environment.Then,the relationship between the objective data and the subjective evaluation was analyzed.Finally,the impacts of the natural environment,history,and cultural factors on the evaluation of the Jingci Temple soundscape were studied.It was found that natural sounds,cultural sounds,and historic sounds were widely acclaimed in people's subjective feelings,which indicated the close relationships among historical and cultural background,soundscape,and natural environment.Thus,the conclusion was made that soundscape should be consistent with the local natural environment and the historical and cultural background. | Jian GE Min GUO Miao YUE | 2013 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2013，14，3： | 7 |
| 15 | Relationship between granulomatous lobular mastitis and methylene tetrahydrofolate reductase gene polymorphism显示文摘BACKGROUND Variations in the methylene tetrahydrofolate reductase(MTHFR)gene have been reported as risk factors for numerous conditions,including cardiovascular disease,thrombophilia,stroke,hypertension and pregnancy-related complications.Moreover,it was reported there is an association between breast cancer and mutations in MTHFR-C677T.However,whether there is an association between MTHFR gene polymorphism and granulomatous lobular mastitis or not has been rarely investigated.AIM To analyze the association between MTHFR gene polymorphism and granulomatous lobular mastitis.METHODS Fifty-one patients with granulomatous lobular mastitis admitted to The First Hospital of Kunming were selected as study samples.Their hospitalization time ranged from February 2018 to February 2019.The 51 patients were included in the experimental group,and another 51 women who underwent physical examination at The First Hospital of Kunming in the same period were included in the control group.Deoxyribonucleic acid and MTFR genetic polymorphism testing were performed in each group.The association between MTHFR gene polymorphism and granulomatous lobular mastitis was observed.RESULTS There were significant differences in genotype frequency and allele frequency of C/C and C/T between the experimental group and the control group(all P<0.05).However,there was no significant difference in frequency of T/T genotype between the two groups(P>0.05).In addition,there was no significant difference in genotype frequency and allele frequency of A/A,A/C and C/C between the two groups(P>0.05).CONCLUSION MTHFR gene C677T locus polymorphism is closely related to granulomatous lobular mastitis. | Qing-Ran Lei Xin Yang Chun-Mei Miao Jin-Chang Wang Yue Yang | 2020 | World Journal of Clinical Cases2020，8，18： | 6 |
| 16 | In silico target fishing for the potential bioactive components contained in Huanglian Jiedu Tang(HLJDD) and elucidating molecular mechanisms for the treatment of sepsis显示文摘The present study was designed to target fish for potential bioactive components contained in a Huang Lian Jie Du decoction(HLJDD) and identify the underlying mechanisms of action for the treatment of sepsis at the molecular level. he bioactive components database of HLJDD was constructed and the sepsis-associated targets were comprehensively investigated. The 3D structures of the PAFR and TXA2 R proteins were established using the homology modelling(HM) method, and the molecular effects for sepsis treatment were analysed by comparing the bioactive components database and the sepsis targets using computational biology methods. The results of the screening were validated with biological testing against the human oral epidermal carcinoma cell line KB in vitro. We found that multiple bioactive compounds contained in the HLJDD interacted with multiple targets. We also predicted the promising compound leads for sepsis treatment, and the first 28 compounds were characterized. Several compounds, such as berberine, berberrubine and epiberberine, dose-dependently inhibited PGE2 production in human KB cells, and the effects were similar in the presence or absence of TPA. This study demonstrates a novel approach to identifying natural chemical compounds as new leads for the treatment of sepsis. | MA Shi-Tang FENG Cheng-Tao DAI Guo-Liang SONG Yue ZHOU Guo-Liang ZHANG Xiao-Lin MIAO Cheng-Gui YU Hao JU Wen-Zheng | 2015 | Chinese Journal of Natural Medicines2015，13，1： | 6 |
| 17 | Proteomic and bioinformatic analyses of possible targetrelated proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells显示文摘Gambogic acid(GA) is an anticancer agent in phase Ⅱb clinical trial in China but its mechanism of action has not been fully clarified. The present study was designed to search the possible target-related proteins of GA in cancer cells using proteomic method and establish possible network using bioinformatic analysis. Cytotoxicity and anti-migration effects of GA in MDA-MB-231 cells were checked using MTT assay, flow cytometry, wound migration assay, and chamber migration assay. Possible target-related proteins of GA at early(3 h) and late stage(24 h) of treatment were searched using a proteomic technology, two-dimensional electrophoresis(2-DE). The possible network of GA was established using bioinformatic analysis. The intracellular expression levels of vimentin, keratin 18, and calumenin were determined using Western blotting. GA inhibited cell proliferation and induced cell cycle arrest at G2/M phase and apoptosis in MDA-MB-231 cells. Additionally, GA exhibited anti-migration effects at non-toxic doses. In 2-DE analysis, totally 23 possible GA targeted proteins were found, including those with functions in cytoskeleton and transport, regulation of redox state, metabolism, ubiquitin-proteasome system, transcription and translation, protein transport and modification, and cytokine. Network analysis of these proteins suggested that cytoskeleton-related proteins might play important roles in the effects of GA. Results of Western blotting confirmed the cleavage of vimentin, increase in keratin 18, and decrease in calumenin levels in GA-treated cells. In summary, GA is a multi-target compound and its anti-cancer effects may be based on several target-related proteins such as cytoskeleton-related proteins. | LI Dong SONG Xiao-Yi Yue Qing-Xi CUI Ya-Jun LIU Miao FENG Li-Xing WU Wan-Ying JIANG Bao-Hong YANG Min QU Xiao-Bo LIU Xuan GUO De-An | 2015 | Chinese Journal of Natural Medicines2015，13，1： | 6 |
| 18 | Throughput Maximization for Multi-UAV Enabled Millimeter Wave WPCN: Joint Time and Power Allocation显示文摘In this paper,we investigate the effective deployment of millimeter wave(mmWave)in unmanned aerial vehicle(UAV)-enabled wireless powered communication network(WPCN).In particular,a novel framework for optimizing the performance of such UAV-enabled WPCN in terms of system throughput is proposed.In the considered model,multiple UAVs monitor in the air along the scheduled flight trajectory and transmit monitoring data to micro base stations(mBSs)with the harvested energy via mmWave.In this case,we propose an algorithm for jointly optimizing transmit power and energy transfer time.To solve the non-convex optimization problem with tightly coupled variables,we decouple the problem into more tractable subproblems.By leveraging successive convex approximation(SCA)and block coordinate descent techniques,the optimal solution is obtained by designing a two-stage joint iteration optimization algorithm.Simulation results show that the proposed algorithm with joint transmit power and energy transfer time optimization achieves significant performance gains over Q-learning method and other benchmark schemes. | Jiansong Miao Pengjie Wang Qian Zhang Yue Wang | 2020 | China Communications2020，17，10： | 6 |
| 19 | Flower-like NiCo_(2)S_(4)nanosheets with high electrochemical performance for sodium-ion batteries显示文摘A three-dimensional flower-like NiCo_(2)S_(4) formed by two-dimensional nanosheets is synthesized by a facile hydrothermal method and utilized as the anode for sodium-ion batteries.Studies have shown that materials can achieve the best performance under the ether-based electrolyte system with voltage ranging from 0.3 to 3 V,which could effectively avoid the dissolution of polysulfides and over-discharge of the material.Here,sodium storage mechanism and charge compensation behaviors of this ternary metal sulfide are comprehensively investigated by ex situ X-ray diffraction.Moreover,ex situ Raman spectra,ex situ X-ray photoelectron spectroscopy and transmission electron microscopy measurements are used to related tests for the first time.Additionally,quantitative kinetic analysis unravels that sodium storage partially depends on the pseudocapacitance mechanism,resulting in good specific capacity and excellent rate performance.The initial discharge capacity is as high as 748 mAh·g^(−1)at a current density of 0.1 A·g^(−1)with the initial coulomb efficiency of 94%,and the capacity can still maintain at 580 mAh·g^(−1)with the Coulomb efficiency close to 100%after following 50 cycles.Moreover,by the long cycle test at a high current density of 2 A·g^(−1),the capacity can still reach at 376 mAh·g^(−1)after over 500 cycles. | Yongqiang Miao Xiaosen Zhao Xin Wang Chenhui Ma Lu Cheng Gang Chen Huijuan Yue Lei Wang Dong Zhang | 2020 | Nano Research2020，13，11： | 5 |
| 20 | Impact of Cerebrovascular Disease Mortality on Life Expectancy in China显示文摘Objective To evaluate the impact of cerebrovascular disease mortality on life expectancy(LE) in China in 2010 compared with 2005, and to identify the high-risk population(age, sex, and region) where cerebrovascular disease mortality has had a major impact on LE. Methods LE and cause-eliminated LE were calculated by using standard life tables which used adjusted mortality data from the Death Surveillance Data Sets in 2005 and 2010 from the National Disease Surveillance System. Decomposition was used to quantitate the impact of cerebrovascular disease in different age groups. Results LE in China was 73.24 years in 2010, which was higher in women and urban residents compared with men and rural residents. The loss of LE caused by cerebrovascular disease mortality was 2.26 years, which was higher in men and rural residents compared with women and urban residents. More than 30% of the loss of LE were attributed to premature death from cerebrovascular disease in people aged <65 years. Compared with 2005, LE in 2010 increased by 0.92 years. The reduction of cerebrovascular disease mortality in urban residents contributed 0.45 years to the increase of LE, but the increase of cerebrovascular disease mortality caused a 0.12-year loss of LE in rural residents. Conclusion Cerebrovascular disease mortality had a major impact on LE in China, with a significant difference between urban and rural residents. LE is likely to be further increased by reducing cerebrovascular disease mortality, and special attention should be paid to reducing premature deaths in people aged <65 years. | LI Guo Qi FAN Jie LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong | 2014 | Biomedical and Environmental Sciences2014，27，3： | 5 |
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