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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | A SYBR green, real-time RT-PCR method to detect and quantitate Norwalk virus in stools显示文摘 | Gary P Richards Michael A Watson David H Kingsley | 2004 | Journal of Virological Methods2004，116，： | 1 |
| 3 | Mild heat and calcium treatment effects on fresh-cut cantaloupe melon during storage 显示文摘 | Olusola Lamikanra Michael A Watson | 2006 | Food Chemistry2006，，10： | 1 |
| 4 | Bulk preparation of metal nanoparticle-decorated car-bon nanotubes 显示文摘 | LIN Y WATSON KENT A FALLBACH MICHAEL J | 2009 | ACS Nano2009，3，： | 1 |
| 5 | An Analytical Model for History Matching Naturally Fractured Reservoir Production Data 显示文摘 | Watson A Gatens T Michael L | 1990 | SPE Reservoir Engineering1990，5，3： | 1 |
| 6 | Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe three-vessel coronary artery disease显示文摘 | Ronaldo S.L Lima Denny D Watson Allen R Goode Mir S Siadaty Michael Ragosta George A Beller Habib Samady | 2003 | Journal of the American College of Cardiology2003，，1： | 1 |
| 7 | Improved detection of renal pathologic features on multiphasic helical CT compared with IVU in patients presenting with microscopic hematuria显示文摘 | Erich K Lang Richard J Macchia Raju Thomas Richard A Watson Michael Marberger Gerhard Lechner Brian Gayle Frank Richter | 2003 | Urology2003，，： | 1 |
| 8 | Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner显示文摘AIM To investigate the role of interleukin-19(IL-19) in a murine model of female-dominant heart failure(HF).METHODS Expression of one copy of a phosphorylation-deficient cyclic adenosine monophosphate response-element binding protein(dn CREB) causes HF, with accelerated morbidity and mortality in female mice compared to males. We assessed expression of IL-19, its receptor isoforms IL-20 R α/β, and downstream IL-19 signaling in this model of female-dominant HF. To test the hypothesis that IL-19 is cardioprotective in dn CREB-mediated HF, we generated a novel double transgenic(DTG) mouse of dn CREB and IL-19 knockout and assessed cardiac morbidity by echocardiography and survival of male and female mice.RESULTS IL-19 is expressed in the murine heart with decreased expression in dn CREB female compared to male mice. Further, the relative expression of the two IL-19 receptor isoforms manifests differently in the heart by sex and by disease. Male DTG mice had accelerated mortality and cardiac morbidity compared to dn CREB males, while female DTG mice showed no additional detriment, supporting the hypothesis that IL-19 is cardioprotective in this model. CONCLUSION Together, these data suggest IL-19 is an important cytokine mediating sex-specific cardiac(dys) function. Ongoing investigations will elucidate the mechanism(s) of sex-specific IL-19 mediated cardiac remodeling. | Danielle R Bruns Alexander R Ghincea Christian V Ghincea Yasu-Taka Azuma Peter A Watson Michael V Autieri Lori A Walker | 2017 | World Journal of Cardiology2017，9，8： | 0 |
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