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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | Delayed assessment and eager adoption of laparoscopic cholecystectomy:Implications for developing surgical technologies显示文摘Despite the prevailing emphasis in the medical literature on establishing evidence,many changes in the practice of surgery have not been achieved using proper evidence-based assessment.This paper examines the adoption of laparoscopic cholecystectomy(LC)into regular use for the treatment of cholecystitis and the process of its acceptance,focusing on the limited role of technology assessment in its appraisal.A review of the published medical literature concerning LC was performed.Approximately 3000 studies of LC have been conducted since 1985,and there have been nearly 8500 publications to date.As LC was adopted enthusiastically into practice,the results of outcome studies generally showed that it compared favorably with the traditional,open cholecystectomy with regard to mortality,complications,and length of hospital stay.However,despite the rapid general agreement on surgical technique,efficacy,and appropriateness,there remained lingering doubts about safety,outcomes,and cost of the procedure that suggested that essential research questions were ignored even as the procedure became standard.Using LC as a case study,there are important lessons to be learned about the need for important guidelines for surgical innovation and the adoption of minimally invasive surgical techniques into current clinical and surgical practice.We highlight one recent example,natural orifice transluminal endoscopic surgery and how necessary it is to properly evaluate this new technology before it is accepted as a safe and effective surgical option. | Alexander C Allori I Michael Leitman Elizabeth Heitman | 2010 | World Journal of Gastroenterology2010，16，33： | 3 |
| 3 | Novel approaches for the treatment of ventricular tachycardia显示文摘Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of SCD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of SCD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. Novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications. | Michael Spartalis Eleftherios Spartalis Eleni Tzatzaki Diamantis I Tsilimigras Demetrios Moris Christos Kontogiannis Efthimios Livanis Dimitrios C Iliopoulos Vassilis Voudris George N Theodorakis | 2018 | World Journal of Cardiology2018，10，7： | 2 |
| 4 | Endoscopic management of biliary complications after orthotopic liver transplantation显示文摘 | Deepak V. Gopal MD FRCP(C) Patrick R. Pfau MD Michael R. Lucey MD FRCP(I) | 2003 | Current Treatment Options in Gastroenterology2003，，6： | 2 |
| 5 | Modeling, design and optimization of a hybrid PSA-membrane gas separation proeess 显示文摘 | Charles O Akinlabib Dimitrios I Gerogiorgisb Michael C Georgisadis | 2007 | Computer Aided Chemical Engineering2007，24，： | 1 |
| 6 | The mars regional atmospheric modeling system-model description显示文摘 | Rafkin S C R Haberle R M Michaels T I | 2001 | Icarus2001，151，： | 1 |
| 7 | Gene expression analysis of toll - like receptor path- ways in heterophils from genetic chicken lines that dif- fer in their susceptibility to salmonella enteritidis 显示文摘 | MICHAEL H K HSIN I C CHRISTINA L S | 2012 | Front Genet2012，3，： | 1 |
| 8 | 0-Defensins: cyclic pep- tides with endless potential显示文摘 | Robert I L Alex M C Michael E S | 2012 | J Biol Chem2012，287，27： | 1 |
| 9 | Evaluation of the sustainability of deep groundwater as an arsenic-safe resource in the Bengal Basin显示文摘 | Michael H A Voss C I | | 0，，： | 1 |
| 10 | Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects显示文摘 | Randall R Stoltz Stuart I Harris Michael E Kuss Diane LeComte Sheela Talwalker Shobha Dhadda Richard C Hubbard | 2002 | The American Journal of Gastroenterology2002，，1： | 1 |
| 11 | An evaluation of instream habitat restoration techniques on salmonid populations in a newfoundland stream 显示文摘 | MICHAEL C VANZYLLDEJONG C M COWX I G | 1997 | Regulated Rivers: Research & Management1997，13，： | 1 |
| 12 | An Environmental Do- main Classification of Canada Using Earth Observation Data for Biodiversity Assessment显示文摘 | Nicholas C C Michael A W Donald I | 2009 | Ecological Informatics2009，4，： | 1 |
| 13 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 14 | Aryl Amidine and Tertiary Amine Switchable Surfactants and Their Appli- cation in the Emulsion Polymerization of Methyl Meth- acrylate显示文摘 | Candace I F Philip G J Michael F C | 2012 | Macromolecules2012，45，7： | 1 |
| 15 | Human tissue kallikreins: physiologic roles and applications in cancer 显示文摘 | Borgono C A Michael I P Diamandis E P | 2004 | Mol Cancer Res2004，2，5： | 1 |
| 16 | Wind tunnel model studies of aerodynamic lifting of roof pavers显示文摘 | Peter I Calin D Michael C | 2012 | Advances in HurricaneEngineering2012，33，9： | 1 |
| 17 | Bioaccumulation behaviour of polybrominated diphenyl ethers(PBDEs) in a Canadian Arctic marine food web显示文摘 | BARRY C K MICHAEL G I JOEL D B | 2008 | Sci Total Environ2008，401，： | 1 |
| 18 | Electrochemical remediation produces a new high-nitrogen compound from NTO wastewaters显示文摘 | MICHAEL P C ANTHONY I D LYNNE W | 2007 | Journal of Hazardous Materials2007，149，： | 1 |
| 19 | Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment:A review显示文摘 | MICHAEL I RIZZO L MCARDELL C S | 2013 | Water research2013，47，3： | 1 |
| 20 | A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation显示文摘 | BORGONO C A MICHAEL I P KOMATSU N | 2007 | J Biol Chem2007，282，6： | 1 |
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