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| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | An exploratory analysis of usability of Flickr tags for land use/land cover attribution显示文摘This study explored the land use/land cover(LULC)separability by the machine-generated and user-generated Flickr photo tags(i.e.the auto-tags and the user-tags,respectively),based on an authoritative LULC dataset for San Diego County in the United States.Ten types of LULCs were derived from the authoritative dataset.It was observed that certain types of the reclassified LULCs had abundant tags(e.g.the parks)or a high tag density(e.g.the commercial lands),compared with the less populated ones(e.g.the agricultural lands).Certain highly weighted terms of the tags derived based on a term frequency–inverse document frequency weighting scheme were helpful for identifying specific types of the LULCs,especially for the commercial recreation lands(e.g.the zoos).However,given the 10 sets of tags retrieved from the corresponding 10 types of LULCs,one set of tags(all the tags located at one specific type of the LULCs)could not fully delineate the corresponding LULC due to semantic overlaps,according to a latent semantic analysis. | Yingwei Yan Michael Schultz Alexander Zipf | 2019 | Geo-Spatial Information Science2019，22，1： | 4 |
| 3 | Gastroenterology service in a teaching hospital in rural New Zealand, 1991-2003显示文摘AIM: To retrospectively collect inpatient and outpatient data and to assess the use of endoscopic procedures during the years 1991, 1997 and 2003 to analyse for trends. METHODS: This retrospective survey was conducted in a University-associated Gastroenterology Unit offering secondary and tertiary health care services for a population of approximately 182 000 people in Southern New Zealand. Data collected included patient contacts (inand outpatients), gastroscopic and colonoscopic investigations. RESULTS: We observed a significant increase in the absolute numbers of patient contacts over the years (1991: 2308 vs 1997: 2022 vs 2003: 2783, P < 0.0001) with inflammatory bowel disease, other diseases of the colon, anus and rectum and iron studies related disorders decreasing significantly but liver disease and constipation increasing linearly over time. The use of endoscopy services remained relatively stable but colonoscopic investigations for a positive family history of colorectal cancer increased significantly while more gastroscopies were performed for unexplained anaemia. CONCLUSION: The whole spectrum of gastroenterology contacts was studied. A substantial proportion of colonoscopies and outpatient consultations were undertaken to screen for colorectal cancer. This proportion is likely to grow further. Our fi ndings have implications for the recruitment and training of the next generation of gastroenterologists. | Michael Schultz Andrew Davidson Sarah Donald Bogna Targonska Angus Turnbull Susan Weggery Vicki Livingstone John D Dockerty | 2009 | World Journal of Gastroenterology2009，15，5： | 3 |
| 4 | Prevalence and knowledge of hepatitis C in a middle-aged population,Dunedin,New Zealand显示文摘AIM:To determine the prevalence of infection with hepatitis C virus(HCV) in those most at risk of advanced liver disease and to identify gaps in knowledge of HCV.METHODS: Questionnaires were mailed to randomly selected residents aged 40-59 to assess the extent of their general knowledge about HCV. The questionnaire assessed demographics, the extent of general knowledge about viral hepatitis, potential risks for infection and the prevalence of risk factors associated with increased progression of liver fibrosis. Anonymised residual laboratory blood samples from 40-59 years old people from Dunedin taken in hospital or in the community, were tested for HCV antibodies and alanine transaminase(ALT), aspartate transaminase(AST), gamma-glutamyl transpeptidase(GGT). Linear regression was performed to examine whether the demographics sex, age, socio-economic status, qualification level and occupation sector(categorical variables) were predictors of level of general knowledge about hepatitis. For the demographics that werefound to be significant predictors of score outcome, multiple regression analysis was used to determine independent effects. χ2 tests were used to compare our selected sample and our responder population demographics, to the demographics of the entire 40-59 years old population in Dunedin using the 2006 NZ census data. Exact confidence intervals for the proportion positive for HCV and HBV were calculated using the binomial distribution.RESULTS: The response rate to the mailed questionnaire was 431/1400(30.8%). On average 59.4% questions were answered correctly. Predictors for higher scores, indicating greater knowledge about symptoms and transmission included sex(female, P < 0.01), higher level of qualification(P < 0.000) and occupation sector(P < 0.000). Sharing intravenous drug utensils was a known risk factor for disease transmission(94.4%), but the sharing of common household items such as a toothbrush was not. 93% of the population were unaware that HCV infection can be asymptomatic. 25% did not know that treatment was available in New Zealand and of those who did know, only 40% assumed it was funded. Six hundred and eighty-two residual anonymised blood samples were tested for HCV antibodies, ALT, AST and GGT. The prevalence for HCV was 4.01%, 95%CI: 2.6%-5.8%. Liver function tests were not useful for identifying likelyhood of HCV infection.CONCLUSION: Prevalence of HCV in our population is high, and the majority have limited knowledge of HCV and its treatment. | Jane Vermunt Margaret Fraser Peter Herbison Anna Wiles Martin Schlup Michael Schultz | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 5 | Lack of correlation between Treg quantification assays in inflammatory bowel disease patients显示文摘AIM:To compare the number of regulatory T-cells( Tregs) measured by flow cytometry with those obtained using a real-time quantitative PCR(q PCR) method in patients suffering from inflammatory bowel disease(IBD).METHODS:Tregs percentages obtained by both flow cytometry and q PCR methods in 35 adult IBD patients,18 out of them with Crohn′s disease(CD)and 17 with ulcerative colitis(UC)were compared to each other as well as to scores on two IBD activity questionnaires using the Harvey Bradshaw Index(HBI)for CD patients and the Simple Colitis Clinical Activity Index(SCCAI)for UC patients.The Treg percentages by flow cytometry were defined as CD4+CD25highCD127lowFOXP3+cells in peripheral blood mononuclear cells,whereas the Treg percentages by q PCR method were determined as FOXP3 promoter demethylation in genomic DNA.RESULTS:We found an average of 1.56%±0.78%Tregs by using flow cytometry,compared to 1.07%±0.53%Tregs by using q PCR in adult IBD patients.There were no significant correlations between either the percentages of Tregs measured by flow cytometry or q PCR and the HBI or SCCAI questionnaire scores in CD or UC patients,respectively.In addition,there was no correlation between Treg percentages measured by q PCR and those measured by flow cytometry(r=-0.06,P=0.73;Spearman Rho).These data suggest that,either Treg-related immune function or the clinical scores in these IBD patients did not accurately reflect actual disease activity.Until the cause(s)for these differences are more clearly defined,the resultssuggest caution in interpreting studies of Tregs in various inflammatory disorders.CONCLUSION:The two methods did not produce equivalent measures of the percentage of total Tregs in the IBD patients studied which is consistent with the conclusion that Tregs subtypes are not equally detected by these two assays. | Gunnar Brandhorst Darinka Todorova Petrova Sebastian Weigand Christoph Eberle Nicolas von Ahsen Jessica Schmitz Frank Christian Schultze Dirk Raddatz Michael Karaus Michael Oellerich Philip D Walson | 2015 | World Journal of Gastroenterology2015，21，11： | 2 |
| 6 | Reduce costs with dividing-wall columns显示文摘 | Schultz Michael A | 2002 | Chemical Engineering Progress2002，98，5： | 1 |
| 7 | Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis显示文摘BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical intervention.Current diagnostic standard of care is an invasive joint aspiration.Aspirations provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(e.g.bacterial)or non-infectious(e.g.gout).Cultures can take days to result,so decisions about surgery are often made with incomplete data.Novel diagnostics are thus needed.The“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute inflammation.It has been validated in multiple cohorts across heterogeneous clinical settings.AIM To study whether the SMS holds diagnostic validity in determining the etiology of acute arthritis.METHODS We conducted a blinded,prospective,non-interventional clinical study of the SMS.All patients undergoing work-up for a septic primary joint were enrolled.Patients proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical results.RESULTS A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative cultures.The SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious conditions.For comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=0.59.At 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further intervention.CONCLUSION In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic biomarkers.This quick blood test could be an important tool for early,accurate identification of acute septic joints and need for emergent surgery,improving clinical care and healthcare spending. | Blake J Schultz Timothy Sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner | 2019 | World Journal of Orthopedics2019，10，12： | 1 |
| 8 | Reduce Costs with Dividiug-Wall Columns 显示文摘 | Michael A Schultz Doughs G Stewart | 2002 | CEP2002，，5： | 1 |
| 9 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C<!-- Doctopic: VH -->显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 10 | Studies on the carbothermal prepara- tion of titanium carbide from different gel precursors 显示文摘 | HENRY PREISS LUTZ -MICHAEL BERGER DIET- RICH SCHULTZE | 1999 | Journal of the European Ceramic Society1999，19，2： | 1 |
| 11 | Evaluation of MODIS LAI, fAPAR and the relation between fAPAR and NDVI in a semi-arid environment using situ measurements显示文摘 | Rasmus Fensholt Inge Sandhoit Michael Schultz Rasmussen | 2004 | Remote Sensing of Environment2004，91，34： | 1 |
| 12 | Retrieval of short ocean wave slope using polarimetric imaging显示文摘 | Christopher J Zappa Michael L Banner Howarde Schultz | 2008 | Measurement Science and Technology2008，19，5： | 1 |
| 13 | Public attitudes towards marine aquaculture: A comparative analysis of Germany and Israel显示文摘 | Shirra Freeman Eran Vigoda-Gadot Horst Sterr Michael Schultz Irina Korchenkov Peter Krost Dror Angel | 2012 | Environmental Science and Policy2012，，： | 1 |
| 14 | Evaluation of Modis LAI and the relation between fAPAR and NDVI in a semi-arid environment using situ measurements显示文摘 | Rasmus Fensholt Inge Sandholt Michael Schultz Rasmussen | 2004 | Remote Sensing of Environment2004，91，： | 1 |
| 15 | Duck hepatitis B virus: an invaluable model system for HBV infection显示文摘 | Ursula Schultz Elizabeth Grgacic and Michael Nassal | 2004 | Ad Virus Res2004，63，： | 1 |
| 16 | Evaluation of MODIS LAI, fAPAIR, and the relation between fAPAR and NDVI in a semi-arid environment using situ measurements显示文摘 | Rasmus Fensholt Inge Sandhoh Michael Schultz Rasmussen | 2004 | Remote Sensing Environment2004，91，： | 1 |
| 17 | Pressure Transcients in short tunnel显示文摘 | Michael Schultz Helmut Sockel | 1991 | Aerodynamics and Ventilation of Vehicle tunnel1991，，： | 1 |
| 18 | Mapping long-term changes in savannah crop productivity in Senegal through trend analysis of time series of remote sensing data显示文摘 | Christian Tottrup Michael Schultz Rasmussen | 2004 | Agriculture Ecosystems and Environment2004，103，3： | 1 |
| 19 | Reduce costs with dividing-wall columns显示文摘 | Douglas G Stewart | 2002 | CEP2002，，5： | 1 |
| 20 | A Turbulent Channel Flow Apparatus for theDetermination of the Adhesion Strength of Microfouling Organisms 显示文摘 | Michael P Schultz John A Finlay Maureen E Callow | 2000 | Biofouling:2000，15，4： | 1 |
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