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| 1 | Interaction between microbiota and immunity in health and disease显示文摘The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease.The microbiome plays critical roles in the training and development of major components of the host's innate and adaptive immune system,while the immune system orchestrates the maintenance of key features of host-microbe symbiosis.In a genetically susceptible host,imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders.Here,we review features of microbiome-immunity crosstalk and their roles in health and disease,while providing examples of molecular mechanisms orchestrating these interactions in the intestine and extra-intestinal organs.We highlight aspects of the current knowledge,challenges and limitations in achieving causal understanding of host immune-microbiome interactions,as well as their impact on immune-mediated diseases,and discuss how these insights may translate towards future development of microbiometargeted therapeutic interventions. | Danping Zheng Timur Liwinski Eran Elinav | 2020 | Cell Research2020，30，6： | 58 |
| 2 | Relationship between Oral Glucose Tolerance Test Characteristics and Adverse Pregnancy Outcomes among Women with Gestational Diabetes Mellitus显示文摘 | Hui Feng Wei-Wei Zhu Hui-Xia Yang Yu-Mei Wei Chen Wang Ri-Na Su Moshe Hod Eran Hadar | 2017 | Chinese Medical Journal2017，，9： | 26 |
| 3 | Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report显示文摘我们报导 intracytoplasmic 精子的成功的结果在有家庭 globozoospermia 的二个兄弟的注射(ICSI ) 治疗。在控制卵巢的亢奋的刺激和卵母细胞提取以后,检索了卵母细胞在 ICSI 和 33.3% 的授精率在第一个案例中被完成以前,机械地被激活。没有卵母细胞激活,第二对夫妇经历了 ICSI, 9.1% 授精率被获得。二个等级的转移我在第一对夫妇和夫妇的胚胎分级我在第二对夫妇的胚胎与健康实时出生导致了临床的怀孕。有 globozoospermia 的案例的主要问题是低授精率,这被结束,并且尽管 ICSI 和卵母细胞激活能增加这率,完成怀孕未必被需要。 | Enver K. Dirican Ahmet Isik KubilayVicdan Eran Sozen Zekiye Suludere | 2008 | Asian Journal of Andrology2008，10，2： | 9 |
| 4 | Photonic Floquet topological insulators in a fractal lattice显示文摘We present Floquet fractal topological insulators:photonic topological insulators in a fractal-dimensional lattice consisting of helical waveguides.The helical modulation induces an artificial gauge field and leads to a trivial-totopological phase transition.The quasi-energy spectrum shows the existence of topological edge states corresponding to real-space Chern number 1.We study the propagation of light along the outer edges of the fractal lattice and find that wavepackets move along the edges without penetrating into the bulk or backscattering even in the presence of disorder.In a similar vein,we find that the inner edges of the fractal lattice also exhibit robust transport when the fractal is of sufficiently high generation.Finally,we find topological edge states that span the circumference of a hybrid half-fractal,half-honeycomb lattice,passing from the edge of the honeycomb lattice to the edge of the fractal structure virtually without scattering,despite the transition from two dimensions to a fractal dimension.Our system offers a realizable experimental platform to study topological fractals and provides new directions for exploring topological physics. | Zhaoju Yang Eran Lustig Yaakov Lumer Mordechai Segev | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 5 | Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial显示文摘AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins(CEP) in Crohn's disease (CD) subjects.METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels.RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CDS+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period.CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation. | Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 6 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 7 | Phages and their potential to modulate the microbiome and immunity显示文摘Bacteriophages(hence termed phages)are viruses that target bacteria and have long been considered as potential future treatments against antibiotic-resistant bacterial infection.However,the molecular nature of phage interactions with bacteria and the human host has remained elusive for decades,limiting their therapeutic application.While many phages and their functional repertoires remain unknown,the advent of next-generation sequencing has increasingly enabled researchers to decode new lytic and lysogenic mechanisms by which they attack and destroy bacteria.Furthermore,the last decade has witnessed a renewed interest in the utilization of phages as therapeutic vectors and as a means of targeting pathogenic or commensal bacteria or inducing immunomodulation.Importantly,the narrow host range,immense antibacterial repertoire,and ease of manipulating phages may potentially allow for their use as targeted modulators of pathogenic,commensal and pathobiont members of the microbiome,thereby impacting mammalian physiology and immunity along mucosal surfaces in health and in microbiomeassociated diseases.In this review,we aim to highlight recent advances in phage biology and how a mechanistic understanding of phage-bacteria-host interactions may facilitate the development of novel phage-based therapeutics.We provide an overview of the challenges of the therapeutic use of phages and how these could be addressed for future use of phages as specific modulators of the human microbiome in a variety of infectious and noncommunicable human diseases. | Sara Federici Samuel P.Nobs Eran Elinav | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 8 | Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs显示文摘 | John L. Rinn Michael Kertesz Jordon K. Wang Sharon L. Squazzo Xiao Xu Samantha A. Brugmann L. Henry Goodnough Jill A. Helms Peggy J. Farnham Eran Segal Howard Y. Chang | 2007 | Cell2007，，7： | 6 |
| 9 | Role of the microbiome in non-gastrointestinal cancers显示文摘'The forgotten organ',the human microbiome,comprises a community of microorganisms that colonizes various sites of the human body.Through coevolution of bacteria,archaea and fungi with the human host over thousands of years,a complex host-microbiome relationship emerged in which many functions,including metabolism and immune responses,became codependent.This coupling becomes evident when disruption in the microbiome composition,termed dysbiosis,is mirrored by the development of pathologies in the host.Among the most serious consequences of dysbiosis,is the development of cancer.As many as 20% of total cancers worldwide are caused by a microbial agent.To date,a vast majority of microbiomecancer studies focus solely on the microbiome of the large intestine and the development of gastrointestinal cancers.Here,we will review the available evidence implicating microbiome involvement in the development and progression of non-gastrointestinal cancers,while distinguishing between viral and bacterial drivers of cancer,as well as 'local' and 'systemic','cancer-stimulating' and 'cancer-suppressing' effects of the microbiome.Developing a system-wide approach to cancer-microbiome studies will be crucial in understanding how microbiome influences carcinogenesis,and may enable to employ microbiome-targeting approaches as part of cancer treatment. | Meirav Pevsner-Fischer Timur Tuganbaev Mariska Meijer Sheng-Hong Zhang Zhi-Rong Zeng Min-Hu Chen Eran Elinav | 2016 | World Journal of Clinical Oncology2016，7，2： | 5 |
| 10 | An ultra-sensitive dual-mode imaging system using metal-enhanced fluorescence in solid phantoms显示文摘在这研究,我们用在稳固的幽灵结合到各种各样的 fluorophores 的金 nanoparticles (GNP ) 开发了一个高度敏感的双模式的成像系统。系统为表面成像,为深织物的成像(多达 1 厘米) 的散开思考(医生) ,和提高金属的荧光(MEF ) 由荧光一生成像显微镜学(FLIM ) 组成。我们检测了熄灭在荧光灯为金 nanospheres (GNS ) 和到荧光黄的金 nanorods (GNR ) 的变化形式的紧张(FI ) ,它在比 GNP 的两种类型的表面电浆子回声(SPR ) 短的波长有一座刺激山峰。提高的 FI 在变化形式被检测到玫瑰精 B (RhB ) 和 Sulforhodamine B (SRB ) ,与在 GNP 的 SPR 区域的刺激山峰。提高的 FI 被 FLIM 大小在答案并且在稳固的幽灵检测。医生大小由记录在相应于 GNR 的吸收系列的波长散布的光的掉的率在稳固的幽灵以内检测了 GNR 的存在。与 MEF 的包括,这种有希望的双模式的成像技术启用有效、敏感的分子、功能的成像。 | Eran A. Barnoy Dror Fixler Rachela Popovtzer Tsviya Nayhoz Krishanu Ray | 2015 | Nano Research2015，8，12： | 4 |
| 11 | Autoimmune pancreatitis misdiagnosed as a tumor of the head of the pancreas显示文摘Autoimmune pancreatitis can mimic pancreatic cancer in its clinical presentation, imaging features and laboratory parameters. Differentiating between those two entities requires implementation of clinical judgment and experience along with objective parameters that may suggest either condition. Few strategies have been proposed for the surgeon to implement when facing borderline cases. The following case is an example of a clinical scenario compatible with an accepted algorithm for diagnosis of pancreatic cancer, which eventually proved wrong. We present a 75-year-old patient who was admitted for obstructive jaundice. Imaging features were highly suggestive for pancreatic cancer as was the carbohydrate antigen 19-9 (CA 19-9) level, leading to a decision for surgery. Pathological examination revealedautoimmune pancreatitis. Though no frank carcinoma was found, premalignant ductal changes of pancreatic intraepithelial neoplasia (PanIN)Ⅰand PanIN Ⅱ were discovered throughout the pancreatic duct. Caution is advised when relying on the combination of highly suggestive radiology features and elevated levels of CA 19-9 in the diagnosis of pancreatic cancer. When the tissue diagnosis is not conclusive, obtaining IgG4 and antinuclear Ab levels is advised, to rule out the rare possibility of autoimmune pancreatitis. Patients with autoimmune pancreatitis should be followed carefully as precancerous lesions may accompany the benign disease and the correlation of these two entities has not been ruled out. | Eran Brauner Jesse Lachter Offir Ben-Ishay Euvgeni Vlodavsky Yoram Kluger | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 4 |
| 12 | Secondary aorto-esophageal fistula after thoracic aortic aneurysm endovascular repair treated by covered esophageal stenting显示文摘Thoracic endovascular aortic repair for thoracic aortic aneurysms is an accepted alternative to open surgery, especially in patients with significant comorbidities. The procedure itself has a low risk of complications and fistulas to surrounding organs are rarely reported. An 86-year-old patient was admitted to our hospital with gastro intestinal(GI) bleeding and a suspected aortoesophageal fistula. Eight months prior, the patient had undergone a stent graft repair of a mycotic thoracic aneurysm. Computerized tomography angiography and upper GI endoscopy confirmed an aortoesophageal fistula, which was treated by esophageal stenting. With early recognition, esophageal stenting may have a role in the initial emergency control of bleeding from and palliation of aortoesophageal fistula. | Mary Tao Eran Shlomovitz Gail Darling Graham Roche-Nagle | 2016 | World Journal of Clinical Cases2016，4，8： | 3 |
| 13 | NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis显示文摘 | Eran Elinav Till Strowig Andrew L. Kau Jorge Henao-Mejia Christoph A. Thaiss Carmen J. Booth David R. Peaper John Bertin Stephanie C. Eisenbarth Jeffrey I. Gordon Richard A. Flavell | 2011 | Cell2011，，5： | 3 |
| 14 | Oral mixture of autologous colon-extracted proteins for the Crohn's disease: A double-blind trial显示文摘AIM: To evaluate the safety and efficacy of oral administration of AlequelTM, an autologous proteincontaining colon extract.a randomized,placebo-controlled,double-blind trial.Patients were orally administered with autologous protein-containing colon extract three doses of autologous study drug per week for 15 wk,for a total of45 doses.Patients were followed for safety parameters.Remission was defined as a Crohn’s disease activity index(CDAI)score of less than or equal to 150.All patients were followed for changes in subsets of T cells by fluorescence-activated cell sorting analysis.RESULTS:Analysis was performed on a total number of evaluable patients of 14 in the study drug group and15 in the placebo group.Treatment was well tolerated by all patients.No major treatment-related adverse events were reported or observed in any of the treated patients during the feeding or follow-up periods.Between weeks 6 and 9 of the study,six of the 14(43%)evaluable subjects who received the study drug achieved a CDAI of 150 or lower.In contrast,five of the 15(33%)evaluable subjects in the placebo group achieved remission.Between weeks 9 and 12,the remission rates were 50%and 33%for the drug group and placebo group,respectively.Among the drug-treated subjects who achieved remission,the effect of the drug was judged as stable in eight of the 14 subjects as measured by at least two CDAI scores indicating remission in the 15-wk treatment period.A decreased percentage of peripheral natural killer T regulatory cells(a decrease of 28%vs an increase of 16%)and an increased ratio of CD4+/CD8+T lymphocytes(an increase of 11%vs a decrease of9%)were noted in subjects with a significant clinical response.CONCLUSION:Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn’s disease. | Eran Israeli Ehud Zigmond Gadi Lalazar Athalia Klein Nilla Hemed Eran Goldin Yaron Ilan | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 15 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 16 | Bigliani/Flatow人工肩治疗肱骨近端四部骨折手术技术显示文摘近代人工肩最初源自损伤修复的需要,由Neer于1953年设计,是关节单侧的肱骨假体。后来由于关节疾病治疗的需要,而出现全肩的假体,即具有肱骨干与肩胛盂二个部件。人工肩应用于损伤修复手术方法中某些步骤有别于应用关切疾病,特别是大小结节的处理,本文主要阐明肱骨近端4部骨折时,进行半肩关节置换手术的方法。 | Louis Bigliani Eran Flatow 钱不凡(编译) | 2007 | 中华创伤骨科杂志2007，9，2： | 2 |
| 17 | A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints显示文摘AIM: To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal complaints.METHODS: For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT scan detected either intraluminal or intestinal wall lesions. These patients underwent colonoscopy serving as gold standard. Patients with prior abdominal pathology or CT findings of appendicitis or diverticulitis were excluded.RESULTS: Five hundred and sixty-eight abdominopelvic CT scans were performed in the ER, 96 had positive colonic findings. Sixty-two patients were excluded, 46 because of diverticulitis or appendicitis, 16 because of prior abdominal pathology. Of the remaining 34 patients, 14 did not undergo colonoscopy during hospitalization.Twenty eligible patients were included in the study. The positive predictive value of the CT scans performed in the ER was calculated to be 45% (95% CI 25-67).CONCLUSION: CT findings correlated with colonoscopic findings only in approximately half of the cases. Relying on non-prepared CT scan findings in planning patient management and colonoscopy may lead to unnecessary diagnostic work-ups. | Michal Mizrahi Yoav Mintz Avraham Rivkind David Kisselgoff Eugene Libson Mayer Brezis Eran Goldin Oren Shibolet | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 18 | Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases显示文摘Familial dysautonomia(FD) is a rare children neurodegenerative disease caused due to a point mutation in the IKBKAP gene that results in decreased IKK complex-associated protein(IKAP) protein production. The disease affects mostly the dorsal root ganglion(DRG) and the sympathetic ganglion. Recently, we found that the molecular mechanisms underlying neurodegeneration in FD patients are defects in axonal transport of nerve growth factors and microtubule stability in the DRG. Neurons are highly polarized cells with very long axons. In order to survive and maintain proper function, neurons depend on transport of proteins and other cellular components from the neuronal body along the axons. We further demonstrated that IKAP is necessary for axon maintenance and showed that phosphatidylserine acts as an HDAC6 inhibitor to rescue neuronal function in FD cells. In this review, we will highlight our latest research findings. | Shiran Naftelberg Gil Ast Eran Perlson | 2017 | Neural Regeneration Research2017，12，4： | 2 |
| 19 | APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes显示文摘Among the risk factors for late onset sporadic Alzheimer's disease(AD)is the expression ofε4 allele of apolipoprotein E(APOE4)gene(Mahley et al.,2006).Elevated amyloid processing and reduced degradation of Aβ,which lead to Ap plaque deposition,are evident in APOE4-positive AD patients and mice(Mahley et al.,2006).These features correlate with neuronal cell loss.Impaired mitochondrial activity and increased oxidative stress have long been recognized as additional hallmarks of AD pathology(Mahley et al.,2006).The effect of APOE4 expression on autophagy and mitochondrial dynamics and activity in astrocytes is discussed in this perspective and is summarized in Figure 1. | Schmukler Eran Pinkas-Kramarski Ronit | 2022 | Neural Regeneration Research2022，17，4： | 2 |
| 20 | MeNA, Controlled by Reversible Methylation of Nicotinate, Is an NAD Precursor that Undergoes Long-Distance Transport in Arabidopsis显示文摘 | Ranran Wu Fengxia Zhang Lingyun Liu Wei Li Eran Pichersky Guodong Wang | 2018 | Molecular Plant2018，11，10： | 2 |
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