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1篇 您的检索式：作者名="Michael WYChan"

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		题名	作者	年代	出处	被引量
	1	Gold nanorods conjugated upconversion nanoparticles nanocomposites for simultaneous bioimaging,local temperature sensing and photothermal therapy of OML-1 oral cancer cells显示文摘The major challenge in photothermal therapy(PTT)is to develop nanocomposites that simultaneously exhibit bioimaging and PTT under a single near-infrared(NIR)irradiation with high therapeutic efficiency.Herein,we present a multifunctional nanocomposite synthesized by linking NaYF_(4):Yb^(3+),Er^(3+)upconversion nanoparticles(UCNPs)with gold nanorods(AuNR)to exhibit fluorescence label-ing,local temperature sensing and photothermal functions simul-taneously with a single NIR laser excitation.The AuNR-NaYF_(4):Yb^(3+),Er^(3+)nanocomposite particles displayed better photothermal prop-erties compared with pure AuNRs or a blend of AuNRs and NaYF_(4):Yb^(3+),Er^(3+)UCNPs.The temperature-dependent upconversion lumi-nescence(UCL)property was used to determine local temperature at the nanocomposite particles,which is useful for selecting appro-priate irradiation dosage for PTT.The therapeutic performance of the nanocomposites in PTT for OML-1 oral cancer cells was deter-mined.For cell labeling,we successfully labeled streptavidin-linked nanocomposite particles on the surface of OML-1 oral cancer using anti-human epidermal growth factor receptor 2(anti-Her2)anti-body.Finally,the nanocomposite particles caused exceptional destruction of cancer cells up to 70%dead cells under 976 nm laser irradiation for only one min at 0.3 W/cm^(2)which is below the maximal permissible exposure of human skin.	Duc Tu Vu Thanh Thu Vu-Le Van Nghia Nguyen Quoc Minh Le Churng-Ren Chris Wang Lai-Kwan Chau Tzyy-Schiuan Yang Michael WYChan Cheng-I Lee Chu-Chi Ting Jiunn-Yuan Lin Hung-Chih Kan Chia Chen Hsu	2021	International Journal of Smart and Nano Materials2021，12，1：	0

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