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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Nipah virus infection in dogs,Malaysia,1999显示文摘 | James NM Asiah NMA Michel LB | 2009 | Emerg Infect Dis2009，15，6： | 1 |
| 3 | Carbonization mechanisms resuiting from intumescence association with the ammonium polyphosphate - pen - taerythritol fire retardant system 显示文摘 | SERGE B MICHEL LB RENE D | 1993 | Carbon1993，，31： | 1 |
| 4 | Exposure to airborne particulate mat- ter in Kathmandu Valley,Nepal 显示文摘 | Anobha G Michelle LB | 2012 | J Expo Sei Environ Epi- demiol2012，22，3： | 1 |
| 5 | Systematic review and meta-analysis of energy and macronutrient intakes during pregnancy in developed countries显示文摘 | Michelle LB Alexis JH Lesley MW | 2012 | International Life Sciences Institute2012，70，6： | 1 |
| 6 | Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevation in interstitial concentration of aspartate and glutamate显示文摘 | Dohald WM Michelle LB | 1993 | Journal of Neurotrauma1993，10，4： | 1 |
| 7 | Nipah virus infection indogs, Malaysia, 1999显示文摘 | James NM Asiah NMA Michel LB | 2009 | Emerg Infect Dis2009，15，6： | 1 |
| 8 | Inhibitory effect of reactive oxygen species on angiotensin I-converting enzyme ( kininase II ) 显示文摘 | Michel B Grima M Nifina LB | 2001 | Clin Exp Pharmacol Physiol2001，283，： | 1 |
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