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| 1 | On hybrid petri Nets显示文摘 | Rene D Hassane A | 2001 | Discrete Event Dynamic Systems2001，11，12： | 2 |
| 2 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 3 | A behavioral multi-agent model for road traffic simulation 显示文摘 | Arnaud D Rene M Sylvain P | 2008 | Engineering Applications of Artificial Intelligence (S0952-1976)2008，21，8： | 1 |
| 4 | Age and experience effects in spatial visualization 显示文摘 | Renee L Babcock D | 1990 | Dev Psychol1990，20，1： | 1 |
| 5 | Excitation-emission matrix fluorescence based determination of carbamate pesticides and polycyclic aromatic hydrocarbons显示文摘 | Renee D J Gary A C Karl S B | 1999 | Analytica Chimica Acta1999，，397： | 1 |
| 6 | Field dvices-models and their Realisation显示文摘 | RENE S PETER N CHRISTIAN D | 2002 | Industrial Technology2002，4，： | 1 |
| 7 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 8 | 基于G-蛋白偶联受体激酶2抑制剂治疗心力衰竭的合理药物设计(英文)显示文摘G protein-coupled receptors(GPCRs)convert extracellular stimuli in the form of hormones,odorants and light into profound changes in cell homeostasis.Their timely desensitization is critical for cells to rapidly respond to changes in their environment and to avoid damage from sustained signaling.Seven GPCR kinases(GRKs)phosphorylate and regulate the activity of most of the^800 GPCRs in the human genome.Although GRKs normally play an adaptive role,in conditions such as chronic heart failure they are overexpressed and linked to disease progression.GRK2 and GRK5 have thus become important targets for the treatment of heart failure and pathological cardiac hypertrophy,respectively.Our lab has determined atomic structures representing all three vertebrate GRK subfamilies,and is now in the midst of a campaign to develop selective inhibitors of these enzymes using structure-based rational design.We have identified the FDA approved drug paroxetine as a selective GRK2 inhibitor,determined the crystal structure of the GRK2·paroxetine complex and,in collaboration with the Koch lab,showed that the drug improves contractility in myocytes and,most impressively,recovery in postmyocardial infarcted mice.Since then,we have identified additional chemical scaffolds that exhibit even higher potency and/or selectivity for GRK5.Using a'hybrid'inhibitor design approach we have generated GRK selective chemical probes that exhibit improved potency and stability and are able to increase inotropy and dampen the hypertrophic response in cardiomyocytes and small animal models.Structural analysis has revealed the molecular basis for selectivity and potency in many of these compounds,allowing for the design of future generations of GRK chemical probes. | John J TESMER Helen V WALDSCHMIDT Marie C CATO Renee BOULEY Osvaldo CRUZ-RODRIGUEZ Scott D LARSEN | 2017 | 中国药理学与毒理学杂志2017，31，10： | 1 |
| 9 | Carotid plaque formation and serum biomarkers 显示文摘 | Linda Hermus Joop D Lefrandt Rene A Tio | 2010 | Atherosclerosis2010，213，： | 1 |
| 10 | Proteomic analysis of log to stationary growth phase Lactobacillus plantarum cells and a 2-DE database显示文摘 | COHEN D P A RENES J BOUWMAN F G | | 0，，： | 1 |
| 11 | Superoxide protonation by weak acids in imidazolium based ionic liquids显示文摘 | Rene A D Hauchard C Hapiot P | 2009 | Journal of Physical Chemistry B2009，113，9： | 1 |
| 12 | Epithelial proliferation, cell death and gene expression in experimental colitis: alterations in carbonic anhydrase I mucin MUC2 and trefoil factor 3 expression 显示文摘 | RENES I B VERBURG M VAN NISPEN D J | 2002 | Int J Colorectal Dis2002，17，： | 1 |
| 13 | Carbonization Mechanisms Resulting from Intumescence Association with the Ammonium Polyphosphate显示文摘 | SERGE B MICHEL L B RENE D | 1993 | Pentaerythritol Fire Retardant System Carbon1993，31，： | 1 |
| 14 | Age and experience effects in spatial visualization 显示文摘 | Timothy A Renee L Babcock D | 1990 | Dev Psychol1990，20，1： | 1 |
| 15 | Body fat content and feeding level interact strongly in the short - and medium - term regulation of plasma leptin during under - feeding and re - feeding in adult sheep 显示文摘 | CAROLE D FRANCQOIS B RENE B | 2007 | British Journal of Nutrition2007，98，： | 1 |
| 16 | Genetic characterization and phylogene-tic analysis of porcine circovirus type 2 (PCV2) strains from cases presenting various clinical conditions显示文摘 | Rene'e Larochelle Ronald Magar Sylvie D'Allaire | 2002 | Virus Research2002，90，： | 1 |
| 17 | Processing Snow for High Strength Roads and Runways 显示文摘 | RENEE M LANG GEORGE L BLAISDELL CHRISTIAN D'URSO | 1997 | Cold Regions Science and Technology1997，25，： | 1 |
| 18 | Optimal network reconfigurations in distribution systems : Part 2 : solution algorithms and numerical results 显示文摘 | Chiang H D Rene J J | 1990 | IEEE Trans on Power Delivery1990，5，3： | 1 |
| 19 | Design and control of warehouse order picking: A literature review显示文摘 | RENE D K LE-DUC T KEES J R | 2007 | European Journal of OperationaIReseareh2007，182，2： | 1 |
| 20 | Performance Evaluation of a Compost Biofiher Treating Toluene Vapours 显示文摘 | Rene E R Murthy D V S Swaminathan T | 2005 | Process Biochem2005，40，8： | 1 |
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