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| 1 | Cartilage repair techniques of the talus: An update显示文摘Symptomatic chondral or osteochondral defects of the talus reduce the quality of life of many patients.Although their pathomechanism is well understood,it is well known that different aetiologic factors play a role in their origin.Additionally,it is well recognised that the talar articular cartilage strongly differs from that in the knee.Despite this fact,many recommendations for the management of talar cartilage defects are based on approaches that were developed for the knee.Conservative treatment seems to work best in paediatric and adolescent patients with osteochondritis dissecans.However,depending on the size of the lesions,surgical approaches are necessary to treat many of these defects.Bone marrow stimulation techniques may achieve good results in small lesions.Large lesions may be treated by open procedures such as osteochondral autograft transfer or allograft transplantation.Autologous chondrocyte transplantation,as a restorative procedure,is well investigated in the knee and has been applied in the talus with increasing popularity and promising results but the evidence to date is poor.The goals of the current article are to summarise the different options for treating chondral and osteochondral defects of the talus and review the available literature. | Mike H Baums Wolfgang Schultz Tanja Kostuj Hans-Michael Klinger | 2014 | World Journal of Orthopedics2014，5，3： | 11 |
| 2 | Low rates of adherence for tumor necrosis factor-α inhibitors in Crohn's disease and rheumatoid arthritis: Results of a systematic review显示文摘AIM:To investigate adherence rates in tumor necrosis factor-α (TNF-α)-inhibitors in Crohn's disease (CD) and rheumatoid arthritis (RA) by systematic review of medical literature. METHODS:A structured search of PubMed between 2001 and 2011 was conducted to identify publications that assessed treatment with TNF-α inhibitors providing data about adherence in CD and RA. Therapeutic agents of interest where adalimumab, infliximab and etanercept, since these are most commonly used for both diseases. Studies assessing only drug survival or continuation rates were excluded. Data describing adherence with TNF-α inhibitors were extracted for each selected study. Given the large variation between definitions of measurement of adherence, the definitions as used by the authors where used in our calculations. Data were tabulated and also presented descriptively. Sample size-weighted pooled proportions of patients adherent to therapy and their 95%CI were calculated.To compare adherence between infliximab, adalimumab and etanercept, the adherence rates where graphed alongside two axes. Possible determinants of adherence were extracted from the selected studies and tabulated using the presented OR. RESULTS:Three studies on CD and three on RA were identified, involving a total of 8147 patients (953 CD and 7194 RA). We identified considerable variation in the definitions and methodologies of measuring adherence between studies. The calculated overall sample size-weighted pooled proportion for adherence to TNF-α inhibitors in CD was 70% (95%CI:67%-73%) and 59% in RA (95%CI:58%-60%). In CD the adherence rate for infliximab (72%) was highercompared to adalimumab (55%), with a relative risk of 1.61 (95%CI:1.27-2.03), whereas in RA adherence for adalimumab (67%) was higher compared to both infliximab (48%) and etanercept (59%), with a relative risk of 1.41 (95%CI:1.3-1.52) and 1.13 (95%CI:1.10-1.18) respectively. In comparative studies in RA adherence to infliximab was better than etanercept and etanercept did better than adalimumab. In three studies, the most consistent factor associated with lower adherence was female gender. Results for age, immunomodulator use and prior TNF-α inhibitors use were conflicting. CONCLUSION:One-third of both CD and RA patients treated with TNF-α inhibitors are non-adherent. Female gender was consistently identified as a negative determinant of adherence. | Herma H Fidder Maartje MJ Singendonk Mike van der Have Bas Oldenburg Martijn GH van Oijen | 2013 | World Journal of Gastroenterology2013，19，27： | 2 |
| 3 | Risk factors contributing to microbiological contamination of Shallow groundwater in Kampa- la, Uganda显示文摘 | Guy H Stephen P Mike B Mail N | 2003 | Water Research2003，8，37： | 1 |
| 4 | Diferential feeding of worker larve affects caste characters in honeybee,Apis mellifera capensis显示文摘 | MIKE H JOHAN NM WILLEM J | 2003 | Behav Ecol Sociobiol2003，，54： | 1 |
| 5 | Neural network modeling of coastal algal blooms显示文摘 | JOSEPH H W LEE Y H MIKE D | 2003 | Ecological Modeling2003，159，23： | 1 |
| 6 | Miniature LTCC filters for digital receivers显示文摘 | Alex B Wes F Mike H | 1997 | IEEE MMT-S Digest1997，2，67： | 1 |
| 7 | Biosensor system for continuous monitoring of organophosphate aerosols 显示文摘 | Heather R L Roby G Mike H B | 2007 | Biosensors and Bioelectronics2007，23，： | 1 |
| 8 | Mediation of elicitin activity on tobacco is assumed by elicitin-sterol complexes显示文摘 | Osman H Vauthrin S Mikes V | 2001 | Molecular Biology of the Cell2001，12，： | 1 |
| 9 | Product complexity, innovation and industrial organi- zation 显示文摘 | Mike H | 1998 | Research Policy1998，，26： | 1 |
| 10 | Validation of a solid-phase microextraction method for headspace analysis of wine aroma components 显示文摘 | HOWARD K L MIKE J H RIESEN R | 2005 | American Journal of Enology and Viticulture2005，56，1： | 1 |
| 11 | Microstructure and fracture toughness of hot-pressed zirconia-toughened SiAION显示文摘 | Cain Marky G Lewis Mike H | 1994 | J Am Ceram Soc1994，76，6： | 1 |
| 12 | The dawn of plant salt tolerance genetics显示文摘 | Mike H Ray B | 2000 | Trends in Plant Science2000，5，8： | 1 |
| 13 | TOPLESS mediates auxin-de- pendent transcriptional repression during Arabidopsis embry- ogenesis显示文摘 | HEIDI S MIKE H JEFF A L | 2008 | Science2008，319，5868： | 1 |
| 14 | Palliation of metastatic bone pain:single fraction versus multifraction radiotherapy-a systematic review of the randomised trials显示文摘 | Wai MS Mike S Ines H | 2004 | Cochrane Database Syst Rev2004，，00： | 1 |
| 15 | Research guidelines for chronic prestatitis:consensus report from the first National Institutes of Health International Prostatitis Collaborative Network显示文摘 | Nyberg LM Mike H | 1999 | Urology1999，54，2： | 1 |
| 16 | Validation of a solid- phase microextraction method for headspace analysis of wine aroma components显示文摘 | Howard K L Mike J H Riesen R | 2005 | American Journal of Enology and Viticulture2005，56，1： | 1 |
| 17 | Application of ritchey-common test in large flat measurements显示文摘 | SEN H NOVAK E MIKE S | 2001 | SPIE2001，4399，： | 1 |
| 18 | Genetic characterization of type 2 porcine circovirus(PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential Pck-restriction fragment lenth polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2显示文摘 | Martijn F Patrick G H Mike G | 2000 | J Clin Microbiol2000，38，7： | 1 |
| 19 | LC/MS Application in Drug Development显示文摘 | Mike S Lee Edward H Kems | | Mass Spectrometry Reviews0，18，： | 1 |
| 20 | Bacterium-based NO2-biosensor for environmental applications显示文摘 | MICHAEL N LARS H MIKE S | 2004 | Applied and Environmental Microbiology2004，70，11： | 1 |
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