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| 1 | Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers显示文摘AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. | Doron Boltin Marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern Samuel B Ho Yaron Niv | 2012 | World Journal of Gastroenterology2012，18，33： | 5 |
| 2 | Computer-based Creativity Enhanced Conceptual Design Model for Non-routine Design of Mechanical Systems显示文摘Computer-based conceptual design for routine design has made great strides, yet non-routine design has not been given due attention, and it is still poorly automated. Considering that the function-behavior-structure(FBS) model is widely used for modeling the conceptual design process, a computer-based creativity enhanced conceptual design model(CECD) for non-routine design of mechanical systems is presented. In the model, the leaf functions in the FBS model are decomposed into and represented with fine-grain basic operation actions(BOA), and the corresponding BOA set in the function domain is then constructed. Choosing building blocks from the database, and expressing their multiple functions with BOAs, the BOA set in the structure domain is formed. Through rule-based dynamic partition of the BOA set in the function domain, many variants of regenerated functional schemes are generated. For enhancing the capability to introduce new design variables into the conceptual design process, and dig out more innovative physical structure schemes, the indirect function-structure matching strategy based on reconstructing the combined structure schemes is adopted. By adjusting the tightness of the partition rules and the granularity of the divided BOA subsets, and making full use of the main function and secondary functions of each basic structure in the process of reconstructing of the physical structures, new design variables and variants are introduced into the physical structure scheme reconstructing process, and a great number of simpler physical structure schemes to accomplish the overall function organically are figured out. The creativity enhanced conceptual design model presented has a dominant capability in introducing new deign variables in function domain and digging out simpler physical structures to accomplish the overall function, therefore it can be utilized to solve non-routine conceptual design problem. | LI Yutong WANG Yuxin DUFFY Alex H B | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 5 |
| 3 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy显示文摘AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New Zealand.METHODS Articles in 2005 through 2015 were retrieved from PubM ed using the keyword 'circumcision' together with 36 relevant subtopics.A further PubM ed search was performed for articles published in 2016.Searches of the EMBASE and Cochrane databases did not yield additional citable articles.Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further.The most relevant andrepresentative of the topic were included.Bibliographies were examined to retrieve further key references.Randomized controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was performed.For efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if available.Internet searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for MC.RESULTS Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health measure.Our systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion criteria.Together,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and 'ballooning' during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penile,prostate and cervical cancer.Our risk-benefit analysis showed that benefits exceeded procedural risks,which are predominantly minor,by up to 200 to 1.We estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime.Wide-ranging evidence from surveys,physiological measurements,and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function,sensitivity or pleasure.United States studies showed that early infant MC is cost saving.The evidence supporting early infant MC has further strengthened since the positive AAP and CDC reviews.CONCLUSION Affirmative MC policies are needed in Australia and New Zealand.Routine provision of accurate,unbiased education,and access in public hospitals,will maximize health and financial benefits. | Brian J Morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman John B Ziegler | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 5 | Expression of nm23-H1 prorein in relation to myometrial invasion in complete hydatidiform moles显示文摘 | Alex S Panikkar B Devi C | 2002 | J Soci Gyneco Invest2002，9，2： | 2 |
| 6 | Ego depletion, atten- tional control, and decision making in sport 显示文摘 | Philip F Alex B Chris E | 2013 | Psychol- ogy of Sport & Exercise2013，14，6： | 1 |
| 7 | The accuracy of management dividend forecasts in Australia显示文摘 | PHILIP B ALEX C JANICE C Y KADIR L | 2000 | Pacific- Basin finance journal2000，，8： | 1 |
| 8 | Elevated jugular venous oxygen saturation after severe head injury显示文摘 | Manuela C Alex B Claudia S | 1999 | J Neurosurg1999，90，1： | 1 |
| 9 | Nanopomus Au: A high yield strength material显示文摘 | Juergen B Andrea M H Alex V H | 2005 | J Appl Phys2005，97，02： | 1 |
| 10 | Transtibial versus anteromedial por-tal drill ing for anterior cruciate ligament reconstruction:a cadaveric study of femoral tunnel length and obliquity 显示文摘 | Asheesh B Brad R Alex M | 2010 | Arthroscopy2010，26，3： | 1 |
| 11 | Disruption of functional connectivity in clinically normal older adults harboring amyloid burden显示文摘 | Trey H Koene RA van Alex B | 2009 | Neurosci2009，29，40： | 1 |
| 12 | Radiation therapy and Malignant Degeneration of Benign Supratentorial Gangliogtiomas 显示文摘 | Christopher S Rumama Alex B Valadka | 1998 | Neurosurgery1998，42，5： | 1 |
| 13 | A synthetic androstene analogue inhibits collagen-inducedarthritis in the mouse显示文摘 | HALINA OFFNER A B ALEX ZAMORA B SANDHYA SUBRAMANIAN | 2004 | Clinical Immunology2004，110，： | 1 |
| 14 | On-line evidence for spontaneous trait inferences at encoding显示文摘 | Uleman James S Hon Alex Roman Robert J Moskowitz Gordon B | 1996 | Personality and Social Psychology Bulletin1996，22，4： | 1 |
| 15 | Regulation of experimental lung inflammation 显示文摘 | Alex B Peter AW | 2001 | Respiration Physiology2001，128，： | 1 |
| 16 | Miniature LTCC filters for digital receivers显示文摘 | Alex B Wes F Mike H | 1997 | IEEE MMT-S Digest1997，2，67： | 1 |
| 17 | GM-CSF deficiency reduces macrophage PPARγ expression and aggravates atherosclerosis in apoE-deficient mice显示文摘 | Michael D Ban H T Alex B | 2006 | Ather Thromb Vasc Biol2006，26，： | 1 |
| 18 | The effect of dexmedetomidine on periop- erative hemodynamics in patients undergoing craniotomy 显示文摘 | Alex B Mary S Marc B | 2008 | Anesth Analg2008，，107： | 1 |
| 19 | Direction-of-arrival estimation for nonuniform sensor arrays:from manifold separation to Fourier domain MUSIC methods显示文摘 | Michael R Alex B | 2009 | IEEE Transactions on Signal Processing2009，57，2： | 1 |
| 20 | Robust adaptive beamforming for general - rank signal models 显示文摘 | Shahram Shahbazpanahi B Gershman Alex Luo Zhiquan | 2003 | IEEE Signal Processing2003，51，9： | 1 |
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