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| 1 | Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model显示文摘Neuroinflammation has been recognized to play a critical role in the pathogenesis of Alzheimer's disease (AD), which is pathologically characterized by the accumulation of senile plaques containing activated microglia and amyloid β-peptides (Aβ). In the present study, we examined the neuroprotective effects of hydrogen sulfide (H2S) on neuroinflammation in rats with Aβ1-40 hippocampal injection. We found that Aβ-induced rats exhibited a disorder of pyramidal cell layer arrangement, and a decrease of mean pyramidal cell number in the CA1 hippocampal region compared with those in sham operated rats. NaHS (a donor of H2S, 5.6 mg/kg/d, i.p.) treatment for 3 weeks rescued neuronal cell death significantly. Moreover, we found that H2S dramatically suppressed the release of TNF-α, IL-1β and IL-6 in the hippocampus. Consistently, both immunohistochemistry and Western blotting assays showed that H2S inhibited the upregulation of COX-2 and the activation of NF-κB in the hippocampus. In conclusion, our data indicate that H2S suppresses neuroinflammation via inhibition of the NF-κB activation pathway in the Aβ-induced rat model and has potential value for AD therapy. | Hao Fan YuGuo Xiaoyan Liang Yibiao Yuan Xiaohong Qi Min Wang Jianhua Ma Hong Zhou | 2013 | The Journal of Biomedical Research2013，27，4： | 10 |
| 2 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 3 | Acute toxicity evaluation for quinolone antibiotics and their chlorination disinfection processes显示文摘Acute toxicity of 21 quinolone antibiotics was monitored using photobacterium Vibrio fischeri assay.The minimum IC20(inhibitory concentration for 20%luminescence elimination)was obtained at the least 18.86μmol/L for the tested quinolones.A quantitative structure–activity relationship model was established to investigate the possible mechanism for the acute toxicity.The critical physicochemical descriptors,describingσandπatom electronegativity,implied that the electron transfer might occur between the quinolones and photobacterium V.fischeri.Although the quinolones exhibited limited acute toxicity to photobacterium,toxicity elevation was detected after their chlorination.Hence,chlorination disinfection treatment of quinolone-containing water should be of concerns. | Min Li Dongbin Wei Yuguo Du | 2014 | Journal of Environmental Sciences2014，26，9： | 4 |
| 4 | Genotoxicity of quinolones: Substituents contribution and transformation products QSAR evaluation using 2D and 3D models显示文摘 | Min Li Dongbin Wei Huimin Zhao Yuguo Du | 2014 | Chemosphere2014，，： | 1 |
| 5 | Research on the Dissemination and Influencing Factors of Big Data and Artificial Intelligence Related Courses in Colleges and Universities-Taking MOOC as an Example显示文摘The rapid development of information technologies such as artificial intelligence,Internet and big data has promoted the deep integration of technology and education,especially the rise of large-scale online courses,which provides a great opportunity for curriculum teaching reform in colleges and universities.At the same time,artificial intelligence,as a cutting-edge technology,has good development prospects and has become a popular professional course in colleges and universities,artificial intelligence technology has become the focus of subject education in many universities.The combination of online education and AI courses will also greatly enhance the enthusiasm of users and expand the dissemination scope of big data and AI related courses.Based on the grounded theory and technology acceptance model,this paper obtains the users’perception evaluation of learning MOOC big data and artificial intelligence courses through field interviews,summarizes the core categories,constructs MOOC user acceptance model,collects sample data by questionnaire and makes an empirical study.It is found that perceived usefulness,expectation confirmation and primary communication effect have a significant positive impact on the secondary communication effect,and the content quality and socialization interaction indirectly affect the secondary communication effect of MOOC curriculum by affecting the primary communication effect. | Zhu Junyan Min Yuguo Li Yudi Chen Xiaoyu Zhou Yu | 2022 | Journal on Artificial Intelligence2022，4，2： | 0 |
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