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| 1 | Using iron fertilizer to control Cd accumulation in rice plants: A new promising technology显示文摘Effects of two kinds of iron fertilizer, FeSO4 and EDTA·Na2Fe were studied on cadmium accumulation in rice plants with two rice genotypes, Zhongzao 22 and Zhongjiazao 02, with soil culture systems. The results showed that application of iron fertilizers could hardly make adverse effects on plant growth and rice grain yield. Soil application of EDTA·Na2Fe significantly reduced the Cd accumulation in rice roots, shoots and rice grain. Cd concentration in white rice of both rice genotypes in the treatment of soil application of EDTA·Na2Fe was much lower than 0.2 mg/kg, the maximal Cd permission concentra- tion in cereal crop foods in State standard. However, soil application of FeSO4 or foliar application of FeSO4 or EDTA·Na2Fe resulted in the significant increase of Cd accumulation in rice plants including rice grain compared with the control. The results also showed iron fertilizers increased the concentra- tion of iron, copper and manganese element in rice grain and also affected zinc concentration in plants. It may be a new promising way to regulate Cd accumulation in rice grain in rice production through soil application of EDTA·Na2Fe fertilizers to maintain higher content of available iron and ferrous iron in soils. | SHAO GuoSheng, CHEN MingXue, WANG DanYing, XU ChunMei, MOU RenXiang, CAO ZhaoYun & ZHANG XiuFu China National Rice Research Institute, Hangzhou 31006, China | 2008 | Science China(Life Sciences)2008，51，3： | 28 |
| 2 | Optimization of regularization parameter of inversion in particle sizing using light extinction method显示文摘In particle sizing by light extinction method, the regularization parameter plays an important role in applying regularization to find the solutionto ill-posed inverse problems. We combine the generalized cross-validation (GCV) and L-curve criteria with the Twomey-NNLS algorithmin parameter optimization. Numerical simulation and experimental validation show that the resistance of the newly developed algorithms tomeasurement errors can be improved leading to stable inversion results for unimodal particle size distribution. | Mingxu Su Feng Xu Xiaoshu Cai Kuanfang Ren Jianqi Shen | 2007 | China Particuology2007，5，4： | 22 |
| 3 | Numerical analysis of the failure process of soil-rock mixtures through computed tomography and PFC3D models显示文摘 | Yang Ju Huafei Sun Mingxu Xing Xiaofei Wang Jiangtao Zheng | 2018 | International Journal of Coal Science & Technology2018，5，2： | 17 |
| 4 | ENHANCED OIL RECOVERY BY FLOODING WITH HYDROPHILIC NANOPARTICLES显示文摘In this paper, the mechanism of enhanced oil recovery using lipophobic and hydrophilic polysilicon (LHP) nanoparticles ranging in size from 10 to 500 nm for changing the wettability of porous media was analysed theoretically. A one-dimensional two-phase mathematical model considering the migration and adsorption of LHP and wettability change in reservoir rock was proposed, and a simulator was developed to quantitatively predict the changes in relative and ef- fective permeability of the oil and water phases and the oil recovery in sandstone after water driving. Numerical simula- tions were conducted to study the distribution of the particle concentration, the reduction in porosity and absolute per- meability, the LHP volume retention on pore walls and in pore throats along a dimensionless distance, and oil production performance. In conclusion, oil recovery can obviously be improved by flooding with hydrophilic nanometer powders though permeability declines for the retention of nanoparticles in porous media. It is suggested that an LHP concentration ranging from 0.02 to 0.03 is preferable to enhance oil recovery. | Binshan Ju Tailiang Fan Mingxue Ma | 2006 | China Particuology2006，4，1： | 16 |
| 5 | Metformin attenuates pressure overload-induceced cardiac hypertrophy via AMPK activation显示文摘 | Yong-nan FU Han XIAO Xiao-wei MA Sheng-yang JIANG MingXU You-yi ZHANG | 2011 | Acta Pharmacologica Sinica2011，32，7： | 15 |
| 6 | Particle size characterization by ultrasonic attenuation spectra显示文摘This paper contributes to extracting information from signals of broadband ultrasonic attenuation spectrum for effective utilization in particle size characterization. The single particle scattering model and the coupled-phase model are formulated simultaneously, the relationship between particle size distribution and ultrasonic spectrum is established, and a convergence criterion for calculation is quantified. Demonstration inversion by the optimum regularization factor method is carried out to yield typical numerical results for discussion. With the experimental set-up developed by the Institute of Particle and Two-Phase Flow Measurement (IPTFM) at the University of Shanghai for Science and Technology, sand sediment particle size is measured by attenuation spectrum and analyzed using the above inversion algorithm and theoretical models. To validate the proposed ultrasonic spectrum particle sizing method, results are compared with those obtained by microscopy. | Mingxu Su, Minghua Xue, Xiaoshu Cai, Zhitao Shang, Feng Xu Institute of Particle and Two-Phase Flow Measurement, University of Shanghai for Science and Technology, Shanghai 200093, China | 2008 | Particuology2008，6，4： | 15 |
| 7 | miR-129-5p suppresses proliferation, migration, and induces apoptosis in pancreatic cancer cells by targeting PBX3显示文摘Pancreatic cancer(PC)is the seventh m ost frequent cause of cancer-related deaths world wide with a high mortality.MicroRNAs(miRNAs)act as im portant regulators for the developm ent of PC and participate in the progression of PC.miR-129-5p was reported to regulate the progression of tum ors,such as thyroid cancer and gastric cancer.However,the function of miR-129-5p in PC is still unclear.In this study,the down-regulation of miR-129-5p was detected in PC tissues and PC cells.miR-129-5p was overexpressed or knocked down in AsPC-1 and BxPC-3 cells.The results showed that miR-129-5p overexpression suppressed proliferation,m igration and invasion,and induced apoptosis of PC cells,whereas miR-129-5p knockdown showed opposite effects:In addition,we found that pre-B-cell leukemia hom eobox 3(PBX3)overexpression prom oted proliferation,m igration and invasion,but reduced apoptosis of PC cells.PBX3 was identified as a target of miR-129-5p by inform atics analysis and dual luciferase reporter assay.Finally,our results indicated that miR-129-5p suppressed cell proliferation and m igration by targeting PBX3.This study dem onstrated that miR-129-5p could function as a tu m o r suppressor in the progression and developm ent of PC by targeting PBX3,providing a reliable prognostic factor and a new therapeutic strategy for PC. | Zhisheng Qiu Xiaochun Wang Yuping Shi Mingxu Da | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 15 |
| 8 | Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells显示文摘瞄准: 调查位于 cepharanthine (CEP ) 的 antitumor 活动下面的分子的机制,从 Stephania cepharantha Hayata 提取的碱。 | ZanChen ChenHuang Yan-lingYang YiDing Han-qiangOu-Yang You-yiZhang MingXu | 2012 | Acta Pharmacologica Sinica2012，33，1： | 14 |
| 9 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 10 | Particle sizing in dense two-phase droplet systems by ultrasonic attenuation and velocity spectra显示文摘Size and size distribution of particles in particulate two-phase flow play an important role in a wide variety of industrial areas,while their measurement still remains a hard task till now.Ultrasonic wave as a mechanical vibration contains plenty of information about medium when it passes through.Thus the size distribution could be extracted from the measured ultrasonic attenuation and velocity spectra by means of well established models and data processing techniques.This paper contributes to the extraction of information of droplet size of a two-phase fat emulsion simultaneously from signals of broad-band ultrasonic attenuation and velocity spectra.According to the formulated single particle scattering model,the relationship between particle size distribution and ultrasonic spectrum is estab-lished.The sensitivities of ultrasonic spectra to the variation of particle size are illustrated.Distin-guishing features for attenuation and velocity spectra are summarized.Demonstration calculations of inversion by optimum regularization factor method are carried out to yield the typical numerical results for discussion.Based on the proposed inversion algorithm and theoretical model,a fat emulsion sam-ple with a volume fraction up to 20% is measured and analyzed.To validate the proposed ultrasonic spectrum particle sizing method,the results are compared to those obtained from optical measure-ment. | SU MingXu CAI XiaoShu XUE MingHua DONG LiLi XU Feng | 2009 | Science China(Technological Sciences)2009，52，6： | 11 |
| 11 | In-line imaging measurements of particle size,velocity and concentration in a particulate two-phase flow显示文摘A novel method is developed for in-line measurements of particle size, velocity and concentration in a dilute, particulate two-phase flow based on trajectory image processing. The measurement system consists of a common industrial CCD camera, an inexpensive LED light and a telecentric lens. In this work,the image pre-processing steps include stitching, illumination correction, binarization, denoising, and the elimination of unreal and defocused particles. A top-hat transformation is found to be very effective for the binarization of images with non-uniform background illumination. Particle trajectories measured within a certain exposure time are used to directly obtain particle size and velocity. The particle concentration is calculated by using the statistics of recognized particles within the field of view. We validate our method by analyzing experiments in a gas-droplet cyclone separator. This in-line image processing method can significantly reduce the measurement cost and avoid the data inversion process involved in the light scattering method. | Xiaozhen Chen Wu Zhou Xiaoshu Cai Mingxu Su Hailong Liu | 2014 | Particuology2014，12，2： | 10 |
| 12 | Optical properties of NaY(MoO4)2:Eu3+ nanophosphors prepared by molten salt method显示文摘We synthesized NaY(MoO4)2:Eu3+phosphors of different doping concentrations by a molten salt method.This facile way possesses advantages such as simple process,lower calcination temperature(350℃)and small particle size(70 nm).The crystal system is tetragonal phase and crystal lattice is body centered.The photo luminescence measurements including emission spectra,excitation spectra and fluorescence decay curves were carried out,elucidating that NaY(MoO4)2:Eu3+can be effectively excited by near UV and blue light.Moreover,it can be concluded that Eu3+energy transfer type is exchange interaction.Huang-Rhys factor and the critical energy transfer distance(Rc)were calculated to be 0.043 and 0.995 nm,respectively.Auzel’s model was used to obtain the intrinsic radiative transition lifetime of5 D0 level(τ0=0.923 ms).Furthermore,a calculation method was used to calculate refractive index n of nontransparent NaY(MoO4)2:1 mol%Eu3+phosphor,and n was obtained to be 1.86. | Lin Bai Qingyu Meng Mingxue Huo Yu Sui | 2019 | Journal of Rare Earths2019，37，12： | 8 |
| 13 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015，6，9： | 8 |
| 14 | Modeling and prediction of ultrasonic attenuations in liquid-solid dispersions containing mixed particles with Monte Carlo method显示文摘We develop a theoretical model for predicting the ultrasonic attenuation in the liquid-solid system containing mixed particles. The ultrasonic attenuation coefficient is obtained by counting the number of phonons that reach the receiver. Using the Monte Carlo method (MCM), numerical simulations were performed to predict the ultrasonic attenuations with not only a single particle type but also monodisperse and polydisperse mixed particles. The simulation results for the systems with a single particle type were compared with various standard models. The results show that they agree well at relatively low particle volume concentrations (within 10%). For systems with mixed particles, the particle volume concentrati on was found to in crease to around 10%, and the variation of the ultrasonic attenuation agai nst the mixing ratio yields a nonlinear trend. Moreover, the ultrasonic attenuation is significantly affected by particle properties. The numerical results also show that both the particle type and particle size distribution should be carefully taken into account in the dispersions with polydisperse mixed particles, where the MCM can give a more direct description of the physics of sound propagation compared with the conventional models. | Jianfei Gu Fengxian Fan Yunsi Li Huinan Yang Mingxu Su Xiaoshu Cai | 2019 | Particuology2019，17，2： | 7 |
| 15 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 16 | Polymorphisms of chemokine receptors and its ligand alleles influencing genetic suscepti-bity to HIV-1 infection in eight ethnic groups in Chinese mainland显示文摘Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15%-28.79%) and SDF1-3’A (19.10% -29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the △32 mutation in CCRS gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/△32 heterozygotes was observed in Uygurian and Mongolian populations. No A32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese | WANG Fusheng JIN lei LIU Mingxu HONG Weiguo SHI Hong LEI Zhouyun WANG Jiming DU Qingyou HOU Jing ZHANG Bing JIANG Jiandong WANG Yue LI Yueqi XU Anlong HUANG Honglian LIU Fajun | 2001 | Chinese Science Bulletin2001，46，12： | 6 |
| 17 | L-arginine administration ameliorates serum and pulmonary cytokine response after gut ischemia-reperfusion in immature rats显示文摘AIM: Small intestinal ischemia-reperfusion (IR) has been demonstrated to result in both local mucosal injury and systemic injuries. The exact role of nitric oxide (NO) in intestinal IR is unclear. We propose that NO and some other cytokines change in the reperfusion period and these changes are associated with lung injury. The aim of this study was to determine the effect of supplementing NO substrate, L-arginine (L-arg), on serum and pulmonary cytokine production during small intestinal IR in immature rats.METHODS: Immature rats underwent 60 min. of superior mesenteric artery occlusion followed by 90 min of reperfusion. L-arg (250 mg/kg) was given intravenously to the experimental group (IR+L-arg) which received L-arg after 45 min of intestinal ischemia. Serum and lung endothelin-1 (ET-1), NO, malondialdehyde (MDA), and tumor necrosis factor α (TNFα) were measured. Sham operation (SHAM) and intestinal IR (IR) groups were performed as control. The lavage fluid of the lung was collected by bronchoalveolar lavage (BAL) and white blood cells and polymorphonuclear cells (PMNs) were immediately counted to identify lung damage.RESULTS: When L-arg was given during small intestinal IR, serum NO concentration increased significantly in IR+L-arg group (162.17±42.93 μmol/L) when compared with IR group (87.57±23.17 μmol/L, t= 3.190, P = 0.008<0.01). Serum MDA reduced significantly in IR+L-arg group (8.93±1.50 nmol/L) when compared with SHAM(23.78±7.81 nmol/L, t = 3.243, P = 0.007<0.01) and IR (25.54±9.32 nmol/L, t = 3.421, P = 0.006<0.01).ET-1 level in lung tissues was significantly lower in IR+L-arg group (13.81±7.84 pg/mL) than that in SHAM(35.52±10.82 pg/mL, t = 2.571, P= 0.03<0.05) and IR(50.83±22.05 pg/mL, t = 3.025, P = 0.009<0.01) groups.MDA contents in lung tissues were significantly lower in IR+L-arg group (10.73±1.99 nmol/L) than in SHAM(16.62±2.28 nmol/L, t = 3.280, P = 0.007<0.01) and IR(21.90±4.82 nmol/L, t= 3.322, P= 0.007<0.01)groups.Serum and lung TNFα concentrations were not significantly different in three groups. NO contents in lung homogenates and white blood cell counts in BAL had no significant difference in three groups; but the percentage of PMNs in BAL was 13.50±8.92, 33.20±16.59, and 22.50±6.09 in SHAM, IR, and IR+L-arg groups, respectively.CONCLUSION: Small intestinal IR induced increases of pulmonary neutrophil infiltration in immature rats.Neutrophil infiltration in lung tissues was reduced by L-arg administration but remained higher than in SHAM group.L-arg administration during intestinal IR enhances serum NO production, reduces serum MDA and lung ET-1 and MDA levels, resulting in the improvement of systemic endothelial function. L-arg supplementation before reperfusion may act as a useful clinical adjunct in the management of intestinal IR, thus preventing the development of adult respiratory distress syndrome, even multiple organ dysfunction syndrome (MODS). | Ting-LiangFu Wen-TongZhang LanZhang FengWang YongGao MingXu | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 18 | Unsteady Flow Variability Driven by Rotor-stator Interaction at Rotor Exit显示文摘Numerical investigation of the unsteady flow variability driven by rotorstator interaction in a transonic axial compressor is performed. Two models with close and far axial gap between rotor and stator rows are studied in the simulation. Particular attention is attached to the analysis of mechanisms involved in driving rotor wake oscillation, rotor wake skewing and flow angle fluctuation at rotor exit. The results show that smaller axial gap is favorable to enhance the interaction in the region between two adjacent rows, and the fluctuation of the static pressure difference between two sides of rotor wake is improved by potential field from down stator, which is the driving force for rotor wake oscillation. The interaction between rotor and stator is weakened by increasing axial distance, rotor wake shifts to suction side of rotor blade with 5%-10% of rotor pitch, the absolute value of flow angle at rotor exit is less than that in the case of close interspace for every time step, and the fluctuation amplitude is also decreased. | ZHAO Ben YANG Ce CHEN Shan QI Mingxu ZHOU Mi | 2012 | Chinese Journal of Aeronautics2012，25，6： | 5 |
| 19 | Effect of controlled low central venous pressure on renal function in major liver resection显示文摘Objective: To investigate the effects of low central venous pressure (LVCP) on blood loss and evaluate its influ- ence on renal function in patients undergoing hepatectomy. Methods: Forty-six patients, ASA classification I–III, undergoing liver resection were randomized into LCVP group (n = 23) and control group (n = 23). In LCVP group, CVP was maintained at 2–4 mmHg and MBP above 60 mmHg during hepatectomy, while in control group hepatectomy was performed routinely without lowering CVP. Volume of blood loss during hepatectomy, volume of blood transfusion, and changes of renal functions were compared between the two groups. Results: There were no significant differences in demographics, ASA score, type of hepatectomy, duration of inflow occlusion, operation time, weight of resected liver tissues, and renal functions between the two groups. LCVP group had a significantly lower volume of total intraoperative blood loss (P < 0.01) and RBC transfusion (P < 0.05). Conclusion: Lowering the CVP to less than 5 mmHg is a simple and effective technique to reduce blood loss and blood infusion during liver resection, and has no detrimental effects on renal functions. | Yuyong Liu Mingxue Cai Shan'e Duan Xuemei Peng Yong Lai Yalan Li | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，1： | 5 |
| 20 | Development cost prediction of general aviation aircraft using combined estimation technique显示文摘Obtaining accurate development cost estimation results of general aviation aircraft is crucial for companies to adopt the best strategy in the development process.To address this problem,this paper proposes a combination of three commonly used single prediction methods.The optimal weight values of the three single prediction methods are determined by utilizing the shortest ideal point method.Ten cost datasets collected from literature are utilized for fitting and testing the combined prediction method,and the weight coefficients of the three individual prediction methods are calculated as 0.6859,0.0035 and 0.3106,respectively.The results of this study indicate that the developed method has better fitting and estimation accuracy than that of the three individual methods,with average fitting and predicting error values of 2.60%and 6.43%,respectively.Additionally,the cost data of military and civil aircraft development from literature are collected for verification.The results further confirm that the proposed method is not only superior to the single prediction methods in terms of high precision but has wider applications.More importantly,this research can provide important reference for general aviation aircraft companies in term of product cost planning and corporate sales strategies. | Xiaonan CHEN Jun HUANG Mingxu YI | 2021 | Chinese Journal of Aeronautics2021，34，4： | 4 |
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