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| 1 | Evolution of Microstructure and Mechanical Property during Long-Term Aging in Udimet 720Li显示文摘Thermal stabilities of microstructure and mechanical property have been investigated on super- alloy U72OLi, which is of great interest of application for jet engine and land-based turbine disc. The results showed that, the primary and secondary γ’?particles maintain good thermal stability at 650 and 7000C with aging time up to 3000 h, while the tertiary γ’?is apparently dependent on aging temperature and time. The tertiary γ’?particles undergo a procedure of coarsening, dissolution and eventually complete disappearance with the increasing of aging time and temper- ature. They exhibit unusual high sensibility upon aging temperature, which is attributed to the lattice misfit between the γ’?precipitates and the matrix in the alloy. The grain boundary phase M23C6 remains stable without forming of sigma phase even with aging time up to 3000 h at 700℃. Microhardness decreases apparently with increasing aging time and aging temperature. Theoretical analysis based on dislocation mechanism indicates that the change of microhardness should be attributed to the evolution of the tertiary γ’?during aging. | Lanzhang ZHOU and Valentino LUPINC CNR-TeMPE, Via R. Cozzi 53, 20125 Milano, Italy Jianting GUO Institute of Metal Research, CAS, 72 Wenhua Road, Shenyang 110016, China | 2001 | Journal of Materials Science & Technology2001，17，6： | 6 |
| 2 | L-arginine administration ameliorates serum and pulmonary cytokine response after gut ischemia-reperfusion in immature rats显示文摘AIM: Small intestinal ischemia-reperfusion (IR) has been demonstrated to result in both local mucosal injury and systemic injuries. The exact role of nitric oxide (NO) in intestinal IR is unclear. We propose that NO and some other cytokines change in the reperfusion period and these changes are associated with lung injury. The aim of this study was to determine the effect of supplementing NO substrate, L-arginine (L-arg), on serum and pulmonary cytokine production during small intestinal IR in immature rats.METHODS: Immature rats underwent 60 min. of superior mesenteric artery occlusion followed by 90 min of reperfusion. L-arg (250 mg/kg) was given intravenously to the experimental group (IR+L-arg) which received L-arg after 45 min of intestinal ischemia. Serum and lung endothelin-1 (ET-1), NO, malondialdehyde (MDA), and tumor necrosis factor α (TNFα) were measured. Sham operation (SHAM) and intestinal IR (IR) groups were performed as control. The lavage fluid of the lung was collected by bronchoalveolar lavage (BAL) and white blood cells and polymorphonuclear cells (PMNs) were immediately counted to identify lung damage.RESULTS: When L-arg was given during small intestinal IR, serum NO concentration increased significantly in IR+L-arg group (162.17±42.93 μmol/L) when compared with IR group (87.57±23.17 μmol/L, t= 3.190, P = 0.008<0.01). Serum MDA reduced significantly in IR+L-arg group (8.93±1.50 nmol/L) when compared with SHAM(23.78±7.81 nmol/L, t = 3.243, P = 0.007<0.01) and IR (25.54±9.32 nmol/L, t = 3.421, P = 0.006<0.01).ET-1 level in lung tissues was significantly lower in IR+L-arg group (13.81±7.84 pg/mL) than that in SHAM(35.52±10.82 pg/mL, t = 2.571, P= 0.03<0.05) and IR(50.83±22.05 pg/mL, t = 3.025, P = 0.009<0.01) groups.MDA contents in lung tissues were significantly lower in IR+L-arg group (10.73±1.99 nmol/L) than in SHAM(16.62±2.28 nmol/L, t = 3.280, P = 0.007<0.01) and IR(21.90±4.82 nmol/L, t= 3.322, P= 0.007<0.01)groups.Serum and lung TNFα concentrations were not significantly different in three groups. NO contents in lung homogenates and white blood cell counts in BAL had no significant difference in three groups; but the percentage of PMNs in BAL was 13.50±8.92, 33.20±16.59, and 22.50±6.09 in SHAM, IR, and IR+L-arg groups, respectively.CONCLUSION: Small intestinal IR induced increases of pulmonary neutrophil infiltration in immature rats.Neutrophil infiltration in lung tissues was reduced by L-arg administration but remained higher than in SHAM group.L-arg administration during intestinal IR enhances serum NO production, reduces serum MDA and lung ET-1 and MDA levels, resulting in the improvement of systemic endothelial function. L-arg supplementation before reperfusion may act as a useful clinical adjunct in the management of intestinal IR, thus preventing the development of adult respiratory distress syndrome, even multiple organ dysfunction syndrome (MODS). | Ting-LiangFu Wen-TongZhang LanZhang FengWang YongGao MingXu | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 3 | Wear properties of NiAl based materials | Jianting Guo Zhensheng Wang Liyuan Sheng Lanzhang Zhou Chao Yuan Zhigang Chen Li Song | 2012 | Progress in Natural Science:Materials International2012，22，5： | 3 |
| 4 | Effect of hot isostatic pressing on microstructure of cast gas-turbine vanes of K452 alloy显示文摘The effect of hot isostatic pressing(HIP) treatment on microstructure of gas-turbine vanes made of K452 alloy was investigated by OM,SEM and TEM. The results showed that HIP treatment played a great role in the porosity healing processing, where 80% of porosities were eliminated and the diameter of remnant porosities decreased to 10 μm. The healing mechanism of the porosities was consistent with existing theories of porosity closure based on vacancy diffusion. According to the result of the tensile test, the plasticity of the alloy was improved as the result of the elimination of the porosities and the improvement of dendritic segregation, while there was not an obvious improvement in the tensile strength after the programmed HIP process. In addition, HIP had a positive effect on narrowing down the dispersion of tensile properties. | Jie Li Chao Yuan Jianting Guo Jieshan Hou Lanzhang Zhou | 2014 | Progress in Natural Science:Materials International2014，24，6： | 2 |
| 5 | Correlation Between Phase Stability and Tensile Properties of the Ni-Based Superalloy MAR-M247显示文摘Phase stability and its effect on tensile properties of MAR-M247 alloy have been investigated during thermal exposure at 800–900°C for up to 10,000 h.Detailed investigations reveal that the larger secondaryγ′phase has no obvious growth,but the smaller tertiaryγ′phase obviously coarsens and the coalescence occurs during thermal exposure at 850°C and below.γ′coarsening behavior is consistent with the description of Ostwald ripening theory beforeγ′coalescence.Hf-rich blocky MC carbide shows excellent thermal stability,but Ta-rich script-type MC carbide gradually degenerates via reaction,MC+γ→M_(23)C_(6)+γ′and finally formsγ film around MC and M_(23)C_(6) carbides.With increasing thermal exposure time,the tensile strength decreases.The ductility first increases and then decreases during exposure at 800°C,but it decreases continuously at 900°C.In addition,the ductility keeps almost constant when the exposure time is longer than 5000 h. | Linxu Li Xiufang Gong Changshuai Wang Yunsheng Wu Hongyao Yu Haijun Su Lanzhang Zhou | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，6： | 2 |
| 6 | Preliminary Investigation of NiAl-TiB_2 Composite Prepared by Reaction Milling显示文摘 | Lanzhang ZHOU and Jianting GUO(Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China To whom correspondence should be addressedE-mail: lzz@imr. ac .cn ) | 1999 | Journal of Materials Science & Technology1999，15，5： | 1 |
| 7 | Sinmhaneous determination of 14/3-1actam antibiotics in cosmetic products by liquid chromatography tandem mass spectrometry method 显示文摘 | Cai Shengwu Jin Lanzhang Yah Lingqiao | 2006 | J Chromatogr B2006，，832： | 1 |
| 8 | Formation Mechanism of NiAl/TiB_2 Nanocomposite by Mechanical Alloying Elemental Powders显示文摘A NiAl/TiB2 nanocomposite is synthesized by mechanical alloying elemental powders. Upon milling for a certain time, an abrupt exothermic reaction occurs and a large amount of NiAl and TiB2 compounds form simultaneously. It is suggested that two separate chemical reactions,i.e. Ni+Al →NiAl and Ti+2B→TiB2, are involved during the exothermic reaction. Additionof Ti and B to Ni-Al system impedes the structural evolution of Ni and Al powders and delays the abrupt reaction. The final products are equilibrium phases without any metastable phases formed. This type of reaction is suggested to be suitable for alloy systems with two large heatrelease reactions. | Lanzhang ZHOU and Jianting GUO(Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 1998 | Journal of Materials Science & Technology1998，14，6： | 1 |
| 9 | Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke显示文摘 | Xian ShuangLiu Zheng GangZhang Rui LanZhang Sara R.Gregg LeiWang TohYier MichaelChopp | 2007 | J Neurosci Res2007，，10： | 1 |
| 10 | Effect of Heat Treatment on the Microstructure of Multiphase NiAl-based Alloy显示文摘合金 Ni-AI26.6-Crl3.4-Co8.1-Ti4.3-W1.3-Mo0.9 (at.pct ) 从超级合金 K44 和艾尔元素使用真空正式就职和扔的技术被制作。到这合金的调查表明拥有低融化的点和差的韧性的新阶段 Cr3Ni2 被形成,它作为沿着 NiAI 矩阵谷物边界的一个网络分布式。随后的不同答案和老化处理被执行并且导致微结构变化到各种各样的程度。当在球的 alpha-Cr 固体答案和像针的 Ni3AI 阶段的形成的在一样的处理结果以后的慢冷却时,为 20 h 的在 1250 ° C 的在答案以后的快速的冷却在标本产生宏裂缝,它在 NiAI 矩阵被嵌入。老化处理开始塑造板条的 Ni3AI 阶段和塑造珍珠的 alpha-Cr 阶段从 NiAI 矩阵猛抛,这是 comfirmed,它与这些拥有取向关系猛抛。 | Yi XIE Lanzhang ZHOU Jianting GUO Hengqiang YE | 2008 | Journal of Materials Science & Technology2008，24，2： | 1 |
| 11 | The effect of reheat treatments on recovering the creep behavior of a corrosion-resistant nickel-based superalloy显示文摘 | Hou Jieshan Zhou Lanzhang Yuan Chao | 2013 | Mater Sci and Eng A2013，260，： | 1 |
| 12 | Thermal Stability of a New Ni-Fe-Cr Base Alloy with Different Ti/Al Ratios显示文摘Influence of Ti/Al ratios on the thermal stability of a new low cost Ni-Fe-Cr base wrought alloy,designed for application at 700℃ in advanced ultra-supercritical coal-fired power plants(700℃A-USC),was investigated both experimentally and thermodynamically. After standard heat treatment,the alloys with different Ti/Al ratios had the same microstructural characteristics. However,compared with the alloys with high Ti/Al ratio,the low Ti/Al ratio can increase the γ'-solvus temperature,decrease γ' coarsening rate and reduce the temperature range of η phase precipitation. For the alloys with low Ti/Al ratio,the yield strength has no obvious decrease during long-term thermal exposure at 700 and 750℃,but after thermal exposure at 750℃ for 5000 h,the yield strength of the alloys with high Ti/Al ratio obviously decreases due to the η phase precipitation. The influence of h phase on mechanical properties is related with its size. When the h phase is small,it has no obvious influence on mechanical properties,but h phase becomes the crack initiation site with the further growth of η phase. It can be concluded that the decrease in Ti/Al ratio can improve the thermal stability to meet the requirement of 700℃ A-USC coal-fired power plants. | Changshuai Wang Tingting Wang Meilin Tan Yongan Guo Jianting Guo Lanzhang Zhou | 2015 | Journal of Materials Science & Technology2015，31，2： | 0 |
| 13 | Microstructural evolution and its influence on the impact toughness of GH984G alloy during long-term thermal exposure显示文摘The microstructure evolution and its effect on the impact toughness of a new Ni-Fe based alloy GH984 G,used in 700℃ ultra-super critical coal-fired power plant,were investigated during thermal exposure at 650℃-750℃ for up to 10,000 h.The results show that the impact toughness at room tempe rature drops rapidly at the early stage during thermal exposure at 700℃ and then has no significant change even if after exposure for 10,000 h.The significant decline of the impact toughness is attributed to the coarsening of M_(23)C_(6) carbides at grain boundaries,which weakens the grain boundary strength and leads to the aging-induced grain boundary embrittlement.The M_(23)C_(6) carbides have almost no change with further thermal exposure and the impact toughness also remains stable.Additionally,the impact toughness rises with the increase of thermal exposure temperature.The size of γ' after thermal exposure at 750℃ for10,000 h is much bigger than that at 650℃ and 700℃ for 10,000 h.There fore,the intragranular strength decreases significantly due to the transformation of the interaction between γ' and dislocation from stro ngly coupled dislocation shearing to Orowan bowing.More plastic deformation occurs within grains after thermal exposure at 750℃ for 10,000 h,which increases the impact toughness. | Yunsheng Wu Xuezhi Qin Changshuai Wang Lanzhang Zhou | 2021 | Journal of Materials Science & Technology2021，，1： | 0 |
| 14 | Development of a Nickel-base Cast Superalloy with High Strength and Superior Creep Properties显示文摘Derived from Russian alloy CHS88U, six experimental Ni-base alloys named as A to F in the Ni-Cr-Co-W-Ti-Al-Hf system are designed, evaluated and processed. One of these alloys, F, shows excellent high temperature tensile strength and ductility with superior creep rupture properties. As predicted by using modeling tools such as PHACOM and NEW PHACOMP, there is hardly the tendency for formation of topologically close-packed phase (TCP) phase in alloy F. Furthermore, through microstructural observation, it is also found that no TCP phase is formed in alloy F after long-time exposure at high temperature. So alloy F has well balance of phase stability and mechanical properties in view of application for gas turbines. It is proved that d-electron approach can be applied for design and development of nickel-base superalloys for gas turbine application. | Jieshan HOU, Jianting GUO, Lanzhang ZHOU and Zhijun LI Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2005 | Journal of Materials Science & Technology2005，21，3： | 0 |
| 15 | Increased expression of α-synuclein in different age APP transgenic mice model of Alzheimer' s disease and intervention by Chinese components显示文摘AIM To investigate the expression change of α-synuclein in the brain of different age AD-like an-imal model and to explore the pathology mechanism of α-synuclein in neural degeneration and protective effect of 2 kinds of Chinese components. METHODS A generally accepted animal model of Alzheimer' s disease-APP V717I transgenic (Tg) mouse was observed from 4 to 16 month old. The Tg mice wererandomly divided into model group(4 month, 10 month and 16 month old), Shen-wu capsule with the dose of 0.4g and 1.2g/kg/d, 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside(TSG), one of effective components in Polygonum muhiflorum, at dose of 0. 05,0.1 and 0.2g/kg/d. | LanZHANG LinLI ShunYU YingXING Cui-feiYE Yao-huaLI BiaoCHEN | 2005 | 中国药理通讯2005，22，2： | 0 |
| 16 | Effects of tetrahydroxystilbene - glucoside on Animal Models of Dementia or Brain Aging显示文摘Aim: To investigate the effects of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside(TSG) from a Chinese Medicinal Herb polygonum multiflorum on dementia or brain aging. Methods. The brain aging model of mice was developed by s. c. injection of D-galactose (50mg/kg/day) for 60 days. The Alzheimer disease (AD) model of | LinLi JinChu LiLiu LingZhao LanZhang | 2004 | 中国药理通讯2004，21，2： | 0 |
| 17 | Cornel iridoid glycoside inhibits tau hyper-phosphorylation by enhancing PP2A activity显示文摘OBJECTIVE The aim of the present study was to investigate the effect of cornel iridoid glycoside(CIG)on tau hyperphosphorylation induced by wortmannin(WT)and GF-109203X(GFX)and the underlying mechanisms.METHODS Human neuroblastoma SK-N-SH cells were pre-incubated with CIG(50,100,and 200μg·mL-1,respectively)for 24 h,and then exposed to WT 10μmol·L-1 and GFX 10μmol·L-1for 3hafter washing out CIG.Immuno-fluorescence was used to observe the microtubular cytoskeleton of the cultured cells.Western blotting was used to measure the phosphorylation level of tau protein,glycogen synthase kinase 3β(GSK-3β)and protein phosphatase 2A(PP2A).The activity of PP2 Awas detected by a biochemical assay.RESULTS Pre-incubation of CIG significantly attenuated the WT/GFX-induced tau hyperphosphorylation at the sites of Thr205,Thr212,Ser214,Thr217Ser396 and PHF-1,and improved the damage of morphology and microtubular cytoskeleton of the cells.CIG did not prevent the decrease in p-AKT-ser473 and pGSK3β-ser9 induced by WT/GFX.However,CIG significantly elevated the activity of PP2 Aby reducing the demethylation of PP2AC at Leu309 and the ratio of PME-1/LCMT in the WT/GFX-treated cells.CONCLUSION CIG obviously attenuated WT/GFX-induced tau hyper-phosphorylation at multiple AD-related sites by increasing the activity of PP2A.The mechanism may be involved in the reduced demethylation of PP2 Avia down regulating the ratio of PME/LCMT. | Cui-cuiYANG Xue-xianKUAI Ya-liLI LiZHANG LinLI LanZHANG | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
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