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| 1 | THE COMPARATIVE STUDY OF EVENT RELATED POTENTIALSIN PATIENTS WITH OBSESSIVE COMPULSIVE DISORDER,DEPRESSION AND ANXIETY显示文摘Objective:To investigate the variations of contingent negative varisations(CNV),P300 and mismatch negativity (MMN) in patients with obsessive compulsive disorder(OCD),depressiopn and anxiety.MEthods:Event-related potentials CNV,P300 and MMN were recorded in 31 patients with OCD by Nicolet SPirit Instrument,and were compared with that of 20 depression controls(DC) and 17 anxiety controls(AC)and 28 normal controls(NC),Results:A significant difference of CNV among 4 sulbject groups was found in both post-imperative negative variation(PINV) and amplitudes(M1)(P<0.01)(emergence of PINV were 45%),60%,35%,and 4% in OCD,DC,AC and NC groups respectively),Compared with NC group,DC and AC groups showed decreased M1 amplitude(P<0.01).A significant difference of P300 among 4 groups was found in both latencies(Cz/N2) and P3 and nontarget-P2 amplitudes(P<0.05-0.01),The delayed MMN latencies of OCD and DC were similar to that of P300 changes,Conclusions:CNV,P300 and MMN are useful tools for assessing the brain malfunction of OCD,DC and AC,and its clinical application are suggested.The characteristics ERPs of those patients might be useful indexes in distinguishing OCD from DC and AC patients. | XIAO Zeping, CHEN Xingshi, ZHANG Mingdao , LOU Feiying, CHEN Jue Department of Psychophysiology, Shanghai Mental Health Center, Shanghai 200030, china. | 2003 | 现代电生理学杂志2003，10，1： | 14 |
| 2 | Generation of Cenozoic intraplate basalts in the big mantle wedge under eastern Asia显示文摘The roles of subduction of the Pacific plate and the big mantle wedge(BMW) in the evolution of east Asian continental margin have attracted lots of attention in past years. This paper reviews recent progresses regarding the composition and chemical heterogeneity of the BMW beneath eastern Asia and geochemistry of Cenozoic basalts in the region, with attempts to put forward a general model accounting for the generation of intraplate magma in a BMW system. Some key points of this review are summarized in the following.(1) Cenozoic basalts from eastern China are interpreted as a mixture of high-Si melts and low-Si melts. Wherever they are from, northeast, north or south China, Cenozoic basalts share a common low-Si basalt endmember, which is characterized by high alkali, Fe_2O_3~T and TiO_2 contents, HIMU-like trace element composition and relatively low ^(206)Pb/^(204)Pb compared to classic HIMU basalts. Their Nd-Hf isotopic compositions resemble that of Pacific Mantle domain and their source is composed of carbonated eclogites and peridotites. The high-Si basalt endmember is characterized by low alkali, Fe_2O_3~T and TiO_2 contents, Indian Mantle-type Pb-Nd-Hf isotopic compositions, and a predominant garnet pyroxenitic source. High-Si basalts show isotopic provinciality, with those from North China and South China displaying EM1-type and EM2-type components, respectively, while basalts from Northeast China containing both EM1-and EM2-type components.(2) The source of Cenozoic basalts from eastern China contains abundant recycled materials, including oceanic crust and lithospheric mantle components as well as carbonate sediments and water. According to their spatial distribution and deep seismic tomography, it is inferred that the recycled components are mostly from stagnant slabs in the mantle transition zone,whereas EM1 and EM2 components are from the shallow mantle.(3) Comparison of solidi of garnet pyroxenite, carbonated eclogite and peridotite with regional geotherm constrains the initial melting depth of high-Si and low-Si basalts at <100 km and^300 km, respectively. It is suggested that the BMW under eastern Asia is vertically heterogeneous, with the upper part containing EM1 and EM2 components and isotopically resembling the Indian mantle domain, whereas the lower part containing components derived from the Pacific mantle domain. Contents of H_2O and CO_2 decrease gradually from bottom to top of the BMW.(4) Melting of the BMW to generate Cenozoic intraplate basalts is triggered by decarbonization and dehydration of the slabs stagnated in the mantle transition zone. | Yigang XU Hongyan LI Lubing HONG Liang MA Qiang MA Mingdao SUN | 2018 | Science China Earth Sciences2018，61，7： | 13 |
| 3 | Differences in P50 and prepulse inhibition of the startle reflex between male smokers and non-smokers with first episode schizophrenia without medical treatment显示文摘 | Song Lisheng Chen Xingshi Chen Meijuan Tang Yunxiang Wang Jijun Zhang Mingdao Lou Feiying Liang Jianhua Chen Chong | 2014 | Chinese Medical Journal2014，，9： | 6 |
| 4 | MOF-derived Co-MOF,O-doped carbon as trifunctional electrocatalysts to enable highly efficient Zn-air batteries and water-splitting显示文摘Development of high-efficiency non-noble electrocatalysts for oxygen reduction reaction(ORR),oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is urgently needed for high-performance Zn-air batteries and overall water splitting.Here,a facile strategy to synthesize novel Co-MOF,O-doped carbon(Co-MOF-T)based on Zn,Co-doped glucosamine and ZIF-8 by pyrolysis at temperature T was demonstrated.The prepared Co-MOF-800 showed a superior oxygen reduction reaction(ORR)activity comparable to that of commercial Pt/C catalyst.In addition,this catalyst shows great potential in the overall water splitting due to the excellent oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)activities.Based on the trifunctional activity,the primary Zn-air batteries using a Co-MOF-800 air electrode achieved a high open-circuit voltage of 1.38 V,a specific capacity of 671.6 mAh g^(-1) Zn,and a prominent peak power density of 144 mW cm^(-2).Also,the rechargeable Zn-air batteries based on CoMOF-800 air electrode could be smoothly run for 510 cycles with a low voltage gap of 0.58 V.Finally,the trifunctional Co-MOF-800 catalyst was applied to boost the electrochemical water splitting,demonstrating its promising potential as a green energy material for practical applications. | Xinde Duan Na Pan Can Sun Kexin Zhang Xukun Zhu Mingdao Zhang Li Song Hegen Zheng | 2021 | Journal of Energy Chemistry2021，30，5： | 5 |
| 5 | Luminescent metal-organic frameworks for nitro explosives detection显示文摘Metal-organic frameworks(MOFs) have been emerging as important multifunctional hybrid materials, not only due to the diversify framework architectures, but also contribute to the rich interactions among metals, ligands and guests. Nitro explosives have important influences for environmental protection and national homeland security. In this review, a brief description of luminescent MOFs is presented, accompanied by a short comment on the four types of metal-based luminescent MOFs as sensing materials for nitro explosives detection. Then the trends and challenges of luminescent MOFs as sensing materials for nitro explosives are also prospected. | Tingting Cheng Jinsong Hu Chunhui Zhou Yueming Wang Mingdao Zhang | 2016 | Science China Chemistry2016，59，8： | 4 |
| 6 | PEPT1-mediated prodrug strategy for oral delivery of peramivir显示文摘Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid ester prodrugs and seven amino acid amide prodrugs have been synthesized. The permeability of these prodrugs across Caco-2 cells were screened. Peramivr-(CH_2)_2-l-Val and Peramivir-l-Ile were of the highest permeability in ester prodrugs and amide prodrugs, respectively, and then they were selected for further studies. Glycylsarcosine(gly-sar) uptake by Caco-2 could be inbihited by Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile in a concentration-dependent manner, and the IC 50 was 1.34 ± 0.31 m M and 1.78 ± 0.48 m M, respectively. The direct uptake of Peramivir-(CH_2)_2-l-Val and Peramivirl-Ile in MDCK-PEPT1 cells were significantly higher than in MDCK mock cells, and could be markedly inhibited by gly-sar. The uptake of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile(0.01 to 50 m M) in MDCK-hPEPT1 cells conformed to Michaelis–Menten Equation. The oral bioavailability of peramivir was 65.3% and 37.3% after the oral administration of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile to rats, respectively. The oral absorption and bioactivation of Peramivir-(CH_2)_2-l-Val was rapid and extensive, and no Peramivir-(CH_2)_2-l-Val was found in plasma. Because the amide bond was relatively stable, Peramivir-l-Ile could not be totally converted to the parent drug in vivo. Peramivir-(CH_2)_2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development. The present study also corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug. | Yongbing Sun Wei Gan Mingdao Lei Wei Jiang Meng Cheng Junwei He Qi Sun Wan Liu Lvjiang Hu Yi Jin | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 7 | Effects of berberine on glucose metabolism in vitro显示文摘 | Jun Yin Renming Hu Mingdao Chen Jinfeng Tang Fengying Li Ying Yang Jialun Chen | 2002 | Metabolism2002，，11： | 2 |
| 8 | Subaqueous volcanism in the Paleo-Pacific Ocean based on Jurassic basaltic tuff and pillow basalt in the Raohe Complex,NE China显示文摘On-land records of subaqueous explosive volcanic eruptions are rarely reported.To understand this phenomenon and discuss its global significance,we studied the geochronology and geochemistry of basaltic tuff and pillow basalt in the Raohe Complex,NE China.The basaltic tuff consists of well-sorted vitreous,crystal(mostly clinopyroxene),and minor lithic fragments.It is characterized by a high Mg O(15.7–15.9%)content and zero Eu anomalies(Eu/Eu~*=99–102).The tuff erupted at 172±1 Ma based on SHRIMP zircon U-Pb dating,coeval with the previously reported age of the pillow basalt.The pillow basalt has intermediate Mg O content and weakly negative Eu anomalies(Eu/Eu~*=90–99).Based on immobile trace element discrimination,the basaltic tuff and pillow basalt belong to alkali basalt displaying an OIB-type trace element pattern,and consistent Nd isotope signatures ofε_(Nd)(t)=4.4–6.2,indicating an identical mantle source.The pillow basalt has coupled Sr-Nd isotopic values,whereas the basaltic tuff has significantly higher initial^(87)Sr/^(86)Sr values that are similar to synchronous seawater.This indicates that the elemental exchange between the mantle-derived material and seawater most likely occurred in a subaqueous explosive volcanic eruption,rather than in an effusive eruption.Detailed calculations suggest that the high efficiency of the Sr-isotope exchange between seawater and the mantle-derived material triggered by a subaqueous explosive volcanic eruption is likely one of the main reasons for the rapid decrease of the global seawater^(87)Sr/^(86)Sr value. | SUN MingDao XU YiGang CHEN HanLin | 2018 | Science China Earth Sciences2018，61，8： | 2 |
| 9 | Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes显示文摘 | Libin Zhou Xiao Wang Ying Yang Ling Wu Fengying Li Rong Zhang Guoyue Yuan Ning Wang Mingdao Chen Guang Ning | 2010 | BBA - Molecular Basis of Disease2010，，4： | 1 |
| 10 | The study on long persistence of SrAl2O4∶Eu2+显示文摘 | Li Changkuan Gao Zhiwu | 1995 | Chin J Lumin1995，16，1： | 1 |
| 11 | Emodin with PPARγ ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells显示文摘 | Ying Yang Wenbin Shang Libin Zhou Boren Jiang Hua Jin Mingdao Chen | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 12 | Analysis of three -fluid separate type heat pipe exchanger显示文摘 | Shi - Chengming Xin Mingdao Chen- Yuanguo | 1992 | Heat Recovery System and CHP1992，12，4： | 1 |
| 13 | Serum leptin levels and adiposity in adult chinese:a preliminary observation显示文摘 | Gu Weiqiong Tang Jinfeng | 1999 | Chinese Medical Journal1999，112，80： | 1 |
| 14 | Effects of berberine on glucose metabolism in vitro显示文摘 | Yin Jun Hu Renming Chen Mingdao | 2002 | Metabolism2002，51，11： | 1 |
| 15 | Ecological Characteristics of Soil Grown with Tricholoma Matsutake显示文摘A 5-year study on the soil ecological environment of matsutake (Trihcholoma Matsutake) growing areas near Changbai Mountains showed that several factors, such as climate, parent material, organism and landform, which form the soil ecosystem provided suitable ecological environment for the formation and growth of matsutake. How to improve the construction and function of the soil ecosystem in order to utilize the natural resource continuously was also studied. | XU GUANGBO FU WEIJIE WEI TIEZHENG LI GUIHUA LIANG YUNJIANG QUAN MINGDAO and YANG SHURONG(Yianbian Agricultural College, Longjing, Jinn 133400 (China)) | 1997 | Pedosphere1997，7，4： | 1 |
| 16 | Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity显示文摘 | Guoyue Yuan Libin Zhou Jinfeng Tang Ying Yang Weiqiong Gu Fengying Li Jie Hong Yanyun Gu Xiaoying Li Guang Ning Mingdao Chen | 2005 | Diabetes Research and Clinical Practice2005，，3： | 1 |
| 17 | Effects of C-reactive protein on adipokines genes expression in 3T3-L1 adipocytes显示文摘 | Guoyue Yuan Jue Jia Liangliang Di Libin Zhou Sijing Dong Jingjing Ye Dong Wang Ling Yang Jifang Wang Lianxi Li Ying Yang Chaoming Mao Mingdao Chen | 2012 | Biochemical and Biophysical Research Communications2012，，3： | 1 |
| 18 | Mental health services in Shanghai显示文摘 | Heqin Y Mingdao Z | 1990 | Hosp Community Psychiatr1990，41，1： | 1 |
| 19 | Augmentation of convective heat transfer inside tubes with three-dimensional internal extended surfaces and twisted-tape inserts 显示文摘 | Liao Qiang Xin Mingdao | 2000 | Chemical Engineering Journal2000，78，： | 1 |
| 20 | Neurological rehabilitation of stroke patients via motor imaginary-based brain-computer interface technology显示文摘The present study utilized motor imaginary-based brain-computer interface technology combined with rehabilitation training in 20 stroke patients.Results from the Berg Balance Scale and the Holden Walking Classification were significantly greater at 4 weeks after treatment (P < 0.01),which suggested that motor imaginary-based brain-computer interface technology improved balance and walking in stroke patients. | Hongyu Sun Yang Xiang Mingdao Yang | 2011 | Neural Regeneration Research2011，6，28： | 0 |
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