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您的检索式：作者名="Minglong Han"
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| 1 | miR-23b promotes cutaneous wound healing through inhibition of the inflammatory responses by targeting ASK1显示文摘Wound healing is a complicated event that develops in three overlapping phases:inflammatory, proliferative,and remodeling.MicroRNAs (miRNAs)have been proved to play an important role in the healing process of skin trauma,and alteration of specific miRNA expression during different phases may be associated with abnormal wound healing.In this study,we determined the variation of miR-23b expression after trauma in normal mice and in cultured cells exposed to lipopolysaccharide.We further demonstrated that excessive miR-23b could significantly accelerate wound healing in vivo.Up-regulation of miR-23b decreases infiltration of inflammatory cells,as evidenced by pathologic staining.Meanwhile,miR-23b could significantly inhibit the expression of pro-inflammatory cytokines,including TNF-α,IL-1β,IL-6,and Ccl2,and significantly increase antiinflammatory factor IL-10.Furthermore,miR-23b could also promote α-SMA expression in a fiber pattern and increase the expression of Col1a1 and Col3a1.Importantly,we also showed that miR- 23b could inhibit inflammation to promote wound healing by targeting apoptotic signal-regulating kinase 1 (ASK1).Notably,knockdown of ASK1 could reduce inflammation factor expression in vitro.Together,our data reveal that miR-23b is a potent therapeutic agent for cutaneous wound healing that shortens the period of inflammatory responses and promotes keratinocyte migration for the re-epithelialization of wound sites. | Hongzhi Li Xiao Han Kuiyang Zuo Li Li Jieting Liu Xiaohuan Yuan Yongchao Shen Minglong Shao Daxin Pang Yanhui Chu Binghai Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 5 |
| 2 | Transport signatures of the topological surface state induced by the size effect in superconductor β-PdBi_(2)显示文摘The superconductivity and nontrivial topological electronic state are key hallmarks of topological superconductors.Here,we focus on the transport signals of possible topological surface state in the topological superconductor candidate β-PdBi_(2) nanoflake with a thickness of 21 nm.The resistance demonstrates a semiconductor-metal transition followed by an upturned behavior as the temperature decreases.A large and unsaturated longitudinal magnetoresistance(MR),accompanied by distinct Shubnikov-de Hass oscillation in Hall resistance,is observed.An analysis of Hall resistance reveals that the carriers present the characteristics of relativistic particles with small effective mass and extremely high mobility.The angle-dependent quantum oscillations demonstrate a two-dimensional Fermi surface topology.A giant anisotropic MR as large as 98%is detected when rotating the magnetic field.These results provide the possible transport signals of a nontrivial topological electronic state,establishing a further understanding of the topological properties of the low-dimensional topological superconductor candidate β-PdBi_(2). | Ankang Zhu Zheng Chen Yuyan Han Mengcheng Zhu Huanhuan Wang Minglong Han Liang Li Xue Liu Guolin Zheng Xiangde Zhu Wenshuai Gao Mingliang Tian | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，7： | 0 |
| 3 | Formation and growth of precipitates in a Mg-7Gd-5Y-1Nd-2Zn-0.5Zr alloy aged at 200℃显示文摘Crystal structures,growth characteristics,and transformation of the precipitates in a Mg-7Gd-5Y-1Nd-2Zn-0.5Zr(wt.%)alloy aged at 200℃for various durations were investigated using transmission electron microscopy(TEM)and high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM).A detailed Mg-Gd type precipitation sequence for Mg-Gd-Y-Nd-Zn alloys was proposed as follows:supersaturated solid solution→solute clusters→zigzag GP zones+β''(I)→β'→β'+protrusions/joints→pre-β_(1)→β_(1)→β.Solute clusters formed in the early stage of aging consisted of one or more rare-earth(RE)/Zn-rich atomic columns with different configura-tions.RE/Zn-rich solute clusters grew into zigzag GP zones andβ''(I)as aging time extending.The paired-zigzag GP zones might grow up to beβ'precipitates directly.In the peak-and plat-aging stages,the number of solute clusters in the matrix decreased until they disappeared,and most existed as zigzag arrays and super hexagons.Protrusions formed at the end ofβ'at an angle of 120°,then grew into joints when two differentβ'variants encountered together.Protrusions/joints comprise zigzag arrays,super-hexagons,β'F,β''(II),β_(T),and hybrid structures rich in solute atoms,and act as catalysts for the growth of theβ'variants.Largerβ'grow by joints consumption while smallerβ'precipitates dissolve to form joints.β_(1)precipitates essentially evolve from pre-β_(1)precipitates,with four-point diamond structures formed by RE/Zn atomic substitution and atomic migration based on the originalα-Mg structure. | Zhiwei Du Yonggang Peng Hang Teng Zhong Cao Kui Zhang Minglong Ma Xiaolei Han Ting Li Cong Che Yongjun Li | 2023 | Journal of Magnesium and Alloys2023，11，7： | 0 |
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