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| 1 | CAF-induced placental growth factor facilitates neoangiogenesis in hepatocellular carcinoma显示文摘As a highly malignant tumor,hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide.In most HCC patients,the development of HCC begins with hepatitis,which is followed by fibrosis and cirrhosis before progressing to HCC.Cancer-associated fibroblasts(CAFs),which are generally believed to be derived from activated hepatic stellate cells(HSCs),are highly involved in the development of HCC through the secretion of cytokines and angiogenic factors.The results of our study showed that a considerable number of CAFs highly expressed CD90 and were enriched in HCC tissues.Bioinformatics analysis of the transcriptome of HCC tissues revealed that placental growth factor(PIGF)is significantly correlated with CD90 expression.The isolated primary CAFs and activated HSCs overexpressed PIGF and CD90.In addition,the results of gene expression profiling interactive analysis based on The Cancer Genome Atlas showed that high levels of both PIGF and CD90 are correlated with tumor angiogenesis markers(CD31,CD34,and CD105)and predict poor HCC patient prognosis.In summary,our results suggest that CAFs can generate PIGF and may provide an effective target for CAFs-reguIated neoangiogenesis in HCC. | Zhongjian Liu Mingmei Chen Rongce Zhao Yuan Huang Fei Liu Bo Li Yang Qin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 5 |
| 2 | Efficient removal for multiple pollutants via Ag_(2)O/BiOBr heterojunction:A promoted photocatalytic process by valid electron transfer pathway显示文摘Multiple pollutants including pathogenic microorganism contaminations and emerging organic contaminations(EOCs)have shown a growing threat to the environment,especially the natural waters.However,the control and removal of pathogenic microorganism contaminations and EOCs have been greatly limited since limited knowledge of their environmental behaviors.Thus,a novel and efficient photocatalyst Ag_(2)O/BiOBr heterojunction was synthesized and used for removal of multiple pollutants including Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),tetracycline and acetaminophen under visible light.The results showed that there were valid electron transfer pathways between BiOBr and Ag_(2)O,the main electron transfer direction was the BiOBr to Ag_(2)O.Photo-generated electrons were stored in Ag_(2)O and thus separation efficiency between holes and photo-generated electrons was obviously enhanced.Active oxygen species were highly produced and eventually end up with the high efficiency of removal of multiple pollutants.For Ag_(2)O/BiOBr with Ag_(2)O content at 3%(the best performance)under visible light,log decrease of E.coli was 7.16(removal efficiency was 100%)in 120 min,log decrease of S.aureus was 7.23(removal efficiency was 100%)in 160 min,C/C0 of tetracycline was 0.06 in 180 min,C/C0 of acetaminophen was 0.17 in 180 min.This work could provide a promising candidate in the actual contaminated natural waters for cleaning multiple pollutants. | Zhiruo Zhou Yanan Li Mingmei Li Yi Li Sihui Zhan | 2020 | Chinese Chemical Letters2020，31，10： | 1 |
| 3 | Kinetic studies of adsorption of Pb(Ⅱ), Cr(Ⅲ) and Cu (Ⅱ) from aqueous solution by sawdust and modified peanut husk 显示文摘 | Qin Li Jianping Zhai Wenyi Zhang Mingmei Wang Jun Zhou | 2007 | Journal of Hazardous Materials2007，141，： | 1 |
| 4 | Hydrothermal syn- thesis of Pbz SnO4 显示文摘 | Wu Mingmei Li Xiuling Shen Guoping | 1999 | Materials Research Bulletin1999，34，7： | 1 |
| 5 | Research of3S Technology in Monitoring Geological Disasters in Coal-Mining Area显示文摘 | Xue Yongan Zhang Mingmei Li Jun | 2012 | Disaster Advances2012，5，4： | 1 |
| 6 | Comparison of mercury speciation and distribution in the water column and sediments between the algal type zone and the macrophytic type zone in a hypereutrephic lake (Dianchi Lake) in Southwestern China显示文摘 | WANG Shaofeng ZHANG Mingmei LI Biao | 2012 | Science of the Total Environment2012，，： | 1 |
| 7 | Development and Research of Non⁃Stirring Conveying Device for Waste Resin in Nuclear Power Plant显示文摘Blockage in the storage and transportation of waste resin is a difficult problem in the radioactive waste treatment process of nuclear power plants.In this study,in order to solve the problems of unstable resin transport concentration and easy blockage of conveying equipment and pipelines in nuclear power plants in China,a set of non⁃stirring conveying devices is developed,and theoretical calculations,simulation analysis and experimental verification are carried out.By transporting resin using the no stirring conveying device developed in this paper,it is not only to eliminate the risk of blockage and ensure the safety of transportation,but also to adjust the concentration of conveying resin to change the transport efficiency according to the operating conditions.The effective bearing rate of waste resin storage tank can be improved,so that the comprehensive performance of waste resin storage and transportation in nuclear power plants can be greatly improved. | Jianfa Li Yongzhen Hua Mingmei Liu Rui Zhang Taishan Lou | 2023 | Journal of Harbin Institute of Technology(New Series)2023，30，3： | 0 |
| 8 | Inorganic Ultrathin 2D Photocatalysts:Modulation Strategies and Environmental/Energy Applications显示文摘CONSPECTUS:Photocatalysis technology has gained extensive attention in the past few decades due to its potential to alleviate or solve energy and environmental contamination problems.The development and design of new photocatalytic semiconductor materials with high catalytic activity has become a research hotspot in this field.In recent years,inorganic ultrathin two-dimensional(2D)semiconductor photocatalysts have shown excellent performance in photocatalytic applications due to their high specific surface area,clear atomic structure,unique electronic structure,intrinsic quantum confined electrons,and high atomic exposure ratio.When the thickness of the bulk semiconductor is decreased to the atomic level,its local atomic structure changes prominently.This is a major reason why the atomic thin 2D materials could show improved inherent properties and produce new properties that are not available in the corresponding bulk semiconductors.Furthermore,compared with the bulk photocatalysts,the surface electronic structure of inorganic ultrathin 2D materials is more sensitive and thus could be regulated more easily by surface and interfacial modification methods,leading to great optimization of photocatalytic properties.Therefore,inorganic ultrathin 2D materials not only provide an ideal reaction model for clearly revealing the relationships between surface/interface structure characteristics and photocatalytic performance but also bring new opportunities for the development of efficient catalysts to resolve energy crises and environmental problems.In this Account,we summarize our previous work on the applications of inorganic ultrathin 2D nanomaterials in the field of photocatalysis.First,we briefly introduce the classification and controlled fabrication of inorganic ultrathin 2D nanomaterials,including metal chalcogenides,bismuth-based photocatalysts,metal oxides,and metal-free materials.Then,we focus on the surface and interfacial modification strategies for effectively engineering the photocatalytic activity of 2D photocatalysts,including defect engineering,metal doping,single atom loading,and heterojunction construction.These strategies can effectively adjust the inherent physical and chemical properties of inorganic ultrathin 2D nanomaterials,change their electronic structure to improve the light absorption ability,promote the separation and migration of photogenerated electrons and holes,optimize the catalytic active sites,and even change the reaction energy barrier of the photocatalytic reaction.Additionally,we discuss the research progress of inorganic ultrathin 2D photocatalysts in hydrogen evolution,contaminant removal,and sterilization.Finally,we put forward the prospects,challenges,and novel viewpoints of feasible solutions of inorganic ultrathin 2D materials in photocatalysis applications.Overall,this Account provides in-depth insight into modulation strategies and the structure−activity relationship of inorganic ultrathin 2D materials for researchers in photocatalytic fields,which is beneficial to accelerate the practical applications of inorganic ultrathin 2D materials in the field of environment and energy. | Mingmei Li He Zhang Zhiyong Zhao Pengfei Wang Yi Li Sihui Zhan | 2023 | Accounts of Materials Research2023，4，1： | 0 |
| 9 | Ultrathin nanobelts-assembled Chinese knot-like 3D TiO2 for fast and stable lithium storage显示文摘 | Qili Wu Shiman He Xianfeng Yang Jingling Yang Gaoren Li Yuying Meng Shengfu Tong Liqiang Mai Mingmei Wu | 2018 | Nano Research2018，11，4： | 0 |
| 10 | Epidemiology, resistant pathogens, and causes of early death in cases of bloodstream infection in patients with hematological malignancies from 2012-2019显示文摘Purpose:To investigate the epidemiology,causative pathogen antibiotic susceptibility,and mortality risk factors of bloodstream infection(BSI)in patients with hematological malignancies(HMs).Methods:Single-center retrospective analysis of BSI cases in patients with HMs in a Chinese tertiary hospital from 2012-2019.Results:Among 17,796 analyzed admissions,508 BSI episodes(2.9%;95%confidence interval:2.6%-3.2%)were identified.Of 522 resulting isolates,326(62.5%)were Gram-negative,173(33.1%)were Gram-positive.The BSI incidence among patients with different HMs(severe aplastic anemia:6.7%;acute leukemia:6.2%;myelodysplastic syndrome:3.2%;multiple myeloma:1.3%;and lymphoma:1.0%)differed significantly(p<0.001).The BSI incidence was significantly higher in the hematopoietic stem cell transplantation(HSCT)group(10.2%)than in the non-HSCT group(2.5%;p<0.001).Escherichia coli(30.7%,160/522)was the most common pathogen,followed by Coagulase-negative staphylococci(19.4%,101/522)and Klebsiella pneumoniae(10.0%,52/522).,The rates of imipenem resistance for E.coli,K.pneumoniae,Pseudomonas aeruginosa,and Acinetobacter baumannii were 6.4%,15.0%,27.8%,and 79.0%,respectively.All the Gram-positive pathogens were linezolid susceptible.Three vancomycin-resistant Enterococcus species were isolated.The overall 14-day mortality was 9.8%(95%confidence interval:7.2%-12.4%).A multivariate analysis showed that HM subtype severe aplastic anemia,A.baumannii,and malignancy non-remission were independent 14-day mortality risk factors.Conclusions:Gram-negative bacteria were the most common pathogens,with E.coli as the predominant strain,causing BSIs in HM patients.A carbapenem-resistant A.baumanni with a high mortality rate in HM patients made empirical antimicrobial choice a highly challenging issue. | Meng Li Mingmei Du Honghua Li Daihong Liu Yunxi Liu | 2022 | Infectious Medicine2022，1，1： | 0 |
| 11 | Assessment of Transcatheter or Surgical Closure of Atrial Septal Defect using Interpretable Deep Keypoint Stadiometry显示文摘Automated echocardiogram interpretation with artificial intelligence(Al)has the potential to facilitate the serial diagnosis of heart defects by primary clinician.However,the fully automated and interpretable analysis pipeline for suggesting a treatment plan is largely underexplored. | Jing Wang Wanqing Xie Mingmei Cheng Qun Wu Fangyun Wang Pei Li Bo Fan Xin Zhang Binbin Wang Xiaofeng Liu | 2023 | Research2023，，2： | 0 |
| 12 | “The Development of Big Data in Guizhou Certainly Makes Sense!”显示文摘The southwest Chinese province of Guizhou is growing into a big data development hub for the new era,becoming the first province in the country to boast government data infrastructure consisting of“one cloud,one network,and one platform”for the whole province,the first root server mirror node in China’s central and western regions,and a hotspot of cloud-based business and living. | Liu Mingmei Li Luqian | 2020 | Qiu Shi2020，12，5： | 0 |
| 13 | Fabricating 3-dimensional human brown adipose microtissues for transplantation studies显示文摘Transplanting cell cultured brown adipocytes(BAs)represents a promising approach to prevent and treat obesity(OB)and its associated metabolic disorders,including type 2 diabetes mellitus(T2DM).However,transplanted BAs have a very low survival rate in vivo.The enzymatic dissociation during the harvest of fully differentiated BAs also loses significant cells.There is a critical need for novel methods that can avoid cell death during cell preparation,transplantation,and in vivo.Here,we reported that preparing BAs as injectable microtissues could overcome the problem.We found that 3D culture promoted BA differentiation and UCP-1 expression,and the optimal initial cell aggregate size was 100μm.The microtissues could be produced at large scales via 3D suspension assisted with a PEG hydrogel and could be cryopreserved.Fabricated microtissues could survive in vivo for long term.They alleviated body weight and fat gain and improved glucose tolerance and insulin sensitivity in high-fat diet(HFD)-induced OB and T2DM mice.Transplanted microtissues impacted multiple organs,secreted protein factors,and influenced the secretion of endogenous adipokines.To our best knowledge,this is the first report on fabricating human BA microtissues and showing their safety and efficacy in T2DM mice.The proposal of transplanting fabricated BA microtissues,the microtissue fabrication method,and the demonstration of efficacy in T2DM mice are all new.Our results show that engineered 3D human BA microtissues have considerable advantages in product scalability,storage,purity,safety,dosage,survival,and efficacy. | Ou Wang Li Han Haishuang Lin Mingmei Tian Shuyang Zhang Bin Duan Soonkyu Chung Chi Zhang Xiaojun Lian Yong Wang Yuguo Lei | 2023 | Bioactive Materials2023，，4： | 0 |
| 14 | Intelligent optimization method for the dynamic scheduling of hot metal ladles of one-ladle technology on ironmaking and steelmaking interface in steel plants显示文摘The one-ladle technology requires an efficient ironmaking and steelmaking interface. The scheduling of the hot metal ladle in the steel plant determines the overall operational efficiency of the interface. Considering the strong uncertainties of real-world production environments, this work studies the dynamic scheduling problem of hot metal ladles and develops a data-driven three-layer approach to solve this problem. A dynamic scheduling optimization model of the hot metal ladle operation with a minimum average turnover time as the optimization objective is also constructed. Furthermore, the intelligent perception of industrial scenes and autonomous identification of disturbances, adaptive configuration of dynamic scheduling strategies, and real-time adjustment of schedules can be realized. The upper layer generates a demand-oriented prescheduling scheme for hot metal ladles. The middle layer adaptively adjusts this scheme to obtain an executable schedule according to the actual supply–demand relationship. In the lower layer, three types of dynamic scheduling strategies are designed according to the characteristics of the dynamic disturbance in the model:real-time flexible fine-tuning, local machine adjustment, and global rescheduling. Case test using 24 h production data on a certain day during the system operation of a steel plant shows that the method and system can effectively reduce the fluctuation and operation time of the hot metal ladle and improve the stability of the ironmaking and steelmaking interface production rhythm. The data-driven dynamic scheduling strategy is feasible and effective, and the proposed method can improve the operation efficiency of hot metal ladles. | Li Zeng Zhong Zheng Xiaoyuan Lian Kai Zhang Mingmei Zhu Kaitian Zhang Chaoyue Xu Fei Wang | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，9： | 0 |
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