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| 1 | IETF softwire unicast and multicast framework for IPv6 transition显示文摘IPv6 protocol plays an important role in the next generation of Internet(NGI) . It is expected that the elegant coexistence of IPv4 and IPv6 is the key point of IPv6 transition. To solve the transition problem,we propose a mesh unicast framework and a multicast framework in this paper. We describe two reference models for the mesh unicast framework,and put forward two potential solutions for the multicast framework. A Linux-based prototype is implemented for IPv4 over IPv6 scenario and a test bed is deployed with 8 nodes on CERNET2. The deployment demon-strates the advantages of the framework. | CUI Yong XU MingWei WU JianPing LI Xing | 2008 | Science in China(Series F)2008，51，11： | 2 |
| 2 | Investigations on heat treatment of a high-speed steel roll 显示文摘 | Fu Hanguang Qu Yinhu Xing Jiandong Zhi Xiaohui Jiang Zhiqiang Li Mingwei Zhang Yi | 2008 | Journal of Materials Engineering and Performance2008，17，4： | 1 |
| 3 | Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens显示文摘Microplastics(MPs)have attracted growing attention worldwide as an increasingly prevalent environmental pollutant.In addition,chicken meat is currently the most widely consumed kind of poultry in the global market.Consumer demand for chicken is on the rise both at home and abroad.As a result,the safety of chicken raising has also received significant attention.The lungs play an essential role in the physiological activities of chickens,and they are also the most vulnerable organs.Lung injury is difficult to repair after the accumulation of contaminants,and the mortality rate is high,which brings huge economic losses to farmers.The research on the toxicity of MPs has mainly focused on the marine ecosystem,while the mechanisms of toxicity and lung damage in chickens have been poorly studied.Thus,this study explored the effects of exposure to polystyrene microplastics(PS-MPs)at various concentrations for 42 d on chicken lungs.PS-MPs could cause lung pathologies and ultrastructural abnormalities,such as endoplasmic reticulum(ER)swelling,inflammatory cell infiltration,chromatin agglutination,and plasma membrane rupture.Simultaneously,PS-MPs increased the expression of genes related to the heat shock protein family(Hsp60,Hsp70,and Hsp90),ER stress signaling(activating) transcription factor 6(ATF0),ATF4,protein kinase RNA-like ER kinase(PERK),and eukaryotic translation initiation factor 2 subunitα(eIF2a),pyroptosis-related genes(NOD)-,LRR-and pyrin domain-containing protein 3(NLRP3),apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),interleukin-1β(IL-1β),cysteinyl aspartate-specific proteinase 1(Caspasel),and gasdermin-D(GSDMD),and the inflammatory signaling pathway(nuclear factor-kB(NF-kB),inducible nitric oxide synthase(iNOS),and cyclooxygenase-2(COX-2).The above results showed that PS-MP exposure could result in lung stress,ER stress,pyroptosis,and inflammation in broilers.Our findings provide new scientific clues for further research on the mechanisms of physical health and toxicology regardingMPs. | Hongmin LU Tiantian GUO Yue ZHANG Dewang LIU Lulu HOU Chengxue MA Mingwei XING | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，3： | 0 |
| 4 | Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage显示文摘The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas exchange, respectively. However, the regulation of proximal–distal patterning at the embryonic stage of human lung development is largely unknown. Here we investigated the early lung development of human embryos at weeks 4–8 post fertilization (Carnegie stages 12–21) using single-cell RNA sequencing, and obtained a transcriptomic atlas of 169,686 cells. We observed discernible gene expression patterns of proximal and distal epithelia at week 4, upon the initiation of lung organogenesis. Moreover, we identified novel transcriptional regulators of the patterning of proximal (e.g., THRB and EGR3) and distal (e.g., ETV1 and SOX6) epithelia. Further dissection revealed various stromal cell populations, including an early-embryonic BDNF+ population, providing a proximal–distal patterning niche with spatial specificity. In addition, we elucidated the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development. Together, our study expands the scope of human lung developmental biology at early embryonic stages. The discovery of intrinsic transcriptional regulators and novel niche providers deepens the understanding of epithelial proximal–distal patterning in human lung development, opening up new avenues for regenerative medicine. | Shangtao Cao Huijian Feng Hongyan Yi Mengjie Pan Lihui Lin Yao Santo Zhang Ziyu Feng Weifang Liang Baomei Cai Qi Li Zhi Xiong Qingmei Shen Minjing Ke Xing Zhao Huilin Chen Qina He Mingwei Min Quanyou Cai He Liu Jie Wang Duanqing Pei Jiekai Chen Yanlin Ma | 2023 | Cell Research2023，33，6： | 0 |
| 5 | Fast response CdS-CdSxTe(1-x)-CdTe core-shell nanobelt photodetector显示文摘Quasi-one-dimensional semiconductor nanostructure-based photodetectors show high sensitivity but suffer from slow response speed due to surface reaction. Here, we report a fast-response CdSCdS_xTe(1-x)-Cd Te core-shell nanobelt photodetector with a rise time of 11μs, which is the fastest among Cd S based photodetectors reported previously. The improved response speed is ascribed to the suppressed possibilities of surface reaction resulting from the core-shell structure and heterojunction among the CdS, CdS_xTe(1-x)and CdTe. The measured response spectrum of CdS-CdS_xTe(1-x)-CdTe core-shell nanobelt photodetector covers a wide range from 355 to 785 nm. Moreover, high responsivity(1,520 A/W)and large 3 dB bandwidth(~22.9 kHz) are obtained along with the fast response. The high performance in responsivity, sensitivity, spectral response and photoresponse speed makes this device a promising candidate for practical application in optical sensing, communication and imaging. | Mingwei Tang Pengfei Xu Zhong Wen Xing Chen Chenlei Pang Xuechu Xu Chao Meng Xiaowei Liu He Tian Nagarajan Raghavan Qing Yang | 2018 | Science Bulletin2018，63，17： | 0 |
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